Redoxal as a new leadstructure for dihydroorotate dehydrogenase inhibitors: a kinetic study of the inhibition mechanism

FEBS Letters

Volumn 467, Issue 1, 2000, Pages 27-30

  Knecht, Wolfgang ^a   Löffler, Monika ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

1,4 Naphthoquinone; Dihydroorotate dehydrogenase; Mitochondrion; Pyrimidine; Redoxal

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; 2 (3,3 DICHLOROALLYL) 3 HYDROXY 1,4 NAPHTHOQUINONE; ATOVAQUONE; BENZOIC ACID DERIVATIVE; DIHYDROOROTATE DEHYDROGENASE; ISOXAZOLE DERIVATIVE; RECOMBINANT ENZYME; REDOXAL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SUCCINIC ACID; UNCLASSIFIED DRUG; 2,2' ((3,3' DIMETHOXY(1,1' BIPHENYL) 4,4' DIYL)DIIMINO)BIS BENZOIC ACID; 2,2'-((3,3'-DIMETHOXY(1,1'-BIPHENYL)-4,4'-DIYL)DIIMINO)BIS-BENZOIC ACID; AMINOBIPHENYL DERIVATIVE; DRUG DERIVATIVE; NAPHTHOQUINONE; NICOTINAMIDE ADENINE DINUCLEOTIDE; OROTIC ACID; OXIDOREDUCTASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME PURIFICATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PYRIMIDINE SYNTHESIS; RAT; SPECIES DIFFERENCE; ANIMAL; CHEMISTRY; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG DESIGN; DRUG EFFECT; ELECTRON TRANSPORT; ENZYMOLOGY; IC 50; KINETICS; LIVER MITOCHONDRION; METABOLISM; OXIDATION REDUCTION REACTION;

AMINOBIPHENYL COMPOUNDS; ANIMALS; ATOVAQUONE; DRUG DESIGN; ELECTRON TRANSPORT; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; MITOCHONDRIA, LIVER; NAD; NAPHTHOQUINONES; OROTIC ACID; OXIDATION-REDUCTION; OXIDOREDUCTASES; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; RATS; SUCCINIC ACID;

EID: 0033621879     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(00)01117-0     Document Type: Article

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