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Volumn 22, Issue 6, 2000, Pages 685-708

Pharmacology of nucleoside and nucleotide reverse transcriptase inhibitor-induced mitochondrial toxicity

Author keywords

Adverse effects; Anti HIV drugs; DNA polymerase; HIV; Mitochondria; Nucleoside and nucleotide reverse transcriptase inhibitors

Indexed keywords

2',3' DIDEOXY 2' FLUOROADENOSINE; ABACAVIR; ADEFOVIR DIPIVOXIL; ADENOSINE DIPHOSPHATE; ADENOSINE KINASE; ADENYLATE KINASE; DIDANOSINE; DNA DIRECTED DNA POLYMERASE GAMMA; LAMIVUDINE; MITOCHONDRIAL ENZYME; NUCLEOSIDE; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE; ZALCITABINE; ZIDOVUDINE;

EID: 0033935975     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/S0149-2918(00)90004-3     Document Type: Article
Times cited : (543)

References (99)
  • 2
    • 0034685037 scopus 로고    scopus 로고
    • Antiretroviral therapy in adults: Updated recommendations of the International AIDS Society USA Panel
    • 2. Carpenter CC, Cooper DA, Fischl MA, et al. Antiretroviral therapy in adults: Updated recommendations of the International AIDS Society USA Panel. JAMA. 2000;283:381-390.
    • (2000) JAMA , vol.283 , pp. 381-390
    • Carpenter, C.C.1    Cooper, D.A.2    Fischl, M.A.3
  • 3
    • 0029563673 scopus 로고
    • Treatment with lamivudine, zidovudine, or both in HIV-positive patients with 200 to 500 CD4+ cells per cubic millimeter
    • 3. Eron JJ, Benoit SL, Jemsek J, et al. Treatment with lamivudine, zidovudine, or both in HIV-positive patients with 200 to 500 CD4+ cells per cubic millimeter. N Engl J Med. 1995;333:1662-1669.
    • (1995) N Engl J Med , vol.333 , pp. 1662-1669
    • Eron, J.J.1    Benoit, S.L.2    Jemsek, J.3
  • 4
    • 0028837503 scopus 로고
    • Combination and monotherapy with zidovudine and zalcitabine in patients with advanced HIV disease
    • 4. Fischl MA, Stanley K, Collier AC, et al. Combination and monotherapy with zidovudine and zalcitabine in patients with advanced HIV disease. Ann Intern Med. 1995;122:24-32.
    • (1995) Ann Intern Med , vol.122 , pp. 24-32
    • Fischl, M.A.1    Stanley, K.2    Collier, A.C.3
  • 5
    • 8944225025 scopus 로고    scopus 로고
    • Safety and efficacy of lamivudine-zidovudine combination therapy in antiretroviral-naive patients: A randomized controlled comparison with zidovudine monotherapy
    • 5. Katlama C, Ingrand D, Loveday C, et al. Safety and efficacy of lamivudine-zidovudine combination therapy in antiretroviral-naive patients: A randomized controlled comparison with zidovudine monotherapy. JAMA. 1996;276:118-125.
    • (1996) JAMA , vol.276 , pp. 118-125
    • Katlama, C.1    Ingrand, D.2    Loveday, C.3
  • 6
    • 0030567824 scopus 로고    scopus 로고
    • Delta: A randomised double-blind controlled trial comparing combinations of zidovudine plus ddI or zalcitabine with zidovudine alone in HIV-infected individuals
    • 6. Delta Coordinating Committee. Delta: A randomised double-blind controlled trial comparing combinations of zidovudine plus ddI or zalcitabine with zidovudine alone in HIV-infected individuals. Lancet. 1996;348:283-291.
    • (1996) Lancet , vol.348 , pp. 283-291
  • 7
    • 10144244674 scopus 로고    scopus 로고
    • A trial comparing nucleoside monotherapy with combination therapy in HIV-infected adults with CD4 cell counts from 200 to 500 per millimeter
    • 7. Hammer SM, Katzenstein DA, Hughes MD, et al. A trial comparing nucleoside monotherapy with combination therapy in HIV-infected adults with CD4 cell counts from 200 to 500 per millimeter. N Engl J Med. 1996;335:1081-1090.
    • (1996) N Engl J Med , vol.335 , pp. 1081-1090
    • Hammer, S.M.1    Katzenstein, D.A.2    Hughes, M.D.3
  • 8
    • 10144258702 scopus 로고    scopus 로고
    • Zidovudine alone or in combination with ddI or zalcitabine in HIV-infected patients with the acquired immunodeficiency syndrome or fewer than 200 CD4 cells per cubic millimeter
    • 8. Saravolatz LD, Winslow DL, Collins C, et al. Zidovudine alone or in combination with ddI or zalcitabine in HIV-infected patients with the acquired immunodeficiency syndrome or fewer than 200 CD4 cells per cubic millimeter. N Engl J Med. 1996;335:1099-1106.
    • (1996) N Engl J Med , vol.335 , pp. 1099-1106
    • Saravolatz, L.D.1    Winslow, D.L.2    Collins, C.3
  • 9
    • 7844252581 scopus 로고    scopus 로고
    • Antiretroviral effect and safety of abacavir alone and in combination with zidovudine in HIV-infected adults
    • 9. Saag MS, Sonnerborg A, Torres RA, et al. Antiretroviral effect and safety of abacavir alone and in combination with zidovudine in HIV-infected adults. AIDS. 1998;12: F203-F209.
    • (1998) AIDS , vol.12
    • Saag, M.S.1    Sonnerborg, A.2    Torres, R.A.3
  • 10
    • 10544249459 scopus 로고    scopus 로고
    • Efficacy of triple combination therapy with zidovudine (ZDV) plus zalcitabine (ddC) plus lamivudine (3TC) versus double (ZDV+3TC) combination therapy in patients previously treated with ZDv+ddC
    • 10. Ruiz L, Romeu J, Martínez-Picado J, et al. Efficacy of triple combination therapy with zidovudine (ZDV) plus zalcitabine (ddC) plus lamivudine (3TC) versus double (ZDV+3TC) combination therapy in patients previously treated with ZDV+ddC. AIDS. 1996;10:F61-F66.
    • (1996) AIDS , vol.10
    • Ruiz, L.1    Romeu, J.2    Martínez-Picado, J.3
  • 11
    • 7844224756 scopus 로고    scopus 로고
    • A dose-ranging study to evaluate the safety and efficacy of abacavir alone or in combination with zidovudine and lamivudine in antiretroviral treatment-naive subjects
    • 11. Staszewski S, Katlama C, Harrer T, et al. A dose-ranging study to evaluate the safety and efficacy of abacavir alone or in combination with zidovudine and lamivudine in antiretroviral treatment-naive subjects. AIDS. 1998;12:F197-F202.
    • (1998) AIDS , vol.12
    • Staszewski, S.1    Katlama, C.2    Harrer, T.3
  • 12
    • 2642709177 scopus 로고    scopus 로고
    • Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection
    • 12. Palella FJ, Delaney KM, Moorman AC, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. N Engl J Med. 1998;338:853-860.
    • (1998) N Engl J Med , vol.338 , pp. 853-860
    • Palella, F.J.1    Delaney, K.M.2    Moorman, A.C.3
  • 13
    • 0033609373 scopus 로고    scopus 로고
    • Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy
    • 13. Zhang L, Ramratnam B, Tenner-Racz K, et al. Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy. N Engl J Med. 1999; 340:1605-1613.
    • (1999) N Engl J Med , vol.340 , pp. 1605-1613
    • Zhang, L.1    Ramratnam, B.2    Tenner-Racz, K.3
  • 14
    • 0034033584 scopus 로고    scopus 로고
    • Mitochondrial toxicity of nucleoside analogue reverse transcriptase inhibitors: A looming obstacle for long-term anti-retroviral therapy?
    • 14. Brinkman K, Kakuda TN. Mitochondrial toxicity of nucleoside analogue reverse transcriptase inhibitors: A looming obstacle for long-term anti-retroviral therapy? Curr Opin Infect Dis. 2000;13:5-11.
    • (2000) Curr Opin Infect Dis , vol.13 , pp. 5-11
    • Brinkman, K.1    Kakuda, T.N.2
  • 15
    • 0031944954 scopus 로고    scopus 로고
    • Severe transient neonatal lactic acidosis during prophylactic zidovudine treatment
    • 15. Scalfaro P, Chesaux JJ, Buchwalder PA, et al. Severe transient neonatal lactic acidosis during prophylactic zidovudine treatment. Intensive Care Med. 1998;24:247-250.
    • (1998) Intensive Care Med , vol.24 , pp. 247-250
    • Scalfaro, P.1    Chesaux, J.J.2    Buchwalder, P.A.3
  • 16
    • 0033604060 scopus 로고    scopus 로고
    • Persistent mitochondrial dysfunction and perinatal exposure to antiretroviral nucleoside analogues
    • 16. Blanche S, Tardieu M, Rustin P, et al. Persistent mitochondrial dysfunction and perinatal exposure to antiretroviral nucleoside analogues. Lancet. 1999;354:1084-1089.
    • (1999) Lancet , vol.354 , pp. 1084-1089
    • Blanche, S.1    Tardieu, M.2    Rustin, P.3
  • 17
    • 0033545441 scopus 로고    scopus 로고
    • Redistribution of body fat in HIV-infected women undergoing combined antiretroviral therapy
    • 17. Gervasoni C, Ridolfo AL, Trifiro G, et al. Redistribution of body fat in HIV-infected women undergoing combined antiretroviral therapy. AIDS. 1998;13:465-471.
    • (1998) AIDS , vol.13 , pp. 465-471
    • Gervasoni, C.1    Ridolfo, A.L.2    Trifiro, G.3
  • 18
    • 0033391005 scopus 로고    scopus 로고
    • A syndrome of peripheral fat wasting (lipodystrophy) in patients receiving long-term nucleoside analogue therapy
    • 18. Saint-Marc T, Partisani M, Poizot-Martin I, et al. A syndrome of peripheral fat wasting (lipodystrophy) in patients receiving long-term nucleoside analogue therapy. AIDS. 1999;13:1659-1667.
    • (1999) AIDS , vol.13 , pp. 1659-1667
    • Saint-Marc, T.1    Partisani, M.2    Poizot-Martin, I.3
  • 19
    • 0033065070 scopus 로고    scopus 로고
    • Lipodystrophy in patients naive to HIV protease inhibitors
    • 19. Madge S, Kinloch-de-Loes S, Mercey D, et al. Lipodystrophy in patients naive to HIV protease inhibitors. AIDS. 1999;13: 735-737.
    • (1999) AIDS , vol.13 , pp. 735-737
    • Madge, S.1    Kinloch-de-Loes, S.2    Mercey, D.3
  • 20
    • 0028990381 scopus 로고
    • Mitochondrial toxicity of antiviral drugs
    • 20. Lewis W, Dalakas MC. Mitochondrial toxicity of antiviral drugs. Nat Med. 1995; 1:417-422.
    • (1995) Nat Med , vol.1 , pp. 417-422
    • Lewis, W.1    Dalakas, M.C.2
  • 21
    • 0032189850 scopus 로고    scopus 로고
    • Adverse effects of reverse transcriptase inhibitors: Mitochondrial toxicity as common pathway
    • 21. Brinkman K, ter Hofstede HJ, Burger DM, et al. Adverse effects of reverse transcriptase inhibitors: Mitochondrial toxicity as common pathway. AIDS. 1998;12:1735-1744.
    • (1998) AIDS , vol.12 , pp. 1735-1744
    • Brinkman, K.1    Ter Hofstede, H.J.2    Burger, D.M.3
  • 22
    • 0033604038 scopus 로고    scopus 로고
    • Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy-related lipodystrophy
    • 22. Brinkman K, Smeitink JA, Romijn JA, Reiss P. Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy-related lipodystrophy. Lancet. 1999;354:1112-1115.
    • (1999) Lancet , vol.354 , pp. 1112-1115
    • Brinkman, K.1    Smeitink, J.A.2    Romijn, J.A.3    Reiss, P.4
  • 23
    • 0032710215 scopus 로고    scopus 로고
    • Nucleoside reverse transcriptase inhibitor-induced mitochondrial toxicity as an etiology for lipodystrophy
    • 23. Kakuda TN, Brundage RC, Anderson PL, Fletcher CV. Nucleoside reverse transcriptase inhibitor-induced mitochondrial toxicity as an etiology for lipodystrophy. AIDS. 1999;13:2311-2312.
    • (1999) AIDS , vol.13 , pp. 2311-2312
    • Kakuda, T.N.1    Brundage, R.C.2    Anderson, P.L.3    Fletcher, C.V.4
  • 24
    • 0032887069 scopus 로고    scopus 로고
    • Adefovir dipivoxil
    • 24. Noble S, Goa KL. Adefovir dipivoxil. Drugs. 1999;58:479-487.
    • (1999) Drugs , vol.58 , pp. 479-487
    • Noble, S.1    Goa, K.L.2
  • 26
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • 26. Green DR, Reed JC. Mitochondria and apoptosis. Science. 1998;281:1309-1312.
    • (1998) Science , vol.281 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 27
    • 0033525924 scopus 로고    scopus 로고
    • Oxidative phosphorylation at the fin de siècle
    • 27. Saraste M. Oxidative phosphorylation at the fin de siècle. Science. 1999;283:1488-1493.
    • (1999) Science , vol.283 , pp. 1488-1493
    • Saraste, M.1
  • 28
    • 0029638664 scopus 로고
    • Mitochondrial DNA and disease
    • 28. Johns DR. Mitochondrial DNA and disease. N Engl J Med. 1995;333:638-644.
    • (1995) N Engl J Med , vol.333 , pp. 638-644
    • Johns, D.R.1
  • 29
    • 0033525773 scopus 로고    scopus 로고
    • Mitochondrial diseases in man and mouse
    • 29. Wallace DC. Mitochondrial diseases in man and mouse. Science. 1999;283:1482-1488.
    • (1999) Science , vol.283 , pp. 1482-1488
    • Wallace, D.C.1
  • 30
    • 0032980279 scopus 로고    scopus 로고
    • Mitochondrial disorders: Clinical and genetic features
    • 30. Simon DK, Johns DR. Mitochondrial disorders: Clinical and genetic features. Annu Rev Med. 1999;50:111-127.
    • (1999) Annu Rev Med , vol.50 , pp. 111-127
    • Simon, D.K.1    Johns, D.R.2
  • 31
    • 0032788739 scopus 로고    scopus 로고
    • Mitochondrial DNA and disease
    • 31. Chinnery PF, Turnbull DM. Mitochondrial DNA and disease. Lancet. 1999;354:17-21.
    • (1999) Lancet , vol.354 , pp. 17-21
    • Chinnery, P.F.1    Turnbull, D.M.2
  • 32
    • 0028205185 scopus 로고
    • Metabolism and mechanism of antiretroviral action of purine and pyrimidine derivatives
    • 32. Balzarini J. Metabolism and mechanism of antiretroviral action of purine and pyrimidine derivatives. Pharm World Sci. 1994;16:113-126.
    • (1994) Pharm World Sci , vol.16 , pp. 113-126
    • Balzarini, J.1
  • 33
    • 0033573045 scopus 로고    scopus 로고
    • Metabolism, mitochondrial uptake and toxicity of 2′,3′-dideoxycytidine
    • 33. Rossi L, Serafini S, Schiavano GF, et al. Metabolism, mitochondrial uptake and toxicity of 2′,3′-dideoxycytidine. Biochem J. 1999;344:915-920.
    • (1999) Biochem J , vol.344 , pp. 915-920
    • Rossi, L.1    Serafini, S.2    Schiavano, G.F.3
  • 34
    • 0030903443 scopus 로고    scopus 로고
    • Unique intracellular activation of the potent anti-human immunodeficiency virus agent 1592U89
    • 34. Faletto MB, Miller WH, Garvey EP, et al. Unique intracellular activation of the potent anti-human immunodeficiency virus agent 1592U89. Antimicrob Agents Chemother. 1997;41:1099-1107.
    • (1997) Antimicrob Agents Chemother , vol.41 , pp. 1099-1107
    • Faletto, M.B.1    Miller, W.H.2    Garvey, E.P.3
  • 35
    • 0024592935 scopus 로고
    • Differential patterns of intracellular metabolism of 2′,3′-didehydro-2′,3′-dideoxythymidine (d4T) and 3′-azido-2′,3′-dideoxythymidine (AZT), two potent anti-HIV compounds
    • 35. Balzarini J, Herdewijn P, De Clercq E. Differential patterns of intracellular metabolism of 2′,3′-didehydro-2′,3′-dideoxythymidine (d4T) and 3′-azido-2′,3′-dideoxythymidine (AZT), two potent anti-HIV compounds. J Biol Chem. 1989;264:6127-6133.
    • (1989) J Biol Chem , vol.264 , pp. 6127-6133
    • Balzarini, J.1    Herdewijn, P.2    De Clercq, E.3
  • 36
    • 0029927011 scopus 로고    scopus 로고
    • Cellular phosphorylation of anti-HIV nucleosides
    • 36. Bourdais J, Biondi R, Sarfati S, et al. Cellular phosphorylation of anti-HIV nucleosides. J Biol Chem. 1996;271:7887-7890.
    • (1996) J Biol Chem , vol.271 , pp. 7887-7890
    • Bourdais, J.1    Biondi, R.2    Sarfati, S.3
  • 37
    • 0027287973 scopus 로고
    • Differential phosphorylation of azidothymidine, dideoxycytidine, and dideoxyinosine in resting and activated peripheral blood mononuclear cells
    • 37. Gao W-Y, Shirasaka T, Johns DG, et al. Differential phosphorylation of azidothymidine, dideoxycytidine, and dideoxyinosine in resting and activated peripheral blood mononuclear cells. J Clin Invest. 1993;91: 2326-2333.
    • (1993) J Clin Invest , vol.91 , pp. 2326-2333
    • Gao, W.-Y.1    Shirasaka, T.2    Johns, D.G.3
  • 38
    • 0028300765 scopus 로고
    • Divergent anti-human immunodeficiency virus activity and anabolic phosphorylation of 2′,3′-dideoxynucleoside analogs in resting and activated human cells
    • 38. Gao W-Y, Agbaria R, Driscoll JS, Mitsuya H. Divergent anti-human immunodeficiency virus activity and anabolic phosphorylation of 2′,3′-dideoxynucleoside analogs in resting and activated human cells. J Biol Chem. 1994;269:12633-12638.
    • (1994) J Biol Chem , vol.269 , pp. 12633-12638
    • Gao, W.-Y.1    Agbaria, R.2    Driscoll, J.S.3    Mitsuya, H.4
  • 39
    • 0023143478 scopus 로고
    • Cellular metabolism of 2′,3′-dideoxycytidine, a compound active against human immunodeficiency virus in vitro
    • 39. Starnes MC, Cheng Y-C. Cellular metabolism of 2′,3′-dideoxycytidine, a compound active against human immunodeficiency virus in vitro. J Biol Chem. 1987; 262:988-991.
    • (1987) J Biol Chem , vol.262 , pp. 988-991
    • Starnes, M.C.1    Cheng, Y.-C.2
  • 40
    • 0026786397 scopus 로고
    • Human DNA polymerases alpha and beta are able to incorporate anti-HIV deoxynucleotides into DNA
    • 40. Copeland WC, Chen MS, Wang TS. Human DNA polymerases alpha and beta are able to incorporate anti-HIV deoxynucleotides into DNA. J Biol Chem. 1992; 267:21459-21464.
    • (1992) J Biol Chem , vol.267 , pp. 21459-21464
    • Copeland, W.C.1    Chen, M.S.2    Wang, T.S.3
  • 41
    • 0033007828 scopus 로고    scopus 로고
    • Incorporation of zidovudine into leukocyte DNA from HIV-1-positive adults and pregnant women, and cord blood from infants exposed in utero
    • 41. Olivero OA, Shearer GM, Chougnet CA, et al. Incorporation of zidovudine into leukocyte DNA from HIV-1-positive adults and pregnant women, and cord blood from infants exposed in utero. AIDS. 1999;13:919-925.
    • (1999) AIDS , vol.13 , pp. 919-925
    • Olivero, O.A.1    Shearer, G.M.2    Chougnet, C.A.3
  • 42
    • 0025552678 scopus 로고
    • DNA polymerases versus HIV reverse transcriptase in AIDS therapy
    • 42. Cheng Y-C, Gao W-Y, Chen CH, et al. DNA polymerases versus HIV reverse transcriptase in AIDS therapy. Ann N Y Acad Sci. 1990;616:217-223.
    • (1990) Ann N Y Acad Sci , vol.616 , pp. 217-223
    • Cheng, Y.-C.1    Gao, W.-Y.2    Chen, C.H.3
  • 43
    • 0026651622 scopus 로고
    • Effects of (-)-2′-deoxy-3′-thiacytidine (lamivudine) 5′-triphosphate on human immunodeficiency virus reverse transcriptase and mammalian DNA polymerases alpha, beta, and gamma
    • 43. Hart GJ, Orr DC, Penn CR, et al. Effects of (-)-2′-deoxy-3′-thiacytidine (lamivudine) 5′-triphosphate on human immunodeficiency virus reverse transcriptase and mammalian DNA polymerases alpha, beta, and gamma. Antimicrob Agents Chemother. 1992;36:1688-1694.
    • (1992) Antimicrob Agents Chemother , vol.36 , pp. 1688-1694
    • Hart, G.J.1    Orr, D.C.2    Penn, C.R.3
  • 44
    • 0028148674 scopus 로고
    • Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis
    • 44. Martin JL, Brown CE, Matthews-Davis N, Reardon JE. Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis. Antimicrob Agents Chemother. 1994;38: 2743-2749.
    • (1994) Antimicrob Agents Chemother , vol.38 , pp. 2743-2749
    • Martin, J.L.1    Brown, C.E.2    Matthews-Davis, N.3    Reardon, J.E.4
  • 45
    • 0032849996 scopus 로고    scopus 로고
    • Sensitive assay for mitochondrial DNA polymerase γ
    • 45. Naviaux RK, Markusic D, Barshop BA, et al. Sensitive assay for mitochondrial DNA polymerase γ. Clin Chem. 1999;45:1725-1733.
    • (1999) Clin Chem , vol.45 , pp. 1725-1733
    • Naviaux, R.K.1    Markusic, D.2    Barshop, B.A.3
  • 46
    • 0024354118 scopus 로고
    • Comparison of the effect of carbovir, AZT, and dideoxynucleoside triphosphates on the activity of human immunodeficiency virus reverse transcriptase and selected human polymerases
    • 46. White EL, Parker WB, Macy LJ, et al. Comparison of the effect of carbovir, AZT, and dideoxynucleoside triphosphates on the activity of human immunodeficiency virus reverse transcriptase and selected human polymerases. Biochem Biophys Res Commun. 1989;161:393-398.
    • (1989) Biochem Biophys Res Commun , vol.161 , pp. 393-398
    • White, E.L.1    Parker, W.B.2    Macy, L.J.3
  • 47
    • 0026077602 scopus 로고
    • The 5′-triphosphates of 3′-azido-3′-deoxythymidine and 2′,3′-dideoxynucleosides inhibit DNA polymerase gamma by different mechanisms
    • 47. Izuta S, Saneyoshi M, Sakurai T, et al. The 5′-triphosphates of 3′-azido-3′-deoxythymidine and 2′,3′-dideoxynucleosides inhibit DNA polymerase gamma by different mechanisms. Biochem Biophys Res Commun. 1991;179:776-783.
    • (1991) Biochem Biophys Res Commun , vol.179 , pp. 776-783
    • Izuta, S.1    Saneyoshi, M.2    Sakurai, T.3
  • 48
    • 0026078484 scopus 로고
    • Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase and human DNA polymerases α, β, and γ by the 5′-triphosphates of carbovir, 3′-azido-3′-deoxythymidine, 2′,3′-dideoxyguanosine, and 3′-deoxythymidine
    • 48. Parker WB, White EL, Shaddix SC, et al. Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase and human DNA polymerases α, β, and γ by the 5′-triphosphates of carbovir, 3′-azido-3′-deoxythymidine, 2′,3′-dideoxyguanosine, and 3′-deoxythymidine. J Biol Chem. 1991;266:1754-1762.
    • (1991) J Biol Chem , vol.266 , pp. 1754-1762
    • Parker, W.B.1    White, E.L.2    Shaddix, S.C.3
  • 49
    • 0028158398 scopus 로고
    • Cardiac mitochondrial DNA polymerase-gamma is inhibited competitively and noncompetitively by phosphorylated zidovudine
    • 49. Lewis W, Simpson JF, Meyer RR. Cardiac mitochondrial DNA polymerase-gamma is inhibited competitively and noncompetitively by phosphorylated zidovudine. Circ Res. 1994;74:344-348.
    • (1994) Circ Res , vol.74 , pp. 344-348
    • Lewis, W.1    Simpson, J.F.2    Meyer, R.R.3
  • 50
    • 0029022494 scopus 로고
    • Kinetic interaction of the diphosphates of 9-(2-phosphonylmethoxyethyl) adenine and other anti-HIV active purine congeners with HIV reverse transcriptase and human DNA polymerases α, β, and γ
    • 50. Cherrington JM, Allen SJW, Bischofberger N, Chen MS. Kinetic interaction of the diphosphates of 9-(2-phosphonylmethoxyethyl) adenine and other anti-HIV active purine congeners with HIV reverse transcriptase and human DNA polymerases α, β, and γ. Antiviral Chem Chemother. 1995;6:217-221.
    • (1995) Antiviral Chem Chemother , vol.6 , pp. 217-221
    • Cherrington, J.M.1    Allen, S.J.W.2    Bischofberger, N.3    Chen, M.S.4
  • 51
    • 0029077056 scopus 로고
    • Efficient incorporation of anti-HIV deoxynucleotides by recombinant yeast mitochondrial DNA polymerase
    • 51. Eriksson S, Xu B, Clayton DA. Efficient incorporation of anti-HIV deoxynucleotides by recombinant yeast mitochondrial DNA polymerase. J Biol Chem. 1995;270:18929-18934.
    • (1995) J Biol Chem , vol.270 , pp. 18929-18934
    • Eriksson, S.1    Xu, B.2    Clayton, D.A.3
  • 52
    • 0031780614 scopus 로고    scopus 로고
    • Interaction of β-l-2′,3′-dideoxy-2′,3′-didehydro-5-CTP with human immunodeficiency virus-1 reverse transcriptase and human DNA polymerases: Implications for human immunodeficiency virus drug design
    • 52. Kukhanova M, Li X, Chen S-H, et al. Interaction of β-L-2′,3′-dideoxy-2′,3′-didehydro-5-CTP with human immunodeficiency virus-1 reverse transcriptase and human DNA polymerases: Implications for human immunodeficiency virus drug design. Mol Pharmacol. 1996;53:801-807.
    • (1996) Mol Pharmacol , vol.53 , pp. 801-807
    • Kukhanova, M.1    Li, X.2    Chen, S.-H.3
  • 53
    • 0028143346 scopus 로고
    • Mechanisms of toxicity of 3′-azido-3′-deoxythymidine. Its interaction with adenylate kinase
    • 53. Barile M, Valenti D, Hobbs GA, et al. Mechanisms of toxicity of 3′-azido-3′-deoxythymidine. Its interaction with adenylate kinase. Biochem Pharmacol. 1994; 48:1405-1412.
    • (1994) Biochem Pharmacol , vol.48 , pp. 1405-1412
    • Barile, M.1    Valenti, D.2    Hobbs, G.A.3
  • 54
    • 0030972845 scopus 로고    scopus 로고
    • 3′-azido-3′-deoxythmidine uptake into isolated rat liver mitochondria and impairment of ADP/ATP translocator
    • 54. Barile M, Valenti D, Passarella S, Quagliariello E. 3′-Azido-3′-deoxythmidine uptake into isolated rat liver mitochondria and impairment of ADP/ATP translocator. Biochem Pharmacol. 1997;53:913-920.
    • (1997) Biochem Pharmacol , vol.53 , pp. 913-920
    • Barile, M.1    Valenti, D.2    Passarella, S.3    Quagliariello, E.4
  • 55
    • 0027170504 scopus 로고
    • AZT causes tissue-specific inhibition of mitochondrial bioenergetic function
    • 55. Modica-Napolitano JS. AZT causes tissue-specific inhibition of mitochondrial bioenergetic function. Biochem Biophys Res Commun. 1993;194:170-177.
    • (1993) Biochem Biophys Res Commun , vol.194 , pp. 170-177
    • Modica-Napolitano, J.S.1
  • 56
    • 0030739644 scopus 로고    scopus 로고
    • Differential effects of zidovudine and zidovudine triphosphate on mitochondrial permeability transition and oxidative phosphorylalion
    • 56. Elimadi A, Morin D, Albengres E, et al. Differential effects of zidovudine and zidovudine triphosphate on mitochondrial permeability transition and oxidative phosphorylalion. Br J Pharmacol. 1997; 121:1295-1300.
    • (1997) Br J Pharmacol , vol.121 , pp. 1295-1300
    • Elimadi, A.1    Morin, D.2    Albengres, E.3
  • 58
    • 0025729392 scopus 로고
    • Effect of anti-human immunodeficiency virus nucleoside analogs on mitochondrial DNA and its implications for delayed toxicity
    • 58. Chen CH, Vazques-Padua M, Cheng Y-C. Effect of anti-human immunodeficiency virus nucleoside analogs on mitochondrial DNA and its implications for delayed toxicity. Mol Pharmacol. 1991;39:625-628.
    • (1991) Mol Pharmacol , vol.39 , pp. 625-628
    • Chen, C.H.1    Vazques-Padua, M.2    Cheng, Y.-C.3
  • 59
    • 0026640705 scopus 로고
    • The role of cytoplasmic deoxycytidine kinase in the mitochondrial effects of the anti-human immunodeficiency virus compound, 2′,3′-dideoxycytidine
    • 59. Chen CH, Cheng Y-C. The role of cytoplasmic deoxycytidine kinase in the mitochondrial effects of the anti-human immunodeficiency virus compound, 2′,3′-dideoxycytidine. J Biol Chem. 1992;267: 2856-2859.
    • (1992) J Biol Chem , vol.267 , pp. 2856-2859
    • Chen, C.H.1    Cheng, Y.-C.2
  • 60
    • 0028109345 scopus 로고
    • Comparison of mitochondrial morphology, mitochondrial DNA content, and cell viability in cultured cells treated with three anti-human immunodeficiency virus dideoxynucleosides
    • 60. Medina DJ, Tsai CH, Hsiung GD, Cheng YC. Comparison of mitochondrial morphology, mitochondrial DNA content, and cell viability in cultured cells treated with three anti-human immunodeficiency virus dideoxynucleosides. Antimicrob Agents Chemother. 1994;38:1824-1828.
    • (1994) Antimicrob Agents Chemother , vol.38 , pp. 1824-1828
    • Medina, D.J.1    Tsai, C.H.2    Hsiung, G.D.3    Cheng, Y.C.4
  • 61
    • 0028006997 scopus 로고
    • Effect of anti-HIV 2′-beta-fluoro-2′,3′-dideoxynucleoside analogs on the cellular content of mitochondrial DNA and on lactate production
    • 61. Tsai CH, Doong SL, Johns DG, et al. Effect of anti-HIV 2′-beta-fluoro-2′,3′-dideoxynucleoside analogs on the cellular content of mitochondrial DNA and on lactate production. Biochem Pharmacol. 1994;48:1477-1481.
    • (1994) Biochem Pharmacol , vol.48 , pp. 1477-1481
    • Tsai, C.H.1    Doong, S.L.2    Johns, D.G.3
  • 62
    • 0030914625 scopus 로고    scopus 로고
    • Lack of mitochondrial toxicity in CEM cells treated with carbovir
    • 62. Parker WB, Shaddix SC, Vince R, Bennett LL Jr. Lack of mitochondrial toxicity in CEM cells treated with carbovir. Antiviral Res. 1997;34:131-136.
    • (1997) Antiviral Res , vol.34 , pp. 131-136
    • Parker, W.B.1    Shaddix, S.C.2    Vince, R.3    Bennett L.L., Jr.4
  • 63
    • 0024381627 scopus 로고
    • Delayed cytotoxicity and selective loss of mitochondrial DNA in cells treated with the anti-human immunodeficiency virus compound 2′,3′-dideoxycytidine
    • 63. Chen CH, Cheng Y-C. Delayed cytotoxicity and selective loss of mitochondrial DNA in cells treated with the anti-human immunodeficiency virus compound 2′,3′-dideoxycytidine. J Biol Chem. 1989;264:11934-11937.
    • (1989) J Biol Chem , vol.264 , pp. 11934-11937
    • Chen, C.H.1    Cheng, Y.-C.2
  • 64
    • 0029976922 scopus 로고    scopus 로고
    • AZT incorporation into mitochondria: Study in a human myeloid cell line
    • 64. Nusbaum NJ, Joseph PE. AZT incorporation into mitochondria: Study in a human myeloid cell line. DNA Cell Biol. 1996; 15:363-366.
    • (1996) DNA Cell Biol , vol.15 , pp. 363-366
    • Nusbaum, N.J.1    Joseph, P.E.2
  • 65
    • 0026544692 scopus 로고
    • The Friend murine erythroleukemia cell, a model system for studying the association between bone marrow toxicity induced by 3′-azido-3′-dideoxythymidine and dideoxynucleoside inhibition of mtDNA replication
    • 65. Hobbs GA, Keilbaugh SA, Simpson MV. The Friend murine erythroleukemia cell, a model system for studying the association between bone marrow toxicity induced by 3′-azido-3′-dideoxythymidine and dideoxynucleoside inhibition of mtDNA replication. Biochem Pharmacol. 1992;43: 1397-1400.
    • (1992) Biochem Pharmacol , vol.43 , pp. 1397-1400
    • Hobbs, G.A.1    Keilbaugh, S.A.2    Simpson, M.V.3
  • 66
    • 0029119381 scopus 로고
    • Cellular targets of 3′-azido-3′-deoxythymidine: An early (non-delayed) effect on oxidative phosphorylation
    • 66. Hobbs GA, Keilbaugh SA, Rief PM, Simpson MV. Cellular targets of 3′-azido-3′-deoxythymidine: An early (non-delayed) effect on oxidative phosphorylation. Biochem Pharmacol. 1995;50:381-390.
    • (1995) Biochem Pharmacol , vol.50 , pp. 381-390
    • Hobbs, G.A.1    Keilbaugh, S.A.2    Rief, P.M.3    Simpson, M.V.4
  • 67
    • 0026721244 scopus 로고
    • Major growth reduction and minor decrease in mitochondrial enzyme activity in cultured human muscle cells after exposure to zidovudine
    • 67. Herzberg NH, Zorn I, Zwart R, et al. Major growth reduction and minor decrease in mitochondrial enzyme activity in cultured human muscle cells after exposure to zidovudine. Muscle Nerve. 1992;15:706-710.
    • (1992) Muscle Nerve , vol.15 , pp. 706-710
    • Herzberg, N.H.1    Zorn, I.2    Zwart, R.3
  • 68
    • 0027980872 scopus 로고
    • Effect of L-carnitine on the zidovudine-induced destruction of human myotubes. Part I: L-carnitine prevents the myotoxicity of AZT in vitro
    • 68. Semino-Mora MC, Leon-Monzon ME, Dalakas MC. Effect of L-carnitine on the zidovudine-induced destruction of human myotubes. Part I: L-carnitine prevents the myotoxicity of AZT in vitro. Lab Invest. 1994;71:102-112.
    • (1994) Lab Invest , vol.71 , pp. 102-112
    • Semino-Mora, M.C.1    Leon-Monzon, M.E.2    Dalakas, M.C.3
  • 69
    • 0028104333 scopus 로고
    • The effect of L-carnitine on the AZT-induced destruction of human myotubes. Part II: Treatment with L-carnitine improves the AZT-induced changes and prevents further destruction
    • 69. Semino-Mora MC, Leon-Monzon ME, Dalakas MC. The effect of L-carnitine on the AZT-induced destruction of human myotubes. Part II: Treatment with L-carnitine improves the AZT-induced changes and prevents further destruction. Lab Invest. 1994;71:773-781.
    • (1994) Lab Invest , vol.71 , pp. 773-781
    • Semino-Mora, M.C.1    Leon-Monzon, M.E.2    Dalakas, M.C.3
  • 70
    • 0031003145 scopus 로고    scopus 로고
    • Cellular and mitochondrial toxicity of zidovudine (AZT), didanosine (ddI) and zalcitabine (ddC) on cultured human muscle cells
    • 70. Benbrik E, Chariot P, Bonavaud S, et al. Cellular and mitochondrial toxicity of zidovudine (AZT), didanosine (ddI) and zalcitabine (ddC) on cultured human muscle cells. J Neurol Sci. 1997;149:19-25.
    • (1997) J Neurol Sci , vol.149 , pp. 19-25
    • Benbrik, E.1    Chariot, P.2    Bonavaud, S.3
  • 71
    • 0027504790 scopus 로고
    • Anti-human immunodeficiency virus type 1 therapy and peripheral neuropathy: Prevention of 2′,3′-dideoxycytidine toxicity in PC12 cells, a neuronal model, by uridine and pyruvate
    • 71. Keilbaugh SA, Hobbs GA, Simpson MV. Anti-human immunodeficiency virus type 1 therapy and peripheral neuropathy: Prevention of 2′,3′-dideoxycytidine toxicity in PC12 cells, a neuronal model, by uridine and pyruvate. Mol Pharmacol. 1993; 44:702-706.
    • (1993) Mol Pharmacol , vol.44 , pp. 702-706
    • Keilbaugh, S.A.1    Hobbs, G.A.2    Simpson, M.V.3
  • 72
    • 0030841716 scopus 로고    scopus 로고
    • Effect of 2′,3′-dideoxycytidine on oxidative phosphorylation in the PC12 cell, a neuronal model
    • 72. Keilbaugh SA, Hobbs GA, Simpson MV. Effect of 2′,3′-dideoxycytidine on oxidative phosphorylation in the PC12 cell, a neuronal model. Biochem Pharmacol. 1997;53:1485-1492.
    • (1997) Biochem Pharmacol , vol.53 , pp. 1485-1492
    • Keilbaugh, S.A.1    Hobbs, G.A.2    Simpson, M.V.3
  • 73
    • 0030981260 scopus 로고    scopus 로고
    • Effect of nucleoside analogs on neurite regeneration and mitochondrial DNA synthesis in PC-12 cells
    • 73. Cui L, Locatelli L, Xie MY, Sommadossi JP. Effect of nucleoside analogs on neurite regeneration and mitochondrial DNA synthesis in PC-12 cells. J Pharmacol Exp Ther. 1997;280:1228-1234.
    • (1997) J Pharmacol Exp Ther , vol.280 , pp. 1228-1234
    • Cui, L.1    Locatelli, L.2    Xie, M.Y.3    Sommadossi, J.P.4
  • 74
    • 0029882328 scopus 로고    scopus 로고
    • Zidovudine and dideoxynucleosides deplete wild-type mitochondrial DNA levels and increase deleted mitochondrial DNA levels in cultured Kearns-Sayre syndrome fibroblasts
    • 74. Wang H, Lemire BD, Cass CE, et al. Zidovudine and dideoxynucleosides deplete wild-type mitochondrial DNA levels and increase deleted mitochondrial DNA levels in cultured Kearns-Sayre syndrome fibroblasts. Biochim Biophys Acta. 1996;1316:51-59.
    • (1996) Biochim Biophys Acta , vol.1316 , pp. 51-59
    • Wang, H.1    Lemire, B.D.2    Cass, C.E.3
  • 75
    • 0030004222 scopus 로고    scopus 로고
    • Nuclear and mitochondrial changes of cocultivated spinal cord, spinal ganglia and muscle fibers following treatment with various doses of zidovudine
    • 75. Schroder JM, Kaldenbach T, Piroth W. Nuclear and mitochondrial changes of cocultivated spinal cord, spinal ganglia and muscle fibers following treatment with various doses of zidovudine. Acta Neuropathol. 1996;92:138-149.
    • (1996) Acta Neuropathol , vol.92 , pp. 138-149
    • Schroder, J.M.1    Kaldenbach, T.2    Piroth, W.3
  • 76
    • 0026046254 scopus 로고
    • Mitochondrial ultrastructural and molecular changes induced by zidovudine in rat hearts
    • 76. Lewis W, Papoian T, Gonzalez B, et al. Mitochondrial ultrastructural and molecular changes induced by zidovudine in rat hearts. Lab Invest. 1991;65:228-236.
    • (1991) Lab Invest , vol.65 , pp. 228-236
    • Lewis, W.1    Papoian, T.2    Gonzalez, B.3
  • 77
    • 0026536252 scopus 로고
    • Disruption of mitochondrial energetics and DNA synthesis by the anti-AIDS drug dideoxyinosine
    • 77. Youssef JA, Badr MZ. Disruption of mitochondrial energetics and DNA synthesis by the anti-AIDS drug dideoxyinosine. Toxicol Lett. 1992;60:197-202.
    • (1992) Toxicol Lett , vol.60 , pp. 197-202
    • Youssef, J.A.1    Badr, M.Z.2
  • 78
    • 0028047177 scopus 로고
    • Schwann cell mitochondrial alterations in peripheral nerves of rabbits treated with 2′,3′-dideoxycytidine
    • 78. Feldman D, Anderson TD. Schwann cell mitochondrial alterations in peripheral nerves of rabbits treated with 2′,3′-dideoxycytidine. Acta Neuropathol. 1994;87:71-80.
    • (1994) Acta Neuropathol , vol.87 , pp. 71-80
    • Feldman, D.1    Anderson, T.D.2
  • 79
    • 0029029472 scopus 로고
    • The universality of bioenergetic disease and amelioration with redox therapy
    • 79. Linnane AW, Degli Esposti M, Generowicz M, et al. The universality of bioenergetic disease and amelioration with redox therapy. Biochim Biophys Acta. 1995; 1271:191-194.
    • (1995) Biochim Biophys Acta , vol.1271 , pp. 191-194
    • Linnane, A.W.1    Degli Esposti, M.2    Generowicz, M.3
  • 80
    • 0030002975 scopus 로고    scopus 로고
    • Hepatic morphological alterations induced by zidovudine (ZDV) in an experimental model
    • 80. Corcuera T, Alonso MJ, Picazo A, et al. Hepatic morphological alterations induced by zidovudine (ZDV) in an experimental model. Pathol Res Pract. 1996;192: 182-187.
    • (1996) Pathol Res Pract , vol.192 , pp. 182-187
    • Corcuera, T.1    Alonso, M.J.2    Picazo, A.3
  • 81
    • 0033017850 scopus 로고    scopus 로고
    • Zidovudine (AZT) causes an oxidation of mitochondrial DNA in mouse liver
    • 81. de la Asuncion JG, del Olmo ML, Sastre J, et al. Zidovudine (AZT) causes an oxidation of mitochondrial DNA in mouse liver. Hepatology. 1999;29:985-987.
    • (1999) Hepatology , vol.29 , pp. 985-987
    • De La Asuncion, J.G.1    Del Olmo, M.L.2    Sastre, J.3
  • 82
    • 0032412213 scopus 로고    scopus 로고
    • Peripheral neuropathy with nucleoside antiretrovirals: Risk factors, incidence and management
    • 82. Moyle GJ, Sadler M. Peripheral neuropathy with nucleoside antiretrovirals: Risk factors, incidence and management. Drug Saf. 1998;19:481-494.
    • (1998) Drug Saf , vol.19 , pp. 481-494
    • Moyle, G.J.1    Sadler, M.2
  • 84
    • 0022471697 scopus 로고
    • Initial studies on the cellular pharmacology of 2′,3′-dideoxycytidine, an inhibitor of HTLV-III infectivity
    • 84. Cooney DA, Dalal M, Mitsuya H, et al. Initial studies on the cellular pharmacology of 2′,3′-dideoxycytidine, an inhibitor of HTLV-III infectivity. Biochem Pharmacol. 1986;35:2065-2068.
    • (1986) Biochem Pharmacol , vol.35 , pp. 2065-2068
    • Cooney, D.A.1    Dalal, M.2    Mitsuya, H.3
  • 85
    • 0030945983 scopus 로고    scopus 로고
    • Hearing loss and antiretroviral therapy in patients infected with HIV-1
    • 85. Marra CM, Wechkin HA, Longstreh WT Jr, et al. Hearing loss and antiretroviral therapy in patients infected with HIV-1. Arch Neurol. 1997;54:407-410.
    • (1997) Arch Neurol , vol.54 , pp. 407-410
    • Marra, C.M.1    Wechkin, H.A.2    Longstreh W.T., Jr.3
  • 86
    • 0029850308 scopus 로고    scopus 로고
    • Didanosine: An update on its antiviral activity, pharmacokinetic properties and therapeutic efficacy in the management of HIV disease
    • 86. Perry CM, Balfour JA. Didanosine: An update on its antiviral activity, pharmacokinetic properties and therapeutic efficacy in the management of HIV disease. Drugs. 1996;52:928-962.
    • (1996) Drugs , vol.52 , pp. 928-962
    • Perry, C.M.1    Balfour, J.A.2
  • 87
    • 0033166681 scopus 로고    scopus 로고
    • Acute pancreatitis in human immunodeficiency virus-infected patients: A review
    • 87. Dassopoulos T, Ehrenpreis ED. Acute pancreatitis in human immunodeficiency virus-infected patients: A review. Am J Med. 1999;107:78-84.
    • (1999) Am J Med , vol.107 , pp. 78-84
    • Dassopoulos, T.1    Ehrenpreis, E.D.2
  • 88
    • 0028010789 scopus 로고
    • A randomized pilot study of alternating or simultaneous zidovudine and ddi therapy in patients with symptomatic human immunodeficiency virus infection
    • 88. Yarchoan R, Lietzau JA, Nguyen BY, et al. A randomized pilot study of alternating or simultaneous zidovudine and ddI therapy in patients with symptomatic human immunodeficiency virus infection. J Infect Dis. 1994;169:9-17.
    • (1994) J Infect Dis , vol.169 , pp. 9-17
    • Yarchoan, R.1    Lietzau, J.A.2    Nguyen, B.Y.3
  • 89
    • 0032816323 scopus 로고    scopus 로고
    • Acute pancreatitis with severe lactic acidosis in an HIV-infected patient on ddI therapy
    • 89. Allaouchiche B, Duflo F, Cotte L, et al. Acute pancreatitis with severe lactic acidosis in an HIV-infected patient on ddI therapy. J Antimicrob Chemother. 1999; 44:137-138.
    • (1999) J Antimicrob Chemother , vol.44 , pp. 137-138
    • Allaouchiche, B.1    Duflo, F.2    Cotte, L.3
  • 90
    • 0032784006 scopus 로고    scopus 로고
    • Stavudine: An update of its use in the treatment of HIV infection
    • 90. Hurst M, Noble S. Stavudine: An update of its use in the treatment of HIV infection. Drugs. 1999;58:919-949.
    • (1999) Drugs , vol.58 , pp. 919-949
    • Hurst, M.1    Noble, S.2
  • 91
    • 0033596267 scopus 로고    scopus 로고
    • Efficacy and safety of adefovir dipivoxil with antiretroviral therapy: A randomized controlled trial
    • 91. Kahn J, Lagakos S, Wulfsohn M, et al. Efficacy and safety of adefovir dipivoxil with antiretroviral therapy: A randomized controlled trial. JAMA. 1999;282:2305-2312.
    • (1999) JAMA , vol.282 , pp. 2305-2312
    • Kahn, J.1    Lagakos, S.2    Wulfsohn, M.3
  • 92
    • 0025878908 scopus 로고
    • Massive conversion of guanosine to 8-hydroxy-guanosine in mouse liver mitochondrial DNA by administration of azidothymidine
    • 92. Hayakawa M, Ogawa T, Sugiyama S, et al. Massive conversion of guanosine to 8-hydroxy-guanosine in mouse liver mitochondrial DNA by administration of azidothymidine. Biochem Biophys Res Commun. 1991;176:87-93.
    • (1991) Biochem Biophys Res Commun , vol.176 , pp. 87-93
    • Hayakawa, M.1    Ogawa, T.2    Sugiyama, S.3
  • 93
    • 0025752280 scopus 로고
    • Zidovudine myopathy: A distinctive disorder associated with mitochondrial dysfunction
    • 93. Mhiri C, Baudrimont M, Bonne G, et al. Zidovudine myopathy: A distinctive disorder associated with mitochondrial dysfunction. Ann Neurol. 1991;29:606-614.
    • (1991) Ann Neurol , vol.29 , pp. 606-614
    • Mhiri, C.1    Baudrimont, M.2    Bonne, G.3
  • 94
    • 0028719493 scopus 로고
    • Histochemical and ultrastructural changes induced by zidovudine in mitochondria of rat cardiac muscle
    • 94. Corcuera Pindado MT, Lopez Bravo A, Martinez-Rodriguez R, et al. Histochemical and ultrastructural changes induced by zidovudine in mitochondria of rat cardiac muscle. Eur J Histochem. 1994;38:311-318.
    • (1994) Eur J Histochem , vol.38 , pp. 311-318
    • Corcuera Pindado, M.T.1    Lopez Bravo, A.2    Martinez-Rodriguez, R.3
  • 95
    • 0032575750 scopus 로고    scopus 로고
    • Caspases: Enemies within
    • 95. Thornberry NA, Lazebnik Y. Caspases: Enemies within. Science. 1998;281:1312-1316.
    • (1998) Science , vol.281 , pp. 1312-1316
    • Thornberry, N.A.1    Lazebnik, Y.2
  • 96
    • 0032483010 scopus 로고    scopus 로고
    • Induction of an apoptotic program in cell-free extracts by 2-chloro-2′-deoxyadenosine 5′-triphosphate and cytochrome c
    • 96. Leoni LM, Chao Q, Cottam HB, et al. Induction of an apoptotic program in cell-free extracts by 2-chloro-2′-deoxyadenosine 5′-triphosphate and cytochrome c. Proc Natl Acad Sci USA. 1998;95:9567-9571.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 9567-9571
    • Leoni, L.M.1    Chao, Q.2    Cottam, H.B.3
  • 97
    • 0031012521 scopus 로고    scopus 로고
    • Stavudine selectively induces apoptosis in HIV type 1-infected cells
    • 97. Hashimoto K-I, Tsunoda R, Okamoto M, et al. Stavudine selectively induces apoptosis in HIV type 1-infected cells. AIDS Res Hum Retroviruses. 1997;13:193-199.
    • (1997) AIDS Res Hum Retroviruses , vol.13 , pp. 193-199
    • Hashimoto, K.-I.1    Tsunoda, R.2    Okamoto, M.3
  • 98
    • 0042438992 scopus 로고    scopus 로고
    • Subcutaneous adipocyte apoptosis in HIV-1 protease inhibitor-associated lipodystrophy
    • 98. Domingo P, Matias-Guiu X, Pujol RM, et al. Subcutaneous adipocyte apoptosis in HIV-1 protease inhibitor-associated lipodystrophy. AIDS. 1999;13:2261-2267.
    • (1999) AIDS , vol.13 , pp. 2261-2267
    • Domingo, P.1    Matias-Guiu, X.2    Pujol, R.M.3
  • 99
    • 0032840166 scopus 로고    scopus 로고
    • Hydroxyurea and HIV: 5 years later - From antiviral to immune-modulating effects
    • 99. Lori F. Hydroxyurea and HIV: 5 years later - from antiviral to immune-modulating effects. AIDS. 1999;13:1433-1442.
    • (1999) AIDS , vol.13 , pp. 1433-1442
    • Lori, F.1


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