Food safety and functional foods in the European Union: Obesity as a paradigmatic example for novel food development

Nutrition Reviews

Volumn 62, Issue 7 II, 2004, Pages

  Palou, Andreu ^a   Picó, Catalina ^a   Bonet, M Luisa ^a  

^a UNIVERSITAT DE LES ILLES BALEARS   (Spain)

Author keywords

European Union; Food safety; Functional foods; Novel foods; Obesity

Indexed keywords

AGOUTI RELATED PROTEIN; ALPHA INTERMEDIN; ANOREXIGENIC AGENT; APPETITE STIMULANT; CHOLECYSTOKININ; COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PEPTIDE; GLUCAGON LIKE PEPTIDE; MELANIN CONCENTRATING HORMONE; NEUROPEPTIDE Y; PROTIRELIN;

CONFERENCE PAPER; EUROPEAN UNION; FOOD; FOOD ANALYSIS; FOOD PROCESSING; FOOD SAFETY; FUNCTIONAL ASSESSMENT; FUNCTIONAL FOOD; GENETIC RISK; HUMAN; MOLECULAR BIOLOGY; OBESITY; TECHNOLOGY; WELLBEING;

AGOUTI;

EID: 4043086484     PISSN: 00296643     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1753-4887.2004.tb00089.x     Document Type: Conference Paper

References (54)

1. Regulation on Novel Foods and Novel Foods Ingredients. Regulation-EC-258/97. 1997.
2. Chagnon YC, Rankinen T, Snyder EE, et al. The human obesity gene map: the 2002 update. Obes Res. 2003;11:313-367.
3. Palou A, Serra F, Bonet ML, Pico C. Obesity: molecular bases of a multifactorial problem. Eur J Nutr. 2000;39:127-144.
4. Palou A, Bonet ML, Pico C. The integrated system of body weight control. In: Palou A, Bonet ML, Serra F, eds. Study on Obesity and Functional Foods in Europe. Luxembourg: European Commission; 2002:40-54.
5. Schwartz MW, Woods SC, Porte D Jr, et al. Central nervous system control of food intake. Nature. 2000;404:661-671.
6. Zhang Y, Proenca R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994;372:425-432.
7. Fantuzzi G, Faggioni R. Leptin in the regulation of immunity, inflammation, and hematopoiesis. J Leukoc Biol. 2000;68:437-446.
8. Orban Z, Bornstein SR, Chrousos GP. The interaction between leptin and the hypothalamic-pituitary-thyroid axis. Horm Metab Res. 1998;30:231-235.
9. Chan JL, Mantzoros CS. Leptin and the hypothalamic-pituitary regulation of the gonadotropin-gonadal axis. Pituitary. 2001;4:87-92.
10. Baldelli R, Dieguez C, Casanueva FF. The role of leptin in reproduction: experimental and clinical aspects. Ann Med. 2002;34:5-18.
11. Mantzoros CS. Role of leptin in reproduction. Ann N Y Acad Sci. 2000;900:174-183.
12. Reseland JE, Syversen U, Bakke I, et al. Leptin is expressed in and secreted from primary cultures of human osteoblasts and promotes bone mineralization. J Bone Miner Res. 2001;16:1426-1433.
13. Ahima RS, Flier JS. Leptin. Annu Rev Physiol. 2000;62:413-437.
14. Batterham RL, Cowley MA, Small CJ, et al. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature. 2002;418:650-654.
15. Woods SC, Seeley RJ. Adiposity signals and the control of energy homeostasis. Nutrition. 2000;16:894-902.
16. Bado A, Levasseur S, Attoub S, et al. The stomach is a source of leptin. Nature 1998;394:790-793.
17. Cinti S, De Matteis R, Pico C, et al. Secretory granules of endocrine and chief cells of human stomach mucosa contain leptin. Int J Obes Relat Metab Disord. 2000;24:789-793.
18. Considine RV, Sinha MK, Heiman ML, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med. 1996;334:292-295.
19. Bellisle F, Perez C. Low-energy substitutes for sugars and fats in the human diet: impact on nutritional regulation. Neurosci Biobehav Rev. 1994;18:197-205.
20. Blundell JE, King N, Halford JCG. Appetite control system and functional foods for the control of energy intake. In: Palou A, Bonet ML, Serra F, eds. Study on Obesity and Functional Foods in Europe. Luxembourg: European Commission; 2002:302-316.
21. Holt SH, Delargy HJ, Lawton CL, Blundell JE. The effects of high-carbohydrate vs high-fat breakfasts on feelings of fullness and alertness, and subsequent food intake. Int J Food Sci Nutr, 1999;50:13-28.
22. Hubert P, King NA, Blundell JE. Uncoupling the effects of energy expenditure and energy intake: appetite response to short-term energy deficit induced by meal omission and physical activity. Appetite. 1998;31:9-19.
23. Rolls BJ, Gnizak N, Summerfelt A, Laster LJ. Food intake in dieters and nondieters after a liquid meal containing medium-chain triglycerides. Am J Clin Nutr. 1988;48:66-71.
24. Lawton CL, Delargy HJ, Brockman J, et al. The degree of saturation of fatty acids influences post-ingestive satiety. Br J Nutr. 2000;83:473-482.
25. Welch I, Saunders K, Read NW. Effect of ileal and intravenous infusions of fat emulsions on feeding and satiety in human volunteers. Gastroenterology. 1985;89:1293-1297.
26. Burns AA, Livingstone MB, Welch RW, et al. The effects of yoghurt containing a novel fat emulsion on energy and macronutrient intakes in non-over-weight, overweight and obese subjects. Int J Obes Relat Metab Disord. 2001;25:1487-1496.
27. Lang V, Bellisle F, Oppert JM, et al. Satiating effect of proteins in healthy subjects: a comparison of egg albumin, casein, gelatin, soy protein, pea protein, and wheat gluten. Am J Clin Nutr. 1998;67:1197-1204.
28. Trigazis L, Orttmann A, Anderson GH. Effect of a cholecystokinin-A receptor blocker on protein-induced food intake suppression in rats. Am J Physiol. 1997;272:R1826-R1833.
29. Blundell JE, Hill AJ. In: Kaufman S, Fernstrom J, Roth R, Woo S, eds. Amino Acids in Health and Disease: New Perspectives. New York: Alan R. Liss, Inc.; 1986:1-14.
30. Hill AJ, Blundell JE. Sensitivity of the appetite control system in obese subjects to nutritional and serotoninergic challenges. Int J Obes. 1990;14:219-233.
31. Hill AJ, Blundell JE. Role of amino acids in appetite control in man. In: Amino Acid Availability and Brain Function in Health and Disease. Berlin: Springer-Verlag; 1988:239-248.
32. Rogers PJ, Keedwell P, Blundell JE. Further analysis of the short-term inhibition of food intake in humans by the dipeptide L-aspartyl-L-phenylalanine methyl ester (aspartame). Physiol Behav. 1991;49:739-743.
33. Rogers PJ, Pleming HC, Blundell JE. Aspartame ingested without tasting inhibits hunger and food intake. Physiol Behav. 1990;47:1239-1243.
34. Rogers PJ, Blundell JE. Separating the actions of sweetness and calories: effects of saccharin and carbohydrates on hunger and food intake in human subjects. Physiol Behav. 1989;45:1093-1099.
35. Bouchard C, Tremblay A, Despres JP, et al. The response to long-term overfeeding in identical twins. N Engl J Med. 1990;322:1477-1482.
36. Maffeis C. Childhood obesity: the genetic-environmental interface. Baillieres Best Pract Res Clin Endocrinol Metab. 1999;13:31-46.
37. Levine JA, Eberhardt NL, Jensen MD. Role of non-exercise activity thermogenesis in resistance to fat gain in humans. Science. 1999;283:212-214.
38. Lowell BB, Spiegelman BM. Towards a molecular understanding of adaptive thermogenesis. Nature. 2000;404:652-660.
39. Palou A, Pico C, Bonet ML, Oliver P. The uncoupling protein, thermogenin. Int J Biochem Cell Biol. 1998;30:7-11.
40. Lowell BB, V S-S, Hamann A, et al. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature. 1993;366:740-742.
41. Cinti S. In: The Adipose Organ: Milan: Kurtis SRL; 1999.
42. Ricquier D, Bouillaud F. The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. J Biochem. 2000;345:161-179.
43. Pico C, Herron D, Palou A, et al. Stabilization of the mRNA for the uncoupling protein thermogenin by transcriptional/translational blockade and by nor-adrenaline in brown adipocytes differentiated in culture: a degradation factor induced by cessation of stimulation? Biochem J. 1994;302:81-86.
44. Cannon B, Jacobsson A, Rehnmark S, Nedergaard J. Signal transduction in brown adipose tissue recruitment: noradrenaline and beyond. Int J Obes Relat Metab Disord. 1996;20:S36-S42.
45. Puigserver P, Vazquez F, Bonet ML, et al. In vitro and in vivo induction of brown adipocyte uncoupling protein (thermogenin) by retinoic acid. Biochem J. 1996;317:827-833.
46. Bonet ML, Puigserver P, Serra F, et al. Retinoic acid modulates retinoid X receptor alpha and retinoic acid receptor alpha levels of cultured brown adipocytes. FEBS Lett. 1997;406:196-200.
47. Bonet ML, Oliver J, Pico C, et al. Opposite effects of feeding a vitamin A-deficient diet and retinoic acid treatment on brown adipose tissue uncoupling protein 1 (UCP1), UCP2 and leptin expression. J Endocrinol. 2000;166:511-517.
48. Ribot J, Felipe F, Bonet ML, Palou A. Changes of adiposity in response to vitamin A status correlate with changes of PPAR gamma 2 expression. Obes Res. 2001;9:500-509.
49. Serra F, Bonet ML, Puigserver P, et al. Stimulation of uncoupling protein 1 expression in brown adipocytes by naturally occurring carotenoids. Int J Obes Relat Metab Disord. 1999;23:650-655.
50. Portillo MP, Serra F, Simon E, et al. Energy restriction with high-fat diet enriched with coconut oil gives higher UCP1 and lower white fat in rats. Int J Obes Relat Metab Disord. 1998;22:974-979.
51. Rodriguez VM, Portillo MP, Pico C, et al. Olive oil feeding up-regulates uncoupling protein genes in rat brown adipose tissue and skeletal muscle. Am J Clin Nutr. 2002;75:213-220.
52. Bray GA, Tartaglia LA. Medicinal strategies in the treatment of obesity. Nature. 2000;404:672-677.
53. Rafecas I, Fernandez-Lopez JA, Remesar X, Alemany M. Pharmacological treatment of obesity. In: Palou A, Serra F, Bonet ML, eds. Study on Obesity and Functional Foods in Europe. Luxembourg: European Commission; 2002:249-285.
54. Cabo JR, Alonso E, Valls V. Dietetic treatment of obesity. In: Palou A, Bonet ML, Serra F, eds. Study on Obesity and Functional Foods in Europe. Luxembourg: European Commission; 2002:237-248.