Hyaluronidase-induced periodic modulation of the interstitial fluid pressure increases selective antibody uptake in human osteosarcoma xenografts

Anticancer Research

Volumn 20, Issue 5 B, 2000, Pages 3513-3519

  Brekken, C ^a   Hjelstuen, M H ^a   Bruland, O S ^a   De Lange Davies, C ^a  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

Hyaluronidase; Interstitial fluid pressure; Monoclonal antibody; Osteosarcoma; Radioimmunotherapy

Indexed keywords

HYALURONOGLUCOSAMINIDASE; IODINE 125; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY TP 3; MONOCLONAL ANTIBODY UPC 10; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG TISSUE LEVEL; DRUG UPTAKE; KIDNEY; LIVER; MOUSE; NONHUMAN; NUDE MOUSE; OSTEOSARCOMA; PERIODICITY; PRIORITY JOURNAL; RADIOACTIVITY; RADIOIMMUNOTHERAPY; SOLID TUMOR; SPLEEN; TISSUE PRESSURE; XENOGRAFT;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; AUTORADIOGRAPHY; CATTLE; EPITOPES; EXTRACELLULAR SPACE; FEMALE; FLOW CYTOMETRY; HUMANS; HYALURONOGLUCOSAMINIDASE; IMMUNOCONJUGATES; IMMUNOGLOBULIN G; INJECTIONS, INTRALESIONAL; IODINE RADIOISOTOPES; MICE; MICE, INBRED BALB C; OSTEOSARCOMA; TISSUE DISTRIBUTION;

EID: 0033635842     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Targeting strategies for cancer radiotherapy
2. Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: Significance of elevated interstitial pressure
3. Direct in vivo measurement of targeted binding in a human tumor xenograft
4. Interstitial hypertension in carcinoma of uterine cervix in patients: Possible correlation with tumor oxygenation and radiation response
5. Dexamethasone reduces the interstitial fluid pressure in a human colon adenocarcinoma xenograft
6. Effect of radiation on the interstitial fluid pressure and oxygenation in a human tumor xenograft
7. Reduction of interstitial fluid pressure after TNF-alpha treatment of three human melanoma xenografts
8. Enhancement of fluid filtration across tumor vessels: Implications for delivery of macromolecules
9. Experimental tumor targeting with radiolabeled ligands
10. Klinische Pharmakologie und Anwndungsmoglichkeiten von Hyaluronidase unter Berucksichtigung von Hyalase 'Dessau'
11. Hyaluronidase reduces the interstitial fluid pressure in solid tumours in a non-linear concentration-dependent manner
12. Hyaluronidase as an antidote to extravasation of vinca alkaloids-clinical results
13. Characteristics of a cell line established from a patient with multiple osteosarcoma, appearing 13 years after treatment for bilateral retinoblastoma
14. New monoclonal antibodies specific for human sarcomas
15. Expression and characteristics of a novel human osteosarcoma-associated cellsurface antigen
16. Determination of the immunoreactive fraction of radiolabeled monoclonal antibodies by linear extrapolation to binding at infinite antigen excess
17. Selective localization of two radiolabelled anti-sarcoma monoclonal antibodies in human osteosarcoma xenografts
18. Spatial distribution of tumor-specific monoclonal antibodies in human melanoma xenografts
19. The significance of the 'tissue pressure' of normal and of neoplastic (Brown-Pearce carcinoma) tissue in the rabbit
20. Lack of general correlation between interstitial fluid pressure and oxygen partial pressure in solid tumors