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Volumn 8, Issue 5, 2003, Pages 463-470

Uridine abrogates mitochondrial toxicity related to nucleoside analogue reverse transcriptase inhibitors in HepG2 cells

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CYCLOOXYGENASE 2; DIDANOSINE; LACTIC ACID; LAMIVUDINE; LIPID; MITOCHONDRIAL DNA; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE; UNCLASSIFIED DRUG; URIDINE; ZALCITABINE;

EID: 0242300115     PISSN: 13596535     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (57)

References (32)
  • 1
    • 0028990381 scopus 로고
    • Mitochondrial toxicity of antiviral drugs
    • Lewis W & Dalakas MC. Mitochondrial toxicity of antiviral drugs. Nature Medicine 1995; 1:417-422.
    • (1995) Nature Medicine , vol.1 , pp. 417-422
    • Lewis, W.1    Dalakas, M.C.2
  • 2
    • 0033604038 scopus 로고    scopus 로고
    • Mitochondrial toxicity induced by nucleoside analogue reverse transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral therapy-related lipodystrophy
    • Brinkman K, Smeitink JA, Romijn JA & Reiss P. Mitochondrial toxicity induced by nucleoside analogue reverse transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral therapy-related lipodystrophy. Lancet 1999; 354:1112-1115.
    • (1999) Lancet , vol.354 , pp. 1112-1115
    • Brinkman, K.1    Smeitink, J.A.2    Romijn, J.A.3    Reiss, P.4
  • 3
    • 0033935975 scopus 로고    scopus 로고
    • Pharmacology of nucleoside and nucleotide reverse transcriptase inhibitor-induced mitochondrial toxicity
    • Kakuda TN. Pharmacology of nucleoside and nucleotide reverse transcriptase inhibitor-induced mitochondrial toxicity. Clinical Therapeutics 2000;22:685-708.
    • (2000) Clinical Therapeutics , vol.22 , pp. 685-708
    • Kakuda, T.N.1
  • 4
    • 0037045058 scopus 로고    scopus 로고
    • Increased long-term mitochondrial toxicity in combinations of nucleoside analogue reverse-transcriptase inhibitors
    • Walker UA, Setzer B & Venhoff N. Increased long-term mitochondrial toxicity in combinations of nucleoside analogue reverse-transcriptase inhibitors. AIDS 2002; 16:2165-2173.
    • (2002) AIDS , vol.16 , pp. 2165-2173
    • Walker, U.A.1    Setzer, B.2    Venhoff, N.3
  • 9
    • 0034491555 scopus 로고    scopus 로고
    • Treatment of nucleoside reverse transcriptase inhibitor-induced lactic acidosis
    • Brinkman K, Vrouenraets S, Kauffman R, Weigel H & Frissen J. Treatment of nucleoside reverse transcriptase inhibitor-induced lactic acidosis. AIDS 2000; 14:2801-2802.
    • (2000) AIDS , vol.14 , pp. 2801-2802
    • Brinkman, K.1    Vrouenraets, S.2    Kauffman, R.3    Weigel, H.4    Frissen, J.5
  • 10
    • 0029135073 scopus 로고
    • The therapy of respiratory chain encephalomyopathy: A critical review of the past and current perspective
    • Walker UA & Byrne E. The therapy of respiratory chain encephalomyopathy: a critical review of the past and current perspective. Acta Neurologica Scandinavica 1995; 92:273-280.
    • (1995) Acta Neurologica Scandinavica , vol.92 , pp. 273-280
    • Walker, U.A.1    Byrne, E.2
  • 12
    • 0032566235 scopus 로고    scopus 로고
    • Riboflavin to treat nucleoside analogue-induced lactic acidosis
    • Fouty B, Frerman F & Reves R. Riboflavin to treat nucleoside analogue-induced lactic acidosis. Lancet 1998; 352:291-292.
    • (1998) Lancet , vol.352 , pp. 291-292
    • Fouty, B.1    Frerman, F.2    Reves, R.3
  • 13
    • 0037192589 scopus 로고    scopus 로고
    • Dietary supplements in the treatment of NRTI-related mitochondrial toxicity
    • Venhoff N, Setzer B, Lebrecht D & Walker UA. Dietary supplements in the treatment of NRTI-related mitochondrial toxicity. AIDS 2002; 16:800-802.
    • (2002) AIDS , vol.16 , pp. 800-802
    • Venhoff, N.1    Setzer, B.2    Lebrecht, D.3    Walker, U.A.4
  • 14
    • 0028931797 scopus 로고
    • Respiratory-deficient human fibroblasts exhibiting defective mitochondrial DNA replication
    • Bodnar AG, Cooper JM, Leonard JV & Schapira AH. Respiratory-deficient human fibroblasts exhibiting defective mitochondrial DNA replication. Biochemical Journal 1995; 305:817-822.
    • (1995) Biochemical Journal , vol.305 , pp. 817-822
    • Bodnar, A.G.1    Cooper, J.M.2    Leonard, J.V.3    Schapira, A.H.4
  • 15
    • 0027504790 scopus 로고
    • Anti-human immunodeficiency virus type 1 therapy and peripheral neuropathy: Prevention of 2′,3′-dideoxycytidine toxicity in PC12 cells, a neuronal model, by uridine and pyruvate
    • Keilbaugh SA, Hobbs GA & Simpson MV. Anti-human immunodeficiency virus type 1 therapy and peripheral neuropathy: prevention of 2′,3′-dideoxycytidine toxicity in PC12 cells, a neuronal model, by uridine and pyruvate. Molecular Pharmacology 1993; 44:702-706.
    • (1993) Molecular Pharmacology , vol.44 , pp. 702-706
    • Keilbaugh, S.A.1    Hobbs, G.A.2    Simpson, M.V.3
  • 16
    • 0023788972 scopus 로고
    • Uridine reverses the toxicity of 3′-azido-3′-deoxythymidine in normal human granulocyte-macrophage progenitor cells in vitro without impairment of antiretroviral activity
    • Sommadossi JP, Carlisle R, Schinazi RF & Zhou Z. Uridine reverses the toxicity of 3′-azido-3′-deoxythymidine in normal human granulocyte-macrophage progenitor cells in vitro without impairment of antiretroviral activity. Antimicrobial Agents & Chemotherapy 1988; 32:997-1001.
    • (1988) Antimicrobial Agents & Chemotherapy , vol.32 , pp. 997-1001
    • Sommadossi, J.P.1    Carlisle, R.2    Schinazi, R.F.3    Zhou, Z.4
  • 18
    • 0036174438 scopus 로고    scopus 로고
    • Assessment of mitochondrial toxicity in human cells treated with tenofovir: Comparison with other nucleoside reverse transcriptase inhibitors
    • Birkus G, Hitchcock MJ & Cihlar T. Assessment of mitochondrial toxicity in human cells treated with tenofovir: comparison with other nucleoside reverse transcriptase inhibitors. Antimicrobial Agents & Chemotherapy 2002; 46:716-723.
    • (2002) Antimicrobial Agents & Chemotherapy , vol.46 , pp. 716-723
    • Birkus, G.1    Hitchcock, M.J.2    Cihlar, T.3
  • 19
    • 0029003333 scopus 로고
    • Complementation and segregation behavior of disease-causing mitochondrial DNA mutations in cellular model systems
    • Attardi G, Yoneda M & Chomyn A. Complementation and segregation behavior of disease-causing mitochondrial DNA mutations in cellular model systems. Biochimica et Biophysica Acta 1995; 1271:241-248.
    • (1995) Biochimica et Biophysica Acta , vol.1271 , pp. 241-248
    • Attardi, G.1    Yoneda, M.2    Chomyn, A.3
  • 20
    • 0030761388 scopus 로고    scopus 로고
    • Dihydroorotat-ubiquinone oxidoreductase links mitochondria in the biosynthesis of pyrimidine nucleotides
    • Löffler M, Jöckel J, Schuster G & Becker C. Dihydroorotat-ubiquinone oxidoreductase links mitochondria in the biosynthesis of pyrimidine nucleotides. Molecular & Cellular Biochemistry 1997; 174:125-129.
    • (1997) Molecular & Cellular Biochemistry , vol.174 , pp. 125-129
    • Löffler, M.1    Jöckel, J.2    Schuster, G.3    Becker, C.4
  • 21
    • 0025221427 scopus 로고
    • Benzylacyclouridine reverses azidothymidine-induced marrow suppression without impairment of anti-human immunodeficiency virus activity
    • Calabresi P, Falcone A, St Clair MH, Wiemann MC, Chu SH & Darnowski JW. Benzylacyclouridine reverses azidothymidine-induced marrow suppression without impairment of anti-human immunodeficiency virus activity. Blood 1990; 76:2210-2215.
    • (1990) Blood , vol.76 , pp. 2210-2215
    • Calabresi, P.1    Falcone, A.2    St. Clair, M.H.3    Wiemann, M.C.4    Chu, S.H.5    Darnowski, J.W.6
  • 22
    • 0028109345 scopus 로고
    • Comparison of mitochondrial morphology, mitochondrial DNA content, and cell viability in cultured cells treated with three anti-human immunodeficiency virus dideoxynucleosides
    • Medina DJ, Tsai CH, Hsiung GD & Cheng YC. Comparison of mitochondrial morphology, mitochondrial DNA content, and cell viability in cultured cells treated with three anti-human immunodeficiency virus dideoxynucleosides. Antimicrobial Agents & Chemotherapy 1994; 38:1824-1828.
    • (1994) Antimicrobial Agents & Chemotherapy , vol.38 , pp. 1824-1828
    • Medina, D.J.1    Tsai, C.H.2    Hsiung, G.D.3    Cheng, Y.C.4
  • 23
    • 24544462907 scopus 로고    scopus 로고
    • Immunosuppressive effect of mtDNA-depletion by d-drugs in healthy human-lymphocytes
    • Setzer B, Schlesier M, Thomas AK & Walker UA. Immunosuppressive effect of mtDNA-depletion by d-drugs in healthy human-lymphocytes. Antiviral Therapy 2003; 8:L43.
    • (2003) Antiviral Therapy , vol.8
    • Setzer, B.1    Schlesier, M.2    Thomas, A.K.3    Walker, U.A.4
  • 24
    • 0029811256 scopus 로고    scopus 로고
    • Mechanism of action of leflunomide: In vivo uridine administration reverses its inhibition of lymphocyte proliferation
    • Silva HT, Cao W, Shorthouse R & Morris RE. Mechanism of action of leflunomide: in vivo uridine administration reverses its inhibition of lymphocyte proliferation. Transplantation Proceedings 1996; 28:3082-3084.
    • (1996) Transplantation Proceedings , vol.28 , pp. 3082-3084
    • Silva, H.T.1    Cao, W.2    Shorthouse, R.3    Morris, R.E.4
  • 26
    • 0022457607 scopus 로고
    • Clinical and pharmacokinetic studies of prolonged administration of high-dose uridine intended for rescue from 5-FU toxicity
    • van Groeningen CJ, Leyva A, Kraal I, Peters GJ & Pinedo HM. Clinical and pharmacokinetic studies of prolonged administration of high-dose uridine intended for rescue from 5-FU toxicity. Cancer Treatment Reports 1986; 70:745-750.
    • (1986) Cancer Treatment Reports , vol.70 , pp. 745-750
    • Van Groeningen, C.J.1    Leyva, A.2    Kraal, I.3    Peters, G.J.4    Pinedo, H.M.5
  • 28
    • 0025327693 scopus 로고
    • The effect in vitro of 2′-deoxycytidine on the metabolism and cytotoxicity of 2′,3′-dideoxycytidine
    • Bhalla KN, Li GR, Grant S, Cole JT, MacLaughlin WW & Volsky DJ. The effect in vitro of 2′-deoxycytidine on the metabolism and cytotoxicity of 2′,3′-dideoxycytidine. AIDS 1990; 4:427-431.
    • (1990) AIDS , vol.4 , pp. 427-431
    • Bhalla, K.N.1    Li, G.R.2    Grant, S.3    Cole, J.T.4    MacLaughlin, W.W.5    Volsky, D.J.6
  • 29
    • 0024462722 scopus 로고
    • 2′-deoxycytidine protects normal human bone marrow progenitor cells in vitro against the cytotoxicity of 3′-azido-3′ -deoxythymidine with preservation of antiretroviral activity
    • Bhalla K, Birkhofer M, Li GR, Grant S, MacLaughlin W, Cole J, Graham G & Volsky DJ. 2′-Deoxycytidine protects normal human bone marrow progenitor cells in vitro against the cytotoxicity of 3′-azido-3′ -deoxythymidine with preservation of antiretroviral activity. Blood 1989; 74:1923-1928.
    • (1989) Blood , vol.74 , pp. 1923-1928
    • Bhalla, K.1    Birkhofer, M.2    Li, G.R.3    Grant, S.4    MacLaughlin, W.5    Cole, J.6    Graham, G.7    Volsky, D.J.8
  • 30
    • 0025198422 scopus 로고
    • Different effect of benzylacyclouridine on the toxic and therapeutic effects of azidothymidine in mice
    • Falcone A, Darnowski JW, Ruprecht RM, Chu SH, Brunetti I & Calabresi P. Different effect of benzylacyclouridine on the toxic and therapeutic effects of azidothymidine in mice. Blood 1990; 76:2216-2221.
    • (1990) Blood , vol.76 , pp. 2216-2221
    • Falcone, A.1    Darnowski, J.W.2    Ruprecht, R.M.3    Chu, S.H.4    Brunetti, I.5    Calabresi, P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.