The 1.1 Å resolution crystal structure of the p130cas SH3 domain and ramifications for ligand selectivity

Journal of Molecular Biology

Volumn 347, Issue 5, 2005, Pages 1005-1014

  Wisniewska, Magdalena ^a   Bossenmaier, Birgit ^b   Georges, Guy ^b   Hesse, Friederike ^b   Dangl, Markus ^b   Künkele, Klaus Peter ^b   Ioannidis, Ioannis ^b   Huber, Robert ^a   Engh, Richard A ^a,b  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b ROCHE DIAGNOSTICS GMBH   (Germany)

Author keywords

Focal adhesion kinase; p130cas; Proline rich motif; SH3 domain

Indexed keywords

CRK ASSOCIATED SUBSTRATE PROTEIN; PROTEIN; UNCLASSIFIED DRUG; BCAR1 PROTEIN, HUMAN; FOCAL ADHESION KINASE; FOCAL ADHESION KINASE 1; LIGAND; PROTEIN P130; PROTEIN TYROSINE KINASE; PTK2 PROTEIN, HUMAN; WATER;

AMINO ACID COMPOSITION; ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; CRYSTALLIZATION; LIGAND BINDING; MOLECULAR MODEL; PRIORITY JOURNAL; SRC HOMOLOGY DOMAIN; X RAY CRYSTALLOGRAPHY; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; HUMAN; HYDROGEN BOND; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; CRK-ASSOCIATED SUBSTRATE PROTEIN; CRYSTALLOGRAPHY, X-RAY; FOCAL ADHESION KINASE 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; HYDROGEN BONDING; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN-TYROSINE KINASES; PROTEINS; RETINOBLASTOMA-LIKE PROTEIN P130; SEQUENCE ALIGNMENT; SRC HOMOLOGY DOMAINS; SUBSTRATE SPECIFICITY; WATER;

EID: 15244351022     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2005.02.017     Document Type: Article

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