Topiramate: Its pharmacological properties and therapeutic efficacy in epilepsy

Mini-Reviews in Medicinal Chemistry

Volumn 8, Issue 1, 2008, Pages 10-23

  Latini, Giuseppe ^a,b   Verrotti, Alberto ^c   Manco, Rossella ^c   Scardapane, Alessandra ^c   Del Vecchio, Antonio ^a   Chiarelli, Francesco ^c  

^a CNR   (Italy)

^b INSTITUTE OF CLINICAL PHYSIOLOGY   (Italy)

^c UNIVERSITY OF CHIETI   (Italy)

Author keywords

Carbonic Anhydrase Isoenzymes; Chloride Currents; GABA receptor; Generalized Seizure; Voltage Sensitive Sodium Channels

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR; ANTICONVULSIVE AGENT; BENZODIAZEPINE; CARBAMAZEPINE; CARBONATE DEHYDRATASE; ETHINYLESTRADIOL; ETHOSUXIMIDE; ETIRACETAM; FLUMAZENIL; GABAPENTIN; ISOENZYME; LAMOTRIGINE; MIDAZOLAM; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NORETHISTERONE; ORAL CONTRACEPTIVE AGENT; OXCARBAZEPINE; PENTOBARBITAL; PHENOBARBITAL; PHENYTOIN; PLACEBO; PROTEIN KINASE; TOPIRAMATE; VALPROIC ACID; VOLTAGE DEPENDENT ANION CHANNEL; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL;

ADD ON THERAPY; ADJUVANT THERAPY; AGGRESSION; ANHIDROSIS; ANOREXIA; ANTICONVULSANT ACTIVITY; ATAXIA; ATTENTION DISTURBANCE; BEDTIME DOSAGE; BEHAVIOR; BLURRED VISION; BRAIN DISEASE; CHANNEL GATING; CHLORIDE CURRENT; CLINICAL EFFECTIVENESS; CLINICAL TRIAL; CLOSED ANGLE GLAUCOMA; COGNITIVE DEFECT; COMBINATION CHEMOTHERAPY; CONCENTRATION LOSS; CONFUSION; DEPRESSION; DIZZINESS; DOSE RESPONSE; DRUG ABSORPTION; DRUG ANTAGONISM; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG DOSE ESCALATION; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG EXCRETION; DRUG INDICATION; DRUG INDUCED HEADACHE; DRUG MECHANISM; DRUG MEGADOSE; DRUG PROTEIN BINDING; DRUG RESPONSE; DRUG STRUCTURE; DRUG TARGETING; DRUG TOLERABILITY; DRUG WITHDRAWAL; ENZYME INHIBITION; EPILEPSY; EPILEPTIC DISCHARGE; EPILEPTIC STATE; EYE PAIN; FATIGUE; FOCAL EPILEPSY; FOOD; FOOD DRUG INTERACTION; GRAND MAL SEIZURE; HEMIPARESIS; HUMAN; HYPERAMMONEMIA; INFANTILE SPASM; INTRAOCULAR PRESSURE; LANGUAGE DISABILITY; LENNOX GASTAUT SYNDROME; LOW DRUG DOSE; MAXIMUM PLASMA CONCENTRATION; MAXIMUM TOLERATED DOSE; MEMORY DISORDER; METABOLIC ACIDOSIS; MONOTHERAPY; MOOD DISORDER; MYOCLONUS EPILEPSY; MYOPIA; NEPHROLITHIASIS; NERVOUSNESS; NEUROTRANSMISSION; NONHUMAN; OPTIMAL DRUG DOSE; PERIORBITAL EDEMA; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PSYCHOMOTOR DISORDER; PSYCHOSIS; REVIEW; RISK REDUCTION; SCLERITIS; SEIZURE; SIDE EFFECT; SINGLE DRUG DOSE; SOMNOLENCE; SPEECH DISORDER; STRUCTURE ACTIVITY RELATION; TONIC CLONIC SEIZURE; UNSPECIFIED SIDE EFFECT; UPPER RESPIRATORY TRACT INFECTION; URINARY EXCRETION; URINE PH; VERTIGO; WEIGHT REDUCTION; WEST SYNDROME;

ANTICONVULSANTS; EPILEPSY; FRUCTOSE; HUMANS; TREATMENT OUTCOME;

EID: 40049086392     PISSN: 13895575     EISSN: None     Source Type: Journal    
DOI: 10.2174/138955708783331568     Document Type: Review

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