Pyrimidine nucleoside depletion sensitizes to the mitochondrial hepatotoxicity of the reverse transcriptase inhibitor stavudine

American Journal of Pathology

Volumn 172, Issue 3, 2008, Pages 681-690

  Setzer, Bernhard ^a   Lebrecht, Dirk ^a   Walker, Ulrich A ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CASPASE 3; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DIHYDROOROTATE DEHYDROGENASE INHIBITOR; MITOCHONDRIAL DNA; PROTEIN P21; PYRIMIDINE NUCLEOSIDE; REDOXAL; STAVUDINE; UNCLASSIFIED DRUG; URIDINE;

APOPTOSIS; ARTICLE; BIOGENESIS; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL DIVISION; CONTROLLED STUDY; CYTOTOXICITY; DNA REPAIR; DRUG POTENTIATION; DRUG TOLERABILITY; ENERGY METABOLISM; ENZYME ACTIVATION; GENE; HEPATOMA CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; MITOCHONDRIAL DNA DEPLETION; MITOCHONDRIAL HEPATOTOXICITY; MITOCHONDRIAL TOXICITY; MITOCHONDRION; NUCLEOTIDE METABOLISM; OXIDATIVE STRESS; PRIORITY JOURNAL; UPREGULATION;

EID: 40449092812     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.2353/ajpath.2008.070613     Document Type: Article

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