메뉴 건너뛰기




Volumn 46, Issue SUPPL. 2, 1997, Pages

α-lipoic acid in the treatment of diabetic peripheral and cardiac autonomic neuropathy

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; PLACEBO; THIOCTIC ACID;

EID: 0030884244     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.46.2.s62     Document Type: Conference Paper
Times cited : (147)

References (38)
  • 1
    • 0028900386 scopus 로고
    • The effect of intensive diabetes therapy on the development and progression of neuropathy
    • The Diabetes Control and Complications Trial Research Group: The effect of intensive diabetes therapy on the development and progression of neuropathy. Ann Intern Med 122:561-568, 1995
    • (1995) Ann Intern Med , vol.122 , pp. 561-568
  • 2
    • 0029558663 scopus 로고
    • Effect of intensive diabetes treatment on nerve conduction in the Diabetes Control and Complications Trial
    • Diabetes Control and Complications Trial (DCCT) Research Group: Effect of intensive diabetes treatment on nerve conduction in the Diabetes Control and Complications Trial. Ann Neurol 38:869-880, 1995
    • (1995) Ann Neurol , vol.38 , pp. 869-880
  • 4
    • 0030019728 scopus 로고    scopus 로고
    • Diagnosis and management of diabetic peripheral neuropathy
    • Ziegler D: Diagnosis and management of diabetic peripheral neuropathy. Diabetic Med 13:S34-S38, 1996
    • (1996) Diabetic Med , vol.13
    • Ziegler, D.1
  • 5
    • 0028658463 scopus 로고
    • Diabetic cardiovascular autonomic neuropathy: Prognosis, diagnosis, and treatment
    • Ziegler D: Diabetic cardiovascular autonomic neuropathy: prognosis, diagnosis, and treatment. Diabetes Metab Rev 10:339-383, 1994
    • (1994) Diabetes Metab Rev , vol.10 , pp. 339-383
    • Ziegler, D.1
  • 6
    • 4243217202 scopus 로고    scopus 로고
    • The natural history of diabetic neuropathy is governed by the degree of glycaemic control: A 10-year prospective study in IDDM
    • Ziegler D, Piolot R, Gries FA: The natural history of diabetic neuropathy is governed by the degree of glycaemic control: a 10-year prospective study in IDDM (Abstract). Diabetologia 39 (Suppl. 1):A35, 1996
    • (1996) Diabetologia , vol.39 , Issue.1 SUPPL.
    • Ziegler, D.1    Piolot, R.2    Gries, F.A.3
  • 7
    • 0028059308 scopus 로고
    • Oxidative damage in neurodegenerative disease
    • Jenner P: Oxidative damage in neurodegenerative disease. Lancet 344:796-798, 1994
    • (1994) Lancet , vol.344 , pp. 796-798
    • Jenner, P.1
  • 8
    • 0025732948 scopus 로고
    • Role of oxidative stress in development of complications in diabetes
    • Baynes JW: Role of oxidative stress in development of complications in diabetes. Diabetes 40:405-412, 1991
    • (1991) Diabetes , vol.40 , pp. 405-412
    • Baynes, J.W.1
  • 9
    • 0028040725 scopus 로고
    • The relationship of vascular changes to metabolic factors in diabetes mellitus and their role in the development of peripheral nerve complications
    • Cameron NE, Cotter MA: The relationship of vascular changes to metabolic factors in diabetes mellitus and their role in the development of peripheral nerve complications. Diabetes Metab Rev 10:189-224, 1994
    • (1994) Diabetes Metab Rev , vol.10 , pp. 189-224
    • Cameron, N.E.1    Cotter, M.A.2
  • 11
    • 0030034465 scopus 로고    scopus 로고
    • Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus
    • Ting HH, Timimi FK, Boles KS, Creager SJ, Ganz P, Creager MA: Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus. J Clin Invest 97:22-28, 1996
    • (1996) J Clin Invest , vol.97 , pp. 22-28
    • Ting, H.H.1    Timimi, F.K.2    Boles, K.S.3    Creager, S.J.4    Ganz, P.5    Creager, M.A.6
  • 12
    • 0028797103 scopus 로고
    • Weakened cellular scavenging activity against oxidative stress in diabetes mellitus: Regulation of glutathione synthesis and efflux
    • Yoshida K, Hirokawa J, Tagami S, Kawakami Y, Urata Y, Kondo T: Weakened cellular scavenging activity against oxidative stress in diabetes mellitus: regulation of glutathione synthesis and efflux. Diabetologia 38:201-210, 1995
    • (1995) Diabetologia , vol.38 , pp. 201-210
    • Yoshida, K.1    Hirokawa, J.2    Tagami, S.3    Kawakami, Y.4    Urata, Y.5    Kondo, T.6
  • 14
    • 0026356525 scopus 로고
    • Thioctic acid and dihydrolipoic acid are novel antioxidants which interact with reactive oxygen species
    • Suzuki YJ, Tsuchiya M, Packer L: Thioctic acid and dihydrolipoic acid are novel antioxidants which interact with reactive oxygen species. Free Radic Res Comms 15:255-263, 1991
    • (1991) Free Radic Res Comms , vol.15 , pp. 255-263
    • Suzuki, Y.J.1    Tsuchiya, M.2    Packer, L.3
  • 15
    • 0029090976 scopus 로고
    • Lipoic acid improves nerve blood flow, reduces oxidative stress and improves distal nerve conduction in experimental diabetic neuropathy
    • Nagamatsu M, Nickander KK, Schmelzer JD, Raya A, Wittrock DA, Tritschler H, Low PA: Lipoic acid improves nerve blood flow, reduces oxidative stress and improves distal nerve conduction in experimental diabetic neuropathy. Diabetes Care 18:1160-1167, 1995
    • (1995) Diabetes Care , vol.18 , pp. 1160-1167
    • Nagamatsu, M.1    Nickander, K.K.2    Schmelzer, J.D.3    Raya, A.4    Wittrock, D.A.5    Tritschler, H.6    Low, P.A.7
  • 16
    • 0029764551 scopus 로고    scopus 로고
    • Alpha-lipoic acid: Antioxidant potency against lipid peroxidation of neural tissues in vitro and implications for diabetic neuropathy
    • Nickander KK, McPhee BR, Low PA, Tritschler H: Alpha-lipoic acid: antioxidant potency against lipid peroxidation of neural tissues in vitro and implications for diabetic neuropathy. Free Radic Biol Med 21:631-639, 1996
    • (1996) Free Radic Biol Med , vol.21 , pp. 631-639
    • Nickander, K.K.1    McPhee, B.R.2    Low, P.A.3    Tritschler, H.4
  • 17
    • 0029011459 scopus 로고
    • Impaired vasoreactivity to nitric oxide in experimental diabetic neuropathy
    • Kihara M, Low PA: Impaired vasoreactivity to nitric oxide in experimental diabetic neuropathy. Exp Neurol 132:180-185, 1994
    • (1994) Exp Neurol , vol.132 , pp. 180-185
    • Kihara, M.1    Low, P.A.2
  • 18
    • 0018882855 scopus 로고
    • Efficacy of thioctic acid in the therapy of peripheral diabetic neuropathy
    • Aspects of Autonomic Neuropathy in Diabetes. Gries FA, Freund HJ, Rabe F, Berger H, Eds. New York, Thieme-Stratton
    • Sachse G, Willms B: Efficacy of thioctic acid in the therapy of peripheral diabetic neuropathy. In Aspects of Autonomic Neuropathy in Diabetes. Gries FA, Freund HJ, Rabe F, Berger H, Eds. Horm Metab Res, Suppl. Series 9, New York, Thieme-Stratton, 1980, p. 105-108
    • (1980) Horm Metab Res, Suppl. Series 9 , pp. 105-108
    • Sachse, G.1    Willms, B.2
  • 20
    • 0023673832 scopus 로고
    • Zur medikamentösen Behandlung der diabetischen Polyneuropathie mit der Alpha-Liponsäure oder Vitamin B-Präparaten
    • Jörg J, Metz F, Scharafinski H: Zur medikamentösen Behandlung der diabetischen Polyneuropathie mit der Alpha-Liponsäure oder Vitamin B-Präparaten. Nervenarzt 59:36-44, 1988
    • (1988) Nervenarzt , vol.59 , pp. 36-44
    • Jörg, J.1    Metz, F.2    Scharafinski, H.3
  • 22
    • 0004568770 scopus 로고
    • Randomisierte Studie Thioctsäure gegenüber Vitamin-B-Kombinationspräparat bei Patienten mit diabetischer Polyneuropathie unter besonderer Berücksichtigung des peripheren Nervensystems
    • Borbe HO, Ulrich H, Eds. Frankfurt, Verlag
    • Delcker A, Fischer P-A, Ulrich H: Randomisierte Studie Thioctsäure gegenüber Vitamin-B-Kombinationspräparat bei Patienten mit diabetischer Polyneuropathie unter besonderer Berücksichtigung des peripheren Nervensystems. In Neue biochemische, pharmakologische und klinische Erkenntnisse zur Thioctsäure. Borbe HO, Ulrich H, Eds. Frankfurt, Verlag, 1989, p. 335-344
    • (1989) Neue Biochemische, Pharmakologische und Klinische Erkenntnisse Zur Thioctsäure , pp. 335-344
    • Delcker, A.1    Fischer, P.-A.2    Ulrich, H.3
  • 23
    • 0004625699 scopus 로고
    • Hochdosierte Langzeitbehandlung mit Thioctsäure bei der diabetischen Polyneuropathie: Ergebnisse einer kontrollierten, randomisierten Studie unter besonderer Berücksichtigung der autonomen Neuropathie
    • Borbe HO, Ulrich H, Eds. Frankfurt, Verlag
    • Reschke B, Zeuzem S, Rosak C, Petzoldt R, Althoff P-H, Ulrich H, Schöffling K: Hochdosierte Langzeitbehandlung mit Thioctsäure bei der diabetischen Polyneuropathie: Ergebnisse einer kontrollierten, randomisierten Studie unter besonderer Berücksichtigung der autonomen Neuropathie. In Neue biochemische, pharmakologische und klinische Erkenntnisse zur Thioctsäure. Borbe HO, Ulrich H, Eds. Frankfurt, Verlag, 1989, p. 318-334
    • (1989) Neue Biochemische, Pharmakologische und Klinische Erkenntnisse Zur Thioctsäure , pp. 318-334
    • Reschke, B.1    Zeuzem, S.2    Rosak, C.3    Petzoldt, R.4    Althoff, P.-H.5    Ulrich, H.6    Schöffling, K.7
  • 25
    • 0002313869 scopus 로고
    • The importance of beta, the type II error, and sample size in the design and interpretation of the randomized controlled trial: Survey of two sets of "negative" trials
    • Bailar JC, Mosteller F, Eds. Boston, NEJM Books
    • Freiman JA, Chalmers TC, Smith H, Kuebler RR: The importance of beta, the type II error, and sample size in the design and interpretation of the randomized controlled trial: survey of two sets of "negative" trials. In Medical Uses of Statistics. Bailar JC, Mosteller F, Eds. Boston, NEJM Books, 1992, p. 357-373
    • (1992) Medical Uses of Statistics , pp. 357-373
    • Freiman, J.A.1    Chalmers, T.C.2    Smith, H.3    Kuebler, R.R.4
  • 26
    • 84971580244 scopus 로고
    • Absence of evidence is not evidence of absence
    • Altman DG, Bland JM: Absence of evidence is not evidence of absence. BMJ 311:485, 1995
    • (1995) BMJ , vol.311 , pp. 485
    • Altman, D.G.1    Bland, J.M.2
  • 27
    • 0028845524 scopus 로고
    • Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant α-lipoic acid: A 3-week randomized controlled trial (ALADIN Study)
    • Ziegler D, Hanefeld M, Ruhnau KJ, Meißner HP, Lobisch M, Schütte K, Gries FA, The ALADIN Study Group: Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant α-lipoic acid: a 3-week randomized controlled trial (ALADIN Study). Diabetologia 38:1425-1433, 1995
    • (1995) Diabetologia , vol.38 , pp. 1425-1433
    • Ziegler, D.1    Hanefeld, M.2    Ruhnau, K.J.3    Meißner, H.P.4    Lobisch, M.5    Schütte, K.6    Gries, F.A.7
  • 28
    • 0020501951 scopus 로고
    • A controlled trial of sorbinil, an aldose reductase inhibitor, in chronic painful diabetic neuropathy
    • Young RJ, Ewing DJ, Clarke BF: A controlled trial of sorbinil, an aldose reductase inhibitor, in chronic painful diabetic neuropathy. Diabetes 32:938-942, 1983
    • (1983) Diabetes , vol.32 , pp. 938-942
    • Young, R.J.1    Ewing, D.J.2    Clarke, B.F.3
  • 30
    • 0021109452 scopus 로고
    • Nerve conduction velocity in diabetes
    • Young RR, Shahani BT: Nerve conduction velocity in diabetes. N Engl J Med 308:190-191, 1983
    • (1983) N Engl J Med , vol.308 , pp. 190-191
    • Young, R.R.1    Shahani, B.T.2
  • 32
    • 0031028636 scopus 로고    scopus 로고
    • Effects of treatment with the antioxidant α-lipoic acid on cardiac autonomie neuropathy in NIDDM patients: A 4-month randomized controlled multicenter trial (DEKAN Study)
    • Ziegler D, Conrad F, Ulrich H, Reichel G, Schatz H, Gries FA, the DEKAN Study Group: Effects of treatment with the antioxidant α-lipoic acid on cardiac autonomie neuropathy in NIDDM patients: a 4-month randomized controlled multicenter trial (DEKAN Study). Diabetes Care 20:369-373, 1997
    • (1997) Diabetes Care , vol.20 , pp. 369-373
    • Ziegler, D.1    Conrad, F.2    Ulrich, H.3    Reichel, G.4    Schatz, H.5    Gries, F.A.6
  • 33
    • 0026562212 scopus 로고
    • Assessment of cardiovascular autonomie function: Age-related normal ranges and reproducibility of spectral analysis, vector analysis, and standard tests of heart rate variation and blood pressure responses
    • Ziegler D, Laux G, Dannehl K, Spüler M, Mühlen H, Mayer P, Gries FA: Assessment of cardiovascular autonomie function: age-related normal ranges and reproducibility of spectral analysis, vector analysis, and standard tests of heart rate variation and blood pressure responses. Diabetic Med 9:166-175, 1992
    • (1992) Diabetic Med , vol.9 , pp. 166-175
    • Ziegler, D.1    Laux, G.2    Dannehl, K.3    Spüler, M.4    Mühlen, H.5    Mayer, P.6    Gries, F.A.7
  • 35
    • 0029085103 scopus 로고
    • Endothelial relaxation is disturbed by oxidative stress in the diabetic rat heart: Influence of tocopherol as antioxidant
    • Rösen P, Ballhausen T, Bloch W, Addicks K: Endothelial relaxation is disturbed by oxidative stress in the diabetic rat heart: influence of tocopherol as antioxidant. Diabetologia 38:1157-1168, 1995
    • (1995) Diabetologia , vol.38 , pp. 1157-1168
    • Rösen, P.1    Ballhausen, T.2    Bloch, W.3    Addicks, K.4
  • 37
    • 0029112095 scopus 로고
    • Diabetic polyneuropathy in controlled clinical trials: Consensus report of the Peripheral Nerve Society
    • Peripheral Nerve Society: Diabetic polyneuropathy in controlled clinical trials: consensus report of the Peripheral Nerve Society. Ann Neurol 38:478-482, 1995
    • (1995) Ann Neurol , vol.38 , pp. 478-482
  • 38
    • 0028859525 scopus 로고
    • Clinical trials of diabetic neuropathy: Past, present, and future
    • Pfeifer MA, Schumer MP: Clinical trials of diabetic neuropathy: past, present, and future. Diabetes 44:1355-1361, 1995
    • (1995) Diabetes , vol.44 , pp. 1355-1361
    • Pfeifer, M.A.1    Schumer, M.P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.