Involvement of the liver in the induction of CD8 T cell tolerance towards oral antigen

Zeitschrift fur Gastroenterologie

Volumn 44, Issue 1, 2006, Pages 51-56

  Knolle, Percy A ^a  

^a UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

Antigen uptake; Cross presentation; Hepatic dendritic cells; Immune tolerance; Liver sinusoidal endothelial cells

Indexed keywords

ANTIGEN; CX3C CHEMOKINE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 2; INTERLEUKIN 4; RAG2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CROSS PRESENTATION; DENDRITIC CELL; ENDOTHELIUM CELL; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; LIVER; LIVER SINUSOID; PORTAL VEIN BLOOD FLOW; REVIEW;

ADMINISTRATION, ORAL; ANIMALS; ANTIGENS; CD8-POSITIVE T-LYMPHOCYTES; HUMANS; IMMUNE TOLERANCE; LIVER;

EID: 31944452650     PISSN: 00442771     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-858988     Document Type: Review

References (46)

1. Cantor H, Dumont A. Hepatic suppression of sensitization to antigen absorbed into the portal system. Nature 1967; 215: 744
2. Callery MP, Kamei T, Flye MW. The effect of portacaval shunt on delayed-hypersensitivity responses following antigen feeding. J Surg Res 1989; 46: 391-394
3. Yang R, Liu Q, Grosfeld JL et al. Intestinal venous drainage through the liver is a prerequisite for oral tolerance induction. J Pediatr Surg 1994; 29: 1145-1148
4. Calne RY. Induction of immunological tolerance by porcine liver allografts. Nature 1969; 223: 472-476
5. Dahmen U, Qian S, Rao AS et al. Split tolerance induced by orthotopic liver transplantation in mice. Transplantation 1994; 58: 1-8
6. Barker CF, Corriere JN Jr. Canine renal homotransplantation with venous drainage via the portal vein. Ann Surg 1967; 165: 279-282
7. Boeckx W, Sobis H, Lacquet A et al. Prolongation of allogeneic heart graft survival in the rat after implantation on portal vein. Transplantation 1975; 19: 145-149
8. Gorczynski RM, Chan Z, Chung S et al. Prolongation of rat small bowel or renal allograft survival by pretransplant transfusion and/or by varying the route of allograft venous drainage. Transplantation 1994; 58: 816-820
9. Yu S, Nakafusa Y, Flye MW. Portal vein administration of donor cells promotes peripheral allospecific hyporesponsiveness and graft tolerance. Surgery 1994; 116: 229-234; discussion 234-235
10. Bertolino P, Bowen DG, McCaughan GW et al. Antigen-specific primary activation of CD8 + T cells within the liver. J Immunol 2001; 166: 5430-5438
11. Bertolino P, McCaughan GW, Bowen DG. Role of primary intrahepatic T-cell activation in the "liver tolerance effect". Immunol Cell Biol 2002; 80: 84-92
12. Bowen DG, Zen M, Holz L et al. The site of primary T cell activation is a determinant of the balance between intrahepatic tolerance and immunity. J Clin Invest 2004; 114: 701-712
13. Richman LK, Klingenstein RJ, Richman JA et al. The murine Kupffer cell. I. Characterization of the cell serving accessory function in antigen-specific T cell proliferation. J Immunol 1979; 123: 2602-2609
14. Rubinstein D, Roska AK, Lipsky PE. Antigen presentation by liver sinusoidal lining cells after antigen exposure in vivo. J Immunol 1987; 138: 1377-1382
15. Knolle P, Schlaak J, Uhrig A et al. Human Kupffer cells secrete IL-10 in response to lipopolysaccharide (LPS) challenge. J Hepatol 1995; 22: 226-229
16. Bissell DM, Wang SS, Jarnagin WR et al. Cell-specific expression of transforming growth factor-beta in rat liver. Evidence for autocrine regulation of hepatocyte proliferation. J Clin Invest 1995; 96: 447-455
17. Callery MP, Kamei T, Flye MW. Kupffer cell blockade inhibits induction of tolerance by the portal venous route. Transplantation 1989; 47: 1092-1094
18. Kamei T, Callery MP, Flye MW. Kupffer cell blockade prevents induction of portal venous tolerance in rat cardiac allograft transplantation. J Surg Res 1990; 48: 393-396
19. Steinman RM, Hawiger D, Liu K et al. Dendritic cell function in vivo during the steady state: a role in peripheral tolerance. Ann N Y Acad Sci 2003; 987: 15-25
20. Goddard S, Youster J, Morgan E et al. Interleukin-10 secretion differentiates dendritic cells from human liver and skin. Am J Pathol 2004; 164: 511-519
21. Jomantaite I, Dikopoulos N, Kroger A et al. Hepatic dendritic cell subsets in the mouse. Eur J Immunol 2004; 34: 355-365
22. Pillarisetty VG, Shah AB, Miller G et al. Liver dendritic cells are less immunogenic than spleen dendritic cells because of differences in subtype composition. J Immunol 2004; 172: 1009-1017
23. Lau AH, Thomson AW. Dendritic cells and immune regulation in the liver. Gut 2003; 52: 307-314
24. Matsuno K, Ezaki T, Kudo S et al. A life stage of particle-laden rat dendritic cells in vivo: their terminal division, active phagocytosis, and translocation from the liver to the draining lymph [see comments]. J Exp Med 1996; 183: 1865-1878
25. Kudo S, Matsuno K, Ezaki T et al. A novel migration pathway for rat dendritic cells from the blood: hepatic sinusoids-lymph translocation. J Exp Med 1997; 185: 777-784
26. Steinbrink K, Wolfl M, Jonuleit H et al. Induction of tolerance by IL-10-treated dendritic cells. J Immunol 1997; 159: 4772-4780
27. Lutz MB, Schuler G. Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity? Trends Immunol 2002; 23: 445-449
28. Steinman RM, Hawiger D, Nussenzweig MC. Tolerogenic dendritic cells. Annu Rev Immunol 2003; 21: 685-711
29. Smedsrod B. Clearance function of scavenger endothelial cells. Comp Hepatol 2004; 3 (Suppl 1): S22
30. Lohse AW, Knolle PA, Bilo K et al. Antigen-presenting function and B7 expression of murine sinusoidal endothelial cells and Kupffer cells. Gastroenterology 1996; 110: 1175-1181
31. Knolle PA, Schmitt E, Jin S et al. Induction of cytokine production in naive CD4(+) T cells by antigen-presenting murine liver sinusoidal endothelial cells but failure to induce differentiation toward Th1 cells. Gastroenterology 1999; 116: 1428-1440
32. Limmer A, Ohl J, Kurts C et al. Efficient presentation of exogenous antigen by liver endothelial cells to CD8 + T cells results in antigen-specific T-cell tolerance. Nat Med 2000; 6: 1348-1354
33. Rescigno M, Urbano M, Valzasina B et al. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat Immunol 2001; 2: 361-367
34. Niess JH, Brand S, Gu X et al. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 2005; 307 (5707): 254-258
35. Mowat AM. Anatomical basis of tolerance and immunity to intestinal antigens. Nat Rev Immunol 2003; 3: 331-341
36. Karlsson M, Lundin S, Dahlgren U et al. "Tolerosomes" are produced by intestinal epithelial cells. Eur J Immunol 2001; 31: 2892-2900
37. Blanas E, Carbone FR, Allison J et al. Induction of autoimmune diabetes by oral administration of autoantigen. Science 1996; 274 (5293): 1707-1709
38. Hanninen A, Braakhuis A, Heath WR et al. Mucosal antigen primes diabetogenic cytotoxic T-lymphocytes regardless of dose or delivery route. Diabetes 2001; 50: 771-775
39. Peng HJ, Turner MW, Strobel S. The kinetics of oral hyposensitization to a protein antigen are determined by immune status and the timing, dose and frequency of antigen administration. Immunology 1989; 67: 425-430
40. Gutgemann I, Fahrer AM, Altman JD et al. Induction of rapid T cell activation and tolerance by systemic presentation of an orally administered antigen. Immunity 1998; 8: 667-673
41. Smith KM, Davidson JM, Garside P. T-cell activation occurs simultaneously in local and peripheral lymphoid tissue following oral administration of a range of doses of immunogenic or tolerogenic antigen although tolerized T cells display a defect in cell division. Immunology 2002; 106: 144-158
42. Watanabe T, Katsukura H, Shirai Y et al. A liver tolerates a portal antigen by generating CD11c+ cells, which select Fas ligand+ Th2 cells via apoptosis. Hepatology 2003; 38: 403-412
43. Watanabe T, Yoshida M, Shirai Y et al. Administration of an antigen at a high dose generates regulatory CD4+ T cells expressing CD95 ligand and secreting IL-4 in the liver. J Immunol 2002; 168: 2188-2199
44. Regnault A, Lankar D, Lacabanne V et al. Fcgamma receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization. J Exp Med 1999; 189: 371-380
45. Limmer A, Ohl J, Wingender G et al. Cross-presentation of oral antigens by liver sinusoidal endothelial cells leads to CD8 T cell tolerance. Eur J Immunol 2005; 35: 2970-2981
46. Campos RA, Szczepanik M, Itakura A et al. Cutaneous immunization rapidly activates liver invariant Valpha14 NKT cells stimulating B-1 B cells to initiate T cell recruitment forelicitation of contact sensitivity. J Exp Med 2003; 198: 1785-1796