-
1
-
-
0031914387
-
Mutations in the promoter of adenylyl cyclase (AC)-III gene, overexpression of AC-III mRNA, and enhanced cAMP generation in islets from the spontaneously diabetic GK rat model of type 2 diabetes
-
Abdel-Halim SM, Guenifi A, He B, Yang B, Mustafa M, Hojeberg B, Hillert J, Bakhiet M, Efendic S (1998) Mutations in the promoter of adenylyl cyclase (AC)-III gene, overexpression of AC-III mRNA, and enhanced cAMP generation in islets from the spontaneously diabetic GK rat model of type 2 diabetes. Diabetes 47:498-504
-
(1998)
Diabetes
, vol.47
, pp. 498-504
-
-
Abdel-Halim, S.M.1
Guenifi, A.2
He, B.3
Yang, B.4
Mustafa, M.5
Hojeberg, B.6
Hillert, J.7
Bakhiet, M.8
Efendic, S.9
-
2
-
-
0036318123
-
Differential effects of hyperlipidemia on insulin secretion in islets of Langerhans from hyperglycemic versus normoglycemic rats
-
Briaud I, Kelpe CL, Johnson LM, Tran PO, Poitout V (2002) Differential effects of hyperlipidemia on insulin secretion in islets of Langerhans from hyperglycemic versus normoglycemic rats. Diabetes 51:662-668
-
(2002)
Diabetes
, vol.51
, pp. 662-668
-
-
Briaud, I.1
Kelpe, C.L.2
Johnson, L.M.3
Tran, P.O.4
Poitout, V.5
-
3
-
-
0034117177
-
Mitochondrial-nuclear translocation of AIF in apoptosis and necrosis
-
Daugas E, Susin SA, Zamzami N, Ferri KF, Irinopoulou T, Larochette N, Prevost MC, Leber B, Andrews D, Penninger J, Kroemer G (2000) Mitochondrial-nuclear translocation of AIF in apoptosis and necrosis. FASEB J 14:729-739
-
(2000)
FASEB J
, vol.14
, pp. 729-739
-
-
Daugas, E.1
Susin, S.A.2
Zamzami, N.3
Ferri, K.F.4
Irinopoulou, T.5
Larochette, N.6
Prevost, M.C.7
Leber, B.8
Andrews, D.9
Penninger, J.10
Kroemer, G.11
-
4
-
-
30944450634
-
Restitution of defective glucose-stimulated insulin secretion in diabetic GK rat by acetylcholine uncovers paradoxical stimulatory effect of beta-cell muscarinic receptor activation on cAMP production
-
Dolz M, Bailbe D, Giroix MH, Calderari S, Gangnerau MN, Serradas P, Rickenbach K, Irminger JC, Portha B (2005) Restitution of defective glucose-stimulated insulin secretion in diabetic GK rat by acetylcholine uncovers paradoxical stimulatory effect of beta-cell muscarinic receptor activation on cAMP production. Diabetes 54:3229-3237
-
(2005)
Diabetes
, vol.54
, pp. 3229-3237
-
-
Dolz, M.1
Bailbe, D.2
Giroix, M.H.3
Calderari, S.4
Gangnerau, M.N.5
Serradas, P.6
Rickenbach, K.7
Irminger, J.C.8
Portha, B.9
-
5
-
-
33644747390
-
Mechanisms of β-cell death in type 2 diabetes
-
Suppl 2
-
Donath MY, Ehses JA, Maedler K, Schumann DM, Ellingsgaard H, Eppler E, Reinecke M (2005) Mechanisms of β-cell death in type 2 diabetes. Diabetes 54(Suppl 2):S108-S113
-
(2005)
Diabetes
, vol.54
-
-
Donath, M.Y.1
Ehses, J.A.2
Maedler, K.3
Schumann, D.M.4
Ellingsgaard, H.5
Eppler, E.6
Reinecke, M.7
-
6
-
-
0022492812
-
Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: Spectral and metabolic properties
-
Emaus RK, Grunwald R, Lemasters JJ (1986) Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic properties. Biochim Biophys Acta 850:436-448
-
(1986)
Biochim Biophys Acta
, vol.850
, pp. 436-448
-
-
Emaus, R.K.1
Grunwald, R.2
Lemasters, J.J.3
-
7
-
-
0033548138
-
Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion
-
Eto K, Tsubamoto Y, Terauchi Y, Sugiyama T, Kishimoto T, Takahashi N, Yamauchi N, Kubota N, Murayama S, Aizawa T, Akanuma Y, Aizawa S, Kasai H, Yazaki Y, Kadowaki T (1999) Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion. Science 283:981-985
-
(1999)
Science
, vol.283
, pp. 981-985
-
-
Eto, K.1
Tsubamoto, Y.2
Terauchi, Y.3
Sugiyama, T.4
Kishimoto, T.5
Takahashi, N.6
Yamauchi, N.7
Kubota, N.8
Murayama, S.9
Aizawa, T.10
Akanuma, Y.11
Aizawa, S.12
Kasai, H.13
Yazaki, Y.14
Kadowaki, T.15
-
8
-
-
33845934827
-
Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high fat diet
-
Fex M, Nitert MD, Wierup N, Sundler F, Ling C, Mulder H (2007) Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high fat diet. Diabetologia 50:74-83
-
(2007)
Diabetologia
, vol.50
, pp. 74-83
-
-
Fex, M.1
Nitert, M.D.2
Wierup, N.3
Sundler, F.4
Ling, C.5
Mulder, H.6
-
9
-
-
0003151519
-
Spontaneous diabetes produced by selective breeding of normal Wistar rats
-
Goto Y, Kakizaki M, Masaki N (1975) Spontaneous diabetes produced by selective breeding of normal Wistar rats. Proc Jpn Acad 51:80-85
-
(1975)
Proc Jpn Acad
, vol.51
, pp. 80-85
-
-
Goto, Y.1
Kakizaki, M.2
Masaki, N.3
-
10
-
-
0024197770
-
Development of diabetes in the non-obese NIDDM rat (GK rat)
-
Goto Y, Suzuki K, Ono T, Sasaki M, Toyota T (1988) Development of diabetes in the non-obese NIDDM rat (GK rat). Adv Exp Med Biol 246:29-31
-
(1988)
Adv Exp Med Biol
, vol.246
, pp. 29-31
-
-
Goto, Y.1
Suzuki, K.2
Ono, T.3
Sasaki, M.4
Toyota, T.5
-
11
-
-
0030470658
-
Increased susceptibility of islets from diabetes-prone Psammomys obesus to the deleterious effects of chronic glucose exposure
-
Gross DJ, Leibowitz G, Cerasi E, Kaiser N (1996) Increased susceptibility of islets from diabetes-prone Psammomys obesus to the deleterious effects of chronic glucose exposure. Endocrinology 137:5610-5615
-
(1996)
Endocrinology
, vol.137
, pp. 5610-5615
-
-
Gross, D.J.1
Leibowitz, G.2
Cerasi, E.3
Kaiser, N.4
-
12
-
-
0028843381
-
Preserved β-cell density in the endocrine pancreas of young, spontaneously diabetic Goto-Kakizaki (GK) rats
-
Guenifi A, Abdel-Halim SM, Hoog A, Falkmer S, Östenson CG (1995) Preserved β-cell density in the endocrine pancreas of young, spontaneously diabetic Goto-Kakizaki (GK) rats. Pancreas 10:148-153
-
(1995)
Pancreas
, vol.10
, pp. 148-153
-
-
Guenifi, A.1
Abdel-Halim, S.M.2
Hoog, A.3
Falkmer, S.4
Östenson, C.G.5
-
13
-
-
0037427440
-
Mitochondria permeability transition: A common pathway to necrosis and apoptosis
-
Kim JS, He L, Lemasters JJ (2003) Mitochondria permeability transition: a common pathway to necrosis and apoptosis. Biochem Biophys Res Comm 304:463-470
-
(2003)
Biochem Biophys Res Comm
, vol.304
, pp. 463-470
-
-
Kim, J.S.1
He, L.2
Lemasters, J.J.3
-
14
-
-
0030747209
-
In situ characterization of islets in diabetes with a mitochondrial DNA mutation at nucleotide position 3243
-
Kobayashi T, Nakanishi K, Nakase H, Kajio H, Okubo M, Murase T, Kosaka K (1997) In situ characterization of islets in diabetes with a mitochondrial DNA mutation at nucleotide position 3243. Diabetes 46:1567-1571
-
(1997)
Diabetes
, vol.46
, pp. 1567-1571
-
-
Kobayashi, T.1
Nakanishi, K.2
Nakase, H.3
Kajio, H.4
Okubo, M.5
Murase, T.6
Kosaka, K.7
-
15
-
-
0034060985
-
Inhibition of progressive reduction of islet β-cell mass in spontaneously diabetic Goto-Kakizaki rats by α-glucosidase inhibitor
-
Koyama M, Wada R, Mizukami H, Sakuraba H, Odaka H, Ikeda H, Yagihashi S (2000) Inhibition of progressive reduction of islet β-cell mass in spontaneously diabetic Goto-Kakizaki rats by α-glucosidase inhibitor. Metabolism 49:1-7
-
(2000)
Metabolism
, vol.49
, pp. 1-7
-
-
Koyama, M.1
Wada, R.2
Mizukami, H.3
Sakuraba, H.4
Odaka, H.5
Ikeda, H.6
Yagihashi, S.7
-
16
-
-
0031857392
-
Accelerated loss of islet β cells in sucrose-fed Goto-Kakizaki rats, a genetic model of non-insulin-dependent diabetes mellitus
-
Koyama M, Wada R, Sakuraba H, Mizukami H, Yagihashi S (1998) Accelerated loss of islet β cells in sucrose-fed Goto-Kakizaki rats, a genetic model of non-insulin-dependent diabetes mellitus. Am J Pathol 153:537-545
-
(1998)
Am J Pathol
, vol.153
, pp. 537-545
-
-
Koyama, M.1
Wada, R.2
Sakuraba, H.3
Mizukami, H.4
Yagihashi, S.5
-
17
-
-
0346340042
-
Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction
-
Krauss S, Zhang CY, Scorrano L, Dalgaard LT, St-Pierre J, Grey ST, Lowell BB (2003) Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction. J Clin Invest 112:1831-1842
-
(2003)
J Clin Invest
, vol.112
, pp. 1831-1842
-
-
Krauss, S.1
Zhang, C.Y.2
Scorrano, L.3
Dalgaard, L.T.4
St-Pierre, J.5
Grey, S.T.6
Lowell, B.B.7
-
18
-
-
0014042613
-
Method for the isolation of intact islets of Langerhans from the rat pancreas
-
Lacy PE, Kostianovsky M (1967) Method for the isolation of intact islets of Langerhans from the rat pancreas. Diabetes 16:35-39
-
(1967)
Diabetes
, vol.16
, pp. 35-39
-
-
Lacy, P.E.1
Kostianovsky, M.2
-
19
-
-
0027947379
-
β-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: Impairment in adipocyte-β-cell relationships
-
Lee Y, Hirose H, Ohneda M, Johnson JH, McGarry JD, Unger RH (1994) β-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-β-cell relationships. Proc Natl Acad Sci U S A 91:10878-10882
-
(1994)
Proc Natl Acad Sci U S a
, vol.91
, pp. 10878-10882
-
-
Lee, Y.1
Hirose, H.2
Ohneda, M.3
Johnson, J.H.4
McGarry, J.D.5
Unger, R.H.6
-
20
-
-
0034728096
-
Mitochondrial respiratory chain disorders II: Neurodegenerative disorders and nuclear gene defects
-
Leonard JV, Schapira AHV (2000) Mitochondrial respiratory chain disorders II: neurodegenerative disorders and nuclear gene defects. Lancet 355:389-394
-
(2000)
Lancet
, vol.355
, pp. 389-394
-
-
Leonard, J.V.1
Schapira, A.H.V.2
-
21
-
-
12344305124
-
Mitochondrial dysfunction in type 2 diabetes
-
Lowell BB, Schulman GI (2005) Mitochondrial dysfunction in type 2 diabetes. Science 307:384-387
-
(2005)
Science
, vol.307
, pp. 384-387
-
-
Lowell, B.B.1
Schulman, G.I.2
-
22
-
-
0025820578
-
Effect of pioglitazone on sucrose-deteriorated diabetic states in spontaneously diabetic GK rats
-
Odaka H, Sugiyama Y, Ikeda H (1991) Effect of pioglitazone on sucrose-deteriorated diabetic states in spontaneously diabetic GK rats. J Jpn Diab Soc 34:523-530
-
(1991)
J Jpn Diab Soc
, vol.34
, pp. 523-530
-
-
Odaka, H.1
Sugiyama, Y.2
Ikeda, H.3
-
23
-
-
0000354503
-
Studies on the pathogenesis of NIDDM in the GK (Goto-Kakizaki) rat
-
Birkhäuser Boston
-
Östenson C-G, Abdel-Halim SM, Andersson A, Guenifi A, Khan A, Larsson O, Berggren PO, Efendic S (1996) Studies on the pathogenesis of NIDDM in the GK (Goto-Kakizaki) rat. In: Shafrir E (ed) Lessons from animal diabetes, VI. Birkhäuser, Boston, pp 299-315
-
(1996)
Lessons from Animal Diabetes, VI
, pp. 299-315
-
-
Östenson, C.-G.1
Abdel-Halim, S.M.2
Andersson, A.3
Guenifi, A.4
Khan, A.5
Larsson, O.6
Berggren, P.O.7
Efendic, S.8
Shafrir, E.9
-
24
-
-
0027339801
-
Abnormal insulin secretion and glucose metabolism in pancreatic islets from the spontaneously diabetic GK rat
-
Östenson CG, Khan A, Abdel-Halim SM, Guenifi A, Suzuki K, Goto Y, Efendic S (1993) Abnormal insulin secretion and glucose metabolism in pancreatic islets from the spontaneously diabetic GK rat. Diabetologia 36:3-8
-
(1993)
Diabetologia
, vol.36
, pp. 3-8
-
-
Östenson, C.G.1
Khan, A.2
Abdel-Halim, S.M.3
Guenifi, A.4
Suzuki, K.5
Goto, Y.6
Efendic, S.7
-
25
-
-
0033609297
-
Molecular and histological evaluation of pancreata from patients with a mitochondrial gene mutation associated with impaired insulin secretion
-
Otabe S, Yasuda K, Mori Y, Shimokawa K, Kadowaki H, Jimi A, Nonaka K, Akanuma Y, Yazaki Y, Kadowaki T (1999) Molecular and histological evaluation of pancreata from patients with a mitochondrial gene mutation associated with impaired insulin secretion. Biochem Biophys Res Commun 259:149-156
-
(1999)
Biochem Biophys Res Commun
, vol.259
, pp. 149-156
-
-
Otabe, S.1
Yasuda, K.2
Mori, Y.3
Shimokawa, K.4
Kadowaki, H.5
Jimi, A.6
Nonaka, K.7
Akanuma, Y.8
Yazaki, Y.9
Kadowaki, T.10
-
26
-
-
0020424116
-
Effect of diet on glucose tolerance and insulin response in chemically diabetic rats
-
Portha B, Giroix MH, Picon L (1982) Effect of diet on glucose tolerance and insulin response in chemically diabetic rats. Metabolism 31:1194-1199
-
(1982)
Metabolism
, vol.31
, pp. 1194-1199
-
-
Portha, B.1
Giroix, M.H.2
Picon, L.3
-
27
-
-
0025877358
-
β-cell insensitivity to glucose in the GK rat, a spontaneous non-obese model for type II diabetes
-
Portha B, Serradas P, Bailbe D, Suzuki K, Goto Y, Giroix MH (1991) β-cell insensitivity to glucose in the GK rat, a spontaneous non-obese model for type II diabetes. Diabetes 40:486-491
-
(1991)
Diabetes
, vol.40
, pp. 486-491
-
-
Portha, B.1
Serradas, P.2
Bailbe, D.3
Suzuki, K.4
Goto, Y.5
Giroix, M.H.6
-
28
-
-
0016590880
-
Effects of sucrose feeding on the intestinal transport of sugars in two strains of rats
-
Reiser S, Michaelis O IV, Putney J, Hallfrisch J (1975) Effects of sucrose feeding on the intestinal transport of sugars in two strains of rats. J Nutr 105:894-905
-
(1975)
J Nutr
, vol.105
, pp. 894-905
-
-
Reiser, S.1
Michaelis IV, O.2
Putney, J.3
Hallfrisch, J.4
-
29
-
-
12344323484
-
Type 2 diabetes: A matter of beta-cell life and death?
-
Rhodes CJ (2005) Type 2 diabetes: a matter of beta-cell life and death? Science 307:380-384
-
(2005)
Science
, vol.307
, pp. 380-384
-
-
Rhodes, C.J.1
-
30
-
-
0037341238
-
Glucose toxicity in beta-cells: Type 2 diabetes, good radicals gone bad, and the glutathione connection
-
Robertson RP, Harmon J, Tran PO, Poitout V (2003) Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection. Diabetes 52:581-587
-
(2003)
Diabetes
, vol.52
, pp. 581-587
-
-
Robertson, R.P.1
Harmon, J.2
Tran, P.O.3
Poitout, V.4
-
31
-
-
0036163156
-
Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients
-
Sakuraba H, Mizukami H, Yagihashi N, Wada R, Hanyu C, Yagihashi S (2002) Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients. Diabetologia 45:85-96
-
(2002)
Diabetologia
, vol.45
, pp. 85-96
-
-
Sakuraba, H.1
Mizukami, H.2
Yagihashi, N.3
Wada, R.4
Hanyu, C.5
Yagihashi, S.6
-
32
-
-
0034944055
-
Brain and liver mitochondria isolated from diabetic Goto-Kakizaki rats show different susceptibility to induced oxidative stress
-
Santos MS, Santos DL, Palmeira CM, Seica R, Moreno AJ, Oliveira CR (2001) Brain and liver mitochondria isolated from diabetic Goto-Kakizaki rats show different susceptibility to induced oxidative stress. Diabetes Metab Res Rev 17:223-230
-
(2001)
Diabetes Metab Res Rev
, vol.17
, pp. 223-230
-
-
Santos, M.S.1
Santos, D.L.2
Palmeira, C.M.3
Seica, R.4
Moreno, A.J.5
Oliveira, C.R.6
-
33
-
-
0028803105
-
Mitochondrial deoxyribonucleic acid content is specifically decreased in adult, but not fetal, pancreatic islets of the Goto-Kakizaki rat, a genetic model of non-insulin-dependent diabetes
-
Serradas P, Giroix MH, Saulnier C, Gangnerau MN, Borg LA, Welsh M, Portha B, Welsh N (1995) Mitochondrial deoxyribonucleic acid content is specifically decreased in adult, but not fetal, pancreatic islets of the Goto-Kakizaki rat, a genetic model of non-insulin-dependent diabetes. Endocrinology 136:5623-5631
-
(1995)
Endocrinology
, vol.136
, pp. 5623-5631
-
-
Serradas, P.1
Giroix, M.H.2
Saulnier, C.3
Gangnerau, M.N.4
Borg, L.A.5
Welsh, M.6
Portha, B.7
Welsh, N.8
-
34
-
-
0030689041
-
Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells
-
Tiedge M, Lortz S, Drinkgern J, Lenzen S (1997) Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells. Diabetes 46:1733-1742
-
(1997)
Diabetes
, vol.46
, pp. 1733-1742
-
-
Tiedge, M.1
Lortz, S.2
Drinkgern, J.3
Lenzen, S.4
-
35
-
-
0022469273
-
Synergistic improvement of glucose intolerance by sucrose feeding and exercise training
-
Vallerand AL, Lupien J, Bukowiecki LJ (1986) Synergistic improvement of glucose intolerance by sucrose feeding and exercise training. Am J Physiol 250:E607-E614
-
(1986)
Am J Physiol
, vol.250
-
-
Vallerand, A.L.1
Lupien, J.2
Bukowiecki, L.J.3
-
36
-
-
1842582779
-
Oxidative stress is a mediator of glucose toxicity in insulin-secreting pancreatic islet cell lines
-
Wu L, Nicholson W, Knobel SM, Steffner RJ, May JM, Piston DW, Powers AC (2004) Oxidative stress is a mediator of glucose toxicity in insulin-secreting pancreatic islet cell lines. J Biol Chem 279:12126-12134
-
(2004)
J Biol Chem
, vol.279
, pp. 12126-12134
-
-
Wu, L.1
Nicholson, W.2
Knobel, S.M.3
Steffner, R.J.4
May, J.M.5
Piston, D.W.6
Powers, A.C.7
-
37
-
-
0034659814
-
Mitochondrial adaptations to obesity-related oxidant stress
-
Yang S, Zhu H, Li Y, Lin H, Gabrielson K, Trush MA, Diehl AM (2000) Mitochondrial adaptations to obesity-related oxidant stress. Arch Biochem Biophys 378:259-268
-
(2000)
Arch Biochem Biophys
, vol.378
, pp. 259-268
-
-
Yang, S.1
Zhu, H.2
Li, Y.3
Lin, H.4
Gabrielson, K.5
Trush, M.A.6
Diehl, A.M.7
|