Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 200-, 400-, and 600-mg daily dosages

Neurology

Volumn 46, Issue 6, 1996, Pages 1684-1690

  Faught, E ^a,f   Wilder, B J ^b   Ramsay, R E ^c   Reife, R A ^d   Kramer, L D ^e   Pledger, G W ^d   Karim, R M ^d  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^d R W JOHNSON PHARMACEUTICAL RES I   (United States)

^e NOVARTIS PHARMA AG   (Switzerland)

^f UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; PHENYTOIN; TOPIRAMATE;

ADULT; AGED; ANTICONVULSANT THERAPY; ARTICLE; ATAXIA; CLINICAL TRIAL; COMPLEX PARTIAL SEIZURE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE CALCULATION; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFICACY; FATIGUE; FEMALE; FOCAL EPILEPSY; HEADACHE; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEIZURE SUSCEPTIBILITY; VERTIGO;

EID: 0029922566     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.46.6.1684     Document Type: Article

References (12)

1. Gardocki JF, Labinsky LS, Brown GL, Maryanoff BE. Anti-convulsant activity of McN-4853 (M) 2,3:4,5-bis-O-(L-methylethylidene)-β-D-fructopyranose sulfamate in mice and rats [abstract]. Epilepsia 1986;27:648-749.
2. Shank RP, Gardocki JF, Vaught JL, et al. Topiramate: preclinical evaluation of a structurally novel anticonvulsant. Epilepsia 1994;35:450-460.
3. Coulter DA, Sombati S, DeLorenzo RJ. Selective effects of topiramate on sustained repetitive firing and spontaneous bursting in cultured hippocampal neurons [abstract]. Epilepsia 1993;34(suppl 2):123.
4. Brown SD, Wolf HH, Swinyard EA, et al. The novel anticonvulsant topiramate enhances GABA-mediated chloride flux [abstract]. Epilepsia 1993;34(suppl 2):122.
5. Doose DR, Scott VV, Margul BL, Marriott TB, Nayak RK. Multiple-dose pharmacokinetics of topiramate in healthy male subjects [abstract]. Epilepsia 1988;29:662.
6. Conover WJ, Iman RL. Rank transformations as a bridge between parametric and nonparametric statistics. Am Stat 1981; 35:124-133.
7. Fleiss JL. Statistical methods for rates and proportions, 2nd ed. New York: John Wiley & Sons, 1981.
8. Hollander M, Wolfe DA. Nonparametric statistical methods. New York: John Wiley & Sons, 1973.
9. Armitage P. Test for linear trend in proportions and frequencies. Biometrics 1955;11:375-386.
10. Lehmann EL. Nonparametrics: statistical methods based on ranks. San Francisco: Holden Day, 1975.
11. The US Gabapentin Study Group No. 5. Gabapentin as add-on therapy in refractory partial epilepsy: a double-blind, placebo-controlled, parallel group study. Neurology 1993;43:2292-2298.
12. Matsuo F, Bergen D, Faught E, et al. Placebo-controlled study of the efficacy and safety of lamotrigine in patients with partial seizures. Neurology 1993;43:2284-2291.