Advances in human artificial chromosome technology

Trends in Genetics

Volumn 18, Issue 6, 2002, Pages 313-319

  Larin, Zoia ^a   Mejía, José E ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b TOULOUSE UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ARTIFICIAL CHROMOSOME; CELL CULTURE; DNA VECTOR; GENE EXPRESSION; GENE FUNCTION; GENE LOCUS; GENE TECHNOLOGY; GENE TRANSFER; GENETIC DISORDER; HUMAN; PRIORITY JOURNAL; REVIEW; TRANSGENE;

ANIMALS; CENTROMERE; CHROMOSOMES, ARTIFICIAL, HUMAN; GENETIC VECTORS; HUMANS;

ANIMALIA;

EID: 0036607376     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-9525(02)02679-3     Document Type: Review

References (62)

1. YACs, BACs, PACs and MACs: Artificial chromosomes as research tools
2. Size matters: Use of YACs, BACs and PACs in transgenic animals
3. The vagaries of variegating transgenes
4. Episomal vectors for gene expression in mammalian cells
5. The case for epigenetic effect on centromere identity and function
6. Sandwiching of a gene within 12 kb of a functional telomere and alpha satellite does not result in silencing
7. Construction of artificial chromosomes in yeast
8. Engineering mammalian chromosomes
9. Functional complementation of a genetic deficiency with human artificial chromosomes
10. Stable gene expression from a mammalian artificial chromosome
11. Engineering human chromosomes for gene therapy studies
12. Functional reintroduction of human telomeres into mammalian cells
13. Targeted breakage of a human chromosome mediated by cloned human telomeric DNA
14. Telomere directed fragmentation of mammalian chromosomes
15. Generation of a human X-derived minichromosome using telomere-associated chromosome fragmentation
16. Mini-chromosomes derived from the human Y chromosome by telomre directed chromosome breakage
17. Human mini-chromosomes with minimal centromeres
18. Efficient modification of human chromosomal alleles using recombination-proficient chicken/human microcell hybrids
19. Generation of an approximately 2.4 Mb human X centromere-based minichromosome by targeted telomere-associated chromosome fragmentation in DT40
20. Formation of de novo centromeres and construction of first-generation human artificial microchromosomes
21. Construction of YAC-based mammalian artificial chromosomes
22. Human artificial chromosomes generated by modification of a yeast artificial chromosome containing both alpha satellite and single-copy DNA sequences
23. Mammalian artificial chromosome formation from circular alphoid input DNA does not require telomere repeats
24. Characterization of a newly derived human sarcoma cell line (HT-1080)
25. The assembly of large BACs by in vivo recombination
26. Gene targeting to the centromeric DNA of a human minichromosome
27. Efficient male and female germline transmission of a human chromosomal vector in mice
28. Domain organization at the centromere and neocentromere
29. Molecular and cytological analysis of a 5.5 Mb minichromosome
30. Novel generation of human satellite DNA-based artificial chromosomes in mammalian cells
31. Heterochromatin function in complex genomes
32. Construction of neocentromere-based human minichromosomes by telomere-associated chromosomal truncation
33. Genomic and genetic definition of a functional human centromere
34. Assay of centromere function using a human artificial chromosome
35. Centromeres, CENP-B and Tigger too
36. Efficiency of de novo centromere formation in human artificial chromosomes
37. Human centromeric DNAs
38. Uterine dysfunction and genetic modifiers in centromere protein B-deficient mice
39. Epigenetic codes for heterochromatin formation and silencing: Rounding up the usual suspects
40. Epigenetic analysis of kinetochore assembly on variant human centromeres
41. Molecular cytogenetic analysis of eight inversion duplications of human chromosome 13q that each contain a neocentromere
42. Centromerization
43. Acquisition and metastability of centromere identity and function: Sequence analysis of a human neocentromere
44. A 330 kb CENP-A binding domain and altered replication timing at a human neocentromere
45. A novel chromatin immunoprecipitation and array (CIA) analysis identifies a 460-kb CENP-A-binding neocentromere DNA
46. The 10q25 neocentromere and its inactive progenitor have identical primary nucleotide sequence: Further evidence for epigenetic modification
47. Neocentromeres and α satellite: A proposed structural code for functional human centromere DNA
48. Functional expression and germline transmission of a human chromosome fragment in chimaeric mice
49. Double trans-chromosomic mice: Maintenance of two individual human chromosome fragments containing Ig heavy and kappa loci and expression of fully human antibodies
50. Manipulation of human minichromosomes to carry greater than megabase-sized chromosome inserts
51. Human mini-chromosomes in mouse embryonal stem cells
52. A structurally defined mini-chromosome vector for the mouse germline
53. Transchromosomal mouse embryonal stem cell lines and chimeric mice that contain freely segregating fragments of chromosome 21
54. Generation of transgenic mice and germline transmission of a mammalian artificial chromosome introduced into embryos by pronuclear microinjection
55. An infectious transfer and expression system for genomic loci in human and mouse cells
56. Efficient in vitro transfer of a 60-Mb mammalian artificial chromosome into murine and hamster cells using cationic lipids and dendrimers
57. Recombinase-mediated gene activation and site-specific integration in mammalian cells
58. Cationic liposome-mediated gene transfer
59. Integrin-mediated vectors for gene transfer and therapy
60. High-efficiency gene transfer mediated by adenovirus coupled to DNA-polylysine complexes
61. Transfer of YACs up to 2.3 Mb intact into human cells with polyethylenimine
62. General protocol for microcell-mediated chromosome transfer