Signal transduction in brown adipose tissue recruitment: Noradrenaline and beyond

International Journal of Obesity

Volumn 20, Issue SUPPL. 3, 1996, Pages

  Cannon, B ^a   Jacobsson, A ^a   Rehnmark, S ^a   Nedergaard, J ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Adrenergic receptors; Brown adipose tissue; C EBP; Cell proliferation; CREB; Differentiation; fos; Noradrenaline; Recruitment; Thermogenesis

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR; BETA 1 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR; CYCLIC AMP; NORADRENALIN; TRANSCRIPTION FACTOR; UNCOUPLING PROTEIN;

BROWN ADIPOSE TISSUE; CELL DIFFERENTIATION; CONFERENCE PAPER; GENE EXPRESSION; ONCOGENE C FOS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THERMOGENESIS;

ADIPOSE TISSUE, BROWN; ANIMALS; BODY TEMPERATURE REGULATION; CELL DIFFERENTIATION; CELL DIVISION; GENE EXPRESSION REGULATION; NOREPINEPHRINE; RECEPTORS, ADRENERGIC; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 0029917837     PISSN: 03070565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (37)

1. Nedergaard J, Lindberg O. The brown fat cell. Int Rev Cytol 1982; 74: 187-286.
2. Cannon B, Nedergaard J. The biochemistry of an inefficient tissue: brown adipose tissue. Essays Biochem 1985; 20: 110-164.
3. Trayhurn P, Nicholls DG (eds). Brown adipose tissue. Edward Arnold: London, 1986.
4. Himms-Hagen J. Brown adipose tissue thermogenesis: role in thermoregulation, energy regulation and obesity. In: E Schönbaum, P Lomax (eds). Thermoregulation: physiology and biochemistry, Pergamon Press: New York, 1990, pp 327-414.
5. Cannon B, Bengtsson T, Dicker A, Jacobsson A, Kuusela P, Thonberg H, Tvrdik P, Zhao J, Nedergaard J. The role of adrenergic stimulation in regulation of heat production and recruitment of brown adipose tissue. In : E Zeisberger, E Schönbaum, P Lomax (eds). Thermal balance in health and disease. Recent basic research and clinical progress. Birkhäuser: Basel, 1994, pp 87-102.
6. 3H)CGP-12177, generally classified as an antagonist, is a thermogenic agonist in brown adipose tissue. Biochem J 1989; 261: 401-405.
7. Bloom JD, Dutia MD, Johnson BD, Wissner A, Burns MG, Largis EE, Dolan JA, Claus TH. Disodium (R,R-5-2-2 - (3 - chlorophenyl) - 2 - hydroxyethyl - aminopropyl -1,3 - benzo-dioxole-2,2-dicarboxylate (CL 316243). A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent. J Med Chem 1992; 35: 3081-3084.
8. Arch JRS, Ainsworth AT. Thermogenic and antiobesity activity of a novel β-adrenoceptor agonist (BRL 26830A) in mice and rats. Am J Clin Nutr 1983; 38: 549-558.
9. 2-adrenergic receptors from hamster brown adipocytes. Life Sci 1982; 30: 1185-1192.
10. 3 receptors during differentiation of brown fat cells (In preparation).
11. 1-adrenergic receptors. Eur J Pharmacol 1983; 92: 15-25.
12. 1-Adrenergic stimulation of phosphatidylinositol turnover and respiration of brown fat cells. Mol Pharmacol 1984; 25: 64-69.
13. + dependent. Biochim Biophys Acta 1987; 930: 438-445.
14. 2+ in brown adipocytes. Eur J Biochem 1984; 141: 187-193.
15. 2+ levels in brown adipocytes. Biochem Biophys Res Commun 1989; 163: 292-300.
16. + and K channel block. Am J Physiol 1993; 264: C217-C228.
17. 1- and β-adrenoreceptors synergistically to maximally induce c-fos expression in brown adipocytes. J Biol Chem 1994; 269: 33179-33186.
18. Tuchiya K, Nagai M. Increase in intracellular calcium in freshly-dispersed single brown adipocytes of the rat by adrenergic stimulation. Biomed Res (Tokyo) 1994; 15: 347-355.
19. Nedergaard J, Cannon B. The uncoupling protein thermogenin and mitochondrial thermogenesis. In: L Ernster (ed). New comprehensive biochemistry, vol. 23, molecular mechanisms in bioenergetics. Elsevier: Amsterdam, 1992, pp 385-420.
20. Pettersson B, Vallin I. Noradrenaline-induced shift in levels of adenosine 3′ : 5′-monophosphate and ATP parallel to increased respiratory rate and lipolysis in isolated hamster brown fat cells. Eur J Biochem 1976; 62: 383-390.
21. Zhao J, Unelius L, Bengtsson T, Cannon B, Nedergaard J. Coexisting β-adrenoceptor subtypes: significance for thermogenic process in brown fat cells. Am J Physiol 1994; 267: C969-C979.
22. Cameron IL, Smith RE. Cytological responses of brown fat tissue in cold-exposed rats. J Cell Biol 1964; 23: 89-100.
23. Mory G, Ricquier D, Hemon P. Effects of chronic treatments upon the brown adipose tissue of rats: II Comparison between the effects of catecholamine injections and cold adaptation. J Physiol (Paris) 1980; 76: 859-864.
24. Rehnmark S, Nedergaard J. DNA synthesis in brown adipose tissue is under β-adrenergic control. Exp Cell Res 1989; 180: 574-579.
25. Géloén A, Collet AJ, Guay G, Bukowiecki LJ. β-Adrenergic stimulation of brown adipocyte proliferation. Am J Physiol 1988; 254: C175-C182.
26. 3 receptors. J Biol Chem 1992; 267: 2006-2013.
27. Néchad M, Kuusela P, Carneheim C, Björntorp P, Nedergaard J, Cannon B. Development of brown fat cells in monolayer culture: I Morphological and biochemical distinction from white fat cells in culture. Exp Cell Res 1983; 149: 105-118.
28. Bouillaud F, Ricquier D, Mory G, Thibault J. Increased level of mRNA for the uncoupling protein in brown adipose tissue of rats during thermogenesis induced by cold exposure or noradrenaline infusion. J Biol Chem 1984; 259: 11583-11586.
29. Jacobsson A, Mühleisen M, Cannon B, Nedergaard J. The uncoupling protein thermogenin during acclimation: indications for pretranslational control. Am J Physiol 1994; 267: R999-R1007.
30. Rehnmark S, Néchad M, Herron D, Cannon B, Nedergaard J. α- and β-adrenergic induction of the expression of the uncoupling protein thermogenin in brown adipocytes differentiated in culture. J Biol Chem 1990; 265: 16464-16471.
31. Herron D, Rehnmark S, Néchad M, Loncar D, Cannon B, Nedergaard J. Noradrenaline-induced synthesis of the uncoupling protein thermogenin (UCP) and its mitochondrial targeting in brown adipocytes differentiated in culture. FEBS Lett 1990; 268: 296-300.
32. Kopecky J, Baudysová M, Zanotti F, Janiková D, Pavelka S, Houstek J. Synthesis of mitochondrial uncoupling protein in brown adipocytes differentiated in cell culture. J Biol Chem 1990; 265: 22204-22209.
33. Kozak UC, Kopecky J, Teisinger J, Enerbäck S, Boyer B, Kozak LP. An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene. Mol Cell Biol 1994; 14: 59-67.
34. Enerbäck S, Gimble JM. Lipoprotein lipase gene expression: physiological regulators at the transcriptional and post-transcriptional level. Biochim Biophys Acta 1993; 1169: 107-125.
35. Mitchell JRD, Jacobsson A, Kirchgessner TG, Schotz MC, Cannon B, Nedergaard J. Regulation of expression of the lipoprotein lipase gene in brown adipose tissue. Am J Physiol 1992; 263: E500-E506.
36. Tvrdik P, Jacobsson A, Sugiaman D, Houstek J, Nedergaard J. Cell proliferation without increased c-myc expression during physiologically induced hyperplasia in brown adipose tissue (In preparation).
37. Rehnmark S, Antonson P, Xanthopoulos KG, Jacobsson A. Differential adrenergic regulation of C/EBPα and C/EBPβ in brown adipose tissue. FEBS Lett 1993; 318: 235-241.