Red wine increases the expression of human endothelial nitric oxide synthase: A mechanism that may contribute to its beneficial cardiovascular effects

Journal of the American College of Cardiology

Volumn 41, Issue 3, 2003, Pages 471-478

  Wallerath, Thomas ^a   Poleo, Daniela ^a   Li, Huige ^a   Förstermann, Ulrich ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; NITRIC OXIDE SYNTHASE;

ALCOHOL CONSUMPTION; ARTICLE; CARDIOVASCULAR SYSTEM; ENDOTHELIUM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RED WINE; REGULATORY MECHANISM; RNA STABILITY; WESTERN BLOTTING; WINE;

EID: 0037419818     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-1097(02)02826-7     Document Type: Article

References (35)

1. Gronbaek M, Deis A, Sorensen TI, Becker U, Schnohr P, Jensen G. Mortality associated with moderate intakes of wine, beer, or spirits. BMJ 1995;310:1165-9.
2. Gronbaek M, Sorensen TI. Alcohol consumption and risk of coronary heart disease. Studies suggest that wine has additional effect to that of ethanol. BMJ 1996;313:365.
3. St Leger AS, Cochrane AL, Moore F. Factors associated with cardiac mortality in developed countries with particular reference to the consumption of wine. Lancet 1979;1:1017-20.
4. German JB, Walzem RL. The health benefits of wine. Annu Rev Nutr 2000;20:561-93.
5. Langer RD, Criqui MH, Reed DM. Lipoproteins and blood pressure as biological pathways for effect of moderate alcohol consumption on coronary heart disease. Circulation 1992;85:910-5.
6. Rimm EB, Klatsky A, Grobbee D, Stampfer MJ. Review of moderate alcohol consumption and reduced risk of coronary, heart disease: is the effect due to beer, wine, or spirits? BMJ 1996;312:731-6.
7. de Lorimier AA. Alcohol, wine, and health. Am J Surg 2000;180:357-61.
8. de Gaetano G, Cerletti C. Wine and cardiovascular disease. Nutr Metab Cardiovasc Dis 2001;11:47-50.
9. Andriambeloson E, Magnier C, Haan-Archipoff G, et al. Natural dietary polyphenolic compounds cause endotheiium-dependent vasorelaxation in rat thoracic aorta. J Nutr 1998;128:2324-33.
10. Flesch M, Schwarz A, Bohm M. Effects of red and white wine on endothelium-dependent vasorelaxation of rat aorta and human coronary arteries. Am J Physiol 1998;275:H1183-90.
11. Wallerath T, Witte K, Schäfer SC, et al. Down-regulation of the expression of endothelial NO synthase is likely to contribute to glucocorticoid-mediated hypertension. Proc Natl Acad Sci U S A 1999;96:13357-62.
12. Li H, Oehrlein SA, Wallerath T, et al. Activation of protein kinase C alpha and/or epsilon enhances transcription of the human endothelial nitric oxide synthase gene. Mol Pharmacol 1998;53:630-7.
13. Borovkov AY, Rivkin MI. XcmI-containing vector for direct cloning of PCR products. Biotechniques 1997;22:812-4.
14. Kleinert H, Wallerath T, Euchenhofer C, Ihrig Biedert I, Li H, Förstermann U. Estrogens increase transcription of the human endothelial NO synthase gene: analysis of the transcription factors involved. Hypertension 1998;31:582-8.
15. Hink U, Li HG, Mollnau H, et al. Mechanisms underlying endothelial dysfunction in diabetes mellitus. Circ Res 2001;88:E14-22.
16. Münzel T, Li H, Mollnau H, et al. Effects of long-term nitroglycerin treatment on endothelial nitric oxide synthase (NOS III) gene expression, NOS III-mediated superoxide production, and vascular NO bioavailability. Circ Res 2000;86:E7-12.
17. Alheid U, Frölich JC, Förstermann U. Endothelium-derived relaxing factor from cultured human endothelial cells inhibits aggregation of human platelets. Thromb Res 1987;47:561-71.
18. Radomski MW, Palmer RM, Moncada S. The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium. Biochem Biophys Res Commun 1987;148:1482-9.
19. Zeiher AM, Fisslthaler B, Schray Utz B, Busse R. Nitric oxide modulates the expression of monocyte chemoattractant protein-1 in cultured human endothelial cells. Circ Res 1995;76:980-6.
20. Kubes P, Suzuki M, Granger DN. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci U S A 1991;88:4651-5.
21. Davenpeck KL, Gauthier TW, Lefer AM. Inhibition of endothelial-derived nitric oxide promotes P-selectin expression and actions in the rat microcirculation. Gastroenterology 1994;107:1050-8.
22. De Caterina R, Libby P, Peng HB, et al. Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. J Clin Invest 1995;96:60-8.
23. Gauthier TW, Scalia R, Murohara T, Guo JP, Lefer AM. Nitric oxide protects against leukocyte-endothelium interactions in the early stages of hypercholesterolemia. Arterioscler Thromb Vasc Biol 1995;15:1652-9.
24. Draijer R, Atsma DE, van der Laarse A, van Hinsbergh VW. cGMP and nitric oxide modulate thrombin-induced endothelial permeability. Regulation via different pathways in human aortic and umbilical vein endothelial cells. Circ Res 1995;76:199-208.
25. Seccia M, Perugini C, Albano E, Bellomo G. Inhibition of Cu2+-induced LDL oxidation by nitric oxide: a study using donors with different half-time of NO release. Biochem Biophys Res Commun 1996;220:306-9.
26. Garg UC, Hassid A. Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest 1989;83:1774-7.
27. Nakaki T, Nakayama M, Kato R. Inhibition by nitric oxide and nitric oxide-producing vasodilators of DNA synthesis in vascular smooth muscle cells. Eur J Pharmacol 1990;189:347-53.
28. Dubey RK, Jackson EK, Lüscher TF. Nitric oxide inhibits angiotensin II-induced migration of rat aortic smooth muscle cell. Role of cyclic-nucleotides and angiotensin-1 receptors. J Clin Invest 1995;96:141-9.
29. Li H, Förstermann U. Nitric oxide in the pathogenesis of vascular disease. J Pathol 2000;190:244-54.
30. Andriambeloson E, Kleschyov AL, Muller B, Beretz A, Stoclet JC, Andriantsitohaina R. Nitric oxide production and endothelium-dependent vasorelaxation induced by wine polyphenols in rat aorta. Br J Pharmacol 1997;120:1053-8.
31. Cishek MB, Galloway MT, Karim M, German JB, Kappagoda CT. Effect of red wine on endothelium-dependent relaxation in rabbits. Clin Sci (Lond) 1997;93:507-11.
32. Andriambeloson E, Stoclet JC, Andriantsitohaina R. Mechanism of endothelial nitric oxide-dependent vasorelaxation induced by wine polyphenols in rat thoracic aorta. J Cardiovasc Pharmacol 1999;33:248-54.
33. Li H, Wallerath T, Förstermann U. Physiological mechanisms regulating the expression of endothelial-type NO synthase. Nitric Oxide Biol Chem 2002;7:132-47.
34. Corder R, Douthwaite JA, Lees DM, et al. Endothelin-1 synthesis reduced by red wine. Nature 2001;414:863-4.
35. Goldberg DM, Yah J, Ng E, et al. A global survey of trans-resveratrol concentrations in commercial wines. Am J Enol Vitic 1995;46:159-65.