메뉴 건너뛰기




Volumn 19, Issue 2, 2008, Pages 167-178

Lentiviral vectors mediate nonimmunosuppressive rapamycin analog-induced production of secreted therapeutic factors in the brain: Regulation at the level of transcription and exocytosis

Author keywords

[No Author keywords available]

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GREEN FLUORESCENT PROTEIN; IMMUNOSUPPRESSIVE AGENT; LENTIVIRUS VECTOR; POLYPEPTIDE; RAPAMYCIN;

EID: 39449107752     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.2007.125     Document Type: Article
Times cited : (12)

References (39)
  • 2
    • 30344473326 scopus 로고    scopus 로고
    • Efficient control of gene expression in the hematopoietic system using a single Tet-on inducible lentiviral vector
    • BARDE, I., ZANTA-BOUSSIF, M.A., PAISANT, S., LEBOEUF, M., RAMEAU, P., DELENDA, C., and DANOS, O. (2006). Efficient control of gene expression in the hematopoietic system using a single Tet-on inducible lentiviral vector. Mol. Ther. 13, 382-390.
    • (2006) Mol. Ther , vol.13 , pp. 382-390
    • BARDE, I.1    ZANTA-BOUSSIF, M.A.2    PAISANT, S.3    LEBOEUF, M.4    RAMEAU, P.5    DELENDA, C.6    DANOS, O.7
  • 3
    • 0343517507 scopus 로고    scopus 로고
    • Lentiviral vectors as gene delivery systems in the mouse midbrain: Cellular and behavioral improvements in a 6-OHDA model of Parkinson's disease using GDNF
    • BENSADOUN, J.-C., DÉGLON, N., TSENG, J.L., RIDET, J.-L., ZURN, A.D., and AEBISCHER, P. (2000). Lentiviral vectors as gene delivery systems in the mouse midbrain: Cellular and behavioral improvements in a 6-OHDA model of Parkinson's disease using GDNF. Exp. Neurol. 164, 15-24.
    • (2000) Exp. Neurol , vol.164 , pp. 15-24
    • BENSADOUN, J.-C.1    DÉGLON, N.2    TSENG, J.L.3    RIDET, J.-L.4    ZURN, A.D.5    AEBISCHER, P.6
  • 4
    • 0030795798 scopus 로고    scopus 로고
    • Intrastriatal injection of an adenoviral vector expressing glial cell line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson's disease
    • BILANG-BLEUEL, A., REVAH, F., COLIN, P., LOCQUET, I., ROBERT, J.J., MALLET, J., and HORELLOU, P. (1997). Intrastriatal injection of an adenoviral vector expressing glial cell line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson's disease. Proc. Natl. Acad. Sci. U.S.A. 94, 8818-8823.
    • (1997) Proc. Natl. Acad. Sci. U.S.A , vol.94 , pp. 8818-8823
    • BILANG-BLEUEL, A.1    REVAH, F.2    COLIN, P.3    LOCQUET, I.4    ROBERT, J.J.5    MALLET, J.6    HORELLOU, P.7
  • 5
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • BRADFORD, M.M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
    • (1976) Anal. Biochem , vol.72 , pp. 248-254
    • BRADFORD, M.M.1
  • 6
    • 0019551730 scopus 로고
    • Western blotting: Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A
    • BURNETTE, W.N. (1981). "Western blotting": Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. Anal. Biochem. 112, 195-203.
    • (1981) Anal. Biochem , vol.112 , pp. 195-203
    • BURNETTE, W.N.1
  • 8
    • 0032716172 scopus 로고    scopus 로고
    • Long-term doxycycline-controlled expression of human tyrosine hydroxylase after direct adenovirus-mediated gene transfer to a rat model of Parkinson's disease
    • CORTI, O., SANCHEZ-CAPELO, A., COLIN, P., HANOUN, N., HAMON, M., and MALLET, J. (1999). Long-term doxycycline-controlled expression of human tyrosine hydroxylase after direct adenovirus-mediated gene transfer to a rat model of Parkinson's disease. Proc. Natl. Acad. Sci. U.S.A. 96, 12120-12125.
    • (1999) Proc. Natl. Acad. Sci. U.S.A , vol.96 , pp. 12120-12125
    • CORTI, O.1    SANCHEZ-CAPELO, A.2    COLIN, P.3    HANOUN, N.4    HAMON, M.5    MALLET, J.6
  • 9
    • 0028903353 scopus 로고
    • A human retinal pigment epithelial cell line that retains epithelial characteristics after prolonged culture
    • DAVIS, A.A., BERNSTEIN, P.S., BOK, D., TURNER, J., NACHTIGAL, M., and HUNT, R.C. (1995). A human retinal pigment epithelial cell line that retains epithelial characteristics after prolonged culture. Invest. Ophthalmol. Vis. Sci. 36, 955-964.
    • (1995) Invest. Ophthalmol. Vis. Sci , vol.36 , pp. 955-964
    • DAVIS, A.A.1    BERNSTEIN, P.S.2    BOK, D.3    TURNER, J.4    NACHTIGAL, M.5    HUNT, R.C.6
  • 10
    • 0034882656 scopus 로고    scopus 로고
    • Dose-dependent effects of central leptin gene therapy on genes that regulate body weight and appetite in the hypothalamus
    • DHILLON, H., KALRA, S.P., and KALRA, P.S. (2001). Dose-dependent effects of central leptin gene therapy on genes that regulate body weight and appetite in the hypothalamus. Mol. Ther. 4, 139-145.
    • (2001) Mol. Ther , vol.4 , pp. 139-145
    • DHILLON, H.1    KALRA, S.P.2    KALRA, P.S.3
  • 13
    • 0035121677 scopus 로고    scopus 로고
    • The impact of mammalian gene regulation concepts on functional genomic research, metabolic engineering, and advanced gene therapies
    • FUSSENEGGER, M. (2001). The impact of mammalian gene regulation concepts on functional genomic research, metabolic engineering, and advanced gene therapies. Biotechnol Prog. 17, 1-51.
    • (2001) Biotechnol Prog , vol.17 , pp. 1-51
    • FUSSENEGGER, M.1
  • 14
    • 0036434879 scopus 로고    scopus 로고
    • Aberrant sprouting and downregulation of tyrosine hydroxylase in lesioned nigrostriatal dopamine neurons induced by long-lasting overexpression of glial cell line-derived neurotrophic factor in the striatum by lentiviral gene transfer
    • GEORGIEVSKA, B., KIRIK, D., and BJÖRKLUND, A. (2002). Aberrant sprouting and downregulation of tyrosine hydroxylase in lesioned nigrostriatal dopamine neurons induced by long-lasting overexpression of glial cell line-derived neurotrophic factor in the striatum by lentiviral gene transfer. Exp. Neurol. 177, 461-474.
    • (2002) Exp. Neurol , vol.177 , pp. 461-474
    • GEORGIEVSKA, B.1    KIRIK, D.2    BJÖRKLUND, A.3
  • 15
    • 3242762057 scopus 로고    scopus 로고
    • Overexpression of glial cell line-derived neurotrophic factor using a lentiviral vector induces time- and dose-dependent downregulation of tyrosine hydroxylase in the intact nigrostriatal dopamine system
    • GEORGIEVSKA, B., KIRIK, D., and BJÖRKLUND, A. (2004). Overexpression of glial cell line-derived neurotrophic factor using a lentiviral vector induces time- and dose-dependent downregulation of tyrosine hydroxylase in the intact nigrostriatal dopamine system. J. Neurosci. 24, 6437-6445.
    • (2004) J. Neurosci , vol.24 , pp. 6437-6445
    • GEORGIEVSKA, B.1    KIRIK, D.2    BJÖRKLUND, A.3
  • 16
    • 0026720075 scopus 로고
    • Tight control of gene expression in mammalian cells by tetracycline responsive promoters
    • GOSSEN, M., and BUJARD, H. (1992). Tight control of gene expression in mammalian cells by tetracycline responsive promoters. Proc. Natl. Acad. Sci. U.S.A. 89, 5547-5551.
    • (1992) Proc. Natl. Acad. Sci. U.S.A , vol.89 , pp. 5547-5551
    • GOSSEN, M.1    BUJARD, H.2
  • 17
    • 0034659835 scopus 로고    scopus 로고
    • Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: Intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system
    • KIRIK, D., ROSENBLAD, C., BJÖRKLUND, A., and MANDEL R.J. (2000). Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: Intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system. J. Neurosci. 20, 4686-4700.
    • (2000) J. Neurosci , vol.20 , pp. 4686-4700
    • KIRIK, D.1    ROSENBLAD, C.2    BJÖRKLUND, A.3    MANDEL, R.J.4
  • 20
    • 0035664438 scopus 로고    scopus 로고
    • Glial cell line derived neurotrophic factor delays photoreceptor degeneration in a transgenic rat model of retinitis pigmentosa
    • MCGEE SANFTNER, L.H., ABEL, H., HAUSWIRTH, W.W., and FLANNERY, J.G. (2001). Glial cell line derived neurotrophic factor delays photoreceptor degeneration in a transgenic rat model of retinitis pigmentosa. Mol. Ther. 4, 622-629.
    • (2001) Mol. Ther , vol.4 , pp. 622-629
    • MCGEE SANFTNER, L.H.1    ABEL, H.2    HAUSWIRTH, W.W.3    FLANNERY, J.G.4
  • 21
    • 1842527497 scopus 로고    scopus 로고
    • Regulated expression of pdx-1 promotes in vitro differentiation of insulin-producing cells from embryonic stem cells
    • MIYAZAKI, S., YAMATO, E., and MIYAZAKI, J.-I. (2004). Regulated expression of pdx-1 promotes in vitro differentiation of insulin-producing cells from embryonic stem cells. Diabetes 53, 1030-1037.
    • (2004) Diabetes , vol.53 , pp. 1030-1037
    • MIYAZAKI, S.1    YAMATO, E.2    MIYAZAKI, J.-I.3
  • 22
    • 0034700090 scopus 로고    scopus 로고
    • Delivery of a stringent dimerizer-regulated gene expression system in a single retroviral vector
    • POLLOCK, R., ISSNER, R., ZOLLER, K., NATESAN, S., RIVERA, V.M., and CLACKSON, T. (2000). Delivery of a stringent dimerizer-regulated gene expression system in a single retroviral vector. Proc. Natl. Acad. Sci. U.S.A. 97, 13221-13226.
    • (2000) Proc. Natl. Acad. Sci. U.S.A , vol.97 , pp. 13221-13226
    • POLLOCK, R.1    ISSNER, R.2    ZOLLER, K.3    NATESAN, S.4    RIVERA, V.M.5    CLACKSON, T.6
  • 23
    • 0035989652 scopus 로고    scopus 로고
    • Regulation of endogenous gene expression with a small-molecule dimerizer
    • POLLOCK, R., GIEL, M., LINHER, K., and CLACKSON, T. (2002). Regulation of endogenous gene expression with a small-molecule dimerizer. Nat. Biotechnol. 20, 729-733.
    • (2002) Nat. Biotechnol , vol.20 , pp. 729-733
    • POLLOCK, R.1    GIEL, M.2    LINHER, K.3    CLACKSON, T.4
  • 27
    • 20744460735 scopus 로고    scopus 로고
    • Long-term glial cell line-derived neurotrophic factor overexpression in the intact nigrostriatal system in rats leads to a decrease of dopamine and increase of tetrahydrobiopterin production
    • SAJADI, A., BAUER, M., THÖNY, B., and AEBISCHER, P. (2005). Long-term glial cell line-derived neurotrophic factor overexpression in the intact nigrostriatal system in rats leads to a decrease of dopamine and increase of tetrahydrobiopterin production. J. Neurochem. 93, 1482-1486.
    • (2005) J. Neurochem , vol.93 , pp. 1482-1486
    • SAJADI, A.1    BAUER, M.2    THÖNY, B.3    AEBISCHER, P.4
  • 30
    • 0034608802 scopus 로고    scopus 로고
    • Exploring the sequence space for tetracycline-dependent transcriptional activators: Novel mutations yield expanded range and sensitivity
    • URLINGER, S., BARON, U., THELLMANN, M., HASAN, M.T., BUJARD, H., and HILLEN, W. (2000). Exploring the sequence space for tetracycline-dependent transcriptional activators: Novel mutations yield expanded range and sensitivity. Proc. Natl. Acad. Sci. U.S.A. 97, 7963-7968.
    • (2000) Proc. Natl. Acad. Sci. U.S.A , vol.97 , pp. 7963-7968
    • URLINGER, S.1    BARON, U.2    THELLMANN, M.3    HASAN, M.T.4    BUJARD, H.5    HILLEN, W.6
  • 31
    • 0036193248 scopus 로고    scopus 로고
    • Robust and efficient regulation of transgene expression in vivo by improved tetracycline-dependent lentiviral vectors
    • VIGNA, E., CAVALIERI, S., AILLES, L., GEUNA, M., LOEW, R., BUJARD, H., and NALDINI, L. (2002). Robust and efficient regulation of transgene expression in vivo by improved tetracycline-dependent lentiviral vectors. Mol. Ther. 5, 252-261.
    • (2002) Mol. Ther , vol.5 , pp. 252-261
    • VIGNA, E.1    CAVALIERI, S.2    AILLES, L.3    GEUNA, M.4    LOEW, R.5    BUJARD, H.6    NALDINI, L.7
  • 32
    • 1142285223 scopus 로고    scopus 로고
    • A single lentivirus vector mediates doxycycline-regulated expression of transgenes in the brain
    • VOGEL, R., AMAR, L., DO THI, A., SAILLOUR, P., and MALLET, J. (2004). A single lentivirus vector mediates doxycycline-regulated expression of transgenes in the brain. Hum. Gene Ther. 15, 157-165.
    • (2004) Hum. Gene Ther , vol.15 , pp. 157-165
    • VOGEL, R.1    AMAR, L.2    DO THI, A.3    SAILLOUR, P.4    MALLET, J.5
  • 33
    • 0037104725 scopus 로고    scopus 로고
    • Neuroprotective effects of glial cell line-derived neurotrophic factor mediated by an adeno-associated virus vector in a transgenic animal model of amyotrophic lateral sclerosis
    • WANG, L.-J., LU, Y.Y., MURAMATSU, S., IKEGUCHI, K., FUJIMOTO, K., OKADA, T., MIZUKAMI, H., MATSUSHITA, T., HANAZONO, Y., KUME, A., NAGATSU, T., OZAWA, K., and NAKANO, I. (2002). Neuroprotective effects of glial cell line-derived neurotrophic factor mediated by an adeno-associated virus vector in a transgenic animal model of amyotrophic lateral sclerosis. J. Neurosci. 22, 6920-6928.
    • (2002) J. Neurosci , vol.22 , pp. 6920-6928
    • WANG, L.-J.1    LU, Y.Y.2    MURAMATSU, S.3    IKEGUCHI, K.4    FUJIMOTO, K.5    OKADA, T.6    MIZUKAMI, H.7    MATSUSHITA, T.8    HANAZONO, Y.9    KUME, A.10    NAGATSU, T.11    OZAWA, K.12    NAKANO, I.13
  • 36
    • 0036426634 scopus 로고    scopus 로고
    • Tetracycline-controlled transcriptional regulation systems: Advances and application in transgenic animal modelling
    • ZHU, Z., ZHENG, T., LEE, C.G., HOMER, R.J., and ELIAS, J.A. (2002). Tetracycline-controlled transcriptional regulation systems: Advances and application in transgenic animal modelling. Semin. Cell. Dev. Biol. 13, 121-128.
    • (2002) Semin. Cell. Dev. Biol , vol.13 , pp. 121-128
    • ZHU, Z.1    ZHENG, T.2    LEE, C.G.3    HOMER, R.J.4    ELIAS, J.A.5
  • 37
    • 0030819379 scopus 로고    scopus 로고
    • Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo
    • ZUFFEREY, R., NAGY, D., MANDEL, R.J., NALDINI, L., and TRONO, D. (1997). Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo. Nat. Biotechnol. 15, 871-875.
    • (1997) Nat. Biotechnol , vol.15 , pp. 871-875
    • ZUFFEREY, R.1    NAGY, D.2    MANDEL, R.J.3    NALDINI, L.4    TRONO, D.5
  • 38
    • 0031743608 scopus 로고    scopus 로고
    • Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery
    • ZUFFEREY, R., DULL, T., MANDEL, R.J., BUKOVSKY, A., QUIROZ, D., NALDINI, L., and TRONO, D. (1998). Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery. J. Virol. 72, 9873-9880.
    • (1998) J. Virol , vol.72 , pp. 9873-9880
    • ZUFFEREY, R.1    DULL, T.2    MANDEL, R.J.3    BUKOVSKY, A.4    QUIROZ, D.5    NALDINI, L.6    TRONO, D.7
  • 39
    • 0032978712 scopus 로고    scopus 로고
    • Woodchuck hepatitis virus posttrancriptional regulatory element enhances expression of transgenes delivered by retroviral vectors
    • ZUFFEREY, R., DONELLO, J.E., TRONO, D., and HOPE, T.J. (1999). Woodchuck hepatitis virus posttrancriptional regulatory element enhances expression of transgenes delivered by retroviral vectors. J. Virol. 73, 2886-2892.
    • (1999) J. Virol , vol.73 , pp. 2886-2892
    • ZUFFEREY, R.1    DONELLO, J.E.2    TRONO, D.3    HOPE, T.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.