Rational design of a novel calcium-binding site adjacent to the ligand-binding site on CD2 increases its CD48 affinity

Protein Science

Volumn 17, Issue 3, 2008, Pages 439-449

  Jones, Lisa M ^a   Yang, Wei ^a   Maniccia, Anna W ^a   Harrison, Alice ^b   Van Der Merwe, P Anton ^b   Yang, Jenny J ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Calcium binding sites; Cell adhesion; Metal selectivity; Metal binding affinity; Rational design

Indexed keywords

CD2 ANTIGEN; CD48 ANTIGEN; DIVALENT CATION; LANTHANIDE; MONOVALENT CATION;

ANTIGEN BINDING; ARTICLE; BETA SHEET; BINDING AFFINITY; BINDING SITE; CALCIUM BINDING; CELL ADHESION; CONFORMATIONAL TRANSITION; ELECTRICITY; LIGAND BINDING; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN FUNCTION; PROTEIN STRUCTURE;

ANTIGENS, CD; ANTIGENS, CD2; BINDING SITES; CALCIUM; CATIONS; CELL ADHESION; ELECTROSTATICS; LANTHANUM; LIGANDS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; TEMPERATURE;

EID: 39549097938     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1110/ps.073328208     Document Type: Article

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