A randomized, placebo-controlled study of topiramate in primary generalized tonic-clonic seizures

Neurology

Volumn 52, Issue 7, 1999, Pages 1330-1337

  Biton, Victor ^a   Montouris, G D ^b   Ritter, F ^c   Riviello, J J ^d   Reife, R ^e   Lim, P ^f   Pledger, G ^f  

^a Arkansas Epilepsy Program   (United States)

^b Epi Care Center   (United States)

^c MINNESOTA EPILEPSY GROUP   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e JOHNSON AND JOHNSON   (United States)

^f R W JOHNSON PHARMACEUTICAL RES I   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; TOPIRAMATE;

ADOLESCENT; ADULT; AMNESIA; ANOREXIA; ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SCREENING; DRUG TOLERABILITY; FATIGUE; FEMALE; GRAND MAL SEIZURE; GRANULOCYTOPENIA; HUMAN; MALE; MULTICENTER STUDY; NERVOUSNESS; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SOMNOLENCE; THROMBOCYTOPENIA; TONIC CLONIC SEIZURE; WEIGHT REDUCTION;

EID: 0033594522     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/wnl.52.7.1330     Document Type: Article

References (17)

1. Shank RP, Gardocki JF, Vaught JL, et al. Topiramate: preclinical evaluation of a structurally novel anticonvulsant. Epilepsia 1994;35:450-460.
2. White HS, Brown SD, Woodhead JH, Skeen GA, Wolf HH. Topiramate enhances GABA-mediated chloride flux and GABA-evoked chloride currents in murine brain neurons and increases seizure threshold. Epilepsy Res 1997;28:167-179.
3. Tassinari CA, Michelucci R, Chauvel P, et al. Double-blind, placebo-controlled trial of topiramate (600 mg daily) for the treatment of refractory partial epilepsy. Epilepsia 1996;37: 763-768.
4. Faught E, Wilder BJ, Ramsay RE. et al. Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 200-, 400-, and 600-mg daily dosages. Neurology 1996;46: 1684-1690.
5. Privitera M, Fincham R, Penry J, et al. Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 600-, 800-, and 1,000-mg daily dosages. Neurology 1996; 46:1678-1683.
6. Sharief M, Viteri C, Ben-Menachem E, et al. Double-blind, placebo-controlled study of topiramate in patients with refractory partial epilepsy. Epilepsy Res 1996;25:217-224.
7. Ben-Menachem E, Henriksen O, Dam M, et al. Double-blind, placebo-controlled trial of topiramate as add-on therapy in patients with refractory partial seizures. Epilepsia 1996;37: 539-543.
8. Shorvon SD. Epidemiology, classification, natural history, and genetics of epilepsy. Lancet 1990;336:93-96.
9. Chadwick D, Leiderman DB, Sauermann W, Alexander J, Garofalo E. Gabapentin in generalized seizures. Epilepsy Res 1996;25:191-197.
10. Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for revised clinical and electroencephalographic classification of epileptic seizures. Epilepsia 1981;22:489-501.
11. Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for classification of epilepsies and epileptic syndromes. Epilepsia 1985;26:268-278.
12. Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia 1989; 30:389-399.
13. SAS/STAT Users' Guide. Version 6, 4th ed. Cary, NC: SAS Institute, May 1992.
14. Conover WJ, Iman RL. Rank transformations as a bridge between parametric and nonparametric statistics. Am Statistician 1981;35:124-133.
15. Fleiss JL. Statistical Methods for Rates and Proportions. 2nd ed. New York: John Wiley and Sons, 1981:173-175.
16. Lehmann EL. Nonparametrics: Statistical Methods Based on Ranks. San Francisco: Holden Day, 1975:5-42.
17. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457-481.