Steady-state and pre-steady-state kinetic evaluation of severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro cysteine protease: Development of an ion-pair model for catalysis

Biochemistry

Volumn 47, Issue 8, 2008, Pages 2617-2630

  Solowiej, James ^a   Thomson, James A ^a   Ryan, Kevin ^a   Luo, Chun ^a,b   He, Mingying ^a   Lou, Jihong ^a   Murray, Brion W ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b Accelagen   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDES; CATALYSIS; ESTERS; HYDROLYSIS; REACTION KINETICS;

CORONAVIRUS; PROTON INVENTORY (PI);

ENZYME ACTIVITY;

CHYMOTRYPSIN; CYSTEINE; CYSTEINE PROTEINASE; ESTER; HISTIDINE; IODOACETAMIDE; ISOTOPE; PAPAIN;

ACYLATION; ARTICLE; CATALYSIS; DEACYLATION; ELECTRICITY; ENZYME MECHANISM; ENZYME RELEASE; HYDROLYSIS; NUCLEOTIDE SEQUENCE; PARAMETER; PH; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTON TRANSPORT; REACTION ANALYSIS; SARS CORONAVIRUS; STEADY STATE;

ACRYLATES; ALKYLATION; CATALYSIS; CYSTEINE; CYSTEINE ENDOPEPTIDASES; DIPEPTIDES; ELECTROSTATICS; ENZYME ACTIVATION; ENZYME INHIBITORS; ENZYME STABILITY; HISTIDINE; HYDROGEN-ION CONCENTRATION; IODOACETAMIDE; IONS; KINETICS; MODELS, BIOLOGICAL; SARS VIRUS; SOLVENTS; TRANSFERASES; VIRAL PROTEINS;

CORONAVIRUS; SARS CORONAVIRUS;

EID: 39749162180     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi702107v     Document Type: Article

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