Cross-priming as a predominant mechanism for inducing CD8+ T cell responses in gene gun DNA immunization

Journal of Immunology

Volumn 167, Issue 10, 2001, Pages 5549-5557

  Jae Ho Cho, ^a   Jin Won Youn, ^a   Young Chul Sung, ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; PLASMID DNA;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE GUN; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNIZATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0035889924     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.10.5549     Document Type: Article

References (68)

1. Protective CTL-dependent immunity and enhanced immunopathology in mice immunized by particle bombardment with DNA encoding an internal virion protein
2. + T cell responses to dominant and subdominant epitopes and protective immunity to Sendal virus infection by DNA vaccination
3. Induction of cytotoxic T lymphocytes by intramuscular immunization with plasmid DNA is facilitated by bone marrow-derived cells
4. Gene vaccination with naked plasmid DNA: Mechanism of CTL priming
5. The dominant role of bone marrow-derived cells in CTL induction following plasmid DNA immunization at different sites
6. DNA-based immunization by in vivo transfection of dendritic cells
7. Contribution of cells at the site of DNA vaccination to the generation of antigen-specific immunity and memory
8. + T cells after gene gun immunization
9. Dendritic cells at a DNA vaccination site express the encoded influenza nucleoprotein and prime MHC class I-restricted cytolytic lymphocytes upon adoptive transfer
10. Expression of a viral protein by muscle cells in vivo induces protective cell-mediated immunity
11. In vivo priming by DNA injection occurs predominantly by antigen transfer
12. Specific immune induction following DNA-based immunization through in vivo transfection and activation of macrophages/APCs
13. DNA vaccination: Transfecfion and activation of dendritic cells as key events for immunity
14. Immunization through dermal delivery of protein-encoding DNA: A role for migratory dendritic cells
15. Freshly isolated spleen dendritic cells and epidermal Langerhans cells undergo similar phenotypic and functional changes during short-term culture
16. Spleen dendritic cells exhibit altered morphology and increased allostimulatory capacity after short-term culture
17. Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro
18. T cell receptor antagonist peptides induce positive selection
19. Interleukin 6: Insights to its function in skin by overexpression in transgenic mice
20. The CD11b promoter directs high-level expression of reporter genes in macrophages in transgenic mice
21. A vector driving the expression of foreign cDNAs in the MHC class II-positive cells of transgenic mice
22. IL-6 induces long-term protective immunity against a lethal challenge of influenza virus
23. Hepatitis C virus core protein inhibits interleukin 12 and nitric oxide production from activated macrophages
24. Selected strategies to augment polynucleotide immunization
25. Enhanced cellular immunity to hepatitis C virus nonstructural proteins by codelivery of granulocyte macrophage-colony stimulating factor gene in intramuscular DNA immunization
26. Limiting-dilution analysis of the HLA restriction of anti-Epstein-Barr virus-specific cytolytic T lymphocytes
27. ELISPOT assay for detection of peptide specific interferon-γ-secreting cells in rhesus macaques
28. Major histocompatibility complex class I-restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction
29. In vivo transfer and expression of a human epidermal' growth factor gene accelerates wound repair
30. Examination of parameters affecting the elicitation of humoral immune responses by particle bombardment-mediated genetic immunization
31. DNA immunization targeting the skin: Molecular control of adaptive immunity
32. Introduction of foreign genes into tissues of living mice by DNA-coated microprojectiles
33. Transgenic expression of PML/RARα impairs myelopoiesis
34. IL-10 transgenic mice present a defect in T cell development reminiscent of SCID patients
35. Dendritic cells in the context of skin immunity
36. Keratinocyte expression of B7-1 in transgenic mice amplifes the primary immune response to cutaneous antigens
37. Differential expression of tissue-specific promoters by gene gun
38. Different Th cell types and antibody isotypes generated by saline and gene gun DNA immunization
39. Granulocyte/macrophage colony-stimulating factor and interleukin 1 mediate the maturation of murine epidermal Langerhans cells into potent immunostimulatory dendritic cells
40. Granulocyte/macrophage colony-stimulating factor is essential for the viability and function of cultured murine epidermal Langerhans cells
41. Injection of DNA encoding granulocyte-macrophage colony-stimulating factor recruits dendritic cells for immune adjuvant effects
42. Transfecfion of immature murine bone marrow-derived dendritic cells with the granulocyte-macrophage colony-stimulating factor gene potently enhances their in vivo antigen-presenting capacity
43. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor-α
44. Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen
45. In vivo cross-priming of MHC class I-restricted antigens requires the TAP transporter
46. + T cell responses to infectious agents, tumors, transplants, and vaccines
47. Degradation of cell proteins and the generation of MHC class I-presented peptides
48. Receptor-mediated uptake of antigen/heat shock protein complexes results in major histocompatibility complex class I antigen presentation via two distinct processing pathways
49. Cytotoxic T cell responses to DNA vaccination: Dependence on antigen presentation via class II MHC
50. + T cell dependent
51. Delivery of multiple CD8 cytotoxic T cell epitopes by DNA vaccination
52. DNA immunization with minigenes: Low frequency of memory cytotoxic T lymphocytes and inefficient antiviral protection are rectified by ubiquitination
53. Induction of cytotoxic T-cell responses by gene gun DNA vaccination with minigenes encoding influenza A virus HA and NP CTL-epitopes
54. Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy
55. T cell activation determined by T cell receptor number and tunable thresholds
56. Naive versus memory CD4 T cell response to antigen: Memory cells are less dependent on accessory cell costimulation and can respond to many APC types including resting B cells
57. Differential dependence on target site tissue for gene gun and intramuscular DNA immunizations
58. Efficient presentation of phagocytosed cellular fragments on the MHC class II products of dendritic cells
59. Linear differentiation of cytotoxic effectors into memory T lymphocytes
60. Control of the immune response at the level of antigen-presenting cells: A comparison of the function of dendritic cells and B lymphocytes
61. The development, maturation, and turnover rate of mouse spleen dendritic cell populations
62. In vivo gene transfer into rabbit thyroid follicular cells by direct DNA injection
63. Requirements for bone marrow-derived antigen-presenting cells in priming cytotoxic T cell responses to intracellular pathogens
64. Involvement of an ATP-dependent peptide chaperone in cross-presentation after DNA immunization
65. Consequences of cell death: Exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells
66. Dendritic cells acquire the MAGE-3 human tumor antigen from apoptotic cells and induce a class I-restricted T cell response
67. Dendritic cells acquire antigen from apoptotic cells and induce class l-restricted CTLs
68. Cell-associated ovalbumin is cross-presented much more efficiently than soluble ovalbumin in vivo