Nicotinamide inhibits tissue factor expression in isolated human pancreatic islets: Implications for clinical islet transplantation

Transplantation

Volumn 76, Issue 9, 2003, Pages 1285-1288

  Moberg, Lisa ^a,g   Olsson, Annika ^a   Berne, Christian ^a   Felldin, Marie ^b   Foss, Aksel ^c   Kallen, Ragnar ^d   Salmela, Kaija ^e   Tibell, Annika ^f   Tufveson, Gunnar ^a   Nilsson, Bo ^a   Korsgren, Olle ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

^d University Hospital   (Sweden)

^e UNIVERSITY OF HELSINKI   (Finland)

^f KAROLINSKA INSTITUTE   (Sweden)

^g UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; MACROPHAGE CHEMOATTRACTANT PROTEIN 1; NICOTINAMIDE; PROTEIN; THROMBOPLASTIN; UNCLASSIFIED DRUG;

ARTICLE; BLOOD; BLOOD GROUP ABO SYSTEM; CONTROLLED STUDY; CORRELATION ANALYSIS; CULTURE MEDIUM; DOSE RESPONSE; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; MONOCYTE; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ARGININE; CELLS, CULTURED; CHEMOKINE CCL2; CYCLOSPORINE; ENALAPRIL; GENE EXPRESSION REGULATION; HUMANS; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; KINETICS; NIACINAMIDE; THROMBOPLASTIN;

EID: 10744233687     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.TP.0000098905.86445.0F     Document Type: Article

References (22)

1. Moberg L, Johansson H, Lukinius A, et al. Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation. Lancet 2002; 360(9350): 2039.
2. Bennet W, Sundberg B, Groth CG, et al. Incompatibility between human blood and isolated islets of Langerhans: A finding with implications for clinical intraportal islet transplantation? Diabetes 1999; 48(10): 1907.
3. Ozmen L, Nilsson Ekdahl K, Elgue G, et al. Inhibition of thrombin abrogates the instant blood-mediated inflammatory reaction triggered by isolated human islets: Possible application of the thrombin inhibitor melagatran in clinical islet transplantation. Diabetes 2002; 51(6): 1779.
4. Piemonti L, Leone BE, Nano R, et al. Human pancreatic islets produce and secrete MCP-1/CCL2: Relevance in human islet transplantation. Diabetes 2002; 51(1): 55.
5. Chen MC, Proost P, Gysemans C, et al. Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 beta-exposed human and rat islet cells. Diabetologia 2001; 44(3): 325.
6. Ryan EA, Lakey JR, Rajotte RV, et al. Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol. Diabetes 2001; 50(4): 710.
7. Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000; 343(4): 230.
8. Rupprecht HD, Akagi Y, Keil A, et al. Nitric oxide inhibits growth of glomerular mesangial cells: Role of the transcription factor EGR-1. Kidney Int 2000; 57(1): 70.
9. Holschermann H, Durfeld F, Maus U, et al. Cyclosporine a inhibits tissue factor expression in monocytes/macrophages. Blood 1996; 88(10): 3837.
10. Napoleone E, Di Santo A, Camera M, et al. Angiotensin-converting enzyme inhibitors downregulate tissue factor synthesis in monocytes. Circ Res 2000; 86(2): 139.
11. Ungerstedt J, Heimersson K, Söderström Y, et al. Nicotinamide inhibits endotoxin induced monocyte TF expression. J Thromb Haemost (in press).
12. Brandhorst H, Brandhorst D, Brendel MD, et al. Assessment of intracellular insulin content during all steps of human islet isolation procedure. Cell Transplant 1998; 7(5): 489.
13. Ricordi C, Lacy PE, Finke EH, et al. Automated method for isolation of human pancreatic islets. Diabetes 1988; 37(4): 413.
14. Lakey JR, Warnock GL, Shapiro AM, et al. Intraductal collagenase delivery into the human pancreas using syringe loading or controlled perfusion. Cell Transplant 1999; 8(3): 285.
15. Gong J, Larsson R, Nilsson Ekdahl K, et al. Tubing loops as a model for cardiopulmonary bypass circuits: Both the biomaterial and the blood-gas phase interfaces induce complement activation in an in vitro model. J Clin Immunol 1996; 16(4): 222.
16. Larsson R, Elgue G, Larsson A, et al. Inhibition of complement activation by soluble recombinant CR1 under conditions resembling those in a cardiopulmonary circuit: Reduced up-regulation of CD11b and complete abrogation of binding of PMNs to the biomaterial surface. Immunopharmacology 1997; 38 (1-2): 119.
17. Mackman N, Brand K, Edgington TS. Lipopolysaccharide-mediated transcriptional activation of the human tissue factor gene in THP-1 monocytic cells requires both activator protein 1 and nuclear factor kappa B binding sites. J Exp Med 1991; 174(6): 1517.
18. Ueda A, Okuda K, Ohno S, et al. NF-kappa B and Sp1 regulate transcription of the human monocyte chemoattractant protein-1 gene. J Immunol 1994; 153(5): 2052.
19. Mackman N. Regulation of the tissue factor gene. FASEB J 1995; 9(10): 883.
20. Oeth P, Parry GC, Mackman N. Regulation of the tissue factor gene in human monocytic cells: Role of AP-1, NF-kappa B/Rel, and Sp1 proteins in uninduced and lipopolysaccharide-induced expression. Arterioscler Thromb Vasc Biol 1997; 17(2): 365.
21. Yan SF, Mackman N, Kisiel W, et al. Hypoxia/hypoxemia-induced activation of the procoagulant pathways and the pathogenesis of ischemia-associated thrombosis. Arterioscler Thromb Vasc Biol 1999; 19(9): 2029.
22. Bretzel RG, Brendel M, Eckhard M, et al. Islet transplantation: Present clinical situation and future aspects. Exp Clin Endocrinol Diabetes 2001; 109(suppl 2): S384.