Proton Inventory Studies of α-Thrombin-Catalyzed Reactions of Substrates with Selected P and P′ Sites

Journal of the American Chemical Society

Volumn 126, Issue 19, 2004, Pages 6017-6024

  Enyedy, Edith J ^a   Kovach, Ildiko M ^a  

^a CATHOLIC UNIVERSITY OF AMERICA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLATION; CATALYSIS; DEUTERIUM; FLUORESCENCE; FRACTIONATION; HYDROLYSIS; QUENCHING; REACTION KINETICS; SOLVENTS;

INVERSE ISOTOPE EFFECTS; SINGLE-PROTON BRIGGE; THROMBIN;

PROTONS;

BENZOYLPHENYLALANYLVALYLARGININE 4 NITROANILIDE; BENZYLOXYCARBONYLPROLYLARGININE 7 AMIDO 4 METHYLCOUMARIN; BLOOD CLOTTING FACTOR 8; DEUTERIUM; DEXTRO PHENYLALANYLPIPECOLYLARGININE 4 NITROANILIDE; N TERT BUTYLOXYCARBONYLVALYLPROLYLARGININE 7 AMIDO 4 METHYLCOUMARIN; PEPTIDE; PROTON; THROMBIN; UNCLASSIFIED DRUG; VALYLPHENYLALANYLPROLYLARGINYLSERYLPHENYLALANYLARGINYLLEUCYLLYSYL 2,4 DINITROPHENYLASPARTIC ACID; VALYLSERYLPROLYLARGINYLSERYLPHENYLALANYLGLYCYLLYSYL 2,4 DINITROPHENYLASPARTIC ACID;

ACYLATION; ARTICLE; BLOOD CLOT LYSIS; CATALYSIS; CHEMICAL REACTION KINETICS; CONFORMATIONAL TRANSITION; FRACTIONATION; HEMOSTASIS; HYDROLYSIS; MOLECULAR RECOGNITION; REACTION ANALYSIS;

ALGORITHMS; BINDING SITES; CATALYSIS; DEUTERIUM; FLUORESCENT DYES; HUMANS; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; INDICATORS AND REAGENTS; KINETICS; PROTONS; SOLUTIONS; SPECTROMETRY, FLUORESCENCE; SPECTROPHOTOMETRY, ULTRAVIOLET; THROMBIN;

EID: 2442461173     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0320166     Document Type: Article

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