Coagulation cascade activation triggers early failure of pig hearts expressing human complement regulatory genes

Xenotransplantation

Volumn 14, Issue 1, 2007, Pages 34-47

  Wu, Guosheng ^a   Pfeiffer, Steffen ^a   Schröder, Carsten ^a   Zhang, Tianshu ^a   Nguyen, Bao N ^a   Kelishadi, Sean ^a   Atkinson, James B ^b   Schuurman, Henk Jan ^c   White, David J G ^d   Azimzadeh, Agnes M ^a   Pierson III, Richard N ^a,e  

^a UNIVERSITY OF MARYLAND   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c Immerge Biotherapeutics Inc   (United States)

^d ROBARTS RESEARCH INSTITUTE   (Canada)

^e UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Coagulation; Decay accelerating factor (CD55); Heart; Hyperacute rejection; Membrane cofactor protein; Pig; Xenoantibody; Xenotransplantation

Indexed keywords

CD20 ANTIBODY; CD40 LIGAND MONOCLONAL ANTIBODY; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAS 914; GLYCOCONJUGATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NEX 1285; RITUXIMAB; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BABOON; BLOOD CLOTTING; COMPLEMENT ACTIVATION; COMPLEMENT DEPOSITION; CONTROLLED STUDY; DISSEMINATED INTRAVASCULAR CLOTTING; FEMALE; GRAFT FAILURE; HEART; HEART TRANSPLANTATION; HETEROTOPIC TRANSPLANTATION; HYPERACUTE GRAFT REJECTION; IMMUNOADSORPTION; IMMUNOSUPPRESSIVE TREATMENT; MALE; NONHUMAN; PAPIO ANUBIS; PRIORITY JOURNAL; PROTEIN DEPLETION; SWINE; THROMBOCYTE; TRANSGENIC PIG; XENOGRAFT;

ACUTE DISEASE; ANIMALS; ANTIBODIES; BIOPSY; BLOOD COAGULATION; COMPLEMENT C1 INHIBITOR PROTEIN; COMPLEMENT C3A; COMPLEMENT INACTIVATOR PROTEINS; GENE EXPRESSION REGULATION; GRAFT REJECTION; HEART; HEART TRANSPLANTATION; HUMANS; IMMUNOHISTOCHEMISTRY; MYOCARDIUM; SWINE; TIME FACTORS; TITRIMETRY; TRANSPLANTATION, HETEROLOGOUS;

EID: 33846078345     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/j.1399-3089.2006.00362.x     Document Type: Article

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