The efficacy of DNA vaccination is enhanced in mice by targeting the encoded protein to dendritic cells

Journal of Clinical Investigation

Volumn 118, Issue 4, 2008, Pages 1427-1436

  Nchinda, Godwin ^a,b   Kuroiwa, Janelle ^a   Oks, Margarita ^a   Trumpfheller, Christine ^a   Chae, Gyu Park ^a   Huang, Yaoxing ^c   Hannaman, Drew ^d   Schlesinger, Sarah J ^a,c   Mizenina, Olga ^a   Nussenzweig, Michel C ^a   Überla, Klaus ^b   Steinman, Ralph M ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b RUHR UNIVERSITY BOCHUM   (Germany)

^c AARON DIAMOND AIDS RESEARCH CENTER   (United States)

^d Ichor Medical Systems Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE; GAG PROTEIN; GAMMA INTERFERON; HIV GAG P41 SCFV DEC205; HYBRID PROTEIN; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHO CELL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DNA IMMUNIZATION; DRUG EFFICACY; ENZYME LINKED IMMUNOSPOT ASSAY; HUMAN; HUMAN CELL; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; VACCINIA VIRUS; WESTERN BLOTTING;

ANIMALS; ANTIBODIES; ANTIGENS; CELL LINE; CRICETINAE; DENDRITIC CELLS; GENE PRODUCTS, GAG; HUMANS; MICE; MUCOUS MEMBRANE; T-LYMPHOCYTES; VACCINES, DNA;

EID: 41849097104     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI34224     Document Type: Article

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