Synthesis of fluorescently tagged isoprenoid bisphosphonates that inhibit protein geranylgeranylation

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 5, 2007, Pages 1959-1966

  Maalouf, Mona A ^a   Wiemer, Andrew J ^b   Kuder, Craig H ^c   Hohl, Raymond J ^b,c   Wiemer, David F ^a,c  

^a E11 SSH   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF IOWA   (United States)

Author keywords

Anthranilate; Bisphosphonate; Fluorescence; Isoprenoid; Protein prenylation

Indexed keywords

ANTHRANILIC ACID DERIVATIVE; BISPHOSPHONIC ACID DERIVATIVE; GERANYLGERANYL PYROPHOSPHATE; GUANOSINE TRIPHOSPHATASE; ISOPRENOID; PROTEIN RAB6; PROTEIN RAP1A; RAB PROTEIN; RAP PROTEIN; RAS PROTEIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BONE MARROW CANCER; BREAST CANCER; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; FRACTURE; HUMAN; HUMAN CELL; IC 50; LUNG CANCER; OSTEOLYSIS; OSTEOPOROSIS; PROSTATE CANCER; PROTEIN GERANYLGERANYLATION; PROTEIN PROCESSING; WESTERN BLOTTING;

BLOTTING, WESTERN; DIPHOSPHONATES; DITERPENES; FLUORESCENT DYES; HUMANS; K562 CELLS; MAGNETIC RESONANCE SPECTROSCOPY; MICROSCOPY, FLUORESCENCE; POLYISOPRENYL PHOSPHATES; PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 33846615517     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.01.002     Document Type: Article

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