Down-Regulation of Caveolin-1 in Glioma Vasculature: Modulation by Radiotherapy

Journal of Neuroscience Research

Volumn 75, Issue 2, 2004, Pages 291-299

  Régina, Anthony ^a   Jodoin, Julie ^a   Khoueir, Paul ^a   Rolland, Yannève ^a   Berthelet, France ^b   Moumdjian, Robert ^b   Fenart, Laurence ^c   Cecchelli, Romeo ^c   Demeule, Michel ^a   Béliveau, Richard ^a  

^a UNIVERSITÉ DU QUÉBEC À MONTRÉAL   (Canada)

^b NOTRE DAME HOSPITAL   (Canada)

^c UNIVERSITÉ D'ARTOIS   (France)

Author keywords

Angiogenesis; Brain tumors; Caveolin 1; Endothelial cells; Irradiation

Indexed keywords

ANGIOGENIC FACTOR; ANGIOGENIC PROTEIN; BRAIN PROTEIN; CAVEOLIN; CAVEOLIN 1; CAVEOLIN-1; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P42;

ANGIOGENESIS; ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOXIA; BRAIN BLOOD VESSEL; BRAIN NERVE CELL; BRAIN TUMOR; CANCER RADIOTHERAPY; CAVEOLA; CELL CULTURE; CELL ISOLATION; COCULTURE; CONTROLLED STUDY; DISEASE MODEL; DOWN REGULATION; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME ACTIVATION; GLIOMA; IN VITRO STUDY; IN VIVO STUDY; MALE; METABOLISM; METASTASIS; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PURIFICATION; RADIATION EXPOSURE; RAT; RAT STRAIN; SHORT SURVEY; TUMOR CELL CULTURE; TUMOR CELL LINE; VASCULARIZATION;

ANGIOGENIC PROTEINS; ANIMALS; ANOXIA; BRAIN NEOPLASMS; CAVEOLAE; CAVEOLIN 1; CAVEOLINS; CELL LINE, TUMOR; COCULTURE TECHNIQUES; DISEASE MODELS, ANIMAL; DOWN-REGULATION; ENDOTHELIAL CELLS; GLIOMA; MALE; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; NEOPLASM METASTASIS; NEOVASCULARIZATION, PATHOLOGIC; PHOSPHORYLATION; RATS; RATS, INBRED LEW;

EID: 9144234108     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10865     Document Type: Short Survey

References (34)

1. Brown G, Rixon HW, Sugrue RJ. 2002. Respiratory syncytial virus assembly occurs in GM1-rich regions of the host-cell membrane and alters the cellular distribution of tyrosine phosphorylated caveolin-1. J Gen Virol 83:1841-1850.
2. Cecchelli R, Dehouck B, Descamps L, Fenart L, Buce-Scherer VV, Duhem C, Lundquist S, Rentfel M, Torpier G, Dehouck MP. 1999. In vitro model for evaluating drug transport across the blood-brain barrier. Adv Drug Deliv Rev 36:165-178.
3. Cohen AW, Park DS, Woodman SE, Williams TM, Chandra M, Shirani J, Pereira DS, Kitsis RN, Russell RG, Weiss LM, Tang B, Jelicks LA, Factor SM, Shtutin V, Tanowitz HB, Lisanti MP. 2003. Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts. Am J Physiol Cell Physiol 284:C457-C474.
4. Demeule M, Labelle M, Regina A, Berthelet F, Beliveau R. 2001. Isolation of endothelial cells from brain, lung, and kidney: expression of the multidrug resistance P-glycoprotein isoforms. Biochem Biophys Res Commun 281:827-834.
5. Engelman JA, Wykoff CC, Yasuhara S, Song KS, Okamoto T, Lisanti MP. 1997. Recombinant expression of caveolin-1 in oncogenically transformed cells abrogates anchorage-independent growth. J Biol Chem 272:16374-16381.
6. Engelman JA, Chu C, Lin A, Jo H, Ikezu T, Okamoto T, Kohtz DS, Lisanti MP. 1998. Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domain. FEBS Lett 428:205-211.
7. Enslen H, Davis RJ. 2001. Regulation of MAP kinases by docking domains. Biol Cell 93:5-14.
8. Fenart L, Casanova A, Dehouck B, Duhem C, Slupek S, Cecchelli R, Betbeder D. 1999. Evaluation of effect of charge and lipid coating on ability of 60-nm nanoparticles to cross an in vitro model of the blood-brain barrier. J Pharmacol Exp Ther 291:1017-1022.
9. Fiucci G, Ravid D, Reich R, Liscovitch M. 2002. Caveolin-1 inhibits anchorage-independent growth, anoikis and invasiveness in MCF-7 human breast cancer cells. Oncogene 21:2365-2675.
10. Folkman J. 1995. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1:27-31.
11. Galbiati F, Volonte D, Engelman JA, Watanabe G, Burk R, Pestell RG, Lisanti MP. 1998. Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade. EMBO J 17:6633-6648.
12. Griffoni C, Spisni E, Santi S, Riccio M, Guarnieri T, Tomasi V. 2000. Knockdown of caveolin-1 by antisense oligonucleosides impairs angiogenesis in vitro and in vivo. Biochem Biophys Res Commun 276:756-761.
13. Ikezu T, Ueda H, Trapp BD, Nishiyama K, Sha JF, Volonte D, Galbiati F, Byrd AL, Bassell G, Serizawa H, Lane WS, Lisanti MP, Okamoto T. 1998. Affinity-purification and characterization of caveolins from the brain: differential expression of caveolin-1, -2, and -3 in brain endothelial and astroglial cell types. Brain Res 804:177-192.
14. Kasper M, Reinmann T, Hempel U, Wenzel KW, Bierhaus A, Schuh D, Dimmer V, Haroske G, Mullerer M. 1998. Loss of caveolin expression in type 1 pneumocytes as an indicator of subcellular alterations during lung fibrogenesis. Histochem Cell Biol 109:41-48.
15. Koleske AJ, Baltimore D, Lisanti MP. 1995. Reduction of caveolin and caveolae in oncogenically transformed cells. Proc Natl Acad Sci USA 92:1381-1385.
16. Labrecque L, Royal I, Surprenant DS, Patterson C, Gingras D, Beliveau R. 2003. Regulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol. Mol Biol Cell 14:334-347.
17. Lakka SS, Jasti SL, Gondi C, Boyd D, Chandrasekar N, Dinh DH, Olivero WC, Gujrati M, Rao JS. 2002. Downregulation of MMP-9 in ERK-mutated stable transfectants inhibits glioma invasion in vitro. Oncogene 21:5601-5608.
18. Liu J, Razani B, Tang S, Terman BI, Ware JA, Lisanti MP. 1999. Angiogenesis activators and inhibitors differentially regulate caveolin-1 expression and caveolae formation in vascular endothelial cells. Angiogenesis inhibitors block vascular endothelial growth factor-induced down-regulation caveolin-1. J Biol Chem 274:15781-15785.
19. Liu J, Wang XB, Park DS, Lisanti MP. 2002. Caveolin-1 expression enhances endothelial capillary tubule formation. J Biol Chem 277:10661-10668.
20. Lopez MB. 2003. Angiogenesis in brain tumors. Microsc Res Techniq 60:225-230.
21. Mandell JW, Hussaini IM, Zecevic M, Weber MJ, Vanden Berg SR. 1998. In situ visualization of intratumor growth factor signalling: immunohistochemical localization of activated ERK/MAP kinase in glial neoplasms. Am J Pathol 153:1411-1423.
22. Mirsky N, Krispel Y, Shoshany Y, Maltz L, Oron U. 2002. Promotion of angiogenesis by low energy laser irradiation. Antiox Redox Signal 4:785-790.
23. Okamoto T, Schlegel A, Scherer PE, Lisanti MP. 1998. Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexe" at the plasma membrane. J Biol Chem 273:5419-5422.
24. Papadopoulos MC, Saadoun S, Davies DC, Bell BA. 2001. Emerging molecular mechanisms of brain tumor oedema. Br J Neurosurg 15:101-108.
25. Régina A, Demeule M, Berube A, Moumdjian R, Berthelet F, Beliveau R. 2003. Differences in multidrug resistance phenotype and matrix metalloproteinases activity between endothelial cells from normal brain and glioma. J Neurochem 84:316-324.
26. Roux F, Durieu-Trautmann O, Chaverot N, Claire M, Mailly P, Bourre JM, Strosberg AD, Couraud PO. 1994. Regulation of gamma-glutamyl transpeptidase and alkaline phosphatase activities in immortalized rat brain microvessel endothelial cells. J Cell Physiol 159:101-113.
27. Sanguinetti AR, Mastick CC. 2003. c-Abl is required for oxidative stress-induced phosphorylation of caveolin-1 on tyrosine 14. Cell Signal 3:289-298.
28. Schubert W, Frank PG, Woodman SE, Hyogo H, Cohen DE, Chow CW, Lisanti MP. 2002. Microvascular hyperpermeability in caveolin-1 (-/-) knock-out mice. Treatment with a specific nitric-oxide synthase inhibitor, L-name, restores normal microvascular permeability in Cav-1 null mice. J Biol Chem 277:40091-40098.
29. Shaul PW, Anderson RG. 1998. Role of plasmalemmal caveolae in signal transduction. Am J Physiol 275:L843-L851.
30. Sonveaux P, Dessy C, Brouet A, Jordan BF, Gregoire V, Gallez B, Balligand JL, Feron O. 2002. Modulation of the tumor vasculature functionality by ionizing radiation accounts for tumor radiosensitization and promotes gene delivery. FASEB J 16:1979-1981.
31. Sonveaux P, Brouet A, Havaux X, Gregoire V, Dessy C, Balligand JL, Feron O. 2003. Irradiation-induced angiogenesis through the upregulation of the nitric oxide pathway: implications for tumor radiotherapy. Cancer Res 63:1012-1019.
32. Turcotte S, Desrosiers RR, Beliveau R. 2003. HIF-1alpha mRNA and protein upregulation involves Rho GTPase expression during hypoxia in renal cell carcinoma. J Cell Sci 116:2247-2260.
33. Virgintino D, Robertson D, Errede M, Benagiano V, Tauer U, Roncali L, Bertossi M. 2002. Expression of caveolin-1 in human brain microvessels. Neuroscience 115:145-152.
34. Wild-Bode C, Weller M, Rinmer A, Dichgans J, Wick W. 2001. Sublethal irradiation promotes migration and invasiveness of glioma cells: implications for radiotherapy of human glioblastoma. Cancer Res 61:2744-2750.