Vitamin K and Bone Health in Adult Humans

Vitamins and Hormones

Volumn 78, Issue , 2008, Pages 393-416

  Bügel, Susanne ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; FARNOQUINONE; GLUTAMIC ACID; OSTEOCALCIN; PHYTOMENADIONE; VITAMIN K GROUP;

ADULT; BIOSYNTHESIS; BONE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DIET; HUMAN; NUTRITIONAL STATUS; OSTEOPOROSIS; PHYSIOLOGY; REVIEW;

ADULT; ANTICOAGULANTS; BONE AND BONES; DIET; GLUTAMIC ACID; HUMANS; NUTRITIONAL STATUS; OSTEOCALCIN; OSTEOPOROSIS; VITAMIN K; VITAMIN K 1; VITAMIN K 2;

EID: 40949094350     PISSN: 00836729     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0083-6729(07)00016-7     Document Type: Review

References (85)

1. Bach A.U., Anderson S.A., Foley A.L., Williams E.C., and Suttie J.W. Assessment of vitamin K status in human subjects administered "minidose" warfarin. Am. J. Clin. Nutr. 64 (1996) 894-902
2. Beavan S.R., Prentice A., Stirling D.M., Dibba B., Yan L., Harrington D.J., and Shearer M.J. Ethnic differences in osteocalcin [gamma]-carboxylation, plasma phylloquinone (vitamin K1) and apolipoprotein E genotype. Eur. J. Clin. Nutr. 59 (2004) 72-81
3. Berkner K.L., and Runge K.W. The physiology of vitamin K nutriture and vitamin K-dependent protein function in atherosclerosis. J. Thromb. Haemost. 2 (2004) 2118-2132
4. Binkley N.C., and Suttie J.W. Vitamin K nutrition and osteoporosis. J. Nutr. 125 (1995) 1812-1821
5. Binkley N.C., Krueger D.C., Engelke J.A., Foley A.L., and Suttie J.W. Vitamin K supplementation reduces serum concentrations of under-{gamma}-carboxylated osteocalcin in healthy young and elderly adults. Am. J. Clin. Nutr. 72 (2000) 1523-1528
6. Binkley N.C., Krueger D.C., Kawahara T.N., Engelke J.A., Chappell R.C., and Suttie J.W. A high phylloquinone intake is required to achieve maximal osteocalcin y-carboxylation. Am. J. Clin. Nutr. 76 (2002) 1055-1060
7. Bolton-Smith C., Price R.J., Fenton S.T., Harrington D.J., and Shearer M.J. Compilation of a provisional UK database for the phylloquinone (vitamin K1) content of foods. Br. J. Nutr. 83 (2000) 389-399
8. Booth S.L., and Suttie J.W. Dietary intake and adequacy of vitamin K1. J. Nutr. 128 (1998) 785-788
9. Booth S.L., Pennington J.A., and Sadowski J.A. Food sources and dietary intakes of vitamin K-1 (phylloquinone) in the American diet: Data from the FDA Total Diet Study. J. Am. Diet. Assoc. 96 (1996) 149-154
10. Booth S.L., O'Brien-Morse M.E., Dallal G.E., Davidson K.W., and Gundberg C.M. Response of vitamin K status to different intakes and sources of phylloquinone-rich foods: Comparison of younger and older adults. Am. J. Clin. Nutr. 70 (1999) 368-377
11. Booth S.L., Tucker K.L., Chen H., Hannan M.T., Gagnon D.R., Cupples L.A., Wilson P.W., Ordovas J., Schaefer E.J., Dawson-Hughes B., and Kiel D.P. Dietary vitamin K intakes are associated with hip fracture but not with bone mineral density in elderly men and women. Am. J. Clin. Nutr. 71 (2000) 1201-1208
12. Booth S.L., Lichtenstein A.H., O'Brien-Morse M., McKeown N.M., Wood R.J., Saltzman E., and Gundberg C.M. Effects of a hydrogenated form of vitamin K on bone formation and resorption. Am. J. Clin. Nutr. 74 (2001) 783-790
13. Booth S.L., Broe K.E., Gagnon D.R., Tucker K.L., Hannan M.T., McLean R.R., Dawson-Hughes B., Wilson P.W., Cupples L.A., and Kiel D.P. Vitamin K intake and bone mineral density in women and men. Am. J. Clin. Nutr. 77 (2003) 512-516
14. Booth S.L., Martini L., Peterson J.W., Saltzman E., Dallal G.E., and Wood R.J. Dietary phylloquinone depletion and repletion in older women. J. Nutr. 133 (2003) 2565-2569
15. Booth S.L., Broe K.E., Peterson J.W., Cheng D.M., Dawson-Hughes B., Gundberg C.M., Cupples L.A., Wilson P.W., and Kiel D.P. Associations between vitamin K biochemical measures and bone mineral density in men and women. J. Clin. Endocrinol. Metab. 89 (2004) 4904-4909
16. Boskey A.L., Gadaleta S., Gundberg C., Doty S.B., Ducy P., and Karsenty G. Fourier transform infrared microspectroscopic analysis of bones of osteocalcin-deficient mice provides insight into the function of osteocalcin. Bone 23 (1998) 187-196
17. Braam L.A., Knapen M.H., Geusens P., Brouns F., Hamulyak K., Gerichhausen M.J., and Vermeer C. Vitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of age. Calcif. Tissue Int. 73 (2003) 21-26
18. Braam L.A., Knapen M.H., Geusens P., Brouns F., and Vermeer C. Factors affecting bone loss in female endurance athletes: A two-year follow-up study. Am. J. Sports Med. 31 (2003) 889-895
19. Bügel S., Sørensen A.D., Mølgaard K., Kristensen M., Hels O., Vermeer C., Jakobsen J., Flynn A., Molgaard C., and Cashman K.D. Effect of phylloquinone supplementation on biochemical markers of vitamin K status and bone turnover in postmenopausal women. Br. J. Nutr. 97 (2007) 373-380
20. Caraballo P.J., Gabriel S.E., Castro M.R., Atkinson E.J., and Melton III L.J. Changes in bone density after exposure to oral anticoagulants: A meta-analysis. Osteoporos. Int. 9 (1999) 441-448
21. Cauley J.A., Zmuda J.M., Yaffe K., Kuller L.H., Ferrell R.E., Wisniewski S.R., and Cummings S.R. Apolipoprotein E polymorphism: A new genetic marker of hip fracture risk-the study of osteoporotic fractures. J. Bone Miner. Res. 14 (1999) 1175-1181
22. Cockayne S., Adamson J., Lanham-New S., Shearer M., Gilbody S., and Torgerson D. Vitamin K and the prevention of fractures. Arch. Intern. Med. 166 (2006) 1256-1261
23. Collins A., Cashman K.D., and Kiely M. Phylloquinone (Vitamin K1) intakes and serum undercarboxylated osteocalcin levels in Irish postmenopausal women. Br. J. Nutr. 95 (2006) 982-988
24. Craciun A.M., Wolf J., Knapen M.H.J., Brouns F., and Vermeer C. Improved bone metabolism in female elite athletes after vitamin K supplementation. Int. J. Sports Med. 19 (1998) 479-484
25. Ducy P., Desbois C., Boyce B., Pinero G., Story B., Dunstan C., Smith E., Bonadio J., Goldstein S., Gundberg C., Bradley A., and Karsenty G. Increased bone formation in osteocalcin-deficient mice. Nature 382 (1996) 448-452
26. Duggan P., Cashman K.D., Flynn A., Bolton-Smith C., and Kiely M. Phylloquinone (vitamin K) intakes and food sources in 18-64-year-old Irish adults. Br. J. Nutr. 92 (2004) 151-158
27. Ferland G., Sadowski J.A., and O'Brien M.E. Dietary-induced subclinical vitamin K deficiency in normal human subjects. J. Clin. Invest. 91 (1993) 1761-1768
28. Feskanich D., Weber P., Willett W.C., Rockett H., Booth S.L., and Colditz G.A. Vitamin K intake and hip fractures in women: A prospective study. Am. J. Clin. Nutr. 69 (1999) 74-79
29. Gijsbers B.L., Jie K.S., and Vermeer C. Effect of food composition on vitamin K absorption in human volunteers. Br. J. Nutr. 76 (1996) 223-229
30. Groenen-Van Dooren M.M.C.L., Ronden J.E., Soute B.A.M., and Vermeer C. Bioavailability of phylloquinone and menaquinones after oral and colorectal administration in vitamin K-deficient rats. Biochem. Pharmacol. 50 (1995) 797-801
31. Harrington D.J., Soper R., Edwards C., Savidge G.F., Hodges S.J., and Shearer M.J. Determination of the urinary aglycone metabolites of vitamin K by HPLC with redox-mode electrochemical detection. J. lipid res. 46 (2005) 1053-1060
32. Hart J., Catterall A., Dodds R., Klenerman L., Shearer M., and Bitensky L. Circulating vitamin K1 levels in fractured neck of femur. Lancet 2 (1984) 283
33. Hauschka P.V., Lian J.B., Cole D.E., and Gundberg C.M. Osteocalcin and matrix Gla protein: Vitamin K-dependent proteins in bone. Physiol. Rev. 69 (1989) 990-1047
34. Hodges S.J., Pilkington M.J., Stamp T.C., Catterall A., Shearer M.J., Bitensky L., and Chayen J. Depressed levels of circulating menaquinones in patients with osteoporotic fractures of the spine and femoral neck. Bone 12 (1991) 387-389
35. Hodges S.J., Akesson K., Vergnaud P., Obrant K., and Delmas P.D. Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture. J. Bone Miner. Res. 8 (1993) 1241-1245
36. Institute of Medicine. "Dietary reference intakes: For Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc." (2001), National Academy Press, Washington, DC
37. Iwamoto J., Takeda T., Ichimura S., Sato Y., and Yeh J.K. Differential effect of vitamin K and vitamin D supplementation on bone mass in young rats fed normal or low calcium diet. Yonsei Med. J. 45 (2004) 314-324
38. Jamal S.A., Browner W.S., Bauer D.C., and Cummings S.R. Warfarin use and risk for osteoporosis in elderly women. Ann. Intern. Med. 128 (1998) 829-832
39. Jie K.G., Bots M.L., Vermeer C., Witteman J.C., and Grobbee D.E. Vitamin K status and bone mass in women with and without aortic atherosclerosis: A population-based study. Calcif. Tissue Int. 59 (1996) 352-356
40. Knapen M.H., Jie K.G., Hamulyák K., and Vermeer C. Vitamin K-induced changes in markers for osteoblast activity and urinary calcium loss. Calcif. Tissue Int. 53 (1993) 81-85
41. Knapen M.H.J., Hamulyák K., and Vermeer C. The effect of vitamin K supplementation on circulating osteocalcin (bone GLA protein) and urinary calcium excretion. Ann. Intern. Med. 111 (1989) 1001-1005
42. Kobayashi M., Hara K., and Akiyama Y. Effects of vitamin K2 (menatetrenone) on calcium balance in ovariectomized rats. Jap. J. Pharmacol. 88 (2002) 55-61
43. Kohlmeier M., Salomon A., Saupe J., and Shearer M.J. Transport of vitamin K to bone in humans. J. Nutr. 126 (1996) 1192S-1196S
44. Kohlmeier M., Saupe J., Shearer M.J., Schaefer K., and Asmus G. Bone health of adult hemodialysis patients is related to vitamin K status. Kidney Int. 51 (1997) 1218-1221
45. Kohlmeier M., Saupe J., Schaefer K., and Asmus G. Bone fracture history and prospective bone fracture risk of hemodialysis patients are related to apolipoprotein E genotype. Calcif. Tissue Int. 62 (1998) 278-281
46. Koshihara Y., Hoshi K., Ishibashi H., and Shiraki M. Vitamin K2 promotes 1alpha, 25(OH)2 vitamin D3-induced mineralization in human periosteal osteoblasts. Calcif. Tissue Int. 59 (1996) 466-473
47. Kulman J.D., Harris J.E., Haldeman B.E., and Davie E.W. Primary structure and tissue distribution of two novel proline-rich g-carboxyglutamic acid proteins. Proc. Natl. Acad. Sci. USA 94 (1997) 9058-9062
48. Kulman J.D., Harris J.E., Xie L., and Davie E.W. Identification of two novel transmembrane g-carboxyglutamic acid proteins expressed broadly in fetal and adult tissues. Proc. Natl. Acad. Sci. USA 98 (2001) 1370-1375
49. Lian J., Stewart C., Puchacz E., Mackowiak S., Shalhoub V., Collart D., Zambetti G., and Stein G. Structure of the rat osteocalcin gene and regulation of vitamin D-dependent expression. Proc. Natl. Acad. Sci. USA 86 (1989) 1143-1147
50. Luo G., Ducy P., McKee M.D., Pinero G.J., Loyer E., Behringer R.R., and Karsenty G. Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature 386 (1997) 78-81
51. Maillard C., Berruyer M., Serre C.M., Dechavanne M., and Delmas P.D. Protein-S, a vitamin K-dependent protein, is a bone matrix component synthesized and secreted by osteoblasts. Endocrinology 130 (1992) 1599-1604
52. Matsunaga S., Ito H., and Sakou T. The effect of vitamin K and D supplementation on ovariectomy-induced bone loss. Calcif. Tissue Int. 65 (1999) 285-289
53. McKeown N.M., Jacques P.F., Gundberg C.M., Peterson J.W., Tucker K.L., Kiel D.P., Wilson P.W.F., and Booth S.L. Dietary and nondietary determinants of vitamin K biochemical measures in men and women. J. Nutr. 132 (2002) 1329-1334
54. Mensink G.B.M., and Beitz R. Food and nutrient intake in East and West Germany, 8 years after the reunification-The German Nutrition Survey 1998. Eur. J. Clin. Nutr. (2004) 1000-1010
55. Monreal M., Olive A., Lafoz E., and del Rio L. Heparins, coumarin, and bone density. Lancet 338 (1991) 706
56. Neogi T., Booth S.L., Zhang Y.Q., Jacques P.F., Terkeltaub R., Aliabadi P., and Felson D.T. Low vitamin K status is associated with osteoarthritis in the hand and knee. Arthritis Rheum. 54 (2006) 1255-1261
57. Nordic council of ministers. Nordic nutrition recommendations 2004 NORD (2004)
58. Pettifor J., and Benson R. Congenital malformations associated with the administration of oral anticoagulants during pregnancy. J. pediatr. 86 (1975) 459-462
59. Philip W.J.U., Martin J.C., Richardson J.M., Reid D.M., Webster J., and Douglas A.S. Decreased axial and peripheral bone density in patients taking long-term warfarin. QJM 88 (1995) 635-640
60. Piro L.D., Whyte M.P., Murphy W.A., and Birge S.J. Normal cortical bone mass in patients after long-term coumadin therapy. J. Clin. Endocrinol. Metab. 54 (1982) 470-473
61. Price P.A., Otsuka A.S., Poser J.W., Kristaponis J., and Raman N. Charcterization of a γ-carboxyglutamic acid-containing protein from bone. Proc. Natl. Acad. Soc. 73 (1976) 1447-1451
62. Price P.A., and Williamson M.K. Primary structure of bovine matrix Gla protein, a new vitamin K-dependent bone protein. J. Biol. Chem. 260 (1985) 14971-14975
63. Proudfoot D., and Shanahan C.M. Molecular mechanisms mediating vascular calcification: Role of matrix Gla protein. Nephrology 11 (2006) 455-461
64. Rejnmark L., Vestergaard P., Charles P., Hermann A., Brot C., Eiken P., and Mosekilde L. No effect of vitamin K1 intake on bone mineral density and fracture risk in perimenopausal women. Osteoporos. Int. 17 (2006) 1122-1132
65. Rosen H.N., Maitland L.A., Suttie J.W., Manning W.J., Glynn R.J., and Greenspan S.L. Vitamin K and maintenance of skeletal integrity in adults. Am. J. Med. 94 (1993) 62-68
66. Sato Y., Honda Y., Kunoh H., and Oizumi K. Long-term Oral Anticoagulation reduces bone mass in patients with previous hemispheric infarction and nonrheumatic atrial fibrillation. Stroke 28 (1997) 2390-2394
67. Saupe J., Shearer M.J., and Kohlmeier M. Phylloquinone transport and its influence on gamma-carboxyglutamate residues of osteocalcin in patients on maintenance hemodialysis. Am. J. Clin. Nutr. 58 (1993) 204-208
68. Schaafsma A., Muskiet F.A., Storm H., Hofstede G.J., Pakan I., and van der V. Vitamin D(3) and vitamin K(1) supplementation of Dutch postmenopausal women with normal and low bone mineral densities: Effects on serum 25-hydroxyvitamin D and carboxylated osteocalcin. Eur. J. Clin. Nutr. 54 (2000) 626-631
69. Schurgers L.J., Geleijnse J.M., Grobbee D.E., Pols H.A., Hofman A., Witteman J.C.M., and Vermeer C. Nutritional intake of vitamin K1 (phylloquinone) and K2 (menaquinone) in The Netherlands. J. Nutr. & Environ. Med. 9 (1999) 115-122
70. Shearer M.J., Barkhan P., and Webster G.R. Absorption and excretion of an oral dose of tritiated vitamin K1 in man. Br. J. Haematol. 18 (1970) 297-308
71. Shiraki M., Shiraki Y., Aoki C., Hosoi T., Inoue S., Kaneki M., and Ouchi Y. Association of bone mineral density with apolipoprotein E phenotype. J. Bone Miner. Res. 12 (1997) 1438-1445
72. Sokoll L.J., Booth S.L., O'Brien M.E., Davidson K.W., Tsaioun K.I., and Sadowski J.A. Changes in serum osteocalcin, plasma phylloquinone, and urinary gamma-carboxyglutamic acid in response to altered intakes of dietary phylloquinone in human subjects. Am. J. Clin. Nutr. 65 (1997) 779-784
73. Sokoll L.J., and Sadowski J.A. Comparison of biochemical indexes for assessing vitamin K nutritional status in an healthy adult population. Am. J. Clin. Nutr. 63 (1996) 566-573
74. Suttie J.W., Mummah-Schendel L.L., Shah D.V., Lyle B.J., and Gregor J.L. Vitamin K deficiency from dietary vitamin K restriction in humans. Am. J. Clin. Nutr. 47 (1988) 475-480
75. Szulc P., Chapuy M.C., Meunier P.J., and Delmas P.D. Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women. J. Clin. Invest. 91 (1993) 1769-1774
76. Szulc P., Chapuy M.C., Meunier P.J., and Delmas P.D. Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture: A three year follow-up study. Bone 18 (1996) 487-488
77. Tabb M.M., Sun A., Zhou C., Grun F., Errandi J., Romero K., Pham H., Inoue S., Mallick S., Lin M., Forman B.M., and Blumberg B. Vitamin K2 regulation of bone homeostasis is mediated by the steroid and xenobiotic receptor SXR. J. Biol. Chem. 278 (2003) 43919-43927
78. Thane C.W., Bolton-Smith C., and Cox D. Comparative dietary intake and sources of phylloquinone (Vitamin K1) among British adults in 1986-7 and 2000-1. Br. J. Nutr. 96 (2006) 1105-1115
79. Thijssen H.H.W., and Drittij-Reijnders M.J. Vitamin K status in human tissues: Tissue-specific accumulation of phylloquinone and menaquinone-4. Br. J. Nutr. 75 (1996) 121-127
80. Ushiroyama T., Ikeda A., and Ueki M. Effect of continuous combined therapy with vitamin K(2) and vitamin D(3) on bone mineral density and coagulofibrinolysis function in postmenopausal women. Maturitas 41 (2002) 211-221
81. Vermeer C., and Hamulyak K. Vitamin K: Lessons from the past. J. Thromb. Haemost. 2 (2004) 2115-2117
82. Vermeer C., Knapen M.H., and Schurgers L.J. Vitamin K and metabolic bone disease. J. Clin. Pathol. 51 (1998) 424-426
83. Vermeer C., Shearer M.J., Zittermann A., Bolton Smith C., Szulc P., Hodges S., Walter P., Rambeck W., Stöcklin E., and Weber P. Beyond deficiency: Potential benefits of increased intakes of vitamin K for bone and vascular health. Eur. J. Nutr. 43 (2004) 325-335
84. Yan Y., Zhou B., Greenberg D., Wang L., Nigdikar S., Prynne C., and Prentice A. Effect of apolipoprotein E genotype on vitamin K status in healthy older adults from China and the UK. Br. J. Nutr. 92 (2004) 939-945
85. Yan L., Zhou B., Nigdikar S., Wang X., Bennett J., and Prentice A. Effect of apolipoprotein E genotype on vitamin K status in healthy older adults from China and the UK. Br. J. Nutr. 94 (2005) 956-961