Structural analysis, identification, and design of calcium-binding sites in proteins

Proteins: Structure, Function and Genetics

Volumn 47, Issue 3, 2002, Pages 344-356

  Yang, Wei ^a   Lee, Hsiau Wei ^a   Hellinga, Homme ^b   Yang, Jenny J ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

^b DUKE UNIVERSITY   (United States)

Author keywords

Calcium binding proteins; Computer algorithm; De novo design; EF hand motif; Magnesium binding

Indexed keywords

ALPHA LACTALBUMIN; BINDING PROTEIN; CALBINDIN; CALCIUM; MAGNESIUM; PARVALBUMIN; THERMITASE;

ALGORITHM; ARTICLE; BINDING SITE; CALCIUM BINDING; GEOMETRY; METAL BINDING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN STRUCTURE;

ALGORITHMS; ANIMALS; BINDING SITES; CALCIUM; CALCIUM-BINDING PROTEINS; CALMODULIN; EF HAND MOTIFS; LACTALBUMIN; MAGNESIUM; MODELS, MOLECULAR; PARVALBUMINS; PROTEIN BINDING; SERINE ENDOPEPTIDASES;

EID: 0037093639     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/prot.10093     Document Type: Article

References (42)

1. Protein structure modeling for structural genomics
2. Structural genomics offers high-speed look at proteins
3. The construction of metal centers in proteins by rational design
4. Determinants that govern high-affinity calcium binding
5. Molecular tuning of ion binding to calcium signaling proteins
6. EF-hands embrace
7. Calcium-binding proteins 1: EF-hands
8. Carp muscle calcium-binding protein. II. Structure determination and general description
9. The structure of a calcium-binding protein from carp muscle
10. Parvalbumins and other soluble high-affinity calcium-binding proteins from muscle
11. Calcium - A life and death signal
12. 2+ on target recognition by calmodulin
13. When size is important. Accommodation of magnesium in a calcium binding regulatory domain
14. Battle for the EF-hands: Magnesium-calcium interference in calmodulin
15. Crystal structure determination and refinement of pike 4.10 parvalbumin (minor component from Esox lucius)
16. Ionic interactions with parvalbumins. Crystal structure determination of pike 4.10 parvalbumin in four different ionic environments
17. Calcium-binding sites in proteins: A structural perspective
18. Structural aspects of metal liganding to functional groups in proteins
19. Identifying and designing of calcium binding sites in proteins by computational algorithm
20. The extracellular calcium-sensing receptor: Its role in health and disease
21. The Ca2+(-)binding proteins parvalbumin and oncomodulin and their genes: New structural and functional findings
22. The S100 family of EF-hand calciumbinding proteins: Functions and pathology
23. Predicting Ca(2+)-binding sites in proteins
24. Where metal ions bind in proteins
25. Are predicted structures good enough to preserve functional sites?
26. Construction of new ligand binding sites in proteins of known structure I. Computer-aided modeling of sites with pre-defined geometry
27. The three-dimensional structure of human S100A12
28. Restrained least squares refinement of native (calcium) and cadmium-substituted carp parvalbumin using X-ray crystallographic data at 1.6-Å resolution
29. Proline cis-trans isomers in calbindin D9k observed by X-ray crystallography
30. Refined structure of baboon α-lactalbumin at 1.7 Å resolution
31. Crystal structure of thermitase at 1.4 Å resolution
32. 9K
33. Crystal structures of the helix-loop-helix calcium-binding proteins
34. 9k mutant with reduced calcium affinity and enhanced cooperativity. Metal ion binding, stability, and structural studies
35. Ca2+/Mg2+ exchange in parvalbumin and other EF-hand proteins. A theoretical study
36. The evolution of lysozyme and alpha-lactalbumin
37. Real-space refinement of the structure of hen egg-white lysozyme
38. Crystal structure at 2.8 A resolution of a soluble form of the cell adhesion molecule CD2
39. Structure of the ColE1 Rop protein at 1.7 Å resolution