Developing DNA vaccines that call to dendritic cells

Journal of Clinical Investigation

Volumn 114, Issue 9, 2004, Pages 1241-1244

  Kutzler, Michele A ^a   Weiner, David B ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; DNA VACCINE; ENVELOPE PROTEIN; FLT3 LIGAND; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOLOGICAL ADJUVANT; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; TETRAMER; CANCER VACCINE; CHEMOKINE; FLT3 LIGAND PROTEIN; MACROPHAGE INFLAMMATORY PROTEIN 1; MEMBRANE PROTEIN;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; CELL ACTIVATION; CELL MATURATION; CELLULAR IMMUNITY; CYTOKINE RELEASE; DENDRITIC CELL; DRUG POTENCY; IMMUNE RESPONSE; IMMUNOGENICITY; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; REVIEW; VACCINATION; ANIMAL; BIOLOGICAL MODEL; CYTOLOGY; HUMAN; METABOLISM; NOTE;

ANIMALS; CANCER VACCINES; CHEMOKINES; DENDRITIC CELLS; HUMANS; IMMUNITY, CELLULAR; MACROPHAGE INFLAMMATORY PROTEIN-1; MEMBRANE PROTEINS; MICE; MODELS, BIOLOGICAL; VACCINES, DNA;

EID: 85047691459     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI23467     Document Type: Review

References (21)

1. Hohlfeld, R., and Engel, A.G. 1994. The immunobiology of muscle. Immunol. Today. 15:269-274.
2. Heath, W.R., and Carbone, F.R. 2001. Cross-presentation in viral immunity and self-tolerance. Nat. Rev. Immunol. 1:126-134.
3. Ulmer, J.B., and Otten, G.R. 2000. Priming of CTL responses by DNA vaccines: direct transfection of antigen presenting cells versus cross-priming. Dev. Biol. (Basel). 104:9-14.
4. Xiang, Z., and Ertl, H.C. 1995. Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines. Immunity. 2:129-135.
5. Kim, J.J., et al. 1997. In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen. J. Immunol. 158:816-826.
6. Gurunathan, S., Wu, C.Y., Freidag, B.L., and Seder, R.A. 2000. DNA vaccines: a key for inducing long-term cellular immunity. Curr. Opin. Immunol. 12:442-447.
7. Chan, K., et al. 2001. The roles of MHC class II, CD40, and B7 costimulation in CTL induction by plasmid DNA. J. Immunol. 166:3061-3066.
8. Shedlock, D.J., and Weiner, D.B. 2000. DNA vaccination: antigen presentation and the induction of immunity. J. Leukoc. Biol. 68:793-806.
9. Kim, J.J., Yang, J.S., Dentchev, T., Dang, K., and Weiner, D.B. 2000. Chemokine gene adjuvants can modulate immune responses induced by DNA vaccines. J. Interferon Cytokine Res. 20:487-498.
10. Pasquini, S., et al. 1997. Cytokines and costimulatory molecules as genetic adjuvants. Immunol. Cell Biol. 75:397-401.
11. Biragyn, A., et al. 2002. DNA vaccines encoding human immunodeficiency virus-1 glycoprotein 120 fusions with proinflammatory chemoattractants induce systemic and mucosal immune responses. Blood. 100:1153-1159.
12. Spies, B., et al. 2003. Vaccination with plasmid DNA activates dendritic cells via Toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice. J. Immunol. 171:5908-5912.
13. Wan, T., et al. 2004. Novel heat shock protein Hsp70L1 activates dendritic cells and acts as a Th1 polarizing adjuvant. Blood. 103:1747-1754.
14. Barouch, D.H., et al. 2000. Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination. Science. 290:486-492.
15. Calarota, S.A., and Weiner, D.B. 2004. Enhancement of human immunodeficiency virus type 1-DNA vaccine potency through incorporation of T-helper 1 molecular adjuvants. Immunol. Rev. 199:84-99.
16. Sumida, S.M., et al. 2004. Recruitment and expansion of dendritic cells in vivo potentiate the immunogenicity of plasmid DNA vaccines. J. Clin. Invest. 114:1334-1342. doi: 10.1172/JCI200422608.
17. McKay, P.F., et al. 2004. Recruitment of different subsets of antigen-presenting cells selectively modulates DNA vaccine-elicited CD4+ and CD8+ T lymphocyte responses. Eur. J. Immunol. 34:1011-1020.
18. Westermann, J., et al. 2004. Flt-3 ligand as adjuvant for DNA vaccination augments immune responses but does not skew TH1/TH2 polarization. Gene Ther. 11:1048-1056.
19. Sin, J., Kim, J.J., Pachuk, C., Satishchandran, C., and Weiner, D.B. 2000. DNA vaccines encoding interleukin-8 and RANTES enhance antigen-specific Th1-type CD4(+) T-cell-mediated protective immunity against herpes simplex virus type 2 in vivo. J. Virol. 74:11173-11180.
20. Chattergoon, M.A., et al. 2000. Targeted antigen delivery to antigen-presenting cells including dendritic cells by engineered Fas-mediated apoptosis. Nat. Biotechnol. 18:974-979.
21. Sasaki, S., Amara, R.R., Oran, A.E., Smith, J.M., and Robinson, H.L. 2001. Apoptosis-mediated enhancement of DNA-raised immune responses by mutant caspases. Nat. Biotechnol. 19:543-547.