GYKI-47261, a new AMPA [2-amino-3-(3-hydroxymethylisoxazole-4-yl)propionic acid] antagonist, is a CYP2E1 inducer

Drug Metabolism and Disposition

Volumn 31, Issue 11, 2003, Pages 1310-1314

  Tamási, Viola ^b   Hazai, Eszter ^b   Porsmyr Palmertz, Margareta ^c   Ingelman Sundberg, Magnus ^c   Vereczkey, László ^b   Monostory, Katalin ^a,b  

^a Hungarian Academy of Sciences ^*  (Hungary)

^b CHEMICAL RESEARCH CENTER   (Hungary)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

2 PROPANOL; 7 ETHOXYCOUMARIN; ACETONE; ALCOHOL; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMINO ACID RECEPTOR BLOCKING AGENT; AMPA RECEPTOR ANTAGONIST; BENZODIAZEPINE DERIVATIVE; CHLORZOXAZONE; CYTOCHROME P450 2E1; DIMETHYL SULFOXIDE; ENZYME INDUCING AGENT; GYKI 47261; IMIDAZOLE; MESSENGER RNA; PYRAZOLE; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CHEMISTRY; CONTROLLED STUDY; DEALKYLATION; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME MECHANISM; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROXYLATION; IN VITRO STUDY; LIVER CELL; MALE; METABOLISM; MOLECULE; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN STABILITY; RAT; RAT STRAIN;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; BENZODIAZEPINES; CYTOCHROME P-450 CYP2E1; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; EXCITATORY AMINO ACID ANTAGONISTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATOCYTES; HUMANS; MALE; RATS; RATS, WISTAR;

ANIMALIA;

EID: 0142212160     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.31.11.1310     Document Type: Article

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