Mono- and dialkyl isoprenoid bisphosphonates as geranylgeranyl diphosphate synthase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 1, 2008, Pages 390-399

  Wiemer, Andrew J ^a   Yu, Jose S ^b   Lamb, Kimberly M ^c   Hohl, Raymond J ^a,c   Wiemer, David F ^b,c  

^a UNIVERSITY OF IOWA   (United States)

^b E11 SSH   (United States)

^c UNIVERSITY OF IOWA   (United States)

Author keywords

Bisphosphonate; Farnesyl diphosphate; Farnesylation; Geranylgeranyl diphosphate; Geranylgeranyl diphosphate synthase; Geranylgeranylation; Prenylation; Rap1a; Ras

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; FARNESYL DIPHOSPHATE; FARNESYL TRANS TRANSFERASE; GERANYLGERANYL PYROPHOSPHATE; ISOPRENOID; PROTEIN FARNESYLTRANSFERASE INHIBITOR; ZOLEDRONIC ACID;

ARTICLE; CELL STRAIN K 562; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

DIPHOSPHONATES; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; HUMANS; K562 CELLS; POLYISOPRENYL PHOSPHATES; PROTEIN PRENYLATION;

EID: 38049035846     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.09.029     Document Type: Article

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