Topiramate, carbamazepine and valproate monotherapy: Double-blind comparison in newly diagnosed epilepsy

Acta Neurologica Scandinavica

Volumn 107, Issue 3, 2003, Pages 165-175

  Privitera, Michael D ^a   Brodie, M J ^b   Mattson, R H ^c   Chadwick, D W ^d   Neto, W ^e   Wang, S ^e  

^a UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

^b WESTERN INFIRMARY   (United Kingdom)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF LIVERPOOL   (United Kingdom)

^e JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Carbamazepine; Epilepsy; Monotherapy; Topiramate; Valproate

Indexed keywords

CARBAMAZEPINE; TOPIRAMATE; VALPROIC ACID;

ABDOMINAL PAIN; ADOLESCENT; ADULT; ALOPECIA; APPETITE DISORDER; ARTICLE; ATTENTION DEFICIT DISORDER; BLOOD SAMPLING; CENTRAL NERVOUS SYSTEM DISEASE; CLINICAL FEATURE; CLINICAL TRIAL; CONFUSION; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG CHOICE; DRUG EFFICACY; DRUG INDICATION; DRUG WITHDRAWAL; EPILEPSY; FATIGUE; FEMALE; FOLLOW UP; HEADACHE; HUMAN; INSOMNIA; LANGUAGE DISABILITY; MAJOR CLINICAL STUDY; MALE; MENSTRUATION DISORDER; MULTICENTER STUDY; NAUSEA; NERVOUSNESS; PARESTHESIA; PHARYNGITIS; RANDOMIZED CONTROLLED TRIAL; RASH; SCHOOL CHILD; SIDE EFFECT; SOMNOLENCE; TREATMENT OUTCOME; TREMOR; UPPER RESPIRATORY TRACT INFECTION; URINARY TRACT INFECTION; VERTIGO; WEIGHT GAIN; WEIGHT REDUCTION;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AGED; ANTICONVULSANTS; CARBAMAZEPINE; CHILD; DOUBLE-BLIND METHOD; EPILEPSY; FEMALE; FRUCTOSE; HUMANS; MALE; MIDDLE AGED; SEIZURES; TREATMENT OUTCOME; VALPROIC ACID;

EID: 0037354372     PISSN: 00016314     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0404.2003.00093.x     Document Type: Article

References (42)

1. BRODIE MJ, DICHTER MA. Antiepileptic drugs. N Engl J Med 1996;334:168-75.
2. MATTSON RH, CRAMER JA, COLLINS JF, DEPARTMENT OF VETERANS AFFAIRS EPILEPSY COOPERATIVE STUDY NO. 264 GROUP. A comparison of VPA with CBZ for the treatment of complex partial seizures and secondarily generalized tonic-clonic seizures in adults. N Engl J Med 1992;327:765-71.
3. FAUGHT E, WILDER BJ, RAMSAY RE et al. TPM placebo-controlled dose-ranging trial in refractory partial epilepsy using 200-, 400-, and 600-mg daily dosages. Neurology 1996;46:1684-90.
4. PRIVITERA M, FINCHAM R, PENRY J et al. TPM placebo-controlled dose-ranging trial in refractory partial epilepsy using 600-, 800-, and 1000-mg daily dosages. Neurology 1996;46:1678-83.
5. SHARIEF M, VITERI C, BEN-MENACHEM E et al. Double-blind, placebo-controlled study of TPM in patients with refractory partial epilepsy. Epilepsy Res 1996;25:217-24.
6. TASSINARI CA, MICHELUCCl R, CHAUVEL P et al. Double-blind, placebo-controlled trial of TPM (600 mg daily) for the treatment of refractory partial epilepsy. Epilepsia 1996;37:763-8.
7. BEN-MENACHEM E, HENRIKSEN O, DAM M et al. Double-blind, placebo-controlled trial of TPM as add-on therapy in patients with refractory partial seizures. Epilepsia 1996;37:539-43.
8. ELTERMAN RD, GLAUSER TA, WYLLIE E et al. A double-blind, randomized trial of TPM as adjunctive therapy for partial-onset seizures in children. Neurology 1999;52:1338-44.
9. BITON V, MONTOURIS GD, RITTER F et al. A randomized, placebo-controlled study of TPM in primary generalized tonic-clonic seizures. Neurology 1999;52:1330-7.
10. SACHDEO RC, GLAUSER TA, RITTER F et al. A double-blind, randomized trial of TPM in Lennox-Gastaut syndrome. Neurology 1999;52:1882-7.
11. BITON V, ROSENFELD WE, TWYMAN R, LIM R. TPM (TPM) in juvenile myoclonic epilepsy (JME): observations from randomized controlled trials in primary generalized tonic-clonic seizures (PGTCS). Epilepsia 1999;40(suppl. 7):218.
12. ROSENFELD WE, SCHAEFER PA, LIPPMANN SM. TPM in patients with juvenile myoclonic epilepsy. Epilepsia 1998;39 (suppl. 6):139.
13. GLAUSER TA, CLARK PO, STRAWSBURG R. A pilot study of TPM in the treatment of infantile spasms. Epilepsia 1998;39:1324-8.
14. GLAUSER TA, CLARK PO, MCGEE K. Long-term response to TPM in patients with West syndrome. Epilepsia 2000;41 (suppl. 1):S91-S94.
15. CROSS JH. TPM monotherapy for childhood absence seizures: results from an open-label pilot study. Epilepsia 1998;39 (suppl. 6):164.
16. SACHDEO RC, REIFE RA, LIM P, PLEDGER G. TPM monotherapy for partial onset seizures. Epilepsia 1997;38:294-300.
17. GILLIAM FG, REIFE R, Wu S-C. A dose-comparison trial of TPM as monotherapy in recently diagnosed partial epilepsy. Neurology 2003;60:196-201.
18. COMMISSION ON CLASSIFICATION AND TERMINOLOGY OF THE INTERNATIONAL LEAGUE AGAINST EPILEPSY. Proposal for revised clinical and electroencephalographic classification of epileptic seizures. Epilepsia 1981;22:489-501.
19. LACHIN JM, FOULKES MA. Evaluation of sample size and power for analyses of survival with allowance for non-uniform patient entry, losses to follow-up, noncompliance, and stratification. Biometrics 1986;42:507-16.
20. CONSIDERATIONS ON DESIGNING CLINICAL TRIALS TO EVALUATE THE PLACE OF NEW ANTIEPILEPTIC DRUGS IN THE TREATMENT OF NEWLY DIAGNOSED AND CHRONIC PATIENTS WITH EPILEPSY. Report of the International League Against Epilepsy Commission on Antiepileptic Drugs. Epilepsia 1998;39: 799-803.
21. LAIRD NM, MOSTELLER F. Some statistical methods for combining experimental results. Int J Technol Assess Health Care 1990;6:5-30.
22. COCHRAN WG. The combination of estimates from different experiments. Biometrics 1954;10:101-29.
23. HELLER AJ, CHESTERMAN P, ELWES RDC et al. Phenobarbitone, phenytoin, CBZ, or sodium VPA for newly diagnosed adult epilepsy: a randomized comparative monotherapy trial. J Neurol Neurosurg Psychiatry 1995;58:44-50.
24. BRODIE MJ, RICHENS A, YUEN AWC, UK LAMOTRIGINE/CBZ MONOTHERAPY TRIAL GROUP. Double-blind comparison of lamotrigine and CBZ in newly diagnosed epilepsy. Lancet 1995;345:476-9.
25. STEINER TJ, DELLAPORTAS CI, FINDLEY LJ et al. Lamotrigine monotherapy in newly diagnosed untreated epilepsy: a double-blind comparison with phenytoin. Epilepsia 1999;40:601-7.
26. MATTSON RH, CRAMER JA, COLLINS JF et al. Comparison of CBZ, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures. N Engl J Med 1985;313:145-51.
27. DE SILVA M, MACARDLE B, MCGOWAN M et al. Randomised comparative monotherapy trial of phenobarbitone, phenytoin, CBZ, or sodium VPA for newly diagnosed childhood epilepsy. Lancet 1996;347:709-13.
28. RICHENS A, DAVIDSON DLW, CARTLIDGE NEF et al. A multicentre comparative trial of sodium VPA and CBZ in adult onset epilepsy. J Neurol Neurosurg Psychiatry 1994;57: 682-7.
29. CHADWICK DW, ANHUT H, GREINER MJ et al. A double-blind trial of gabapentin monotherapy for newly diagnosed partial seizures. Neurology 1998;51:1282-8.
30. REUNANEN M, DAM M, YUEN AWC. A randomised open multicentre comparative trial of lamotrigine and CBZ as monotherapy in patients with newly diagnosed or recurrent epilepsy. Epilepsy Res 1996;23:149-55.
31. CHADWICK D, VIGABATRIN EUROPEAN MONOTHERAPY STUDY GROUP. Safety and efficacy of vigabatrin and CBZ in newly diagnosed epilepsy: a multicentre randomised double-blind study. Lancet 1999;354:13-19.
32. KALVIAINEN R, AIKIA M, SAUKKONEN AM, MERVAALA E, RIEKKINEN PJ. Vigabatrin vs CBZ monotherapy in patients with newly diagnosed epilepsy. Arch Neurol 1995;52: 989-96.
33. CHRISTE W, KRAMER G, VIGONIUS U et al. A double-blind controlled clinical trial: oxcarbazepine versus sodium VPA in adults with newly diagnosed epilepsy. Epilepsy Res 1997;26:451-60.
34. BILL PA, VIGONIUS U, POHLMANN H et al. A double-blind controlled clinical trial of oxcarbazepine versus phenytoin in adults with previously untreated epilepsy. Epilepsy Res 1997;27:195-204.
35. GUERREIRO MM, VIGONIUS U, POHLMANN H et al. A double-blind controlled clinical trial of oxcarbazepine versus phenytoin in children and adolescents with epilepsy. Epilepsy Res 1997;27:205-13.
36. MANFORD M, HART YM, SANDER JWAS, SHORVON SD. The National General Practice Study of Epilepsy: the syndromic classification of the International League Against Epilepsy applied to epilepsy in a general population. Arch Neurol 1992;49:801-8.
37. BERG AT, SHINNAR S, LEVY SR, TESTA FM, SMITH-RAPAPORT S, BECKERMAN B. HOW well can epilepsy syndromes be identified at diagnosis? A reassessment 2 years after initial diagnosis. Epilepsia 2000;41:1269-75.
38. KWAN P, BRODIE MJ. Effectiveness of first antiepileptic drug. Epilepsia 2001;42:1255-60.
39. MATTSON RH, CRAMER JA, COLLINS JF, DEPARTMENT OF VETERANS AAIRS EPILEPSY COOPERATIVE STUDIES NO. 18 AND NO. 264 GROUP. Prognosis for total control of complex partial and secondarily generalized tonic clonic seizures. Neurology 1996;47:68-76.
40. REIFE R, PLEDGER G, WU S-C. TPM as add-on therapy: pooled analysis of randomized controlled trials in adults. Epilepsia 2000;41 (suppl, 1):S66-S71.
41. MORITA DA, GLAUSER TA, HAMANT E, Guo SS. Effect of TPM on linear growth in children with refractory complex partial seizures. Neurology 2000;54(suppl. 3):A193.
42. ARROYO S, SQUIRES L, WANG S, TWYMAN R. Topiramate (TPM): effective as monotherapy in dose-response study in newly diagnosed epilepsy. Epilepsia 2002; 43 (suppl. 7):241.