메뉴 건너뛰기




Volumn 17, Issue 14, 1998, Pages 3921-3930

Ca2+ binding to synaptotagmin: How many Ca2+ ions bind to the tip of a C2-domain?

Author keywords

C2 domain; Ca2+ binding; Protein NMR; Synaptotagmin; Syntaxin

Indexed keywords

CALCIUM BINDING PROTEIN; CALCIUM ION; PHOSPHOLIPID; SYNAPTOTAGMIN; SYNTAXIN; CALCIUM; DIVALENT CATION; HYBRID PROTEIN; MANGANESE; MEMBRANE PROTEIN; NERVE PROTEIN; SYNAPTOTAGMIN I; SYT1 PROTEIN, RAT;

EID: 0032527312     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.14.3921     Document Type: Article
Times cited : (260)

References (45)
  • 2
    • 0026778460 scopus 로고
    • Syntaxin: A synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones
    • Bennett,M., Calakos,N. and Scheller,R.H. (1992) Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones. Science, 257, 255-259.
    • (1992) Science , vol.257 , pp. 255-259
    • Bennett, M.1    Calakos, N.2    Scheller, R.H.3
  • 3
    • 36849117843 scopus 로고
    • Proton relaxation times in paramagnetic solutions
    • Bloembergen,N. (1957) Proton relaxation times in paramagnetic solutions. J. Chem. Phys., 27, 572-573.
    • (1957) J. Chem. Phys. , vol.27 , pp. 572-573
    • Bloembergen, N.1
  • 4
    • 0000195671 scopus 로고
    • Natural abundance nitrogen-15 NMR by enhanced heteronuclear spectroscopy
    • Bodenhausen,G. and Ruben,D.J. (1980) Natural abundance nitrogen-15 NMR by enhanced heteronuclear spectroscopy. Chem. Phys. Lett., 69, 185-199.
    • (1980) Chem. Phys. Lett. , vol.69 , pp. 185-199
    • Bodenhausen, G.1    Ruben, D.J.2
  • 5
    • 0027269605 scopus 로고
    • Inhibition of neurotransmitter release by C2- Domain peptides implicates synaptotagmin in exocytosis
    • Bommert,K., Charlton,M.P., DeBello,W.M., Chin,G.J., Betz,H. and Augustine,G.J. (1993) Inhibition of neurotransmitter release by C2- domain peptides implicates synaptotagmin in exocytosis. Nature, 363, 163-165.
    • (1993) Nature , vol.363 , pp. 163-165
    • Bommert, K.1    Charlton, M.P.2    Debello, W.M.3    Chin, G.J.4    Betz, H.5    Augustine, G.J.6
  • 6
    • 0026631563 scopus 로고
    • Synaptotagmin: A calcium sensor on the synaptic vesicle surface
    • Brose,N., Petrenko,A.G., Südhof,T.C. and Jahn,R. (1992) Synaptotagmin: a calcium sensor on the synaptic vesicle surface. Science, 256, 1021-1025.
    • (1992) Science , vol.256 , pp. 1021-1025
    • Brose, N.1    Petrenko, A.G.2    Südhof, T.C.3    Jahn, R.4
  • 8
    • 33845378943 scopus 로고
    • 1H NMR spectra via two-dimensional homonuclear Hartmann-Hahn spectroscopy
    • 1H NMR spectra via two-dimensional homonuclear Hartmann-Hahn spectroscopy. J. Am. Chem. Soc., 107, 2820-2821.
    • (1985) J. Am. Chem. Soc. , vol.107 , pp. 2820-2821
    • Davis, D.G.1    Bax, A.2
  • 10
    • 0028351171 scopus 로고
    • The effect on synaptic physiology of synaptotagmin mutations in Drosophila
    • DiAntonio,A. and Schwarz,T.L. (1994) The effect on synaptic physiology of synaptotagmin mutations in Drosophila. Neuron, 12, 909-920.
    • (1994) Neuron , vol.12 , pp. 909-920
    • Diantonio, A.1    Schwarz, T.L.2
  • 11
    • 0027459033 scopus 로고
    • A role for synaptotagmin (p65) in regulated exocytosis
    • Elferink,L.A., Peterson,M.R. and Scheller,R.H. (1993) A role for synaptotagmin (p65) in regulated exocytosis. Cell, 72, 153-159.
    • (1993) Cell , vol.72 , pp. 153-159
    • Elferink, L.A.1    Peterson, M.R.2    Scheller, R.H.3
  • 12
    • 0029924329 scopus 로고    scopus 로고
    • Crystal structure of a mammalian phosphoinositide-specific phospholipase Cδ
    • Essen,L.-O., Perisic,O., Cheung,R., Katan,M. and Williams,R.L. (1996) Crystal structure of a mammalian phosphoinositide-specific phospholipase Cδ. Nature, 380, 595-602.
    • (1996) Nature , vol.380 , pp. 595-602
    • Essen, L.-O.1    Perisic, O.2    Cheung, R.3    Katan, M.4    Williams, R.L.5
  • 16
    • 0027399659 scopus 로고
    • Interaction of synaptotagmin with the cytoplasmic domains of neurexins
    • Hata,Y., Davletov,B., Petrenko,A.G., Jahn,R. and Südhof,T.C. (1993) Interaction of synaptotagmin with the cytoplasmic domains of neurexins. Neuron, 10, 307-315.
    • (1993) Neuron , vol.10 , pp. 307-315
    • Hata, Y.1    Davletov, B.2    Petrenko, A.G.3    Jahn, R.4    Südhof, T.C.5
  • 17
    • 0028023444 scopus 로고
    • Calcium dependence of the rate of exocytosis in a synaptic terminal
    • Heidelberger,R., Heinemann,C., Neher,E. and Mathews,G. (1994) Calcium dependence of the rate of exocytosis in a synaptic terminal. Nature, 371, 513-515.
    • (1994) Nature , vol.371 , pp. 513-515
    • Heidelberger, R.1    Heinemann, C.2    Neher, E.3    Mathews, G.4
  • 18
    • 0029917101 scopus 로고    scopus 로고
    • Localization of synaptotagmin-binding domains on syntaxin
    • Kee,Y. and Scheller,R.H. (1996) Localization of synaptotagmin-binding domains on syntaxin. J. Neurosci., 16, 1975-1981.
    • (1996) J. Neurosci. , vol.16 , pp. 1975-1981
    • Kee, Y.1    Scheller, R.H.2
  • 20
    • 0029894147 scopus 로고    scopus 로고
    • The role of Glu57 in the mechanism of the Escherichia coli MutT enzyme by mutagenesis and heteronuclear NMR
    • Lin,J., Abeygunawardana,C., Frick,D.N., Bessman,M.J. and Mildvan,A.S. (1996) The role of Glu57 in the mechanism of the Escherichia coli MutT enzyme by mutagenesis and heteronuclear NMR. Biochemistry, 35, 6715-6726.
    • (1996) Biochemistry , vol.35 , pp. 6715-6726
    • Lin, J.1    Abeygunawardana, C.2    Frick, D.N.3    Bessman, M.J.4    Mildvan, A.S.5
  • 23
    • 0014717220 scopus 로고
    • Aspects of enzyme mechanisms studied by nuclear spin relaxation induced by paramagnetic probes
    • Mildvan,A.S. and Cohn,M. (1970) Aspects of enzyme mechanisms studied by nuclear spin relaxation induced by paramagnetic probes. Adv. Enzymol. Relat. Areas Mol. Biol., 33, 1-70.
    • (1970) Adv. Enzymol. Relat. Areas Mol. Biol. , vol.33 , pp. 1-70
    • Mildvan, A.S.1    Cohn, M.2
  • 24
    • 0029980542 scopus 로고    scopus 로고
    • Structural basis of calcium-induced E-cadherin rigidification and dimerization
    • Nagar,B., Overduin,M., Ikura,M. and Rini,J.M. (1996) Structural basis of calcium-induced E-cadherin rigidification and dimerization. Nature, 380, 360-364.
    • (1996) Nature , vol.380 , pp. 360-364
    • Nagar, B.1    Overduin, M.2    Ikura, M.3    Rini, J.M.4
  • 25
    • 0030467967 scopus 로고    scopus 로고
    • The C2 domain calcium-binding motif: Structural and functional diversity
    • Nalefski,E.A. and Falke,J.J. (1996) The C2 domain calcium-binding motif: structural and functional diversity. Protein Sci., 5, 2375-2390.
    • (1996) Protein Sci. , vol.5 , pp. 2375-2390
    • Nalefski, E.A.1    Falke, J.J.2
  • 27
    • 0026319199 scopus 로고
    • Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons
    • Nicholls,A., Sharp,K.A. and Honig,B. (1991) Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. Proteins, 11, 281-296.
    • (1991) Proteins , vol.11 , pp. 281-296
    • Nicholls, A.1    Sharp, K.A.2    Honig, B.3
  • 28
    • 0027319325 scopus 로고
    • Synaptic function is impaired but not eliminated in C.elegans mutants lacking synaptotagmin
    • Nonet,M.L., Grundahl,K., Meyer,B.J. and Rand,J.B. (1993) Synaptic function is impaired but not eliminated in C.elegans mutants lacking synaptotagmin. Cell, 73, 1291-1305.
    • (1993) Cell , vol.73 , pp. 1291-1305
    • Nonet, M.L.1    Grundahl, K.2    Meyer, B.J.3    Rand, J.B.4
  • 29
    • 0025270739 scopus 로고
    • Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C
    • Perin,M.S., Fried,V.A., Mignery,G.A., Jahn,R. and Sudhof,T.C. (1990) Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C. Nature, 345, 260-263.
    • (1990) Nature , vol.345 , pp. 260-263
    • Perin, M.S.1    Fried, V.A.2    Mignery, G.A.3    Jahn, R.4    Sudhof, T.C.5
  • 30
    • 0026088029 scopus 로고
    • Structural and functional conservation of synaptotagmin (p65) in Drosophila and humans
    • Perin,M.S., Johnston,P.A., Özcelik,T., Jahn,R., Francke,U. and Südhof,T.C. (1991a) Structural and functional conservation of synaptotagmin (p65) in Drosophila and humans. J. Biol. Chem., 266, 615-622.
    • (1991) J. Biol. Chem. , vol.266 , pp. 615-622
    • Perin, M.S.1    Johnston, P.A.2    Özcelik, T.3    Jahn, R.4    Francke, U.5    Südhof, T.C.6
  • 32
    • 0031892519 scopus 로고    scopus 로고
    • Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2
    • Perisic,O., Fong,S., Lynch,D.E., Bycroft,M. and Williams,R.L. (1998) Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2. J. Biol. Chem., 273, 1596-1604.
    • (1998) J. Biol. Chem. , vol.273 , pp. 1596-1604
    • Perisic, O.1    Fong, S.2    Lynch, D.E.3    Bycroft, M.4    Williams, R.L.5
  • 33
    • 0025776680 scopus 로고
    • Binding of synaptotagmin to the alpha- Latrotoxin receptor implicates both in synaptic vesicle exocytosis
    • Petrenko,A.G., Perin,M.S., Davletov,B.A., Ushkaryov,Y.A., Geppert,M. and Südhof,T.C. (1991) Binding of synaptotagmin to the alpha- latrotoxin receptor implicates both in synaptic vesicle exocytosis. Nature, 353, 65-68.
    • (1991) Nature , vol.353 , pp. 65-68
    • Petrenko, A.G.1    Perin, M.S.2    Davletov, B.A.3    Ushkaryov, Y.A.4    Geppert, M.5    Südhof, T.C.6
  • 35
    • 0029058492 scopus 로고
    • Membrane trafficking in the presynaptic nerve terminal
    • Scheller,R.H. (1995) Membrane trafficking in the presynaptic nerve terminal. Neuron, 14, 893-897.
    • (1995) Neuron , vol.14 , pp. 893-897
    • Scheller, R.H.1
  • 39
    • 0029026392 scopus 로고
    • The synaptic vesicle cycle: A cascade of protein- Protein interactions
    • Südhof,T.C. (1995) The synaptic vesicle cycle: a cascade of protein- protein interactions. Nature, 375, 645-653.
    • (1995) Nature , vol.375 , pp. 645-653
    • Südhof, T.C.1
  • 40
    • 0030222771 scopus 로고    scopus 로고
    • 2-domain proteins that regulate membrane traffic
    • 2-domain proteins that regulate membrane traffic. Neuron, 17, 379-388.
    • (1996) Neuron , vol.17 , pp. 379-388
    • Sudhof, T.C.1    Rizo, J.2
  • 44
    • 0028541866 scopus 로고
    • 15N assignments of the N-terminal SH3 domain of drk in folded and unfolded states using enhanced-sensitivity pulsed field gradient NMR techniques
    • 15N assignments of the N-terminal SH3 domain of drk in folded and unfolded states using enhanced-sensitivity pulsed field gradient NMR techniques. J. Biomol. NMR, 4, 845-858.
    • (1994) J. Biomol. NMR , vol.4 , pp. 845-858
    • Zhang, O.1    Kay, L.E.2    Olivier, J.P.3    Forman-Kay, J.D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.