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Volumn 10, Issue 15, 2004, Pages 5123-5130

Elevated S-phase kinase-associated protein 2 protein expression in acute myelogenous leukemia: Its association with constitutive phosphorylation of phosphatase and tensin homologue protein and poor prognosis

Author keywords

[No Author keywords available]

Indexed keywords

F BOX PROTEIN; LACTATE DEHYDROGENASE; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P27; S PHASE KINASE ASSOCIATED PROTEIN 2;

EID: 4143117855     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-04-0136     Document Type: Article
Times cited : (36)

References (63)
  • 1
    • 0035835828 scopus 로고    scopus 로고
    • p27(Kip1): Regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer
    • Philipp-Staheli J, Payne SR, Kemp CJ. p27(Kip1): regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer. Exp Cell Res 2001;264:148-68.
    • (2001) Exp Cell Res , vol.264 , pp. 148-168
    • Philipp-Staheli, J.1    Payne, S.R.2    Kemp, C.J.3
  • 2
    • 0034092911 scopus 로고    scopus 로고
    • Regulation of the Cdk inhibitor p27 and its deregulation in cancer
    • Slingerland J, Pagano M. Regulation of the Cdk inhibitor p27 and its deregulation in cancer. J Cell Physiol 2000;183:10-7.
    • (2000) J Cell Physiol , vol.183 , pp. 10-17
    • Slingerland, J.1    Pagano, M.2
  • 3
    • 0030894787 scopus 로고    scopus 로고
    • The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomas
    • Tan P, Cady B, Wanner M, et al. The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomas. Cancer Res 1997;57:1259-63.
    • (1997) Cancer Res , vol.57 , pp. 1259-1263
    • Tan, P.1    Cady, B.2    Wanner, M.3
  • 4
    • 16944363001 scopus 로고    scopus 로고
    • Decreased levels of the cell-cycle inhibitor p27Kip1 protein: Prognostic implications in primary breast cancer
    • Catzavelos C, Bhattacharya N, Ung YC, et al. Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer. Nat Med 1997;3:227-30.
    • (1997) Nat Med , vol.3 , pp. 227-230
    • Catzavelos, C.1    Bhattacharya, N.2    Ung, Y.C.3
  • 5
    • 0030947356 scopus 로고    scopus 로고
    • High level expression of p27(Kip1) and cyclin D1 in some human breast cells: Inverse correlation between the expression of p27(Kip1) and degree of malignancy in human breast and colorectal cancers
    • Fredersdorf S, Burns J, Milne AM, et al. High level expression of p27(Kip1) and cyclin D1 in some human breast cells: inverse correlation between the expression of p27(Kip1) and degree of malignancy in human breast and colorectal cancers. Proc Natl Acad Sci USA 1997;94:6380-5.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 6380-6385
    • Fredersdorf, S.1    Burns, J.2    Milne, A.M.3
  • 6
    • 0031048236 scopus 로고    scopus 로고
    • Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal cancers
    • Loda M, Cukor B, Tam SW, et al. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal cancers. Nat Med 1997;3:231-4.
    • (1997) Nat Med , vol.3 , pp. 231-234
    • Loda, M.1    Cukor, B.2    Tam, S.W.3
  • 8
    • 14444268041 scopus 로고    scopus 로고
    • Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer
    • Esposito V, Baldi A, De Luca A, et al. Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer. Cancer Res 1997;57:3381-5.
    • (1997) Cancer Res , vol.57 , pp. 3381-3385
    • Esposito, V.1    Baldi, A.2    De Luca, A.3
  • 9
    • 0036847690 scopus 로고    scopus 로고
    • Elevated Skp2 protein expression in human prostate cancer: Association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival
    • Yang G, Ayala G, De Marzo A, et al. Elevated Skp2 protein expression in human prostate cancer: association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival. Clin Cancer Res 2002;8:3419-26.
    • (2002) Clin Cancer Res , vol.8 , pp. 3419-3426
    • Yang, G.1    Ayala, G.2    De Marzo, A.3
  • 10
    • 12944283204 scopus 로고    scopus 로고
    • Increased proteasome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma
    • Chiarle R, Budel LM, Skolink J, et al. Increased proteasome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma. Blood 2000;95:619-26.
    • (2000) Blood , vol.95 , pp. 619-626
    • Chiarle, R.1    Budel, L.M.2    Skolink, J.3
  • 11
    • 0029024015 scopus 로고
    • Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27
    • Pagano M, Tam SW, Theodoras AM, et al. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science (Wash DC) 1995;269:682-5.
    • (1995) Science (Wash DC) , vol.269 , pp. 682-685
    • Pagano, M.1    Tam, S.W.2    Theodoras, A.M.3
  • 12
    • 0033135878 scopus 로고    scopus 로고
    • Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation
    • Montagnoli A, Fiore F, Eytan E, et al. Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation. Genes Dev 1999;13:1181-9.
    • (1999) Genes Dev , vol.13 , pp. 1181-1189
    • Montagnoli, A.1    Fiore, F.2    Eytan, E.3
  • 13
    • 0032905150 scopus 로고    scopus 로고
    • Cell-free degradation of p27(kip1), a G1 cyclin-dependent kinase inhibitor, is dependent on CDK2 activity and the proteasome
    • Nguyen H, Gitig DM, Koff A. Cell-free degradation of p27(kip1), a G1 cyclin-dependent kinase inhibitor, is dependent on CDK2 activity and the proteasome. Mol Cell Biol 1999;19:1190-201.
    • (1999) Mol Cell Biol , vol.19 , pp. 1190-1201
    • Nguyen, H.1    Gitig, D.M.2    Koff, A.3
  • 15
    • 0028980273 scopus 로고
    • p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase
    • Zhang H, Kobayashi R, Galaktionov K, Beach D. p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase. Cell 1995;82:915-25.
    • (1995) Cell , vol.82 , pp. 915-925
    • Zhang, H.1    Kobayashi, R.2    Galaktionov, K.3    Beach, D.4
  • 16
    • 0033176887 scopus 로고    scopus 로고
    • SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
    • Carrano AC, Eytan E, Hershko A, Pagano M. SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol 1999;1:193-9.
    • (1999) Nat Cell Biol , vol.1 , pp. 193-199
    • Carrano, A.C.1    Eytan, E.2    Hershko, A.3    Pagano, M.4
  • 17
    • 0033174070 scopus 로고    scopus 로고
    • p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells
    • Sutterluty H, Chatelain E, Marti A, et al. p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells. Nat Cell Biol 1999;1:207-14.
    • (1999) Nat Cell Biol , vol.1 , pp. 207-214
    • Sutterluty, H.1    Chatelain, E.2    Marti, A.3
  • 18
    • 0033578073 scopus 로고    scopus 로고
    • p27(Kip1) ubiquitin and degradation is regulated by the SCF (Skp2) complex through phosphorylated Thr187 in p27
    • Tsvetkov LM, Yeh KH, Lee SJ, Sun H, Zhang H. p27(Kip1) ubiquitin and degradation is regulated by the SCF (Skp2) complex through phosphorylated Thr187 in p27. Curr Biol 1999;9:661-4.
    • (1999) Curr Biol , vol.9 , pp. 661-664
    • Tsvetkov, L.M.1    Yeh, K.H.2    Lee, S.J.3    Sun, H.4    Zhang, H.5
  • 19
    • 0034595292 scopus 로고    scopus 로고
    • Targeted disrup tion of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication
    • Nakayama K, Nagahama H, Minamishima YA, et al. Targeted disrup tion of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. EMBO J 2000;19:2069-81.
    • (2000) EMBO J , vol.19 , pp. 2069-2081
    • Nakayama, K.1    Nagahama, H.2    Minamishima, Y.A.3
  • 20
    • 0032030883 scopus 로고    scopus 로고
    • Overexpression of cyclin A but not Skp2 correlates with the tumor relapse of human hepatocellular carcinoma
    • Chao Y, Shih YL, Chiu JH, et al. Overexpression of cyclin A but not Skp2 correlates with the tumor relapse of human hepatocellular carcinoma. Cancer Res 1998;58:985-90.
    • (1998) Cancer Res , vol.58 , pp. 985-990
    • Chao, Y.1    Shih, Y.L.2    Chiu, J.H.3
  • 21
    • 0035340719 scopus 로고    scopus 로고
    • Inverse relation between levels of p27(Kip1) and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas
    • Hershko D, Bornstein G, Ben-Izhak O, et al. Inverse relation between levels of p27(Kip1) and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas. Cancer (Phila) 2001;91:1745-51.
    • (2001) Cancer (Phila) , vol.91 , pp. 1745-1751
    • Hershko, D.1    Bornstein, G.2    Ben-Izhak, O.3
  • 22
    • 0035942224 scopus 로고    scopus 로고
    • Skp2 is oncogenic and overexpressed in human cancers
    • Gstaiger M, Jordan R, Lim M, et al. Skp2 is oncogenic and overexpressed in human cancers. Proc Natl Acad Sci USA, 2001;98:5043-8.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 5043-5048
    • Gstaiger, M.1    Jordan, R.2    Lim, M.3
  • 23
    • 0035476237 scopus 로고    scopus 로고
    • High expression of S-phase kinase-interacting protein 2, human F-box protein, correlates with poor prognosis in oral squamous cell carcinomas
    • Kudo Y, Kitajima S, Sato S, Miyauchi M, Ogawa I, Takata T. High expression of S-phase kinase-interacting protein 2, human F-box protein, correlates with poor prognosis in oral squamous cell carcinomas. Cancer Res 2001;61:7044-7.
    • (2001) Cancer Res , vol.61 , pp. 7044-7047
    • Kudo, Y.1    Kitajima, S.2    Sato, S.3    Miyauchi, M.4    Ogawa, I.5    Takata, T.6
  • 24
    • 0037989911 scopus 로고    scopus 로고
    • Skp2 overexpression is a prognostic factor in patients with ovarian adenocarcinoma
    • Shigemasa K, Gu L, O'Brien TJ, Ohama K. Skp2 overexpression is a prognostic factor in patients with ovarian adenocarcinoma. Clin Cancer Res 2003;9:1756-63.
    • (2003) Clin Cancer Res , vol.9 , pp. 1756-1763
    • Shigemasa, K.1    Gu, L.2    O'Brien, T.J.3    Ohama, K.4
  • 25
  • 26
    • 0036645405 scopus 로고    scopus 로고
    • Clinical and biological significance of S-phase kinase-associated protein (Skp2) gene expression in gastric carcinoma: Modulation of malignant phenotype by Skp2 overexpression, possibly via p27 proteolysis
    • Masuda T, Inoue H, Sonoda H, et al. Clinical and biological significance of S-phase kinase-associated protein (Skp2) gene expression in gastric carcinoma: modulation of malignant phenotype by Skp2 overexpression, possibly via p27 proteolysis. Cancer Res, 2002;62:3819-25.
    • (2002) Cancer Res , vol.62 , pp. 3819-3825
    • Masuda, T.1    Inoue, H.2    Sonoda, H.3
  • 28
    • 0037108299 scopus 로고    scopus 로고
    • Kip1 ubiquitin ligase, in malignant lymphoma: Correlation with p27Kip1 and proliferation index
    • Kip1 ubiquitin ligase, in malignant lymphoma: correlation with p27Kip1 and proliferation index. Blood 2002;100:2950-6.
    • (2002) Blood , vol.100 , pp. 2950-2956
    • Lim, M.S.1    Adamson, A.2    Lin, Z.3
  • 29
    • 0036861277 scopus 로고    scopus 로고
    • Over-expression of p45(SKP2) in Kaposi's sarcoma correlates with higher tumor stage and extracutaneous involvement but is not directly related to p27(KIP1) down-regulation
    • Penin RM, Fernandez-Figueras MT, Puig L, Rex J, Ferrandiz C, Ariza A. Over-expression of p45(SKP2) in Kaposi's sarcoma correlates with higher tumor stage and extracutaneous involvement but is not directly related to p27(KIP1) down-regulation. Mod Pathol 2002;15:1227-35.
    • (2002) Mod Pathol , vol.15 , pp. 1227-1235
    • Penin, R.M.1    Fernandez-Figueras, M.T.2    Puig, L.3    Rex, J.4    Ferrandiz, C.5    Ariza, A.6
  • 30
    • 0030936323 scopus 로고    scopus 로고
    • PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
    • Li J, Yen C, Liaw D, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science (Wash DC) 1997;275:1943-7.
    • (1997) Science (Wash DC) , vol.275 , pp. 1943-1947
    • Li, J.1    Yen, C.2    Liaw, D.3
  • 31
    • 17144436629 scopus 로고    scopus 로고
    • Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
    • Steck PA, Pershouse MA, Jasser SA, et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 1997;15:356-62.
    • (1997) Nat Genet , vol.15 , pp. 356-362
    • Steck, P.A.1    Pershouse, M.A.2    Jasser, S.A.3
  • 32
    • 0030837555 scopus 로고    scopus 로고
    • P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase
    • Myers MP, Stolarov JP, Eng C, et al. P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc Natl Acad Sci USA 1997;94:9052-7.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 9052-9057
    • Myers, M.P.1    Stolarov, J.P.2    Eng, C.3
  • 33
    • 0032577699 scopus 로고    scopus 로고
    • The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
    • Maehama T, Dixon JE. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 1998;273:13375-8.
    • (1998) J Biol Chem , vol.273 , pp. 13375-13378
    • Maehama, T.1    Dixon, J.E.2
  • 34
    • 3643119742 scopus 로고    scopus 로고
    • The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells
    • Fumari FB, Huang HJ, Cavenee WK. The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells. Cancer Res 1998;58:5002-8.
    • (1998) Cancer Res , vol.58 , pp. 5002-5008
    • Fumari, F.B.1    Huang, H.J.2    Cavenee, W.K.3
  • 35
    • 0033579163 scopus 로고    scopus 로고
    • Mutational spectra of PTEN/MMAC1 gene: A tumor suppressor with lipid phosphatase activity
    • Ali IU, Schriml LM, Dean M. Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity. J Natl Cancer Inst (Bethesda) 1999;91:1922-32.
    • (1999) J Natl Cancer Inst (Bethesda) , vol.91 , pp. 1922-1932
    • Ali, I.U.1    Schriml, L.M.2    Dean, M.3
  • 38
    • 0034669945 scopus 로고    scopus 로고
    • Loss of PTEN expression leading to high Akt activation in human multiple myelomas
    • Hyun T, Yam A, Pece S, et al. Loss of PTEN expression leading to high Akt activation in human multiple myelomas. Blood 2000;96:3560-8.
    • (2000) Blood , vol.96 , pp. 3560-3568
    • Hyun, T.1    Yam, A.2    Pece, S.3
  • 40
    • 0035916325 scopus 로고    scopus 로고
    • PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2)
    • Mamillapalli R, Gavrilova N, Mihaylova VT, et al. PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2). Curr Biol 2001;11:263-7.
    • (2001) Curr Biol , vol.11 , pp. 263-267
    • Mamillapalli, R.1    Gavrilova, N.2    Mihaylova, V.T.3
  • 42
    • 0033868859 scopus 로고    scopus 로고
    • Mutational analysis of the tumor suppressor gene MMAC1/PTEN in malignant myeloid disorders
    • Aggerholm A, Gronbaek K, Guldberg P, Hokland P. Mutational analysis of the tumor suppressor gene MMAC1/PTEN in malignant myeloid disorders. Eur J Haematol 2000;65:109-13.
    • (2000) Eur J Haematol , vol.65 , pp. 109-113
    • Aggerholm, A.1    Gronbaek, K.2    Guldberg, P.3    Hokland, P.4
  • 43
    • 0043130432 scopus 로고    scopus 로고
    • Phosphatase and tensin homologue phosphorylation in the C-terminal regulatory domain is frequently observed in acute myeloid leukaemia and associated with poor clinical outcome
    • Cheong JW, Eom JI, Maeng HY, et al. Phosphatase and tensin homologue phosphorylation in the C-terminal regulatory domain is frequently observed in acute myeloid leukaemia and associated with poor clinical outcome. Br J Haematol 2003;122:454-6.
    • (2003) Br J Haematol , vol.122 , pp. 454-456
    • Cheong, J.W.1    Eom, J.I.2    Maeng, H.Y.3
  • 44
    • 0025261428 scopus 로고
    • Report of the National Cancer Institute-sponsored workshop on definitions of diagnosis and response in acute myeloid leukemia
    • Cheson BD, Cassileth PA, Head DR, et al. Report of the National Cancer Institute-sponsored workshop on definitions of diagnosis and response in acute myeloid leukemia. J Clin Oncol 1990;8:813-9.
    • (1990) J Clin Oncol , vol.8 , pp. 813-819
    • Cheson, B.D.1    Cassileth, P.A.2    Head, D.R.3
  • 45
    • 0034899224 scopus 로고    scopus 로고
    • AC133 antigen as a prognostic factor in acute leukemia
    • Lee ST, Jang JH, Min YH, Hahn JS, Ko YW. AC133 antigen as a prognostic factor in acute leukemia. Leuk Res 2001;25:757-67.
    • (2001) Leuk Res , vol.25 , pp. 757-767
    • Lee, S.T.1    Jang, J.H.2    Min, Y.H.3    Hahn, J.S.4    Ko, Y.W.5
  • 46
    • 0035419867 scopus 로고    scopus 로고
    • ErbB2/neu kinase modulates cellular p27(Kip1) and cyclin D1 through multiple signaling pathways
    • Lenferink AE, Busse D, Flanagan WM, Yakes FM, Arteaga CL. ErbB2/neu kinase modulates cellular p27(Kip1) and cyclin D1 through multiple signaling pathways. Cancer Res 2001;61:6583-91.
    • (2001) Cancer Res , vol.61 , pp. 6583-6591
    • Lenferink, A.E.1    Busse, D.2    Flanagan, W.M.3    Yakes, F.M.4    Arteaga, C.L.5
  • 47
    • 0035966104 scopus 로고    scopus 로고
    • Degradation of p27Kip1 at the G0-G1 transition mediated by a Skp2-independent ubiquitination pathway
    • Hara T, Kamura T, Nakayama K, Oshikawa K, Hatakeyama S, Nakayama KI. Degradation of p27Kip1 at the G0-G1 transition mediated by a Skp2-independent ubiquitination pathway. J Biol Chem 2001;276:48937-43.
    • (2001) J Biol Chem , vol.276 , pp. 48937-48943
    • Hara, T.1    Kamura, T.2    Nakayama, K.3    Oshikawa, K.4    Hatakeyama, S.5    Nakayama, K.I.6
  • 48
    • 0032696891 scopus 로고    scopus 로고
    • Overexpressed cyclin D3 contributes to retaining the growth inhibitor p27 in the cytoplasm of thyroid tumor cells
    • Baldassarre G, Belletti B, Bruni P, et al. Overexpressed cyclin D3 contributes to retaining the growth inhibitor p27 in the cytoplasm of thyroid tumor cells. J Clin Investig 1999;104:865-74.
    • (1999) J Clin Investig , vol.104 , pp. 865-874
    • Baldassarre, G.1    Belletti, B.2    Bruni, P.3
  • 49
    • 0031594186 scopus 로고    scopus 로고
    • Localization and expression of p27KIP1 in multistage colorectal carcinogenesis
    • Ciaparrone M, Yamamoto H, Yao Y, et al. Localization and expression of p27KIP1 in multistage colorectal carcinogenesis. Cancer Res 1998;58:114-22.
    • (1998) Cancer Res , vol.58 , pp. 114-122
    • Ciaparrone, M.1    Yamamoto, H.2    Yao, Y.3
  • 50
    • 0032522414 scopus 로고    scopus 로고
    • Loss or altered subcellular localization of p27 in Barrett's associated adenocarcinoma
    • Singh SP, Lipman J, Goldman H, et al. Loss or altered subcellular localization of p27 in Barrett's associated adenocarcinoma. Cancer Res 1998;58:1730-5.
    • (1998) Cancer Res , vol.58 , pp. 1730-1735
    • Singh, S.P.1    Lipman, J.2    Goldman, H.3
  • 51
    • 0034641709 scopus 로고    scopus 로고
    • Abnormal integrin-mediated regulation of chronic myelogenous leukemia CD34+ cell proliferation: BCR/ABL up-regulates the cyclin-dependent kinase inhibitor, p27Kip, which is relocated to the cell cytoplasm and incapable of regulating cdk2 activity
    • Jiang Y, Zhao RC, Verfaillie CM. Abnormal integrin-mediated regulation of chronic myelogenous leukemia CD34+ cell proliferation: BCR/ABL up-regulates the cyclin-dependent kinase inhibitor, p27Kip, which is relocated to the cell cytoplasm and incapable of regulating cdk2 activity. Proc Natl Acad Sci USA 2000;97:10538-43.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 10538-10543
    • Jiang, Y.1    Zhao, R.C.2    Verfaillie, C.M.3
  • 52
    • 0032430241 scopus 로고    scopus 로고
    • Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2
    • Soucek T, Yeung RS, Hengstschlager M. Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2. Proc Natl Acad Sci USA 1998;95:15653-8.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 15653-15658
    • Soucek, T.1    Yeung, R.S.2    Hengstschlager, M.3
  • 53
    • 0032554775 scopus 로고    scopus 로고
    • Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cells
    • Orend G, Hunter T, Ruoslahti E. Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cells. Oncogene 1998;16:2575-83.
    • (1998) Oncogene , vol.16 , pp. 2575-2583
    • Orend, G.1    Hunter, T.2    Ruoslahti, E.3
  • 54
    • 0033135934 scopus 로고    scopus 로고
    • Subcellular and cell-cycle expression profiles of CDK-inhibitors in normal differentiating myeloid cells
    • Yaroslavskiy B, Watkins S, Donnenberg AD, Patton TJ, Steinman RA. Subcellular and cell-cycle expression profiles of CDK-inhibitors in normal differentiating myeloid cells. Blood 1999;93:2907-17.
    • (1999) Blood , vol.93 , pp. 2907-2917
    • Yaroslavskiy, B.1    Watkins, S.2    Donnenberg, A.D.3    Patton, T.J.4    Steinman, R.A.5
  • 55
    • 18644376449 scopus 로고    scopus 로고
    • PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest
    • Liang J, Zubovitz J, Petrocelli T, et al. PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. Nat Med 2002;8:1153-60.
    • (2002) Nat Med , vol.8 , pp. 1153-1160
    • Liang, J.1    Zubovitz, J.2    Petrocelli, T.3
  • 56
    • 0036799377 scopus 로고    scopus 로고
    • Kip1 at threonine 157 and modulation of its cellular localization
    • Kip1 at threonine 157 and modulation of its cellular localization. Nat Med 2002;10:1145-52.
    • (2002) Nat Med , vol.10 , pp. 1145-1152
    • Shin, I.1    Yakes, F.M.2    Rojo, F.3
  • 57
    • 18644370396 scopus 로고    scopus 로고
    • Kip1 by PKB/Akt-mediated phosphorylation in breast cancer
    • Kip1 by PKB/Akt-mediated phosphorylation in breast cancer. Nat Med 2002;8:1136-43.
    • (2002) Nat Med , vol.8 , pp. 1136-1143
    • Viglietto, G.1    Motti, M.L.2    Bruni, P.3
  • 58
    • 0033004889 scopus 로고    scopus 로고
    • Skp2 induction and phosphorylation is associated with the late G1 phase of proliferating hepatocytes
    • Bilodeau M, Talarmin H, Ilyin G, et al. Skp2 induction and phosphorylation is associated with the late G1 phase of proliferating hepatocytes. FEBS Lett 1999;452:247-53.
    • (1999) FEBS Lett , vol.452 , pp. 247-253
    • Bilodeau, M.1    Talarmin, H.2    Ilyin, G.3
  • 59
    • 0032147113 scopus 로고    scopus 로고
    • Expression of cyclin E and the cyclin-dependent kinase inhibitor p27 in malignant lymphoma-prognostic implications
    • Erlanson M, Portin C, Linderholm B, Lindh J, Roos G, Landberg G. Expression of cyclin E and the cyclin-dependent kinase inhibitor p27 in malignant lymphoma-prognostic implications. Blood 1998;92:770-7.
    • (1998) Blood , vol.92 , pp. 770-777
    • Erlanson, M.1    Portin, C.2    Linderholm, B.3    Lindh, J.4    Roos, G.5    Landberg, G.6
  • 60
    • 0033946740 scopus 로고    scopus 로고
    • Phosphorylation of the PTEN tail regulates protein stability and function
    • Vazquez F, Ramaswamy S, Nakamura N, Sellers WR. Phosphorylation of the PTEN tail regulates protein stability and function. Mol Cell Biol 2000;20:5010-8.
    • (2000) Mol Cell Biol , vol.20 , pp. 5010-5018
    • Vazquez, F.1    Ramaswamy, S.2    Nakamura, N.3    Sellers, W.R.4
  • 61
    • 0035966127 scopus 로고    scopus 로고
    • Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex
    • Vazquez F, Grossman SR, Takahashi Y, Rokas MV, Nakamura N, Sellers WR. Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex. J Biol Chem 2001;276:48627-30.
    • (2001) J Biol Chem , vol.276 , pp. 48627-48630
    • Vazquez, F.1    Grossman, S.R.2    Takahashi, Y.3    Rokas, M.V.4    Nakamura, N.5    Sellers, W.R.6
  • 63
    • 0017162163 scopus 로고
    • Proposals for the classification of the acute leukaemias (FAB cooperative group)
    • Bennett JM, Catovsky D, Daniel MT, et al. Proposals for the classification of the acute leukaemias (FAB cooperative group). Br J Maematol 1976;33:451-8.
    • (1976) Br J Maematol , vol.33 , pp. 451-458
    • Bennett, J.M.1    Catovsky, D.2    Daniel, M.T.3


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