Effects of cytokines on microglial phenotypes and astroglial coupling in an inflammatory coculture model

GLIA

Volumn 52, Issue 2, 2005, Pages 85-97

  Hinkerohe, Daniel ^a   Smikalla, Dirk ^a   Haghikia, Aiden ^a   Heupel, Katharina ^a   Haase, Claus G ^a   Dermietzel, Rolf ^a   Faustmann, Pedro M ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Astroglia; Cytokines; Gap junction; Inflammation; Microglia

Indexed keywords

BETA1 INTERFERON; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 6; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; EVALUATION; GAP JUNCTION; MACROGLIA; MEMBRANE DEPOLARIZATION; MICROGLIA; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT;

ANIMALS; ASTROCYTES; CELL COMMUNICATION; COCULTURE TECHNIQUES; CONNEXIN 43; CYTOKINES; ELECTROPHYSIOLOGY; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; INFLAMMATION; INTERFERON TYPE I, RECOMBINANT; MALE; MEMBRANE POTENTIALS; MICROGLIA; PHENOTYPE; RATS; RATS, WISTAR; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 27844512920     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/glia.20223     Document Type: Article

References (69)

1. Ahmed S, Tsuchiya T. 2004. Novel mechanism of tumorigenesis: increased transforming growth factor-beta 1 suppresses the expression of connexin 43 in BALB/cJ mice after implantation of poly-L-lactic acid. J Biomed Mater Res 70A:335-340.
2. Aloisi F. 2001. Immune function of microglia. Glia 36:165-179.
3. Aloisi F, Penna G, Cerase J, Menendez Iglesias B, Adorini L. 1997. IL-12 production by central nervous system microglia is inhibited by astrocytes. J Immunol 159:1604-1612.
4. Banati RB, Gehrmann J, Schubert P, Kreutzberg GW. 1993. Cytotoxicity of microglia. Glia 7:111-118.
5. Barres BA. 1991. New roles for glia. J Neurosci 11:3685-3694.
6. Basu A, Krady JK, Enterline JR, Levison SW. 2002. Transforming growth factor betal prevents IL-1beta-induced microglial activation, whereas TNFalpha- and IL-6-stimulated activation are not antagonized. Glia 40:109-120.
7. Bordey A, Sontheimer H. 1998. Properties of human glial cells associated with epileptic seizure foci. Epilepsy Res 32:286-303.
8. Brod SA, Marshall GD Jr, Henninger EM, Sriram S, Khan M, Wolinsky JS. 1996. Interferon-beta 1b treatment decreases tumor necrosis factor-alpha and increases interleukin-6 production in multiple sclerosis. Neurology 46:1633-168.
9. Brosnan CF, Scemes E, Spray DC. 2001. Cytokine regulation of gap junction connectivity: an open-and-shut case or changing partners at the Nexus? Am J Pathol 158:1565-1569.
10. Bruzzone R, White TW, Paul DL. 1996. Connections with connexins: the molecular basis of direct intercellular signaling. Eur J Biochem 238:1-27.
11. Cannella B, Raine CS. 1995. The adhesion molecule and cytokine profile of multiple sclerosis lesions. Ann Neurol 37:424-435.
12. Chabot S, Williams G, Yong VW. 1997. Microglial production of TNF-alpha is induced by activated T lymphocytes. Involvement of VLA-4 and inhibition by interferonbeta-1b. J Clin Invest 100:604-612.
13. +-induced increase in Gap junctional communication between mouse spinal cord astrocytes. J Neurosci 21:6635-6643.
14. Dermietzel R, Hertberg EL, Kessler JA, Spray DC. 1991. Gap junctions between cultured astrocytes: immunocytochemical, molecular, and electrophysiological analysis. J Neurosci 11:1421-1432.
15. Dermietzel R, Spray DC. 1998. From neuro-glue ("Nervenkitt") to glia: a prologue. Glia 24:1-7.
16. DeWitt DA, Perry G, Cohen M, Doller C, Silver J. 1998. Astrocytes regulate microglial phagocytosis of senile plaque cores of Alzheimer's disease. Exp Neurol 149:329-340.
17. Dickson DW, Lee SC, Mattiace LA, Yen SH, Brosnan C. 1993. Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease. Glia 7:75-83.
18. Dijkstra CD, Dopp EA, Joling P, Kraal G. 1985. The heterogeneity of mononuclear phagocytes in lymphoid organs: distinct macrophage subpopulations in the rat recognized by monoclonal antibodies ED1, ED2 and ED3. Immunology 54:589-599.
19. Dinarello CA. 1991. The proinflammatory cytokines interleukin-1 and tumor necrosis factor and treatment of the septic shock syndrome. J Infect Dis 163:1177-1184.
20. Duffy HS, John GR, Lee SC, Brosnan CF, Spray DC. 2000. Reciprocal regulation of the junctional proteins claudin-1 and connexin43 by interleukin-1beta in primary human fetal astrocytes. J Neurosci 20:RC114.
21. + concentration. J Neurochem 62:489-495.
22. Eugenin EA, Eckardt D, Theis M, Willecke K, Bennett MV, Saez JC. 2001. Microglia at brain stab wounds express connexin 43 and in vitro form functional gap junctions after treatment with interferon-gamma and tumor necrosis factor-alpha. Proc Natl Acad Sci USA 98:4190-415.
23. Faustmann PM, Haase CG, Romberg S, Hinkerohe D, Szlachta D, Smikalla D, Krause D, Dermietzel R. 2003. Microglia activation influences dye coupling and Cx43 expression of the astrocytic network. Glia 42:101-108.
24. Fernandez-Cobo M, Gingalewski C, Drujan D, De Maio A. 1999. Down-regulation of connexin 43 gene expression in rat heart during inflammation. The role of tumour necrosis factor. Cytokine 11:216-224.
25. Flott B, Seifert W. 1991. Characterization of glutamate uptake systems in astrocyte primary cultures from rat brain. Glia 4:293-304.
26. Frantseva MV, Kokarovtseva L, Naus CG, Carlen PL, MacFabe D, Perez Velazquez JL. 2002. Specific gap junctions enhance the neuronal vulnerability to brain traumatic injury. J Neurosci 22:644-653.
27. Frantseva MV, Kokarovtseva L, Perez Velazquez JL. 2002. Ischemia-induced brain damage depends on specific gap-junctional coupling. J Cereb Blood Flow Metab 22:453-462.
28. Giaume C, Fromaget C, el Aoumari A, Cordier J, Glowinski J, Gros D. 1991. Gap junctions in cultured astrocytes: single-channel currents and characterization of channel-forming protein. Neuron 6:133-143.
29. Haase CG, Faustmann PM. 2004. Benign multiple sclerosis is characterized by a stable neuroimmunologic network. Neuroimmunomodulation 11:273-277.
30. Hailer NP, Heppner FL, Haas D, Nitsch R. 1997. Fluorescent dye prelabelled microglial cells migrate into organotypic hippocampal slice cultures and ramify. Eur J Neurosci 9:863-866.
31. Hailer NP, Heppner FL, Haas D, Nitsch R. 1998. Astrocytic factors deactivate antigen presenting cells that invade the central nervous system. Brain Pathol 8:459-474.
32. Hauser SL, Doolittle TH, Lincoln R, Brown RH, Dinarello CA. 1990. Cytokine accumulations in CSF of multiple sclerosis patients: frequent detection of interleukin-1 and tumor necrosis factor but not interleukin-6. Neurology 40:1735-1739.
33. Hinterkeuser S, Schroder W, Hager G, Seifert G, Blumcke I, Elger CE, Schramm J, Steinhauser C. 2000. Astrocytes in the hippocampus of patients with temporal lobe epilepsy display changes in potassium conductances. Eur J Neurosci 12:2087-2096.
34. Hofer A, Saez JC, Chang CC, Trosko JE, Spray DC, Dermietzel R. 1996. C-erbB2/neu transfection induces gap junctional communication incompetence in glial cells. J Neurosci 16:4311-4321.
35. Hofman FM, Hinton DR, Johnson K, Merrill JE. 1989. Tumor necrosis factor identified in multiple sclerosis brain. J Exp Med 170:607-612.
36. John GR, Scemes E, Suadicani SO, Liu JS, Charles PC, Lee SC, Spray DC, Brosnan CF. 1999. IL-1beta differentially regulates calcium wave propagation between primary human fetal astrocytes via pathways involving P2 receptors and gap junction channels. Proc Natl Acad Sci USA 96:11613-11618.
37. Khoury SJ, Hancock WW, Weiner HL. 1992. Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain. J Exp Med 176:1355-1364.
38. + in primary astrocyte cultures. J Neurosci 9:1141-1149.
39. + conductance. NeuroReport 9:1375-1378.
40. Kreutzberg GW. 1996. Microglia: a sensor for pathological events in the CNS. Trends Neurosci 19:312-318.
41. Ladage K, Hinkerohe D, Smikalla D, Dermietzel R, Faustmann PM. 2004. Levitiracetam normalises Connexin 43 expression and intercellular communication in rat primary astrocytes. J Neurol 251:P508.
42. Larrick JW, Wright SC. 1990. Cytotoxic mechanism of tumor necrosis factor-alpha. FASEB J 4:3215-3223.
43. Larson DM, Wrobleski MJ, Sagar GD, Westphale EM, Beyer EC. 1997. Differential regulation of connexin43 and connexin37 in endothelial cells by cell density, growth, and TGF-betal. Am J Physiol 272(2 Pt 1):C405-415.
44. Lau AF, Hatch-Pigott V, Crow DS. 1991. Evidence that heart connexin43 is a phosphoprotein. J Mol Cell Cardiol 23:659-663.
45. Ledeboer A, Breve JJ, Poole S, Tilders FJ, Van Dam AM. 2000. Interleukin-10, interleukin-4, and transforming growth factor-beta differentially regulate lipopolysaccharide-induced production of pro-inflammatory cytokines and nitric oxide in co-cultures of rat astroglial and microglial cells. Glia 30:134-142.
46. Lin JH, Weigel H, Cotrina ML, Liu S, Bueno E, Hansen AJ, Hansen TW, Goldman S, Nedergaard M. 1998. Gap-junction-mediated propagation and amplification of cell injury. Nat Neurosci 1:494-500.
47. Lu HT, Riley JL, Babcock GT, Huston M, Stark GR, Boss JM, Ransohoff RM. 1995. Interferon (IFN) beta acts downstream of IFN-gamma-induced class II transactivator messenger RNA accumulation to block major histocompatibility complex class II gene expression and requires the 48-kD DNA-binding protein, ISGFS-gamma. J Exp Med 182:1517-1525.
48. Lux HD, Heinemann U, Dietzel I. 1986. Ionic changes and alterations in the size of the extracellular space during epileptic activity. Adv Neurol 44:619-639.
49. McCormack PL, Scott LJ. 2004. Interferon-beta-1b: a review of its use in relapsing-remitting and secondary progressive multiple sclerosis. CNS Drugs 18:521-546.
50. McGeer PL, Kawamata T, Walker DG, Akiyama H, Tooyama I, McGeer EG. 1993. Microglia in degenerative neurological disease. Glia 7:84-92.
51. Merrill JE, Benveniste EN. 1996. Cytokines in inflammatory brain lesions: helpful and harmful. Trends Neurosci 19:331-338.
52. Moreau T, Coles A, Wing M, Isaacs J, Hale G, Waldmann H, Compston A. 1996. Transient increase in symptoms associated with cytokine release in patients with multiple sclerosis. Brain 119 (Pt 1):225-237.
53. Nagy JI, Li WE. 2000. A brain slice model for in vitro analyses of astrocytic gap junction and connexin43 regulation: actions of ischemia, glutamate and elevated potassium. Eur J Neurosci 12:4567-4572.
54. Ossege LM, Sindern E, Voss B, Malin JP. 1998. Corticosteroids induce expression of transforming-growth-factor-betal mRNA in peripheral blood mononuclear cells of patients with multiple sclerosis. J Neuroimmunol 84:1-6.
55. Ossege LM, Sindern E, Voss B, Malin JP. 1999. Immunomodulatory effects of IFNbeta-1b on the mRNA-expression of TGFbeta-1 and TNFalpha in vitro. Immunopharmacology 43:39-46.
56. Pearson VL, Rothwell NJ, Toulmond S. 1999. Excitotoxic brain damage in the rat induces interleukin-1beta protein in microglia and astrocytes: correlation with the progression of cell death. Glia 25:311-323.
57. Petereit HF, Richter N, Pukrop R, Bamborschke S. 2000. Interferon gamma production in blood lymphocytes correlates with disability score in multiple sclerosis patients. Mult Scler 6:19-23.
58. Polman CH, Dijkstra CD, Sminia T, Koetsier JC. 1986. Immunohistological analysis of macrophages in the central nervous system of Lewis rats with acute experimental allergic encephalomyelitis. J Neuroimmunol 11:215-222.
59. Porrini AM, Reder AT. 1994. IFN-gamma, IFN-beta, and PGE1 affect monokine secretion: relevance to monocyte activation in multiple sclerosis. Cell Immunol 157:428-438.
60. Porrini AM, Gambi D, Reder AT. 1995. Interferon effects on interleukin-10 secretion. Mononuclear cell response to interleukin-10 is normal in multiple sclerosis patients. J Neuroimmunol 61:27-34.
61. Rawanduzy A, Hansen A, Hansen TW, Nedergaard M. 1997. Effective reduction of infarct volume by gap junction blockade in a rodent model of stroke. J Neurosurg 87:916-920.
62. Reuss B, Unsicker K. 1998. Regulation of gap junction communication by growth factors from non-neural cells to astroglia: a brief review. Glia 24:32-38.
63. Robe PA, Register B, Merville MP, Bours V. 2000. Growth regulation of astrocytes and C6 cells by TGFbeta1: correlation with gap junctions. NeuroReport 11:2837-2841.
64. Rouach N, Calvo CF, Glowinski J, Giaume C. 2002. Brain macrophages inhibit gap junctional communication and downregulate connexin 43 expression in cultured astrocytes. Eur J Neurosci 15:403-407.
65. Rudick RA, Ransohoff RM, Peppler R, VanderBrug Medendorp S, Lehmann P, Alam J. 1996. Interferon beta induces interleukin-10 expression: relevance to multiple sclerosis. Ann Neurol 40:618-627.
66. + channel expression in microglia via distinct signalling pathways. Eur J Neurosci 14:463-473.
67. Soroceanu L, Manning TJ Jr, Sontheimer H. 2001. Reduced expression of connexin-43 and functional gap junction coupling in human gliomas. Glia 33:107-117.
68. Stelmasiak Z, Koziol-Montewka M, Dobosz B, Rejdak K. 2001. IL-6 and sIL-6R concentration in the cerebrospinal fluid and serum of MS patients. Med Sci Monit 7:914-918.
69. Stoll G, Jander S, Schroeter M. 1998. Inflammation and glial responses in ischemic brain lesions. Prog Neurobiol 56:149-171.