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Kuwaki K, Knosalla C, Dor FJ, et al. Suppression of natural and elicited antibodies in pig-to-baboon heart transplantation using a human antihuman CD154 mAb-based regimen. Am J Transplant 2004; 4:363-372.
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Kuwaki, K.1
Knosalla, C.2
Dor, F.J.3
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52
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Effective antiplatelet therapy does not prolong transgenic pig to baboon cardiac xenograft survival
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Schirmer JM, Fass DN, Byrne GW, et al. Effective antiplatelet therapy does not prolong transgenic pig to baboon cardiac xenograft survival. Xenotransplantation 2004; 11:436-443.
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Schirmer, J.M.1
Fass, D.N.2
Byrne, G.W.3
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53
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33846239410
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Adenovirus-mediated expression of the anticoagulant hirudin in human islets: A tool to make the islets biocompatible to blood
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Expression of hirudin on the islet surface reduced thrombogenicity but also compromised function. This demonstrates the potential benefits but also the potential pitfalls of gene transfer to isolated islets
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Cabric S, Elgue G, Nilsson B, et al. Adenovirus-mediated expression of the anticoagulant hirudin in human islets: a tool to make the islets biocompatible to blood. Cell Transplant 2006; 15:759-767. Expression of hirudin on the islet surface reduced thrombogenicity but also compromised function. This demonstrates the potential benefits but also the potential pitfalls of gene transfer to isolated islets.
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(2006)
Cell Transplant
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, pp. 759-767
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Cabric, S.1
Elgue, G.2
Nilsson, B.3
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54
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Composite islet-endothelial cell grafts: A novel approach to counteract innate immunity in islet transplantation
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Johansson U, Elgue G, Nilsson B, Korsgren O. Composite islet-endothelial cell grafts: a novel approach to counteract innate immunity in islet transplantation. Am J Transplant 2005; 5:2632-2639.
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Johansson, U.1
Elgue, G.2
Nilsson, B.3
Korsgren, O.4
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55
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Cytoprotection of PEG-modified adult porcine pancreatic islets for improved xenotransplantation
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Xie D, Smyth CA, Eckstein C, et al. Cytoprotection of PEG-modified adult porcine pancreatic islets for improved xenotransplantation. Biomaterials 2005; 26:403-412.
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Biomaterials
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Xie, D.1
Smyth, C.A.2
Eckstein, C.3
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56
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Encapsulation of islets with ultra-thin polyion complex membrane through poly(ethylene glycol)-phospholipids anchored to cell membrane
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Miura S, Teramura Y, Iwata H. Encapsulation of islets with ultra-thin polyion complex membrane through poly(ethylene glycol)-phospholipids anchored to cell membrane. Biomaterials 2006; 27:5828-5835.
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Miura, S.1
Teramura, Y.2
Iwata, H.3
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57
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Surface re-engineering of pancreatic islets with recombinant azido-thrombomodulin
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A novel approach to protectively coating islets by incorporating a 'bioactive' layer
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Stabler CL, Sun XL, Cui W, et al. Surface re-engineering of pancreatic islets with recombinant azido-thrombomodulin. Bioconjug Chem 2007; 18:1713-1715. A novel approach to protectively coating islets by incorporating a 'bioactive' layer.
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Bioconjug Chem
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, pp. 1713-1715
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Stabler, C.L.1
Sun, X.L.2
Cui, W.3
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58
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Islet surface heparinization prevents the instant blood-mediated inflammatory reaction in islet transplantation
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This report describes an extremely promising biochemical method for protecting islet allografts and potentially xenografts from IBMIR
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Cabric S, Sanchez J, Lundgren T, et al. Islet surface heparinization prevents the instant blood-mediated inflammatory reaction in islet transplantation. Diabetes 2007; 56:2008-2015. This report describes an extremely promising biochemical method for protecting islet allografts and potentially xenografts from IBMIR.
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(2007)
Diabetes
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, pp. 2008-2015
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Cabric, S.1
Sanchez, J.2
Lundgren, T.3
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59
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Nicotinamide inhibits tissue factor expression in isolated human pancreatic islets: Implications for clinical islet transplantation
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Moberg L, Olsson A, Berne C, et al. Nicotinamide inhibits tissue factor expression in isolated human pancreatic islets: implications for clinical islet transplantation. Transplantation 2003; 76:1285-1288.
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Moberg, L.1
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Berne, C.3
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Lewis EC, Shapiro L, Bowers OJ, Dinarello CA. Alpha1-antitrypsin monotherapy prolongs islet allograft survival in mice. Proc Natl Acad Sci USA 2005; 102:12153-12158.
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Lewis EC, Shapiro L, Bowers OJ, Dinarello CA. Alpha1-antitrypsin monotherapy prolongs islet allograft survival in mice. Proc Natl Acad Sci USA 2005; 102:12153-12158.
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61
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Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation
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Dwyer KM, Robson SC, Nandurkar HH, et al. Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation. J Clin Invest 2004; 113:1440-1446.
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Dwyer, K.M.1
Robson, S.C.2
Nandurkar, H.H.3
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Fgl2 deficiency causes neonatal death and cardiac dysfunction during embryonic and postnatal development in mice
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Mu J, Qu D, Bartczak A, et al. Fgl2 deficiency causes neonatal death and cardiac dysfunction during embryonic and postnatal development in mice. Physiol Genomics 2007; 31:53-62.
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Physiol Genomics
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Mu, J.1
Qu, D.2
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Dwyer KM, Mysore TB, Crikis S, et al. The transgenic expression of human CD39 on murine islets inhibits clotting of human blood. Transplantation 2006; 82:428-432. This study by our group provides the first evidence that a transgenic approach may be a part of the solution to the problem of IBMIR.
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Dwyer KM, Mysore TB, Crikis S, et al. The transgenic expression of human CD39 on murine islets inhibits clotting of human blood. Transplantation 2006; 82:428-432. This study by our group provides the first evidence that a transgenic approach may be a part of the solution to the problem of IBMIR.
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