Orexin A stimulates cortisol secretion from human adrenocortical cells through activation of the adenylate cyclase-dependent signaling cascade

Journal of Clinical Endocrinology and Metabolism

Volumn 86, Issue 2, 2001, Pages 778-782

  Mazzocchi, G ^a,b   Malendowicz, L K ^a   Gottardo, L ^a   Aragona, F ^a   Nussdorfer, G G ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b Section of Anatomy   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

9 (TETRAHYDRO 2 FURYL)ADENINE; ADENYLATE CYCLASE; ALDOSTERONE; ANGIOTENSIN; CATECHOLAMINE; CORTICOTROPIN; CYCLIC AMP; ENDOTHELIN 1; GUANINE NUCLEOTIDE BINDING PROTEIN; HYDROCORTISONE; MESSENGER RNA; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; OREXIN A; OREXIN B;

ADRENAL CORTEX CELL; ADRENAL GLAND; ADRENAL MEDULLA; ADULT; ARTICLE; BODY WEIGHT; ENZYME ACTIVATION; ENZYME ACTIVITY; FOOD INTAKE; HUMAN; HUMAN TISSUE; HYDROCORTISONE RELEASE; LIVEDO RETICULARIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SLEEP; ZONA FASCICULATA;

EID: 0035097290     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.86.2.7233     Document Type: Article

References (38)

1. Central nervous system control of hyperphagia in hypothalamic obesity: Dependence on adrenal glucocorticoids
2. Effect of adrenalectomy and glucocorticoid replacement on development of obesity
3. Regulation of activity in the hypothalamo-pituitary-adrenal axis is integral to a larger hypothalamic system that determines caloric flow
4. Endocrine abnormalities of obesity
5. The loop system between neuropeptide Y and leptin in normal and obese rodents
6. Leptin
7. Leptin: In search of role(s) in human physiology and pathophysiology
8. Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress
9. Acute effects of recombinant murine leptin on rat pituitary-adrenocortical function
10. A regulatory loop between the hypothalamopituitary-adrenal (HPA) axis and circulating leptin: A physiological role of ACTH
11. Interactions between the neuropeptide Y system and the hypothalamic-pituitary-adrenal axis
12. Paracrine control of adrenal cortical function by medullary chromaffin cells
13. Evidence for a novel peripheral action of leptin as a metabolic signal to adrenal gland. Leptin inhibits cortisol release directly
14. Expression of Ob receptor in normal human adrenals: Differential regulation of adrenocortical and adrenomedullary function by leptin
15. Neuropeptide-Y family of peptides in the autocrine-paracrine regulation of adrenocortical function
16. Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour
17. Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin
18. Orexins: A newly discovered family of hypothalamic regulators of food intake
19. The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
20. Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation
21. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene
22. Orexin receptors are expressed in the adrenal medulla of the rat
23. Orexins stimulate corticosterone secretion of rat adrenocortical cells, through the activation of the adenylate cyclase-dependent signaling cascade
24. Cerebellin enhances in vitro secretory activity of human adrenal gland
25. Pituitary adenylate cyclase-activating peptide (PACAP) enhances aldosterone secretion of human adrenal gland: Evidence for an indirect mechanism probably involving the local release of catecholamines
26. Effects of adrenomedullin on the human adrenal glands: An in vitro study
27. Gene expression, localization and characterization of endothelin A and B receptors in the human adrenal cortex
28. Human cultured adrenal fasciculata-reticularis cells are targets for angiotensin II: Effects on cytochrome P450 cholesterol side-chain cleavage, cytochrome P450 17α-hydroxylase and 3β-hydroxysteroid dehydrogenase messenger ribonucleic acid and proteins and on steroidogenic responsiveness to corticotropin and angiotensin II
29. Endothelin-1 stimulates steroid secretion of human adrenocortical cells ex vivo via both ETA and ETB receptor subtypes
30. Isolation, characterization and synthesis of a corticotropin-inhibiting peptide from human pituitary glands
31. Interleukin-1β enhances corticosterone secretion by acting directly on the rat adrenal gland
32. Role of calcium and other mediators in aldosterone secretion from adrenal glomerulosa cells
33. Reversal of synaptic depression by serotonin at Aplysia sensory neuron synapses involves activation of adenyl cyclase
34. Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthe-sized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(pbromocinnamylamino)ethyl]-5-iso-quinolinesulfonamide (H-89), of PC12D pheochromocytoma cells
35. Plasma leptin levels in healthy children and adolescents: Dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone
36. Serum immunoreactive-leptin levels are increased in patients with Cushing's syndrome
37. Leptin secretion in Cushing's syndrome: Preservation of diurnal rhythm and absent response to corticotropin-releasing hormone
38. Hypothalamic orexin expression. Modulation by blood glucose and feeding