Effect of Two Types of Soy Milk and Dairy Milk on Plasma Lipids in Hypercholesterolemic Adults: A Randomized Trial

Journal of the American College of Nutrition

Volumn 26, Issue 6, 2007, Pages 669-677

  Gardner, Christopher D ^a   Kiazand, Alexandre ^a   Morris, Jennifer L ^a   Messina, Mark ^b   Franke, Adrian A ^c  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LOMA LINDA UNIVERSITY   (United States)

^c UNIVERSITY OF HAWAII CANCER CENTER   (United States)

Author keywords

Hypercholesterolemic adults; LDL cholesterol; Lipids; Soy milk; Soy protein

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYPOCHOLESTEROLEMIC AGENT; INSULIN; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SOYBEAN PROTEIN;

ADULT; AGED; ANIMAL; ARTICLE; BLOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET THERAPY; DOUBLE BLIND PROCEDURE; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERCHOLESTEROLEMIA; MALE; METABOLISM; MIDDLE AGED; MILK; RANDOMIZED CONTROLLED TRIAL; SOYBEAN MILK; TREATMENT OUTCOME;

ADULT; AGED; ANIMALS; ANTICHOLESTEREMIC AGENTS; BLOOD GLUCOSE; CHOLESTEROL; CHOLESTEROL, HDL; CHOLESTEROL, LDL; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYPERCHOLESTEROLEMIA; INSULIN; LIPIDS; MALE; MIDDLE AGED; MILK; SOY MILK; SOYBEAN PROTEINS; TREATMENT OUTCOME;

EID: 40749125296     PISSN: 07315724     EISSN: 15411087     Source Type: Journal    
DOI: 10.1080/07315724.2007.10719646     Document Type: Article

References (50)

1. Hodges RE, Krehl WA, Stone DB, Lopez A: Dietary carbohydrates and low cholesterol diets: effects on serum lipids on man. Am J Clin Nutr 20: 198-208, 1967.
2. Meeker DR, Kesten HD: Effect of high protein diets on experimental atherosclerosis in rabbits. Arch Pathol 31: 147-162, 1941.
3. Anderson JW, Johnstone BM, Cook-Newell ME: Meta-analysis of the effects of soy protein intake on serum lipids. N Engl J Med 333: 276-282, 1995.
4. Food and Drug Adminstration: Food labeling, health claims, soyprotein, and coronary heart disease. Federal Register 57: 699-733, 1999.
5. Balk E, Chung M, Chew P, Ip S, Raman G, Kupelnick B, Tatsioni A, Sun Y, Wolk B, DeVine D, Lau J: Effects of soy on health outcomes. Evidence Report/Technology Assessment No. 126. Agency for Healthcare Research and Quality, ed. Rockville, Maryland: (Prepared by Tufts-New England Medical Center Evidence-Based Practice Center under Contract No. 29-02-0022.), 2005.
6. Sacks FM, Lichtenstein A, Van Horn L, Harris W, Kris-Etherton P, Winston M: Soy protein, isoflavones, and cardiovascular health: an American Heart Association Science Advisory for professionals from the Nutrition Committee. Circulation 113: 1034-1044, 2006.
7. Zhan S, Ho SC: Meta-analysis of the effects of soy protein containing isoflavones on the lipid profile. Am J Clin Nutr 81: 397-408, 2005.
8. Crouse JR, 3rd, Morgan T, Terry JG, Ellis J, Vitolins M, Burke GL: A randomized trial comparing the effect of casein with that of soy protein containing varying amounts of isoflavones on plasma concentrations of lipids and lipoproteins. Arch Intern Med 159: 2070-2076, 1999.
9. Adams MR, Golden DL, Franke AA, Potter SM, Smith HS, Anthony MS: Dietary soy beta-conglycinin (7S globulin) inhibits atherosclerosis in mice. J Nutr 134: 511-516, 2004.
10. Duranti M, Lovati MR, Dani V, Barbiroli A, Scarafoni A, Castiglioni S, Ponzone C, Morazzoni P: The alpha' subunit from soybean 7S globulin lowers plasma lipids and upregulates liver beta-VLDL receptors in rats fed a hypercholesterolemic diet. J Nutr 134: 1334-1339, 2004.
11. Lichtenstein AH, Jalbert SM, Adlercreutz H, Goldin BR, Rasmussen H, Schaefer EJ, Ausman LM: Lipoprotein response to diets high in soy or animal protein with and without isoflavones in moderately hypercholesterolemic subjects. Arterioscler Thromb Vasc Biol 22: 1852-1858, 2002.
12. Zhuo XG, Melby MK, Watanabe S. Soy isoflavone intake lowers serum LDL cholesterol: a meta-analysis of 8 randomized controlled trials in humans. J Nutr 134: 2395-2400, 2004.
13. Franke AA, Custer LJ: HPLC Assay of isoflavonoids and coumestrol from human urine. J. Chromatogr B 662: 47-60, 1994.
14. Lampe JW, Karr SC, Hutchins AM, Slavin JL: Urinary equol excretion with a soy challenge: influence of habitual diet. Proc Soc Exp Biol Med 217: 335-339, 1998.
15. Setchell KD, Brown NM, Lydeking-Olsen E: The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavones. J Nutr 132: 3577-3584, 2002.
16. Meyer BJ, Larkin TA, Owen AJ, Astheimer LB, Tapsell LC, Howe PR: Limited lipid-lowering effects of regular consumption of whole soybean foods. Ann Nutr Metab 48: 67-78, 2004.
17. Gardner CD, Newell KA, Cherin R, Haskell WL: The effect of soy protein with or without isoflavones relative to milk protein on plasma lipids in hypercholesterolemic postmenopausal women. Am J Clin Nutr 73: 728-735, 2001.
18. Bricarello LP, Kasinski N, Bertolami MC, Faludi A, Pinto LA, Relvas WG, Izar MC, Ihara SS, Tufik S, Fonseca FA: Comparison between the effects of soy milk and non-fat cow milk on lipid profile and lipid peroxidation in patients with primary hypercholesterolemia. Nutrition 20: 200-294, 2004.
19. Sirtori CR, Bosisio R, Pazzucconi F, Bondioli A, Gatti E, Lovati MR, Murphy P: Soy milk with a high glycitein content does not reduce low-density lipoprotein cholesterolemia in type II hypercholesterolemic patients. Ann Nutr Metab 46: 88-92, 2002.
20. Takatsuka N, Nagata C, Kurisu Y, Inaba S, Kawakami N, Shimizu H: Hypocholesterolemic effect of soymilk supplementation with usual diet in premenopausal normolipidemic Japanese women. Prev Med 31: 308-314, 2000.
21. Ashton E, Ball M: Effects of soy as tofu vs meat on lipoprotein concentrations: Eur J Clin Nutr 54: 14-19, 2000.
22. Mitchell JH, Collins AR: Effects of a soy milk supplement on plasma cholesterol levels and oxidative DNA damage in men-a pilot study. Eur J Nutr 38: 143-148, 1999.
23. Wilson PW, D'Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB: Prediction of coronary heart disease using risk factor categories. Circulation 97: 1837-1847, 1998.
24. Krauss RM, Eckel RH, Howard B, Appel LJ, Daniels SR, Deckelbaum RJ, Erdman JW Jr, Kris-Etherton P, Goldberg IJ, Kotchen TA, Lichtenstein AH, Mitch WE, Mullis R, Robinson K, Wylie-Rosett J, St Jeor S, Suttie J, Tribble DL, Bazzarre TL: AHA Dietary Guidelines: revision 2000: A statement for healthcare professionals from the Nutrition Committee of the American Heart Association. Circulation 102: 2284-2299, 2000.
25. Franke AA, Hankin JH, Yu MC, Maskarinec G, Low SH, Custer LJ: Isoflavone levels in soy foods consumed by multiethnic populations in Singapore and Hawaii. J Agric Food Chem 47: 977-986, 1999.
26. Franke AA, Custer LJ, Wilkens LR, Le Marchand LL, Nomura AM, Goodman MT, Kolonel LN: Liquid chromatographicphotodiode array mass spectrometric analysis of dietary phytoestrogens from human urine and blood. J Chromatogr B Analyt Technol Biomed Life Sci 777: 45-59, 2002.
27. Blair RM, Appt SE, Franke AA, Clarkson TB: Treatment with antibiotics reduces plasma equol concentration in cynomolgus monkeys (Macaca fascicularis). J Nutr 33: 2262-2267, 2003.
28. Cline JM, Franke AA, Register TC, Golden DL, Adams MR: Effects of dietary isoflavone aglycones on the reproductive tract of male and female mice. Toxicol Pathol 32: 91-99, 2004.
29. Allain CC, Poon LS, Chan CS, Richmond W, Fu PC: Enzymatic determination of total serum cholesterol. Clin Chem 20: 470-475, 1974.
30. Sampson EJ, Demers LM, Krieg AF: Faster enzymatic procedure for serum triglycerides. Clin Chem 21: 1983-1985, 1975.
31. Warnick GR, Albers JJ: A comprehensive evaluation of the heparin-manganese precipitation procedure for estimating high density lipoprotein cholesterol. J Lipid Res 19: 65-76, 1978.
32. Friedewald W, Levy R, Fredrickson D: Estimation of the concentration of low-density lipoprotein cholesterol in plasma, with use of the preparative ultracentrifuge. Clin Chem 18: 499-502, 1972.
33. Hegsted DM, Ausman LM, Johnson JA, Dallal GE: Dietary fat and serum lipids: an evaluation of the experimental data. Am J Clin Nutr 57: 875-883, 1993.
34. Mensink RP, Katan MB: Effect of dietary fatty acids on serum lipids and lipoproteins. A meta-analysis of 27 trials. Arterioscler Thromb 12: 911-919, 1992.
35. Morgan CR, Lazarow A: Immunoassay of insulin: Two antibody system. Plasma insulin levels in normal, sub diabetic, and diabetic rats. Diabetes 12: 115, 1963.
36. Trinder P: Determination of blood glucose using an oxidaseperoxidase system with a non-carcinogenic chromogen. J Clin Pathol 22: 158-161, 1969.
37. Anderson JW, Zeigler JA, Deakins DA, Floore TL, Dillon DW, Wood CL, Oeltgen PR, Whitley RJ: Metabolic effects of highcarbohydrate, high-fiber diets for insulin-dependent diabetic individuals. Am J Clin Nutr 54: 936-943, 1991.
38. Nestel P: Isoflavones: their effects on cardiovascular risk and functions. Curr Opin Lipidol 14: 3-8, 2003.
39. Sirtori CR, Agradi E, Conti F, Mantero O, Gatti E: Soybeanprotein diet in the treatment of type-II hyperlipoproteinaemia. Lancet 1: 275-277, 1977.
40. Erdman JW, Jr: AHA Science Advisory: Soy protein and cardiovascular disease: A statement for healthcare professionals from the Nutrition Committee of the AHA. Circulation 102: 2555-2559, 2000.
41. Teixeira SR, Potter SM, Weigel R, Hannum S, Erdman JW, Jr., Hasler CM: Effects of feeding 4 levels of soy protein for 3 and 6 wk on blood lipids and apolipoproteins in moderately hypercholesterolemic men. Am J Clin Nutr 71: 1077-1084, 2000.
42. Tonstad S, Smerud K, Hoie L: A comparison of the effects of 2 doses of soy protein or casein on serum lipids, serum lipoproteins, and plasma total homocysteine in hypercholesterolemic subjects. Am J Clin Nutr 76: 78-84, 2002.
43. Lovati MR, Manzoni C, Canavesi A, Sirtori M, Vaccarino V, Marchi M, Gaddi G, Sirtori CR: Soybean protein diet increases low density lipoprotein receptor activity in mononuclear cells from hypercholesterolemic patients. J Clin Invest 80: 1498-1502, 1987.
44. Holme I: An analysis of randomized trials evaluating the effect of cholesterol reduction on total mortality and coronary heart disease incidence. Circulation 82: 1916-1924, 1990.
45. Law MR, Wald NJ, Thompson SG: By how much and how quickly does reduction in serum cholesterol concentration lower risk of ischaemic heart disease? BMJ 308: 367-372, 1994.
46. Desroches S, Mauger JF, Ausman LM, Lichtenstein AH, Lamarche B: Soy protein favorably affects LDL size independently of isoflavones in hypercholesterolemic men and women. J Nutr 134: 574-579, 2004.
47. Cuevas AM, Irribarra VL, Castillo OA, Yanez MD, Germain AM: Isolated soy protein improves endothelial function in postmenopausal hypercholesterolemic women. Eur J Clin Nutr 57: 889-894, 2003.
48. Steinberg FM, Guthrie NL, Villablanca AC, Kumar K, Murray MJ: Soy protein with isoflavones has favorable effects on endothelial function that are independent of lipid and antioxidant effects in healthy postmenopausal women. Am J Clin Nutr 78: 123-130, 2003.
49. Wiseman H, O'Reilly JD, Adlercreutz H, Mallet AI, Bowey EA, Rowland IR, Sanders TA: Isoflavone phytoestrogens consumed in soy decrease F(2)-isoprostane concentrations and increase resistance of low-density lipoprotein to oxidation in humans. Am J Clin Nutr 72: 395-400, 2000.
50. Gardner CD, Coulston AC, Chatterjee L, Rigby A, Spiller GA, Farquhar JW: The effect of a plant-based diet on plasma lipids in hypercholesterolemic adults: A randomized trial. Ann Int Med 142: 725-733, 2005.