Stimulation of amylase release by Orexin is mediated by Orexin 2 receptor in AR42J cells

Pancreas

Volumn 25, Issue 4, 2002, Pages 405-410

  Harris, D M ^a   Go, V L W ^a   Reeve Jr , J R ^a   Wu, S V ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Acinar cells; Amylase; Orexin; Orexin receptor; Pancreas

Indexed keywords

AMYLASE; CALCIUM; CYCLIC AMP; DNA; GLYCINE; HYPOCRETIN 2 GLYCINE; OREXIN; OREXIN 2 RECEPTOR; OREXIN A; OREXIN B; THYMIDINE; TRITIUM; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMYLASE RELEASE; ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; CARBOXY TERMINAL SEQUENCE; CELL FUNCTION; CELL LINE; CELL PROLIFERATION; CULTURE MEDIUM; DNA SYNTHESIS; DOSE RESPONSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; AMYLASES; ANIMALS; CALCIUM; CARRIER PROTEINS; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MOLECULAR SEQUENCE DATA; NEUROPEPTIDES; PANCREAS; RATS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; RNA, MESSENGER; SEQUENCE ALIGNMENT; TUMOR CELLS, CULTURED;

EID: 0036830223     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006676-200211000-00014     Document Type: Article

References (19)

1. Sakurai T, Amemiya A, Ishii M, et al. Orexins and Orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 1998;92:573-85.
2. de Lecea L, Kilduff TS, Peyron C, et al. The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci U S A 1998;95:322-7.
3. Trivedi P, Yu H, MacNeil DJ, et al. Distribution of Orexin receptor mRNA in the rat brain. FEBS Lett 1998;438:71-5.
4. Willie JT, Chemelli RM, Sinton CM, et al. To eat or to sleep? Orexin in the regulation of feeding and wakefulness. Annu Rev Neurosci 2001;24:429-58.
5. Jessop NW, Hay RJ. Characteristics of two rat pancreatic exocrine cell lines derived from transplantable tumors. In Vitro 1980;16:212-6.
6. Christophe J. Pancreatic tumoral cell line AR42J: An amphicrine model. Am J Physiol 1994;266:G963-71.
7. Harris DM, Flannigan KL, Go VL, et al. Regulation of cholecystokinin-mediated amylase secretion by leptin in rat pancreatic acinar tumor cell line AR42J. Pancreas 1999;19:224-30.
8. Wu SV, Yang M, Avedian D, et al. Single amino acid substitution of serine82 to asparagine in first intracellular loop of human cholecystokinin (CCK)-B receptor confers full cyclic AMP responses to CCK and gastrin, Mol Pharmacol 1999;55:795-803.
9. Walsh JH, Reeve JR, Jr. Mammalian bombesin-like peptides: Neuromodulators of gastric function and autocrine regulators of lung cancer growth. Peptides 1985;6(Suppl):63-8.
10. Kane JK, Tanaka H, Parker SL, et al. Sensitivity of Orexin-A binding to phospholipase C inhibitors, neuropeptide Y, and secretin. Biochem Biophys Res Commun 2000;272:959-65.
11. Lopez M, Senaris R, Gallego R, et al. Orexin receptors are expressed in the adrenal medulla of the rat. Endocrinology 1999;140:5991-4.
12. Bingham S, Davey PT, Babbs AJ, et al. Orexin-A, an hypothalamic peptide with analgesic properties. Pain 2001;92:81-90.
13. Kirchgessner AL, Liu M. Orexin synthesis and response in the gut. Neuron 1999;24:941-51.
14. Nowak KW, Maackowiak P, Switoanska MM, et al. Acute Orexin effects on insulin secretion in the rat: in vivo and in vitro studies. Life Sci 2000;66:449-54.
15. Rosewicz S, Ahnert-Hilger G, Haller H, et al. Rat pancreatic AR42J cells: Amphicrine cells as an in vitro model to study peptide hormone receptor regulation. Ann N Y Acad Sci 1994;733:407-15.
16. Marcus JN, Aschkenasi CJ, Lee CE, et al. Differential expression of Orexin receptors 1 and 2 in the rat brain. J Comp Neurol 2001;435:6-25.
17. Solomon TE, Varga G, Zeng N, et al. Different actions of secretin and Gly-extended secretin predict secretin receptor subtypes. Am J Physiol Gastrointest Liver Physiol 2001;280:G88-94.
18. van den Pol AN, Gao XB, Obrietan K, et al. Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/Orexin. J Neurosci 1998;18:7962-71.
19. Bamhart DC, Sarosi GA, Jr, Romanchuk G, et al. Calcium signaling induced by angiotensin 11 in the pancreatic acinar cell line AR42J. Pancreas 1999;18:189-96.