Pivaloyloxymethyl-modified isoprenoid bisphosphonates display enhanced inhibition of cellular geranylgeranylation

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 7, 2008, Pages 3652-3660

  Wiemer, Andrew J ^a   Yu, Jose S ^b   Shull, Larry W ^b   Barney, Rocky J ^b   Wasko, Brian M ^a   Lamb, Kimberly M ^c   Hohl, Raymond J ^a,c,d   Wiemer, David F ^b,d  

^a UNIVERSITY OF IOWA   (United States)

^b E11 SSH   (United States)

^c UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

^d UNIVERSITY OF IOWA   (United States)

Author keywords

Bisphosphonate; Farnesyl diphosphate; Geranylgeranyl diphosphate; Geranylgeranyl diphosphate synthase; Geranylgeranyl pyrophosphate; Geranylgeranylation; Pivaloyloxymethyl; POM; Prenylation; Prodrug; Rap1a; Ras

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; FARNESYL TRANS TRANSFERASE; TETRAPIVALOYLOXYMETHYL 2,6,12,16 TETRAMETHYLHEPTADECA 2,6,11,15 TETRAENE 9,9 DIYLDIPHOSPHONATE; TETRAPIVALOYLOXYMETHYL 2,8 DIMETHYLNONA 2,7 DIENE 5,5 DIYLDIPHOSPHONATE; TETRAPIVALOYLOXYMETHYL 2,8,12 TRIMETHYLTRIDECA 2,7,11 TRIENE 5,5 DIYLDIPHOSPHONATE; TETRAPIVALOYLOXYMETHYL 4,8 DIMETHYLNONA 3,7 DIENE 1,1 DIYLDIPHOSPHONATE; TETRAPIVALOYLOXYMETHYL 4,8,12 TRIMETHYLTRIDECA 3,7,11 TRIENE 1,1 DIYLDIPHOSPHONATE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; INHIBITION KINETICS; PH;

CELL SURVIVAL; DIPHOSPHONATES; HUMANS; HYDROPHOBICITY; K562 CELLS; METHYLATION; MOLECULAR STRUCTURE; PROTEIN PRENYLATION; STRUCTURE-ACTIVITY RELATIONSHIP; TERPENES;

EID: 41649106235     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.02.016     Document Type: Article

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