Expression of human thrombomodulin cofactor activity in porcine endothelial cells

Transplantation

Volumn 66, Issue 2, 1998, Pages 244-251

  Kopp, Christoph W ^a   Grey, Shane T ^a   Siegel, Jonathan B ^a   McShea, Andrew ^a   Vetr, Helga ^a   Wrighton, Christopher J ^a   Schulte Am Esch II, Jan ^a   Bach, Fritz H ^a   Robson, Simon C ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIN; PROTEIN C; THROMBOMODULIN; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANTICOAGULATION; ARTICLE; CELL ACTIVATION; DISEASE PREDISPOSITION; DOWN REGULATION; GENE EXPRESSION; GENETIC CODE; GENETIC TRANSDUCTION; GRAFT REJECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SWINE; THROMBOCYTE ACTIVATION; THROMBOSIS; XENOGRAFT;

ANIMALS; ANTIOXIDANTS; CELLS, CULTURED; CLONING, MOLECULAR; ENDOTHELIUM, VASCULAR; HUMANS; MALE; RETROVIRIDAE; SUPEROXIDES; SWINE; THROMBOMODULIN; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032558117     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199807270-00019     Document Type: Article

References (43)

1. Bach FH, Robson SC, Ferran C, et al. Endothelial cell activation and thromboregulation during xenograft rejection. Immunol Rev 1994; 141: 5.
2. Bartha K, Brisson C, Archipoff G, et al. Thrombin regulates tissue factor and thrombomodulin mRNA levels and activities in human saphenous vein endothelial cells by distinct mechanisms. J Biol Chem 1993; 168: 421.
3. Colotta F, Sciacca FL, Sironi M, Luini W, Rabiet MJ, Mantovani A. Expression of monocyte chemotactic protein-1 by monocytes and endothelial cells exposed to thrombin. Am J Pathol 1994; 144: 975.
4. Sugama Y, Tirrupathi C, Janakidevi K, Anderson TT, Fenton JW II, Malik AB. Thrombin-induced expression of endothelial P-selectin and intercellular adhesion molecule-1: a mechanism for stabilizing neutrophil adhesion. J Cell Biol 1992; 119: 935.
5. Maruyama Y, Maruyama I, Soejima Y. Thrombin receptor agonist peptide decreases thrombomodulin activity in cultured human umbilical vein endothelial cells. Biochem Biophys Res Commun 1994; 199; 1262.
6. Siegel JB, Grey S, Lesnikosky BA, et al. Xenogeneic endothelial cells activate human prothrombin. Transplantation 1997; 64: 888.
7. Robson S, Siegel J, Lesnikosky B, et al. Aggregation of human platelets induced by porcine endothelial cells is dependent upon both activation of complement and thrombin generation. Xenotransplantation 1996; 3: 24.
8. Esmon CT. The regulation of natural anticoagulant pathways. Science 1987; 235: 1348.
9. Suzuki K, Stenflo J, Dahlback B, Teodorsson B. Inactivation of human coagulation factor V by activated protein C. J Biol Chem 1983; 258: 1914.
10. Fulcher CA, Gardiner JE, Griffin JH, Zimmermann TS. Proteolytic inactivation of human factor VIII procoagulant protein by activated protein C. Blood 1984; 63: 486.
11. Walker FJ. Regulation of activated protein C by a new protein: a possible function for protein S. J Biol Chem 1980; 255: 5521.
12. Nydahl S, Frebelius S, Swedenborg J. Thrombin inactivation and the effects of antithrombin and heparin in a recirculating Langendorff preparation. Thromb Res 1992; 65: 365.
13. Kishida A, Ueno Y, Fukudome N, Yashima E, Maruyama I, Akashi M. Immobilization of human thrombomodulin onto polyether urethane urea for developing antithrombogenic blood-contacting materials. Biomaterials 1994; 15: 848.
14. Nawroth PP, Stern DM. Modulation of endothelial cell hemostatic properties by tumor necrosis factor. J Exp Med 1986; 163: 740.
15. Nawroth PP, Handley DA, Esmon CT, Stern DM. Interleukin 1 induces endothelial cell procoagulant while suppressing cell surface anticoagulant activity. Proc Natl Acad Sci 1986; 83: 3460.
16. Moore KL, Andreoli SP, Esmon NL, Esmon CT, Bang NU. Endotoxin enhances tissue factor and suppresses thrombomodulin expression of human vascular endothelium in vitro. J Clin Invest 1987; 79: 124.
17. Conway EM, Rosenberg RD. Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells. Mol Cell Biol 1988; 8: 5588.
18. Kapiotis S, Besemer J, Bevec D, et al. Interleukin-4 counteracts pyrogen-induced downregulation of thrombomodulin in cultured human vascular endothelial cells. Blood 1991; 78: 410.
19. Scarpati EM, Sadler JE. Regulation of endothelial cell coagulant properties. J Biol Chem 1989; 264: 20705.
20. Lawson JH, Platt JL. Molecular barriers to xenotransplantation. Transplantation 1996; 3: 303.
21. Warren JB. The endothelium: an introduction to current research. New York: Wiley-Liss, 1990.
22. Sambrook J, Fritsch EF, Maniatis T. Mapping RNA with nuclease S-1. In: Nolan C, ed. Molecular cloning, vol 1. New York: Cold Spring Harbor Laboratory Press, 1989: 7.58.
23. Suzuki K, Kusumoto H, Deyashiki Y, et al. Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation. EMBO J 1987; 6: 1891.
24. Hayashi T, Suzuki K. Monoclonal antibodies for human thrombomodulin which recognize binding sites for thrombin and protein C. J Biochem 1990; 108: 874.
25. Robson SC, Kaczmarek E, Siegel JB, et al. Loss of ATP diphosphohydrolase (ATPDase) activity with endothelial cell activation. J Exp Med 1997; 185: 153.
26. Wen DZ, Dittman WA, Ye RD, Deaven LL, Majerus PW, Sadler JE. Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene. Biochemistry 1987; 26: 4350.
27. Keller G, Paige C, Gilboa E, Wagner EF. Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent hematopoietic precursors. Nature 1985; 318: 149.
28. DeBault LE, Esmon NL, Esmon CT, Edgel CJ. Thrombomodulin expressed in human endothelial cell hybrid. Fed Proc 1984; 43: 7183.
29. Wrighton CJ, Kopp CW, McShea A, Vetr H, Bach FH. High-level expression of functional human thrombomodulin in cultured porcine aortic endothelial cells. Transplant Proc 1995; 27: 288.
30. Dalmasso AP, Vercelotti GM, Platt JL, Bach FH. Inhibition of complement-mediated endothelial cell cytotoxicity by decay-accelerating factor: potential for prevention of xenograft hyperacute rejection. Transplantation 1991; 52: 530.
31. Cozzi E, Yannoutsos N, Langford GA, et al. Effect of transgenic expression of human decay-accelerating factor on the inhibition of hyperacute rejection of pig organs. In: Cooper DKC, Kemp E, Platt JL, White DJG, eds. Xenotransplantation: the transplantation of organs and tissues between species, 2nd ed. Berlin: Springer-Verlag, 1997: 665.
32. Kopp CW, Siegel JB, Hancock WW, et al. Effect of porcine tissue factor pathway inhibitor on human coagulation factors. Transplantation 1997; 63: 749.
33. McKnight SL. Analysis of transcriptional regulatory signals of the HSV thymidine kinase gene: identification of an upstream control region. Cell 1981; 25: 385.
34. Moore KL, Esmon CT, Esmon NL. Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture. Blood 1989; 73: 159.
35. Glaser CB, Morser J, Clarke JH, et al. Oxidation of a specific methionine in thrombomodulin by activated neutrophil products blocks cofactor activity: a potential rapid mechanism for modulation of coagulation. J Clin Invest 1992; 90: 2565.
36. Radi R, Beckman JS, Bush KM, Freeman BA. Peroxynitrite oxidation of sulfhydryls: the cytotoxic potential of superoxide and nitric oxide. J Biol Chem 1991; 266: 4244.
37. Matsubara T, Ziff M. Increased superoxide anion release from human endothelial cells in response to cytokines. J Immunol 1986; 137: 3295.
38. Kono Y, Fridovich I. Superoxide radical inhibits catalase. J Biol Chem 1982; 257: 5751.
39. Kinnula VL, Whorton RA, Chang L-Y, Crapo JD. Regulation of hydrogen peroxide generation in cultured endothelial cells. Am J Respir Cell Mol Biol 1992; 6: 175.
40. Friedl HP, Till GO, Ryan US, Ward PA. Mediator-induced activation of xanthine oxidase in endothelial cells. FASEB J 1989; 3: 2512.
41. Phan SH, Gannon DE, Varani J, Ryan US, Ward PA. Xanthine oxidase activity in rat pulmonary artery endothelial cells and its alteration by activated neutrophils. Am J Pathol 1989; 134: 1201.
42. Bach FH, Ferran C, Soares M, et al. Modification of vascular responses in xenotransplantation: inflammation and apoptosis. Nature Med 1997; 3: 944.
43. Grey ST, Hancock WW. A physiologic anti-inflammatory pathway based on thrombomodulin expression and generation of activated protein C by human mononuclear phagocytes. J Immunol 1996; 156: 2256.