Improved bone metabolism in female elite athletes after vitamin K supplementation

International Journal of Sports Medicine

Volumn 19, Issue 7, 1998, Pages 479-484

  Craciun, A M ^a   Wolf, J ^a   Knapen, M H J ^a   Brouns, F ^b   Vermeer, C ^a,b  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Bone loss; Bone mass; Calcium metabolism; Exercise; Osteoporosis; Phylloquinone

Indexed keywords

CALCIUM; CALCIUM BINDING PROTEIN; ESTROGEN; OSTEOCALCIN; PHYTOMENADIONE; VITAMIN K GROUP;

ADULT; AMENORRHEA; ARTICLE; ATHLETE; BONE MASS; BONE METABOLISM; CALCIUM URINE LEVEL; DIET SUPPLEMENTATION; FEMALE; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; OSSIFICATION; OSTEOLYSIS; OSTEOPOROSIS; PHYSICAL ACTIVITY;

ADULT; BIOLOGICAL MARKERS; BONE AND BONES; BONE RESORPTION; DIETARY SUPPLEMENTS; ESTRADIOL; EXERCISE; FEMALE; FOLLICLE STIMULATING HORMONE; HUMANS; LUTEINIZING HORMONE; RUNNING; VITAMIN K;

EID: 0031737088     PISSN: 01724622     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-971948     Document Type: Article

References (31)

1. Brixen K, Nielsen HK, Eriksen EF, Charles P, Mosekilde L. Efficacy of wheat germ lectin-precipitated alkaline phosphatase in serum as an estimator of bone mineralization rate: comparison to serum total alkaline phosphatase and serum bone Gla-protein. Calcif Tissue Int 1989; 44: 3-98
2. Brouns F, Saris W, Schneider H. Rationale for upper limits of electrolyte replacement during exercise. Int J Sport Nutr 1992; 2: 229-38
3. Chilibeck PD, Digby GS, Webber CE. Exercise and bone mineral density. Sports Med 1995; 19: 103-22
4. Constantini NW. Clinical consequences of athletic amenorrhoea. Sports Med 1994; 17: 213-23
5. Dalsky GP. Effect of exercise on bone: permissive influence of estrogen and calcium. Med Sci Sports Exerc 1990; 22: 281-5
6. Drinkwater BL, Nilson K, Chestnut CH, Bremner WJ, Shainholtz S, Southworth MB. Bone mineral content of amenorrheic and eumenorrheic athletes. N Engl J Med 1984; 311: 277-81
7. Furie B, Furie BC. The molecular basis of blood coagulation. Cell 1988; 53: 505-18
8. Garnero P, Sornay-Rendu E, Delmas PD. Decreased bone turnover in oral contraceptive users. Bone 1995; 16: 499-503
9. 1 levels in fractured neck of femur. Lancet 1984; II: 283
10. Hart JP, Shearer MJ, Klenerman L, Catterall A, Reeve J, Sambrook PN, Dodds RA, Bitenski L, Chayen J. Electrochemical detection of depressed circulating levels of vitamin K1 in osteoporosis. J Endocrinol Metab 1985; 60: 268-1269
11. Hauschka PV, Lian JB, Cole DEC, Gundberg CM. Osteocalcin and matrix GLa protein: vitamin K dependent proteins in bone. Phys Rev 1989; 69: 990-1047
12. Highet R. Athletic amenorrhoea: an update on aetiology, complications and management. Sports Med 1989; 7: 82-108
13. Hodges SJ, Akesson K, Vergnaud P, Obrant K, Delmas PD. Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture. J Bone Miner Res 1993; 8: 1241-5
14. Knapen MHJ, Hamulyák K, Vermeer C. The effect of vitamin K supplementation on circulating osteocalcin (bone Gla-protein) and urinary calcium excretion. Ann Int Med 1989; 111: 1001-5
15. Knapen MHJ, Jie K-SG, Hamulyák K, Vermeer C. Vitamin K-induced changes in markers for osteoblast activity and urinary calcium loss. Calcif Tissue Int 1993; 53: 81-5
16. Kuwada M, Katayama K. An improved method for the determination of γ-carboxyglutamic acid in proteins, bone, and urine. Analyt Biochem 1983; 131: 173-9
17. Lindsay R. Estrogens and osteoporosis: clinical. In: Papapoulos SE, Lips P, Pols HAP, Johnston CC, Delmas PD (eds.): Osteoporosis 1996. Amsterdam: Elsevier Science 1996: 251-5
18. Loucks AB, Mortola JF, Girton L, Yen SSC. Alterations in the hypothalamic-pituitary-ovarian and the hypothalamic-pituitary-adrenal axes in the athletic women. J Clin Endocrinol Metab 1989; 68: 402-11
19. Luo G, Ducy P, McKee MD, Pinero GJ, Loyer E, Behringer RR, Karsenty G. Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature 1997; 386: 78-81
20. Mansfield MJ, Emans SJ. Anorexia nervosa, athletics, and amenorrhoea. Ped Clin N Am 1989; 36: 533-49
21. Marti B. Health effects of recreational running in women: some epidemiological and preventive aspects. Sports Med 1991; 11: 20-51
22. Nakano T, Kawamoto K, Kishino J, Nomura K, Higashino K, Arita H. Requirement of γ-carboxyglutamic acid residues for the biological activity of Gas6: contribution of endogenous Gas6 to the proliferation of vascular smooth muscle cells. Biochem J 1997; 323: 387-92
23. Orimo H, Fujita T, Onomura T, Inoue T, Kushida K, Shiraki M. Clinical evaluation of Ea-0167 (Menatetrenone) in the treatment of osteoporosis. Clin Eval (Japan) 1992; 20: 45-100
24. Plantalech LC, Chapuy MC, Guillaumont M, Chapuy P, Leclercq M, Delmas PD. Impaired carboxylation of serum osteocalcin in elderly women: Effect of vitamin K1 treatment. In: Christiansen C, Overgaard K (eds.): Osteoporosis 1990. Copenhagen: Osteopress 1990: 345-7
25. Prior JC, Vigna YM, McKay D. Reproduction for the athletic women: new understanding of physiology and management. Sports Med 1992; 14: 190-9
26. Rambaut PC, Goode WA. Skeletal changes during space flight. Lancet 1985; ii: 1050-2
27. Sundgot-Borgen J. Eating disorders in female athletes. Sports Med 1994; 17: 176-88
28. Thijssen HHW, Drittij-Reijnders MJ, Fischer MAJC. Phylloquinone and menaquinone-4 distribution in rats: synthesis rather than uptake determines menaquinone-4 organ concentrations. J Nutr 1996; 126: 537-43
29. Van Erp-Baart AMJ, Saris WHM, Binkhorst RA, Vos JA, Elvers JWH. Nationwide survey on nutritional habits in elite athletes Part II. Mineral and vitamin intake. Int J Sports Med 1989; 10: 11-6
30. Vermeer C. Gamma-carboxyglutamate-containing proteins and the vitamin K-dependent carboxylase. Biochem J 1990; 266: 625-36
31. Vermeer C, Hamulyák K. Pathophysiology of vitamin K deficiency and oral anticoagulants. Thromb Haemostas 1991; 66: 153-9