Central orexin facilitates gastric relaxation and contractility in rats

Neuroscience Letters

Volumn 332, Issue 3, 2002, Pages 171-174

  Kobashi, Motoi ^a   Furudono, Yuichi ^b   Matsuo, Ryuji ^a   Yamamoto, Takashi ^b  

^a OKAYAMA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

Gastric; Motility; Orexin; Relaxation; Stomach; Vagus

Indexed keywords

OREXIN A;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH MOTILITY; STOMACH MUSCLE; VAGOTOMY;

ANIMALS; CARRIER PROTEINS; GASTROINTESTINAL MOTILITY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NEUROPEPTIDES; PRESSURE; RATS; RATS, SPRAGUE-DAWLEY; STOMACH; VAGOTOMY;

EID: 0037044692     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(02)00958-8     Document Type: Article

References (20)

1. Azpiroz F., Malagelada J.-R. Physiological variations in canine gastric tone measured by an electronic barostat. Am. J. Physiol. Gastrointest. Liver Physiol. 248:1985;G229-G237.
2. Bauer F.E., Zintel A., Kenny M.J., Calder D., Ghatei M.A., Bloom S.R. Inhibitory effect of galanin on postprandial gastrointestinal motility and gut hormone release in humans. Gastroenterology. 97:1989;260-264.
3. de Lecea L., Kilduff T.S., Peyron C., Gao X., Foye P.E., Danielson P.E., Fukuhara C., Battenberg E.L., Gautvik V.T., Bartlett F.S. 2nd, Frankel W.N., van den Pol A.N., Bloom F.E., Gautvik K.M., Sutcliffe J.G. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc. Natl. Acad. Sci. USA. 95:1998;322-327.
4. Edwards C.M., Abusnana S., Sunter D., Murphy K.G., Ghatei M.A., Bloom S.R. The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin. J. Endocrinol. 160:1999;R7-R12.
5. Harrison T.A., Chen C.T., Dun N.J., Chang J.K. Hypothalamic orexin A-immunoreactive neurons project to the rat dorsal medulla. Neurosci. Lett. 273:1999;17-20.
6. Hwang L.L., Chen C.T., Dun N.J. Mechanisms of orexin-induced depolarizations in rat dorsal motor nucleus of vagus neurones in vitro. J. Physiol. (Lond.). 537:2001;511-520.
7. Kobashi M., Koga T., Mizutani M., Matsuo R. Suppression of vagal motor activities evokes laryngeal afferent-mediated inhibition of gastric motility. Am. J. Physiol. Regul. Integr. Comp. Physiol. 282:2002;R818-R827.
8. Kobashi M., Mizutani M., Matsuo R. Water stimulation of the posterior oral cavity induces inhibition of gastric motility. Am. J. Physiol. Regul. Integr. Comp. Physiol. 279:2000;R778-R786.
9. Krowicki Z.K., Berthoud H.R., Burmeister M.A., Hornby P.J. Orexin-A in the dorsal motor nucleus of the vagus potently increases gastric motor function via orexin 1 receptor in rats. Gasrotroenterology. 120:(Suppl. 1):2001;A113. (Abstract).
10. Kunii K., Yamanaka A., Nambu T., Matsuzaki I., Goto K., Sakurai T. Orexins/hypocretins regulate drinking behaviour. Brain Res. 842:1999;256-261.
11. Marcus J.N., Aschkenasi C.J., Lee C.E., Chemelli R.M., Saper C.B., Yanagisawa M., Elmquist J.K. Differential expression of orexin receptors 1 and 2 in the rat brain. J. Comp. Neurol. 435:2001;6-25.
12. Masuda Y., Tanaka T., Inomata N., Ohnuma N., Tanaka S., Itoh Z., Hosoda H., Kojima M., Kangawa K. Ghrelin stimulates gastric acid secretion and motility in rats. Biochem. Biophys. Res. Commun. 276:2000;905-908.
13. Meyer E.A. The physiology of gastric storage and emptying. Johnson L.R., Physiology of the Gastrointestinal Tract. 3rd Edition. 1994;929-976 Raven Press, New York.
14. Miolan J.P., Roman C. Discharge of efferent vagal fibers supplying gastric antrum: indirect study by nerve suture technique. Am. J. Physiol. Endocrinol. Metab. Gastrointest. Physiol. 235:1978;E366-E373.
15. Mondal M.S., Nakazato M., Matsukura S. Orexins (hypocretins): novel hypothalamic peptides with divergent functions. Biochem. Cell Biol. 78:2000;299-305.
16. Sakurai T., Amemiya A., Ishii M., Matsuzaki I., Chemelli R.M., Tanaka H., Williams S.C., Richarson J.A., Kozlowski G.P., Wilson S., Arch J.R., Buckingham R.E., Haynes A.C., Carr S.A., Annan R.S., McNulty D.E., Liu W.S., Terrett J.A., Elshourbagy N.A., Bergsma D.J., Yanagisawa M. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 92:1998;573-585.
17. Samson W.K., Gosnell B., Chang J.K., Resch Z.T., Murphy T.C. Cardiovascular regulatory actions of the hypocretins in brain. Brain Res. 831:1999;248-253.
18. Sheikh S.P. Neuropeptide Y peptide YY: major modulators of gastrointestinal blood flow and function. Am. J. Physiol. 261:1991;G701-G715.
19. Takahashi N., Okumura T., Yamada H., Kohgo Y. Stimulation of gastric acid secretion by centrally administered orexin-A in conscious rats. Biochem. Biophys. Res. Commun. 254:1999;623-627.
20. Travagli R.A., Rogers R.C. Receptors and transmission in the brain-gut axis: potential for novel therapies. V. Fast and slow extrinsic modulation of dorsal vagal complex circuits. Am. J. Physiol. Gastrointest. Liver Physiol. 281:2001;G595-G601.