Role of Hypoxia-Inducible Factor-2α in Endothelial Development and Hematopoiesis

Methods in Enzymology

Volumn 435, Issue , 2007, Pages 199-218

  Ohneda, Osamu ^a,b   Nagano, Masumi ^a,b   Fujii Kuriyama, Yoshiaki ^a,b  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GROWTH FACTOR; HYPOXIA INDUCIBLE FACTOR 2ALPHA; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; ENDOTHELIAL PAS DOMAIN CONTAINING PROTEIN 1; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; UNCLASSIFIED DRUG;

ANGIOGENESIS; CELL FUNCTION; CELL MATURATION; CELL SURVIVAL; EMBRYO DEVELOPMENT; ENDOTHELIUM CELL; GENE TARGETING; HEMATOPOIESIS; HEMATOPOIETIC CELL; IN VIVO STUDY; KNOCKDOWN MOUSE; KNOCKOUT MOUSE; MICROENVIRONMENT; MOUSE STRAIN; NONHUMAN; NULL MOUSE; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; STROMA CELL; ANIMAL; GENETICS; MOUSE; MOUSE MUTANT; PHYSIOLOGY; PRENATAL DEVELOPMENT; VASCULAR ENDOTHELIUM;

MUS;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; ENDOTHELIUM, VASCULAR; HEMATOPOIESIS; MICE; MICE, KNOCKOUT; NEOVASCULARIZATION, PHYSIOLOGIC;

EID: 39749158529     PISSN: 00766879     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0076-6879(07)35011-8     Document Type: Review

References (59)

1. Adelman D.M., Maltepe E., and Simon M.C. Multilineage embryonic hematopoiesis requires hypoxic ARNT activity. Genes & Dev. 13 (1999) 2478-2483
2. Aiello L.P., Pierce E.A., Foley E.D., Takagi H., Chen H., Riddle L., Ferrara N., King G.L., and Smith L.E. Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. Proc. Natl. Acad. Sci. USA 92 (1995) 10457-10461
3. Anagnostou A., Lee E.S., Kessimian N., Levinson R., and Steiner M. Erythropoietin has a mitogenic and positive chemotactic effect on endothelial cells. Proc. Natl. Acad. Sci. USA 87 (1990) 5978-5982
4. Ben-yosef Y., Lahat N., Shapiro S., Bitterman H., and Miller A. Regulation of endothelial matrix metalloproteinase-2 by hypoxia/reoxygenation. Circ. Res. 90 (2002) 784-791
5. Carlini R.G., Alonzo E.J., Dominguez J., Blanca I., Weisinger J.R., Rothstein M., and Bellorin-Font E. Effect of recombinant human erythropoietin on endothelial cell apoptosis. Kidney Int. 55 (1999) 546-553
6. Carmeliet P. Mechanisms of angiogenesis and arteriogenesis. Nature Med. 6 (2000) 389-395
7. Carmeliet P., and Jain R.K. Angiogenesis in cancer and other diseases. Nature 407 (2000) 249-257
8. Ceradini D.J., Kulkarni A.R., Callaghan M.J., Tepper O.M., Bastidas N., Kleinman M.E., Capla J.M., Galiano R.D., Levine J.P., and Gurtner G.C. Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nature Med. 10 (2004) 858-864
9. Chen J., Lansford R., Stewart V., Young F., and Alt F.W. RAG-2-deficient blastocyst complementation: An assay of gene function in lymphocyte development. Proc. Natl. Acad. Sci. USA 90 (1993) 4528-4532
10. Cleaver O., and Melton D.A. Endothelial signaling during development. Nature Med. 9 (2003) 661-668
11. Compernolle V., Brusselmans K., Acker T., Hoet P., Tjwa M., Beck H., Plaisance S., Dor Y., Keshet E., Lupu F., Nemery B., Dewerchin M., et al. Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevent fatal respiratory distress in premature mice. Nature Med. 8 (2002) 702-710
12. Cramer T., Yamanishi Y., Clausen B.E., Förster I., Pawlinski R., Mackman N., Haase V.H., Jaenisch R., Corr M., Nizet V., Firestein G.S., Gerber H.-P., Ferrara N., and Johnson R.S. HIF-1α is essential for myeloid cell-mediated inflammation. Cell 112 (2003) 645-657
13. Currie M.J., Gunningham S.P., Turner K., Han C., Scott P.A., Robinson B.A., Chong W., Harris A.L., and Fox S.B. Expression of the angiopoietins and their receptor Tie2 in human renal clear cell carcinomas; regulation by the von Hippel-Lindau gene and hypoxia. J. Pathol. 198 (2002) 502-510
14. Enholm B., Paavonen K., Ristimäki A., Kumar V., Gunji Y., Klefstrom J., Kivinen L., Laiho M., Olofsson B., Joukov V., Eriksson U., and Alitalo K. Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia. Oncogene 14 (1997) 2475-2483
15. Ferrara N., and Davis-Smyth T. The biology of vascular endothelial growth factor. Endocrine Rev. 18 (1997) 4-25
16. Ferrara N., Carver-Moore K., Chen H., Dowd M., Lu L., O'Shea K.S., Powell-Braxton L., Hillan K.J., and Moore M.W. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380 (1996) 439-442
17. Flamme I., Frolich T., and Risau W. Molecular mechanisms of vasculogenesis and embryonic angiogenesis. J. Cell Physiol. 173 (1997) 206-210
18. Folkman J., and Klagsbrun M. Angiogenic factors. Science 235 (1987) 442-447
19. Gerber H.-P., Condorelli F., Park J., and Ferrara N. Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. J. Biol. Chem. 272 (1997) 23659-23667
20. Hu C.-J., Wang L.-Y., Chodosh L.A., Keith B., and Simon M.C. Differential roles of hypoxia-inducible factor 1alpha (HIF-1α) and HIF-2α in hypoxic gene regulation. Mol. Cell. Biol. 23 (2003) 9361-9374
21. 2 homeostasis by hypoxia-inducible factor 1α. Genes & Dev. 12 (1998) 149-162
22. Kappel A., Rönicke V., Damaert A., Flamme I., Risau W., and Breier G. Identification of vascular endothelial growth factor (VEGF) receptor-2 (flk-1) promoter/enhancer sequences sufficient for angioblast and endothelial cell-specific transcription in transgenic mice. Blood 93 (1999) 4284-4292
23. Kisanuki Y.Y., Hammer R.E., Miyazaki J., Williams S.C., Richardson J.A., and Yanagisawa M. Tie2-Cre transgenic mice: A new model for endothelial cell-lineage analysis in vivo. Dev. Biol. 230 (2001) 230-242
24. Kojima H., Gu H., Nomura S., Cadwell C.C., Kobata T., Carmeliet P., Semenza G.L., and Sitkovsky M.V. Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1α-deficient chimeric mice. Proc. Natl. Acad. Sci. USA 99 (2002) 2170-2174
25. Kotch L.E., Iyer N.V., Laughner E., and Semenza G.L. Defective vascularization of HIF-1α-null embryos is not associated with VEGF deficiency but with mesenchymal cell death. Dev. Biol. 209 (1999) 254-267
26. Kuwabara K., Ogawa S., Matsumoto M., Koga S., Clauss M., Pinsky D.J., Lyn P., Leavy J., Witte L., Joseph-Silverstein J., Furie M.B., Torcia G., et al. Hypoxia-mediated induction of acidic/basic fibroblast growth factor and platelet-derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells. Proc. Natl. Acad. Sci. USA 92 (1995) 4606-4610
27. Makino Y., Cao R., Svensson K., Bertilsson G., Asman M., Tanaka H., Cao Y., Berkenstam A., and Poellinger L. Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature 414 (2001) 550-554
28. Maltepe E., Schmidt J.V., Baunoch D., Bradfield C.A., and Simon M.C. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature 386 (1997) 403-407
29. Miyamoto N., Mandai M., Takagi H., Suzuma I., Suzuma K., Koyama S., Otani A., Oh H., and Honda Y. Contrasting effect of estrogen on VEGF induction under different oxygen status and its role in murine ROP. Invest. Ophthalmol. Vis. Sci. 43 (2002) 2007-2014
30. Morita M., Ohneda O., Yamashita T., Takahashi S., Suzuki N., Nakajima O., Kawauchi S., Ema M., Shibahara S., Udono T., Tomita K., Tamai M., et al. HLF/HIF-2α is key factor in retinopathy of prematurity in association with erythropoietin. EMBO J. 22 (2003) 1134-1146
31. Moss S.E., Klein R., and Klein B.E. Ten-year incidence of visual loss in a diabetic population. Ophthalmology 101 (1994) 1061-1070
32. Nicosia R.F. What is the role of vascular endothelial growth factor-related molecules in tumor angiogenesis?. Am. J. Pathol. 153 (1998) 11-16
33. Niwa H., Araki K., Kimura S., Taniguchi S., Wakasugi S., and Yamamura K. An efficient gene-trap method using poly A trap vectors and characterization of gene-trap events. J. Biochem. (Tokyo) 113 (1993) 343-349
34. Oh H., Takagi H., Suzuma K., Otani A., Matsumura M., and Honda Y. Hypoxia and vascular endothelial growth factor selectively up-regulate angiopoietin-2 in bovine microvascular endothelial cells. J. Biol. Chem. 274 (1999) 15732-15739
35. Ohneda O., Ohneda K., Arai F., Lee J., Miyamoto T., Fukushima Y., Dowbenko D., Lasky L.A., and Suda T. ALCAM (CD166): Its role in hematopoietic and endothelial development. Blood 98 (2001) 2134-2142
36. Ozaki H., Yu A.Y., Della N., Ozaki K., Luna J.D., Yamada H., Hackett S.F., Okamoto N., Zack D.J., Semenza G.L., and Campochiaro P.A. Hypoxia inducible factor-1α is increased in ischemic retina: Temporal and spatial correlation with VEGF expression. Invest. Ophthalmol. Vis. Sci. 40 (1999) 182-189
37. Park S.-K., Dadak A.M., Haase V.H., Fontana L., Giaccia A.J., and Johnson R.S. Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1α (HIF-1α): Role of cytoplasmic trapping of HIF-2α. Mol. Cell. Biol. 23 (2003) 4959-4971
38. Peng J., Zhang L., Drysdale L., and Fong G.-H. The transcription factor EPAS-1/hypoxia-inducible factor-2α plays an important role in vascular remodeling. Proc. Natl, Acad. Sci. USA 97 (2000) 8386-8391
39. Pierce E.A., Avery R.L., Foley E.D., Aiello L.P., and Smith L.E. Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization. Proc. Natl. Acad. Sci. USA 92 (1995) 905-909
40. Prost M. Experimental studies on the pathogenesis of retinopathy of prematurity. Br. J. Ophthalmol. 72 (1988) 363-367
41. Rafii S., and Lyden D. Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration. Nature Med. 9 (2003) 702-712
42. Ramírez-Bergeron D.L., Runge A., Adelman D.M., Gohil M., and Simon M.C. HIF-dependent hematopoietic factors regulate the development of the embryonic vasculature. Dev. Cell 11 (2006) 81-92
43. Ribati D., Presta M., Vacca A., Ria R., Giuliani R., Dell'Era P., Nico B., Roncali L., and Dammacco F. Human erythropoietin induces a pro-angiogenic phenotype in cultured endotherial cells and stimulates neovascularization in vivo. Blood 93 (1999) 2627-2636
44. Risau W. Mechanism of angiogenesis. Nature 386 (1997) 671-674
45. Risau W., and Flamme I. Vasculogenesis. Ann. Rev. Cell. Dev. Biol. 11 (1995) 73-91
46. Ryan H.E., Lo J., and Johnson R.S. HIF-1α is required for solid tumor formation and embryonic vascularization. EMBO J. 17 (1998) 3005-3015
47. Ryan H.E., Poloni M., McNulty W., Elson D., Gassmann M., Arbeit J.M., and Johnson R.S. Hypoxia-inducible factor-1α is a positive factor in solid tumor growth. Cancer Res. 60 (2000) 4010-4015
48. Sadlon T.J., Lewis I.D., and D'Andrea R.J. BMP4: Its role of development of the hematopoietic system and potential as a hematopoietic growth factor. Stem Cells 22 (2004) 457-474
49. Schioppa T., Uranchimeg B., Saccani A., Biswas S.K., Doni A., Raspisarda A., Bernasconi S., Saccani S., Nebuloni M., Vago L., Mantovani A., Melillo G., and Sica A. Regulation of the chemokine receptor CXCR4 by hypoxia. J. Exp. Med. 198 (2003) 1391-1402
50. Scortegagna M., Morris M.A., Oktay Y., Bennett M., and Garci J.A. The HIF family member EPAS1/HIF-2α is required for normal hematopoiesis in mice. Blood 102 (2003) 1634-1640
51. -/- mice. Nature Genet. 35 (2003) 331-340
52. Scortegagna M., Ding K., Zhang Q., Oktay Y., Bennett M.J., Bennett M., Shelton J.M., Richardson J.A., Moe O., and Garcia J.A. HIF-2α regulates murine hematopoietic development in an erythropoietin-dependent manner. Blood 105 (2005) 3133-3140
53. Seo M.S., Kwak N., Ozaki H., Yamada H., Okamoto N., Yamada E., Fabbro D., Hofmann F., Wood J.M., and Campochiaro P.A. Dramatic inhibition of retinal and choroidal neovascularization by oral administration of a kinase inhibitor. Am. J. Pathol. 154 (1999) 1743-1753
54. Smith L.E., Wesolowski E., McLellan A., Kostyk S.K., D'Amato R., Sullivan R., and D'Amore P.A. Oxygen-induced retinopathy in the mouse. Invest. Ophthalmol. Vis. Sci. 35 (1994) 101-111
55. Tang N., Wang L., Esko J., Giordano F.J., Huang Y., Gerber H.-P., Ferrara N., and Johnson R.S. Loss of HIF-1α in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell. 6 (2004) 485-495
56. Tian H., Hammer R.E., Matsumoto A.M., Russell D.W., and McKnight S.L. The hypoxia-responsive transcription factor EPAS-1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes & Dev. 12 (1998) 3320-3324
57. 2 tension. Proc. Natl. Acad. USA 92 (1995) 5510-5514
58. Yancopoulos G.D., Davis S., Gale N.W., Rudge J.S., Wiegand S.J., and Holash J. Vascular-specific growth factors and blood vessel formation. Nature 407 (2000) 242-248
59. Yin T., and Li L. The stem cell niches in bone. J. Clin. Invest. 116 (2006) 1195-1201