Leflunomide inhibits pyrimidine de novo synthesis in mitogen-stimulated T-lymphocytes from healthy humans

Journal of Biological Chemistry

Volumn 273, Issue 34, 1998, Pages 21682-21691

  Rückemann, Katarzyna ^a,e   Fairbanks, Lynette D ^a   Carrey, Elizabeth A ^c   Hawrylowicz, Catherine M ^b   Richards, David F ^b   Kirschbaum, Bernhard ^d   Simmonds, H Anne ^a,b  

^a GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c ROYAL FREE HOSPITAL   (United Kingdom)

^d SANOFI   (France)

^e MEDICAL UNIVERSITY OF GDANSK   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

BREQUINAR; DIHYDROOROTATE DEHYDROGENASE; LEFLUNOMIDE; PYRIMIDINE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL CYCLE; CELL PROLIFERATION; DRUG MECHANISM; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOMODULATION; MITOGENESIS; PRIORITY JOURNAL; PURINE SYNTHESIS; PYRIMIDINE SYNTHESIS; T LYMPHOCYTE;

ADENOSINE TRIPHOSPHATE; ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BIPHENYL COMPOUNDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; IMMUNOSUPPRESSIVE AGENTS; ISOXAZOLES; LYMPHOCYTE ACTIVATION; MICE; MITOGENS; OXIDOREDUCTASES; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; PHYTOHEMAGGLUTININS; PYRIMIDINES; T-LYMPHOCYTES; URIDINE; URIDINE TRIPHOSPHATE;

EID: 0032555586     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.34.21682     Document Type: Article

References (45)

1. Bartlett, R., Campion, G., Musikic, P., Schleyerbach, R., Zielinski, T., and Schorlemmer, H.-U. (1994) in Nonsteroidal Anti-Inflammatory Drugs: Mechanisms and Clinical Uses (Lewis, A. J., and Furst, D. E., eds) pp. 349-366, Marcel Dekker, Inc., New York
2. Bartlett, R. R., Dimitrijevic, M., Mattar, T., Zielinski, T., Germann, T., Rude, E., Thoenes, G. H., Küchle, C. C. A., Schorlemmer, H.-U., Bremmer, E., Finnegan, A., and Schleyerbach, R. (1991) Agents Actions 32, 10-21
3. Silva, H. T., Jr., and Morris, R. E. (1997) Exp. Opin. Invest. Drugs 6, 51-64
4. Silva, H. T., Jr., Gao, W., Shorthouse, R. A., Löffler, M., and Morris, R. E. (1997) Transplant. Proc. 29, 1292-1293
5. Cherwinski, H. M., McCarley, D., Schatzman, R., Devens, B., and Ransom, J. T. (1995) J. Pharmacol. Exp. Ther. 272, 460-468
6. Cherwinski, H. M., Byars, N., Ballaron, G., Nakano, G., Young, J., and Ransom, J. (1995) Inflammation Res. 44, 317-322
7. Cherwinski, H. M., Cohn, R., Cheung, P., Webster, D., Xu, Y., Caulfield, J., Young, J., Nakano, G., and Ransom, J. (1995) J. Pharmacol. Exp. Ther. 275, 1043-1049
8. Makowka, L., Sher, L., and Cramer, D. (1993) Immunol. Rev. 136, 51-70
9. Peters, G. J., Sharma, E., Laurensse, E., and Pinedo, H. M. (1987) Invest. New Drugs 253B, 375-381
10. Peters, G. J., Schwartsmann, G., Nadal, J. C., Laurensse, E., Groeningen, C. J. V., Vijgh, W. J. F. V. D., and Pinedo, H. M. (1990) Cancer Res. 50, 4644-4649
11. Peters, G. J., Kraal, I., and Pinedo, H. M. (1992) Br. J. Cancer 365, 229-233
12. Simon, P., Townsend, R., Harris, R., Jones, E., and Jaffee, B. (1993) Transplant. Proc. 25, Suppl. 2, 77-80
13. Nair, R. V., Cao, W., and Morris, R. E. (1995) Immunol. Lett. 47, 171-174
14. Mladenovic, V., Domljan, Z., Rozman, B., Jajic, I., Mihajlovic, D., Dordevic, J., Popovic, M., Dimitrijevic, M., Zivkovic, M., and Campion, G. (1995) Arthritis Rheum. 38, 1595-1603
15. Chong, A. S.-F., Rezai, K., Gebel, H., Finnegan, A., Foster, P., Xu, X., and Williams, J. (1996) Transplantation (Baltimore) 61, 140-147
16. Mattar, T., Kochar, K., Bartlett, R., Bremer, E. G., and Finnegan, (1993) FEBS Lett. 334, 161-164
17. Nikcevich, D. A., Finnegan, A., Chong, A. S.-F., Williams, J. W., and Bremer, E. G. (1994) Agents Actions 41, C279-C282
18. Samelson, L., Davidson, W., Morse, H., and Klausner, R. (1986) Nature 324, 674-676
19. Siemasko, K., Chong, A. S.-F., Williams, J., Bremer, E., and Finnegan, A. (1996) Transplantation (Baltimore) 61, 635-642
20. Zielinski, T., Hermann, M., Müllner, S., Riedel, N., and Bartlett, R. R. (1994) Agent Actions 41, 205-207
21. Elder, R., Xu, X., Williams, J., Gong, H., Finnegan, A., and Chong, A. S.-F. (1997) J. Immunol. 159, 22-27
22. Xu, X., Williams, J. W., Bremer, E. G., Finnegan, A., and Chong, A. S.-F. (1995) J. Biol. Chem. 270, 12398-12403
23. Xu, X., Williams, J. W., Gong, H., Finnegan, A., and Chong, A. S.-F. (1996) Biochem. Pharmacol. 52, 527-534
24. Xu, X., Blinder, L., Shen, J., Gong, H., Finnegan, A., Williams, J. W., and Chong, A. S.-F. (1997) J. Immunol. 159, 167-174
25. Williamson, R., Yea, C., Robson, P., Curnock, A., Gadhert, S., Hambleton, A., Woodwar, K., Bruneau, J. M., Hambleton, P., Moss, D., Thomsen, T. A., Spinella-Jaegle, S., Morand, P., Courtin, O., Sautés, C., Westwood, R., Hercend, T., Kuo, E. A., and Ruuth, E. (1995) J. Biol. Chem. 270, 22467-22472
26. Zielinski, T., Zeitter, D., Müllner, S., and Bartlett, R. R. (1995) Inflammation Res. 44, S207-S208
27. Cleaveland, E. S., Monks, A., Vaigro-Wolff, A., Zaharevitz, D. W., Paull, K., Ardalan, K., Cooney, D. A., and Ford, J. R. (1995) Biochem. Pharmacol. 49, 947-954
28. Greene, S., Watanabe, K., Braatz-Trulson, J., and Lou, L. (1995) Biochem. Pharmacol. 50, 861-867
29. Knecht, W., Bergjohann, U., Gonski, S., Kirschbaum, B., and Löffler, M. (1996) Eur. J. Biochem. 240, 292-301
30. Simmonds, H. A. (1995) Biochem. Soc. Trans. 23, 877-879
31. Fairbanks, L., Bofill, M., Rückemann, K., and Simmonds, H. A. (1995) J. Biol. Chem. 270, 29682-29689
32. Marijnen, Y. M. T., de Korte, D., Haverkort, W. A., den Breejen, E. J. S., van Gennip, A. H., and Roos, D. (1989) Biochim. Biophys. Acta 1012, 148-155
33. van den Berg, A. A., van Lenthe, H., Busch, S., de Korte, D., van Kuilenburg, A. B. P., and van Gennip, A. H. (1994) Leukemia (Baltimore) 8, 1375-1378
34. Webster, D. R., Becroft, D. M. O., and Suttle, D. P. (1995) in The Metabolic and Molecular Basis of Inherited Disease (Scriver, C. R., Beaudet, A. L., Sly, W. S., and Valle, D., eds) 7th Ed., pp. 1725-1768, McGraw-Hill Book Co., New York
35. Bofill, M., Fairbanks, L. D., Rückemann, K., Lipman, M., and Simmonds, H. A. (1995) J. Biol. Chem. 270, 29690-29697
36. Simmonds, H. A., Duley, J. A., and Davies, P. M. (1991) in Techniques in Diagnostic Human Biochemical Genetics: A Laboratory Manual (Hommes, F., ed) pp. 397-424, Wiley-Liss, New York
37. Sebesta, I., Fairbanks, L. D., Davies, P. M., Simmonds, H. A., and Leonard, J. V. (1994) Clin. Chim. Acta 224, 45-54
38. Hemmens, B. P., and Carrey, E. A. (1994) Eur. J. Biochem. 225, 845-853
39. Christopherson, R. I., and Jones, M. E. (1979) J. Biol. Chem. 254, 12506-12512
40. Kemp, A. J., Lyons, S. D., and Christopherson, R. I. (1986) J. Biol. Chem. 261, 14891-14895
41. Eugui, E. M., Almquist, S. J., Muller, C. D., and Allison, A. C. (1991) Scand. J. Immunol. 33, 161-173
42. Sokolowski, J. A., and Sartorelli, A. C. (1987) Int. J. Cancer 39, 764-768
43. Sasvari-Székely, M., Spasokukotskaja, T., and Staub, M. (1993) Biochem. Biophys. Res. Commun. 194, 966-972
44. Baringa, M. (1997) Science 278, 1036-1039
45. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. (1951) J. Biol. Chem. 193, 265-275