Controlling hair follicle signaling pathways through polyubiquitination

Journal of Investigative Dermatology

Volumn 128, Issue 5, 2008, Pages 1081-1087

  Huntzicker, Erik G ^a,b   Oro, Anthony E ^a  

^a STANFORD UNIVERSITY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; GLYCOGEN SYNTHASE KINASE 3BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR; UBIQUITIN;

CELLULAR DISTRIBUTION; CONFERENCE PAPER; HAIR FOLLICLE; HUMAN; KERATINOCYTE; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGENERATION; UBIQUITINATION;

EID: 42149108455     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/sj.jid.5700957     Document Type: Conference Paper

References (57)

1. Bhatia N, Thiyagarajan S, Elcheva I, Saleem M, Dlugosz A, Mukhtar H et al. (2006) Gli2 is targeted for ubiquitination and degradation by beta-TrCP ubiquitin ligase. J Biol Chem 281:19320-6
2. Bignell GR, Warren W, Seal S, Takahashi M, Rapley E, Barfoot R et al. (2000) Identification of the familial cylindromatosis tumour-suppressor gene. Nat Genet 25:160-5
3. Botchkarev VA, Fessing MY (2005) Edar signaling in the control of hair follicle development. J Investig Dermatol Symp Proc 10:247-51
4. Brummelkamp TR, Nijman SMB, Dirac AMG, Bernards R (2003) Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-[kappa]B. Nature 424:797-801
5. Callahan CA, Oro AE (2001) Monstrous attempts at adnexogenesis: regulating hair follicle progenitors through Sonic hedgehog signaling. Curr Opin Genet Dev 11:541-6
6. Chan EF, Gat U, McNiff JM, Fuchs E (1999) A common human skin tumour is caused by activating mutations in beta-catenin. Nat Genet 21:410-3
7. Chuong CM. Molecular Basis of Epithelial Appendage Morphogenesis. Austin: R.G. Landes, 1998
8. Chuong CM, Wu P, Plikus M, Jiang TX, Bruce Widelitz R (2006) Engineering stem cells into organs: topobiological transformations demonstrated by beak, feather, and other ectodermal organ morphogenesis. Curr Top Dev Biol 72:237-74
9. Cui CY, Durmowicz M, Ottolenghi C, Hashimoto T, Griggs B, Srivastava AK et al. (2003) Inducible mEDA-A1 transgene mediates sebaceous gland hyperplasia and differential formation of two types of mouse hair follicles. Hum Mol Genet 12:2931-40
10. Dajee M, Lazarov M, Zhang JY, Cai T, Green CL, Russell AJ et al. (2003) NF-[kappa]B blockade and oncogenic Ras trigger invasive human epidermal neoplasia. Nature 421:639-43
11. Dennis AP, O'Malley BW (2005) Rush hour at the promoter: how the ubiquitin-proteasome pathway polices the traffic flow of nuclear receptor-dependent transcription. J Steroid Biochem Mol Biol 93:139-51
12. Dhananjayan SC, Ismail A, Nawaz Z (2005) Ubiquitin and control of transcription. Essays Biochem 41:69-80
13. Di Marcotullio L, Ferretti E, Greco A, De Smaele E, Po A, Sico MA et al. (2006) Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination. Nat Cell Biol 8:1415-23
14. Fuchs E, Tumbar T, Guasch G (2004) Socializing with the neighbors: stem cells and their niche. Cell 116:769-78
15. Ghosh S, Karin M (2002) Missing Pieces in the NF-[kappa]B Puzzle. Cell 109:S81-96
16. Gumbiner B (1992) Epithelial Morphogenesis. Cell 69:385-7
17. Han G, Li AG, Liang YY, Owens P, He W, Lu S et al. (2006) Smad7-induced beta-catenin degradation alters epidermal appendage development. Dev Cell 11:301-12
18. Hart M, Concordet JP, Lassot I, Albert I, del los Santos R, Durand H et al. (1999) The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell. Curr Biol 9:207-10
19. Hart MJ, de los Santos R, Albert IN, Rubinfeld B, Polakis P (1998) Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta. Curr Biol 8:573-81
20. Headon DJ, Overbeek PA (1999) Involvement of a novel Tnf receptor homologue in hair follicle induction. Nat Genet 22:370-4
21. Huelsken J, Vogel R, Erdmann B, Cotsarelis G, Birchmeier W (2001) beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell 105: 533-45
22. Huntzicker EG, Estay IS, Zhen H, Lokteva LA, Jackson PK, Oro AE (2006) Dual degradation signals control Gli protein stability and tumor formation. Genes Dev 20:276-81
23. Kajino Y, Yamaguchi A, Hashimoto N, Matsuura A, Sato N, Kikuchi K (2001) Beta-Catenin gene mutation in human hair follicle-related tumors. Pathol Int 51:543-8
24. Karin M, Ben-Neriah Y (2000) Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu Rev Immunol 18: 621-63
25. Kavsak P, Rasmussen RK, Causing CG, Bonni S, Zhu H, Thomsen GH et al. (2000) Smad7 Binds to Smurf2 to Form an E3 Ubiquitin Ligase that Targets the TGF[beta] Receptor for Degradation. Mol Cell 6:1365-75
26. Kent D, Bush EW, Hooper JE (2006) Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus. Development 133:2001-10
27. Kovalenko A, Chable-Bessia C, Cantarella G, Israel A, Wallach D, Courtois G (2003) The tumour suppressor CYLD negatively regulates NF-[kappa]B signalling by deubiquitination. Nature 424:801-5
28. Lazar AJF, Calonje E, Grayson W, Dei Tos AP, Mihm MC, Redston M et al. (2005) Pilomatrix carcinomas contain mutations in CTNNB1, the gene encoding Beta;-catenin. J Cutan Pathol 32:148-57
29. Levy V, Lindon C, Harfe BD, Morgan BA (2005) Distinct stem cell populations regenerate the follicle and interfollicular epidermis. Dev Cell 9:855-61
30. Li Z, Wang D, Messing EM, Wu G (2005) VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1alpha. EMBO R 6:373-8
31. Liu J, Stevens J, Rote CA, Yost HJ, Hu Y, Neufeld KL et al. (2001) Siah-1 mediates a novel [beta]-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein. Mol Cell 7:927-36
32. Lo RS, Massague J (1999) Ubiquitin-dependent degradation of TGF-beta-activated smad2. Nat Cell Biol 1:472-8
33. Matsuzawa S-i, Reed JC (2001) Siah-1, SIP, and Ebi collaborate in a novel pathway for [beta]-catenin degradation linked to p53 responses. Mol Cell 7:915-26
34. McGill MA, McGlade CJ (2003) Mammalian Numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain. J Biol Chem 278:23196-203
35. Moreno-Bueno G, Gamallo C, Perez-Gallego L, Contreras F, Palacios J (2001) Beta-catenin expression in pilomatrixomas. Relationship with beta-catenin gene mutations and comparison with beta-catenin expression in normal hair follicles. Br J Dermatol 145: 576-81
36. Mou C, Jackson B, Schneider P, Overbeek PA, Headon DJ (2006) Generation of the primary hair follicle pattern. Proc Natl Acad Sci USA 103:9075-80
37. Mukhopadhyay D, Riezman H (2007) Proteasome-independent functions of ubiquitin in endocytosis and signaling. Science 315:201-5
38. Oro AE, Higgins K (2003) Hair cycle regulation of Hedgehog signal reception. Dev Biol 255:238-48
39. Pan Y, Bai CB, Joyner AL, Wang B (2006) Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. Mol Cell Biol 26:3365-77
40. Pickart CM, Eddins MJ (2004) Ubiquitin: structures, functions, mechanisms. Biochim Biophys Acta 1695:55-72
41. Rechsteiner M (1987) Ubiquitin-mediated pathways for intracellular proteolysis. Annu Rev Cell Biol 3:1-30
42. Reinstein E, Ciechanover A (2006) Narrative review: protein degradation and human diseases: the ubiquitin connection. Ann Intern Med 145:676-84
43. Salic A, Lee E, Mayer L, Kirschner MW (2000) Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts. Mol Cell 5:523-32
44. Silva-Vargas V, Lo Celso C, Giangreco A, Ofstad T, Prowse DM, Braun KM et al. (2005) [beta]-Catenin and hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells. Dev Cell 9:121-31
45. St-Jacques B, Dassule HR, Karavanova I, Botchkarev VA, Li J, Danielian PS et al. (1998) Sonic hedgehog signaling is essential for hair development. Curr Biol 8:1058-69
46. Takahashi M, Rapley E, Biggs PJ, Lakhani SR, Cooke D, Hansen J et al. (2000) Linkage and LOH studies in 19 cylindromatosis families show no evidence of genetic heterogeneity and refine the CYLD locus on chromosome 16q12-q13. Hum Genet 106:58-65
47. Tempé D, Casas M, Karaz S, Blanchet-Tournier M-F, Concordet J-P (2006) Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP. Mol Cell Biol 26:4316-26
48. Trompouki E, Hatzivassiliou E, Tsichritzis T, Farmer H, Ashworth A, Mosialos G (2003) CYLD is a deubiquitinating enzyme that negatively regulates NF-[kappa]B activation by TNFR family members. Nature 424:793-6
49. Van Mater D, Kolligs FT, Dlugosz AA, Fearon ER (2003) Transient activation of beta-catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice. Genes Dev 17:1219-24
50. Varadan R, Assfalg M, Haririnia A, Raasi S, Pickart C, Fushman D (2004) Solution conformation of Lys63-linked Di-ubiquitin chain provides clues to functional diversity of polyubiquitin signaling. J Biol Chem 279:7055-63
51. Wang B, Li Y (2006) Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing. Proc Natl Acad Sci USA 103:33-8
52. Wang LC, Liu Z-Y, Gambardella L, Delacour A, Shapiro R, Yang J et al. (2000) Conditional disruption of hedgehog signaling pathway defines its critical role in hair development and regeneration. J Invest Dermatol 114: 901-8
53. Watt F, Hogan B (2000) Out of Eden: stem cells and their niches. Science 287:1427-30
54. Weis WI, Nelson WJ (2006) Re-solving the Cadherin-Catenin-Actin Conundrum. J Biol Chem 281:35593-7
55. Wu C-J, Conze DB, Li T, Srinivasula SM, Ashwell JD (2006) Sensing of Lys 63-linked poly-ubiquitination by NEMO is a key event in NF-[kappa]B activation. Nat Cell Biol 8: 398-406
56. Zhang D, Zaugg K, Mak TW, Elledge SJ (2006a) A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. Cell 126:529-42
57. Zhang Q, Zhang L, Wang B, Ou CY, Chien CT, Jiang J (2006b) A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor. Dev Cell 10:719-29