Effects of topiramate on cognitive function

Journal of Neurology Neurosurgery and Psychiatry

Volumn 69, Issue 5, 2000, Pages 636-641

  Thompson, P J ^a,b   Baxendale, S A ^a,b   Duncan, J S ^a,b   Sander, J W A S ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b EPILEPSY SOCIETY   (United Kingdom)

Author keywords

Epilepsy; Intellect; Memory; Seizures; Topiramate

Indexed keywords

CLONAZEPAM; ETIRACETAM; GABAPENTIN; LAMOTRIGINE; PHENYTOIN; TOPIRAMATE; VALPROIC ACID; VIGABATRIN;

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG WITHDRAWAL; FEMALE; HUMAN; INTELLECT; INTRACTABLE EPILEPSY; MALE; NEUROPSYCHOLOGICAL TEST; PRIORITY JOURNAL; TASK PERFORMANCE;

ADOLESCENT; ADULT; ANTICONVULSANTS; COGNITION; EPILEPSY; FEMALE; FRUCTOSE; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS;

EID: 0033785369     PISSN: 00223050     EISSN: None     Source Type: Journal    
DOI: 10.1136/jnnp.69.5.636     Document Type: Article

References (19)

1. Tassarini CA, Michelucci R, Chauvel P, et al. Double-blind placebo controlled trial of topiramate (600 mg daily) for the treatment of refractory epilepsy. Epilepsia 1996;37:763-8
2. Privitera M, Fincham R, Penry J, et al. Topiramate placebo controlled dose: ranging trial in refractory partial epilepsy using 600, 800, and 1000 mg daily dosages. Neurology 1996;46:1678-83.
3. Elterman RD, Glauser TA, Wyllie E, et al. A double-blind,randomized trial of topiramate as adjunctive therapy for partial-onset seizures in children. Topiramate YP Study Group. Neurology 1999;52:1338-44.
4. Kellert MW, Smith DF, Stockton PA, et al. Topiramate in clinical practice: first years postlicensing experience in a specialist epilepsy clinic. J Neurol Neurosurg Psychiatry 1999;66:759-63.
5. Crawford P. An audit of topiramate use in a general neurology clinic. Seizure 1998;7:207-11.
6. Jones MW. Topiramate: safety and tolerability. Can J Neurol Sci 1998;25:S13-15.
7. Burton LA, Harden C. Effect of topiramate on attention. Epilepsy Res 1997;27:29-32.
8. Martin R, Kuzniecky R, Ho S, et al. Cognitive effects of topiramate, gabapentin and lamotrogine in healthy young adults. Neurology 1999;52:321-7.
9. Thompson PJ, Trimble MR. Neuropsychological aspects of epilepsy. In: Grant I, Adams K, eds. Neuropsychological assessment of neuropsychiatric disorders. New York :Oxford University Press, 1996:263-88.
10. Wechsler D. Wechsler adult intelligence scale, revised. San Antonio. TX: The Psychological Corporation, 1981.
11. Coughlan A, Hollows S. Adult memory and information processing battery. Leeds, UK: St James Hospital, 1985.
12. McKenna P, Warrington E. The graded naming test. Windsor, UK: NFER Nelson, 1983.
13. Coughlan AK, Warrington EK. Word comprehension and word retrieval in patients with localised brain lesions. Brain 1978;101:63-185.
14. Warrington EK, James M. The visual object and space perception battery. Bury St Edmunds: Thames Valley Test Company, 1991.
15. Sziklas VG, Montour-Proulx I, Andermann F, et al. Cognitive effects of topiramate therapy in patients with intractable partial epilepsy. Epilepsia 1999;40(suppl7):56.
16. Aldenkamp AP, Baker G, Mulder OG, et al. A randomized clinical study comparing the cognitive effects of topiramate versus valproate in a first line add on design. Epilepsia 1999;40(suppl 7):83-4.
17. Vermeulen J, Aldenkamp AP. Cognitive side-effects of chronic antiepileptic drug treatment: a review of 25 years research. Epilepsy Res 1995;22:65-95.
18. Meador KJ. The cognitive effects of new AEDs. Neurologist 1998;4:S35-9.
19. Jokeit H, Ebner A. Long term effects of refractory temporal lobe epilepsy on cognitive abilities: a cross sectional study. J Neurol Neurosurg Psychiatry 1999;67:44-50.