Effects of vitamin K2 (menatetrenone) on calcium balance in ovariectomized rats

Japanese Journal of Pharmacology

Volumn 88, Issue 1, 2002, Pages 55-61

  Kobayashi, Masatoshi ^a   Hara, Kuniko ^a   Akiyama, Yasuhiro ^a  

^a EISAI CO LTD   (Japan)

Author keywords

Bone mineral density; Calcium absorption; Ovariectomy; Vitamin K2

Indexed keywords

CALCIUM; MENATETRENONE; DRUG DERIVATIVE; FARNOQUINONE;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE ATROPHY; BONE DENSITY; BONE MINERAL; CALCIUM ABSORPTION; CALCIUM BALANCE; CALCIUM TRANSPORT; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORTICAL BONE; DIAPHYSIS; DIET SUPPLEMENTATION; DRUG EFFECT; ELECTROLYTE DISTURBANCE; FEMALE; FEMUR; IN VIVO STUDY; INTESTINE FUNCTION; JAPAN; METAPHYSIS; MOUSE; NONHUMAN; OVARIECTOMY; POSTMENOPAUSE OSTEOPOROSIS; RAT; ANIMAL; BODY WEIGHT; CHEMISTRY; FECES; FISCHER 344 RAT; HISTOLOGY; HOMEOSTASIS; INTESTINE; METABOLISM; ORGAN SIZE; OSTEOPOROSIS; TRANSPORT AT THE CELLULAR LEVEL; URINE; UTERUS;

ANIMALS; BIOLOGICAL TRANSPORT; BODY WEIGHT; BONE DENSITY; CALCIUM; FECES; FEMALE; FEMUR; HOMEOSTASIS; INTESTINES; ORGAN SIZE; OSTEOPOROSIS; OVARIECTOMY; RATS; RATS, INBRED F344; UTERUS; VITAMIN K 2;

EID: 0036007933     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.88.55     Document Type: Article

References (29)

1. Pathophysiology of osteoporosis
2. Calcium absorption in women: Relationships to calcium intake, estrogen status, and age
3. Evidence for a renal calcium leak in postmenopausal women
4. Calcium absorption in normal and osteoporotic postmenopausal women
5. 2 (menaquinone) homologues and their effects on blood coagulation in rats with hypoprothrombinaemia
6. Characterization of a γ-carboxyglutamic acid-containing protein from bone
7. New biochemical marker for bone metabolism
8. Biochemical markers of bone turnover for the clinical assessment of metabolic bone disease
9. Effects of warfarin on bone
10. Direct identification of the calcium-binding amino acid, γ-carboxyglutamate, in mineralized tissue
11. Effects of menatetrenone on bone loss induced by ovariectomy in rats
12. 2 (menatetrenone) on bone resorption in ovariectomized rats: A histomorphometric and dual energy X-ray absorptiometric study
13. Effects of menatetrenone on prednisolone-induced bone loss in rats
14. 2 (menatetrenone) on osteoclast-like cell formation in mouse bone marrow cultures
15. The inhibitory effect of menatetrenone on bone resorption may be related to its side chain
16. 3-induced mineralization in human periosteal osteoblasts
17. Effects of menatetrenone on the decrease in calcium balance induced by vitamin K-deficient diet and sodium loading in rats
18. The ovariectomized, lactating rat as an experimental model for osteopenia: Calcium metabolism and bone changes
19. The ovariectomized rat model of postmenopausal bone loss
20. Influence of ovariectomy and estradiol treatment on calcium homeostasis during aging in rats
21. Estrogen regulation of intestinal calcium absorption in the intact and ovariectomized adult rat
22. Effects of ovariectomy on duodenal calcium transport in the rat: Altered ability to adapt to low-calcium diet
23. Calcium absorption and bone loss in ovariectomized rats fed varing levels of dietary calcium
24. Oophorectomy in young rats impairs calcium balance by increasing intestinal calcium secretion
25. Regulation of duodenal insulin-like growth factor I and active calcium transport by ovariectomy in female rats
26. Ipriflavone, a synthetic phytoestrogen, enhances intestinal calcium transport in vitro
27. Oestrogen deficiency impairs intestinal calcium absorption in the rat
28. 3 in the development of osteopenia in oophorectomized rats
29. 2 inhibits osteoclastic bone resorption by inducing osteoclast apoptosis