Rapid estrogen signaling in the brain

NeuroSignals

Volumn 16, Issue 2-3, 2008, Pages 140-153

  Raz, Limor ^a   Khan, Mohammad M ^a   Mahesh, Virendra B ^a   Vadlamudi, Ratna K ^b   Brann, Darrell W ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

Estradiol, nongenomic; Estrogen receptor; GPR30 synapse; Kinase; Membrane; Neuron

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CALCIUM CHANNEL; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; ESTRADIOL; ESTROGEN RECEPTOR; G PROTEIN COUPLED RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; SCAFFOLD PROTEIN;

BRAIN REGION; CANCER CELL CULTURE; ELECTROPHYSIOLOGY; HOMEOSTASIS; HUMAN; NERVE CELL; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; REVIEW;

ANIMALS; BRAIN; ESTROGENS; HUMANS; NEURONAL PLASTICITY; RECEPTORS, ESTROGEN; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 39349110405     PISSN: 1424862X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000111559     Document Type: Review

References (129)

1. Brann DW, Dhandapandi KM, Wakade C, Mahesh VB, Khan MM: Neurotrophic and neuroprotective actions of estrogen: basic mechanisms and clinical implications. Steroids 2007;72:381-405.
2. Petersen SL, Ottem EN, Carpenter CD: Direct and indirect regulation of gonadotropin-releasing hormone neurons by estrogen. Biol Reprod 2003;69:17771-17778.
3. Kelly MJ, Qiu J, Ronnekleiv OK: Estrogen signaling in the hypothalamus. Vitam Horm 2005;71:123-145.
4. Brann DW, Mills TM, Mahesh VB: Female reproduction: the ovulatory cycle; in Witorsch RJ (ed): Reproductive Toxicology, ed 2. New York, Raven Press, 1995, pp 23-44.
5. McEwen BS, Alves SE: Estrogen actions in the central nervous system. Endocr Rev 1999;20:279-307.
6. Teede HJ: Sex hormones and the cardiovascular system: effects on arterial function in women. Clin Exp Pharmacol Physiol 2007;34:672-676.
7. Turner RT, Riggs BL, Spelsberg TC: Skeletal effects of estrogen. Endocr Rev 1994;15:275-300.
8. Henderson VW: Estrogen-containing hormone therapy and Alzheimer's disease risk: understanding discrepant inferences from observational and experimental research. Neuroscience 2006;138:1031-1039.
9. Sherwin BB: Estrogen and cognitive functioning in women. Endocr Rev 2003;24:133-151.
10. Yang SH, Liu R, Perez EJ, Wang X, Simpkins JW: Estrogens as protectants of the neurovascular unit against ischemic stroke. Curr Drug Targets CNS Neurol Disord 2005;4:169-177.
11. Dhandapani KM, Brann DW: Protective effects of estrogen and selective estrogen receptor modulators in the brain. Biol Reprod 2002;67:1379-1385.
12. Callier S, Morissette M, Grandbois M, Di Paolo T: Stereospecific prevention by 17beta-estradiol of MPTP-induced dopamine depletion in mice. Synapse 2000;37:245-251.
13. Dluzen D, Horstink M: Estrogen as neuroprotectant of nigrostriatal dopaminergic system: laboratory and clinical studies. Endocrine 2003;21:67-75.
14. O'Lone R, Frith MC, Karlsson EK, Hansen U: Genomic targets of nuclear estrogen receptors. Mol Endocrinol 2004;18:1859-1875.
15. Brann DW, Hendry LB, Mahesh VB: emerging diversities in the mechanism of action of steroid hormones. J Steroid Biochem Mol Biol 1955;52:113-133.
16. Manavathi B, Kumar R: Steering estrogen signals from the plasma membrane to the nucleus: two sides of the coin. J Cell Physiol 2006;207:594-604.
17. Moriarty K, Kim KH, Bender JR: Minireview: estrogen receptor-mediated rapid signaling. Endocrinology 2006;147:5557-5563.
18. Mhyre AJ, Dorsa DM: Estrogen activates rapid signaling in the brain: role of estrogen receptor alpha and estrogen receptor beta in neurons and glia. Neuroscience 2006;138:851-858.
19. Boonyaratanakornkit V, Edwards DP: Receptor mechanisms mediating non-genomic actions of sex steroids. Semin Reprod Med 2007;25:139-153.
20. Hall JM, Couse JF, Korach KS: The multifaceted mechanisms of estradiol and estrogen receptor signaling. J Biol Chem 2001;276:36869-36872.
21. Levin ER: Integration of the extranuclear and nuclear actions of estrogen. Mol Endocrinol 2005;19:1951-1959.
22. Lincoln DW: Unit activity in the hypothalamus, septum and preoptic area of the rat: characteristics of spontaneous activity and the effect of estrogen. J Endocrinol 1967;37:177-189.
23. Bueno J, Pfaff DW: Single unit recordings in the hypothalamus and preoptic area of estrogen-treated and untreated ovariectomized rats. Brain Res 1976;101:67-78.
24. Yagi K: Changes in firing rates of single preoptic and hypothalamic units following an intravenous administration of estrogen in the castrated female rat. Brain Res 1973;53:343-352.
25. Dufy B, Partouche C, Poulain D, Dufy-Barbe L, Vincent JD: Effects of estrogen on the electrical activity of identified and unidentified hypothalamic units. Neuroendocrinology 1976;22:38-47.
26. Kelly MJ, Moss RL, Dudley CA: Differential sensitivity of preoptic-septal neurons to microelectrophoresed estrogen during the estrous cycle. Brain Res 1976;114:152-157.
27. Kelly MJ, Moss RL, Dudley CA: The effects of microelectrophoretically applied estrogen, cortisol and acetylcholine on medial preoptic-septal unit activity throughout the estrous cycle of the female rat. Exp Brain Res 1977;30:53-64.
28. Kelly MJ, Moss RL, Dudley CA. Fawcett CP: The specificity of the response of preopticseptal area neurons to estrogen: 17α-estradiol versus 17β-estradiol and the response of extrahypothalamic neurons. Exp Brain Res 1977;30:43-52.
29. Kelly MJ, Moss RL, Dudley CA: The effects of ovariectomy on the responsiveness of preoptic-septal neurons to microlectrophoresed estrogen. Neuroendocrinology 1978;25:204-211.
30. Nakekura J, Oomura Y, Minami T, Mizuno Y, Fukuda A: Mechanism of the rapid effect of 17β-estradiol on medial amygdala neurons. Science 1986;232:226-228.
31. Smith S: The effects of estrogen and progesterone on GABA and glutamate responses at extrahypothalmic sites; in Costa E, Paul S: Neurosteroids and Brain Function. New York, Thieme Medical Publishers, 1991, pp 87-94.
32. Wong M, Moss RL: Long-term and short-term electrophysiological effects of estrogen on the synaptic properties of hippocampal CA1 neurons. J Neurosci 1992;12:3217-3225.
33. Gu Q, Moss RL:17-beta-Estradiol potentiates kainite-induced currents via activation of the cAMP cascade. J Neurosci 1996;16:3620-3629.
34. Watters JJ, Campbell JS, Cunningham MJ, Krebs EG, Dorsa DM: Rapid membrane effects of steroids in neuroblastoma cells: effects of estrogen on mitogen activated protein kinase signaling cascade and c-fos immediate early gene transcription. Endocrinology 1997;138:4030-4033.
35. Singh M, Setalo G Jr, Guan X, Warren M, Toran-Allerand CD: Estrogen-induced activation of mitogen-activated protein kinase in cerebral cortical explants: convergence of estrogen and neurotropin signaling pathways. J Neurosci 1999;19:1179-1188.
36. Setalo G Jr, Singh M, Nethrapalli IS, Toran-Allerand CD: Protein kinase C activity is necessary for estrogen-induced ERK phosphorylation in neocortical explants. Neurochem Res 2005;30:779-790.
37. Mannella P, Brinton RD: Estrogen receptor protein interaction with phosphatidylinositol 3-kinase leads to activation of phosphorylated Akt and extracellular signal-regulated kinase 1/2 in the same population of cortical neurons: a unified mechanism of estrogen action. J Neurosci 2006;26:9439-9447.
38. Dominguez R, Liu R, Baudry M: 17-Beta-estradiol-mediated activation of extracellular-signal regulated kinase, phosphatidylinositol 3-kinase/protein kinase B-Akt and N-methyl-D-aspartate receptor phosphorylation in cortical synaptoneurosomes. J Neurochem 2007;101:232-240.
39. Manthey D, Heck S, Engert S, Behl C: Estrogen induces a rapid secretion of amyloid beta precursor protein via the mitogen-activated protein kinase pathway. Eur J Biochem 2001;268:4285-4291.
40. Wu TW, Wang JM, Chen S, Brinton RD: 17Beta-estradiol induced Ca2+ influx via L-type calcium channels activates the Src/ ERK/cyclic-AMP response element binding protein signal pathway and BCL-2 expression in rat hippocampal neurons: a potential initiation mechanism for estrogen-induced neuroprotection. Neuroscience 2005;135:59-72.
41. Kuroki Y, Fukushima K, Kanda Y, Mizuno K, Watanabe Y: Putative membrane-bound estrogen receptors possibly stimulate mitogen-activated protein kinase in the rat hippocampus. Eur J Pharmacol 2000;400:205-209.
42. Bryant DN, Bosch MA, Ronnekleiv OK, Dorsa DM:17-Beta-estradiol rapidly enhances extracellular signal-regulated kinase 2 phosphorylation in the rat brain. Neuroscience 2005;133:343-352.
43. Honda K, Sawada H, Kihara T, Urushitani M, Nakamizo T, Akaike A, Shimohama S: Phosphatidylinositol-3-kinase mediates neuroprotection by estrogen in cultured cortical neurons. J Neurosci Res 2000;60:321-327.
44. Honda K, Shimohama S, Sawada S, Sawada H, Kihara T, Nakamizo T, Shibasaki H, Akailke A: Nongenomic antiapoptotic signal transduction by estrogen in cultured cortical neurons. J Neurosci Res 2001;64:466-475.
45. Wilson ME, Liu Y, Wise PM: Estradiol enhances Akt activation in cortical explant cultures following neuronal injury. Brain Res Mol Brain Res 2002;102:48-54.
46. Mermelstein PG, Becker JB, Surmeier DJ: Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor. J Neurosci 1996;16:595-604.
47. Huang Y, Huang YL, Zhang S, Zhu YC, Yao T: Estradiol acutely attenuates glutamate-induced calcium overload in primarily cultured rat hippocampal neurons through a membrane receptor-dependent mechanism. Brain Res 2004;1026:254-260.
48. Beyer C, Raab H: Nongenomic effects of oestrogen: embryonic mouse midbrain neurones respond with a rapid release of calcium from intracellular stores. Eur J Neurosci 1998;10:255-262.
49. 2+ rise and subsequent cyclic AMP response element-binding protein activation in hippocampal neurons: a potential initiation mechanism for estrogen neuroprotection. Neuroscience 2005;132:299-311.
50. Kelly MJ, Qiu J, Rønnekleiv OK: Estrogen modulation of G-protein-coupled receptor activation of potassium channels in the central nervous system. Ann NY Acad Sci 2003;1007:6-16.
51. Kelly MJ, Lagrange AH, Wagner EJ, Rønnekleiv OK: Rapid effects of estrogen to modulate G protein-coupled receptors via activation of protein kinase A and protein kinase C pathways. Steroids 1999;64:64-75.
52. Numakawa Y, Matsumoto T, Yokomaku D, Taguchi T, Niki E, Hatanaka H, Kunugi H, Numakawa T: 17Beta-estradiol protects cortical neurons against oxidative stress-induced cell death through reduction in the activity of mitogen-activated protein kinase and in the accumulation of intracellular calcium. Endocrinology 2007;148:627-637.
53. Guerra B, Diaz M, Alonso R, Marin R: Plasma membrane estrogen receptors mediates neuroprotection against beta-amyloid toxicity through activation of Raf-1/MEK/ERK cascade in septal-derived cholinergic SN56 neurons. J Neurochem 2004;91:99-109.
54. Kuroki Y, Fukushima K, Kanda Y, Mizuno K, Watanabe Y: Neuroprotection by estrogen via extracellular signal-regulated kinase against quinolinic acid-induced cell death in the rat hippocampus. Eur J Neurosci 2001;13:472-476.
55. Jover-Mengual T, Zukin RS, Etgen AM: MAPK signaling is critical to estradiol protection of CA1 neurons in global ischemia. Endocrinology 2007;148:1131-1143.
56. Wang R, Zhang QG, Han D, Xu J, Lu Q, Zhang GY: Inhibition of MLK3-MKK4/7-JNK1/2 pathway by Akt1 in exogenous estrogen-induced neuroprotection against transient global ischemia by a non-genomic mechanism in male rats. J Neurochem 2006;99:1543-1554.
57. Beyer C, Karolczak M: estrogenic stimulation of neurite growth in midbrain dopaminergic neurons depends on cAMP/protein kinase A signaling. J Neurosci Res 2000;59:107-116.
58. Mukai H, et al: Rapid modulation of long-term depression and spinogenesis via synaptic estrogen receptors in hippocampal principal neurons. J Neurochem 2007;100:950-967.
59. Khan MM, Dhandapani KM, Wakade C, De Sevilla LM, Mahesh VB, Brann DW: Regulation of synaptic proteins and spine density in the prefrontal and somatosensory cortex by 17b-estradiol: implications for synaptic remodeling in the brain. Program No. 405.12. 2005 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience; 2005; online.
60. Glidewell-Kenney C, Hurley LA, Pfaff L, Weiss J, Levine JE, Jameson JL: Nonclassical estrogen receptor alpha signaling mediates negative feedback in the female mouse reproductive axis. Proc Natl Acad Sci USA 2007;104:8173-8177.
61. McDevitt MA, Glidewell-Kenney C, Weiss J, Chambon P, Jameson JL Levine JE: Estrogen response element-independent estrogen receptor (ER)-alpha signaling does not rescue sexual behavior but restores normal testosterone secretion in male ERalpha knockout mice. Endocrinology 2007;148:5288-5294.
62. Carrer HF, Cambiasso MJ, Gorosito S: Effects of estrogen on neuronal growth and differentiation. J Steroid Biochem Mol Biol 2005;93:319-323.
63. Singo AS, Kito S: Estradiol induces PKA activation through the putative membrane receptor in the living hippocampal neuron. J Neural Transm 2005;112:1469-1473.
64. Beyer C, Raab H: Nongenomic effects of oestrogen: embryonic mouse midbrain neurons respond with a rapid release of calcium from intracellular stores. Eur J Neurosci 1998;10:255-262.
65. Micevych PE, Chaban V, Ogi J, Dewing P, Lu JK, Sinchak K: Estradiol stimulates progesterone synthesis in hypothalamic astrocyte cultures. Endocrinology 2007;148:782-789.
66. Qui J, Bosch MA, Tobias SC, Grandy DK, Scanlan TS, Ronnekleiv OK, Kelly MJ: Rapid signaling of estrogen in hypothalamic neurons involves a novel G-protein-coupled estrogen receptor that activates protein kinase C. J Neurosci 2003;23:9529-9540.
67. Stevis PE, Deecher DC, Suhadolnik L, Mallis LM, Frail DE: Differential effects of estradiol and estradiol-BSA conjugates. Endocrinology 1999;140:5455-5458.
68. Taguchi Y, Koslowski M, Bodenner DL: Binding of estrogen receptor with estrogen conjugated to bovine serum albumin (BSA). Nucl Recept 2004;19:5.
69. Harrington WR, Kim SH, Funk CC, Madak-Erdogan Z, Schiff R, Katzenellenbogen JA, Katzenellenbogen BS: Estrogen dendrimer conjugates that preferentially activate extranuclear, nongenomic versus genomic pathways of estrogen action. Mol Endocrinol 2006;20:491-502.
70. Vasudevan N, Pfaff DW: Molecular mechanisms of crosstalk between thyroid hormones and estrogens. Curr Opin Endocrinol Diabetes 2005;12:381-388.
71. Vasudevan N, Pfaff DW: Membrane-initiated actions of estrogens in neuroendocrinology: emerging principles. Endocrine Rev 2007;28:1-19.
72. Rai D, Frolova A, Frasor J, Carpenter AE, Katzenellenbogen BS: Distinctive actions of membrane-targeted versus nuclear localized estrogen receptors in breast cancer cells. Mol Endocrinol 2005;19:1606-1617.
73. Vasudevan N, Kow LM, Pfaff DW: Early membrane estrogenic effects required for full expression of slower genomic actions in a nerve cell line. Proc Natl Acad Sci USA 2001;98:12267-12271.
74. Kow LM, Pfaff DW: The membrane actions of estrogens can potentiate their lordosis behavior-facilitating genomic actions. Proc Natl Acad Sci USA 2004;101:12354-12357.
75. Milner TA, McEwen BS, Hayashi S, Li CJ, Reagan LP, Alves SE: Ultrastructural evidence that hippocampal alpha estrogen receptors are located at extranuclear sites. J Comp Neurol 2001;429:355-371.
76. Milner TA, Ayoola K, Drake CT, Herrick SP, Tabori NE, McEwen BS, Warrier S, Alves SE: Ultrastructural localization of estrogen receptor beta immunoreactvity in the rat hippocampal formation. J Comp Neurol 2005;491:81-95.
77. Romeo RD, McCarthy JB, Wang A, Milner TA, McEwen BS: Sex differences in hippocampal estradiol-induced N-methyl-D-aspartic cid binding and ultrastructural localization of estrogen receptor-alpha. Neuroendocrinology 2005;81:391-399.
78. Marin R, Guerra B, Morales A, Diaz M, Alonso R: An oestrogen membrane receptor participates in estradiol actions for the prevention of amyloid-beta peptide1-40-induced toxicity in septal-derived cholinergic SN56 cells. J Neurochem 2003;85:1180-1189.
79. Marin R, Guerra B, Morales A, Diaz M, Alonso R: An ICI 182,780-sensitive, membrane-related estrogen receptor contributes to estrogenic neuroprotective actions against amyloid-beta toxicity. Ann NY Acad Sci 2003;1007:108-116.
80. Xu Y, Traystman RJ, Hurn PD, Wang MM: Neurite-localized estrogen receptor-alpha mediates rapid signaling by estrogen. J Neurosci Res 2003;74:1-11.
81. Toran-Allerand CD, Guan X, Maclusky NJ, Horvath TL, Dino S, Singh M, Connolly ES Jr, Nethrapalli IS, Tinnikov AA: ER-X: a novel, plasma membrane-associated, putative estrogen receptor that is regulated during development and afer ischemic brain injury. J Neurosci 2002;22:8391-8401.
82. Acconcia F, Ascenzi P, Fabozzi G, Visca P, Marino M: S-pamiltoylation modulates human estrogen receptor-alpha functions. Biochem Biophys Re Communi 2004;316:878-883.
83. Acoconcia F, Ascenzi P, Bocedi A, Spisni E, Tomasi V, Trentalance A, Visca P, Marino M: palmitoylation-dependent estrogen receptor-a membrane localization: regulation by 17 β-estradiol. Mol Biol Cell 2005;16:231-237.
84. Pedram A, Razandi M, Sainson RC, Kim JK, Hughes CC, Levin ER: A conserved mechanism for steroid receptor translocation to the plasma membrane. J Biol Chem 2007;282:22278-22288.
85. 2+ signaling in mouse dorsal root ganglion neurons. J Neurosci Res 2005;81:3-37.
86. Abraham IM, Han SK, Todman MG, Korach KS, Herbison AE: estrogen receptor beta mediates rapid estrogen actions on gonadotropin-releasing hormone neurons in vivo. J Neurosci 2003;23:5771-5777.
87. Abraham IM, Todman MG, Koeach KS, Herbison AE: Critical in vivo roles for classical estrogen receptors in rapid estrogen actions on intracellular signaling in mouse brain. Endocrinology 2004;145:3055-3061.
88. Singh M, Setalo G Jr, Guan X, Frail DE, Toran-Allerand CD: Estrogen-induced activation of mitogen-activated protein kinase cascade in the cerebral cortex of estrogen receptor-alpha knock-out mice. J Neurosci 2000;20:1694-1700.
89. Dominguez-Salazar E, Shetty S, Rissman EF: Rapid neural Fos responses to oestradiol in oestrogen receptor alphabeta double knockout mice. J Neuroendocrinol 2006;18:195-202.
90. Carmeci C, Thompson DA, Ring HZ, Francke U, Weigel RJ: Identification of a gene (GPR30) with homology to the G-protein-coupled receptor superfamily associated with estrogen receptor expression in breast cancer. Genomics 1997;45:607-617.
91. Filardo EJ, Quinn JA, Bland KI, Frackelton AR Jr: Estrogen-induced activation of ERK-1 and ERK-2 requires G-protein coupled receptor homolog, GPR30, and occurs via transactivation of the epidermal growth factor receptor through release of HB-EGF. Mol Endocrinol 2000;14:1649-1660.
92. Revankar CM, Cimino DF, Sklar LA, Arterburn JB, Prossnitz ER: A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science 2005;307:1625-1630.
93. Filardo EJ, Thomas P: GPR30: a seven-transmembrane-spanning estrogen receptor that triggers EGF release. Trends Endocrinol Metab 2005;16:363-367.
94. Thomas P, Pang Y, Filardo EJ, Dong J: Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology 2005;146:624-632.
95. Khan MM, De Sevilla LM, Hadman M, Brann DW: Cellular and subcellular organization of a novel G-protein coupled estrogen receptor (GPR30) in brain: implication for synaptic functions. Program No. 659.19. 2006 Neuroscience Meeting Planner. Atlanta, Society for Neuroscience, 2006; online.
96. Funakoshi T, Yanai A, Shinoda K, Kawano MM, Mizukami Y: G protein-coupled receptor 30 is an estrogen receptor in the plasma membrane. Biochem Biophys Res Commun 2006;346:904-910.
97. Pedram A, Razandi M, Levin ER: Nature of functional estrogen receptors at the plasma membrane. Mol Endocrinol 2006;20:1996-2009.
98. Brailiou E, Dun SL, Brailou GC, Mizou K, Sklar LA, Oprea TI, Prossnitz ER, Dun NJ: distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system. J Endocrinol 2007;193:311-321.
99. i -coupled plasma membrane estrogen receptors in immortalized gonadotropin-releasing hormone neurons. Mol Endocrinol 2003;17:1792-1804.
100. Ronnekleiv OK, Kelly MJ: Diversity of ovarian steroid signaling in the hypothalamus. Front Neuroendocrinol 2005;26:65-84.
101. Vadlamudi RK, Wang RK, Mazumdar A, Kim Y, Shin J, Sahin A, Kumar R: Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor-a. J Biol Chem 2001;276:38272-38279.
102. Wong CW, McNally C, Nickbarg E, Komm BS, Cheskis BJ: Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src-Erk phosphorylation cascade. Proc Natl Acad Sci USA 2002;99:14783-14788.
103. Khan MM, Hadman M, Wakade C, De Sevilla LM, Dhandapani KM, Mahesh VB, Vadlamudi RK, Brann DW: Cloning, expression, and localization of MNAR/PELP1 in rodent brain: colocalization in estrogen receptor-alpha but not in gonadotropin-releasing hormone-positive neurons. Endocrinology 2005;146:5215-5227.
104. Lu Q, Pallas DC, Surks HK, Baur WE, Mendelsohn ME, Karas RH: Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha. Proc Natl Acad Sci USA 2004;101:17126-17131.
105. Cabodi S, Moro L, Baj G, Smeriglio M, Di Stefano P, Gippone S, Surico N, Silengo L, Turco E, Tarone G, Defilippi P: P130Cas interacts with estrogen receptor alpha and modulates non-genomic estrogen signaling in breast cancer cells. J Cell Sci 2004;117:1603-1611.
106. Khan MM, Hadman M, De Sevilla LM, Mahesh VB, Buccafusco J, Hill WD, Brann WB: Cloning, distribution, and colocalization of MNAR/PELP1 with glucocorticoid receptors in primate and nonprimate brain. Neuroendocrinology 2006;84:317-329.
107. Vadlamudi RK, Kumar R: Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR. Nucl Recept Signal 2007;5:e004.
108. Greger JG, Fursov N, Cooch N, Mclarney S, Freedman LP, Edwards DP, Cheskis BJ: phosphorylation of MNAR promotes estrogen activation of phosphatidylinositol 3-kinase. Mol Cell Biol 2007;27:1904-1913.
109. Castets F, Bartoli M, Barnier JV, Baillat G, Salin P, Moqrich A, Bourgeois JP, Denizot F, Rougon G, Calothy G, Monneron A: A novel calmodulin-binding protein, belonging to the WD-repeat family, is localized in dendrites of a subset of CNS neurons. J Cell Biol 1996;134:1051-1062.
110. Moqrich A, Mattei MG, Bartoli M, Rakitina T, Baillat G, Monneron A, Castets F: Cloning of human striatin cDNA (STRN), gene mapping to 2p22-p21, and preferential expression in brain. Genomics 1998;51:136-139.
111. Gaillard S, Bailly Y, Benoist M, Rakitina T, Kessler JP, Fronzaroli-Molinières L, Dargent B, Castets F: Targeting of proteins of the striatin family to dendritic spines: role of the coiled-coil domain. Traffic 2006;7:74-84.
112. Salin P, Kachidian P, Bartoli M, Castets F: Distribution of striatin, a newly identified calmodulin-binding protein in the rat brain: an in situ hybridization and immunocytochemical study. J Comp Neurol 1998;397:41-59.
113. Bartoli M, Monneron A, Ladant D: Interaction of calmodulin with striatin, a WD-repeat protein present in neuronal dendritic spines. J Biol Chem 1998;273:22248-22253.
114. Castets F, Rakitina T, Gaillard S, Moqrich A, Mattei MG, Monneron A: Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain. J Biol Chem 2000;275:19970-19977.
115. Kachidian P, Vuillet J, Bartoli M, Castets F, Nieoullon A, Kerkerian-Le Goff L: Relationships between striatin-containing neurons and cortical or thalamic afferent fibers in the rat striatum: an ultrastructural study by dual labeling. Neuroscience 1998;85:111-122.
116. Benoist M, Gaillard S, Castets F: The striatin family: a new signaling platform in dendritic spines. J Physiol Paris 2006;99:146-153.
117. Raz L, Khan MM, De Sevilla LM, Brann DW: Expression and distribution of estrogen receptor interacting proteins p130Cas and striatin in female rat brain. Program No. 625.12.2007 Neuroscience Meeting Planner. San Diego, Society for Neuroscience, 2007; online.
118. Razandi M, Oh P, Pedram A, Schnitzer J, Levin ER: ERs associate with and regulate the production of caveolin: implications for signaling and cellular actions. Mol Endocrinol 2002;16:100-115.
119. Gilad LA, Schwartz B: Association of estrogen receptor beta with plasma-membrane caveola components: implication in control of vitamin D receptor. J Mol Endocrinol 2007;38:603-618.
120. Li T, Sotgia F, Vuolo MA, Li M, Yang WC, Pestell RG, Sparano JA, Lisanti MP: Caveolin-1 mutations in human breast cancer: functional association with estrogen receptor alpha-positive status. Am J Pathol 2006;168:1998-2013.
121. Evinger AJ 3rd, Levin ER: Requirements for estrogen receptor alpha membrane localization and function. Steroids 2005;70:361-363.
122. Sakai R, Iwamatsu A, Hirano N, Ogawa S, Tanaka T, Mano H, Yazaki Y, Hirai H: A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. EMBO J 1994;13:3748-3756.
123. Wisniewska M, Bossenmaier B, Georges G, Hesse F, Dangl M, Künkele KP, Ioannidis I, Huber R, Engh RA: The 1.1 A resolution crystal structure of the p130cas SH3 domain and ramifications for ligand selectivity. J Mol Biol 2005;347:1005-1014.
124. Nasertorabi F, Garcia-Guzman M, Briknarová K, Larsen E, Havert ML, Vuori K, Ely KR: Organization of functional domains in the docking protein p130Cas. Biochem Biophys Res Commun 2004;324:993-998.
125. Bargon SD, Gunning PW, O'Neill GM: The Cas family docking protein, HEF1, promotes the formation of neurite-like membrane extensions. Biochim Biophys Acta 2005;1746:143-154.
126. Vuori K, Hirai H, Aizawa S, Ruoslahti E: Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases. Mol Cell 1996;16:2606-2613.
127. Liu G, Li W, Gao X, Li X, Jürgensen C, Park HT, Shin NY, Yu J, He ML, Hanks SK, Wu JY, Guan KL, Roa Y: P130 cas is required for netrin signaling and commissural axon guidance. J Neurosci 2007;27:957-968.
128. Modzelewska K, Newman LP, Desai R, Keely PJ: Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas. J Biol Chem 2006;281:37527-37535.
129. Etienne S, Adamson P, Greenwood J, Strosberg AD, Cazaubon S, Couraud PO: ICAM-1 signaling pathways associated with Rho activation in microvascular brain endothelial cells. J Immunol 1998;161:5755-5761.