Putative membrane-bound estrogen receptors possibly stimulate mitogen-activated protein kinase in the rat hippocampus

European Journal of Pharmacology

Volumn 400, Issue 2-3, 2000, Pages 205-209

  Kuroki, Yasutomi ^a   Fukushima, Kouji ^a   Kanda, Yasunari ^a   Mizuno, Katsushige ^a   Watanabe, Yasuhiro ^a  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

Author keywords

ERK (extracellular signal regulated kinase); Estrogen; Hippocampus, rat; Non genomic effect

Indexed keywords

BOVINE SERUM ALBUMIN; ESTRADIOL; ESTROGEN RECEPTOR; FULVESTRANT; MITOGEN ACTIVATED PROTEIN KINASE; TAMOXIFEN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CELL MEMBRANE; CELL NUCLEUS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATORS; ESTRADIOL; ESTROGEN RECEPTOR MODULATORS; HIPPOCAMPUS; MALE; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ESTROGEN; TAMOXIFEN;

EID: 0034698358     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00425-8     Document Type: Article

References (16)

1. Aronica S.M., Kraus W.L., Katzenellenbogen B.S. Estrogen action via the cAMP signaling pathway: stimulation of adenylate cyclase and cAMP-regulated gene transcription. Proc. Natl. Acad. Sci. U. S. A. 91:1994;8517-8521.
2. Behl C., Widmann M., Trapp T., Holsboer F. 17-β-Estradiol protects neurons from oxidative stress-induced cell death in vitro. Biochem. Biophys. Res. Commun. 216:1995;473-482.
3. Chen J., Adachi N., Liu K., Arai T. The effects of 17β-estradiol on ischemia-induced neuronal damage in the gerbil hippocampus. Neuroscience. 87:1998;817-822.
4. Emerson C.S., Headrick J.P., Vink R. Estrogen improves biochemical and neurologic outcome following traumatic brain injury in male rats, but not in females. Brain Res. 608:1993;95-100.
5. Endoh H., Sasaki H., Maruyama K., Takeyama K., Waga I., Shimizu T., Kato S., Kawashima H. Rapid activation of MAP kinase by estrogen in the bone cell line. Biochem. Biophys. Res. Commun. 235:1997;99-102.
6. Goodman Y., Bruce A.J., Cheng B., Mattson M.P. Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid β-peptide toxicity in hippocampal neurons. J. Neurochem. 66:1996;1836-1844.
7. Green P.S., Gridley K.E., Simpkins J.W. Estradiol protects against β-amyloid (25-35)-induced toxicity in SK-N-SH human neuroblastoma cells. Neurosci. Lett. 218:1996;165-168.
8. Gu Q., Moss R.L. 17β-Estradiol potentiates kainate-induced currents via activation of the cAMP cascade. J. Neurosci. 16:1996;3620-3629.
9. Matsuda S., Kadowaki Y., Ichino M., Akiyama T., Toyoshima K., Yamamoto T. 17β-Estradiol mimics ligand activity of the c-erbB2 protooncogene product. Proc. Natl. Acad. Sci. U. S. A. 90:1993;10803-10807.
10. ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells. EMBO J. 15:1996;1292-1300.
11. Ohkura T., Isse K., Akazawa K., Hamamoto M., Yaoi Y., Hagino N. Evaluation of estrogen treatment in female patients with dementia of the Alzheimer type. Endocr. J. 41:1994;361-371.
12. Pappas T.C., Gametchu B., Watson C.S. Membrane estrogen receptors identified by multiple antibody labeling and impeded-ligand binding. FASEB J. 9:1995;404-410.
13. Simpkins J.W., Singh M., Bishop J. The potential role for estrogen replacement therapy in the treatment of the cognitive decline and neurodegeneration associated with Alzheimer's disease. Neurobiol. Aging. Suppl. 15:1994;195-197.
14. Singer C.A., Figueroa-Masot X.A., Batchelor R.H., Dorsa D.M. The mitogen-activated protein kinase pathway mediates estrogen neuroprotection after glutamate toxicity in primary cortical neurons. J. Neurosci. 19:1999;2455-2463.
15. Singh M., Sétáló G. Jr., Guan X., Warren M., Toran-Allerand C.D. Estrogen-induced activation of mitogen-activated protein kinase in cerebral cortical explants: convergence of estrogen and neurotrophin signaling pathways. J. Neurosci. 19:1999;1179-1188.
16. Watters J.J., Campbell J.S., Cunningham M.J., Krebs E.G., Dorsa D.M. Rapid membrane effects of steroids in neuroblastoma cells: effects of estrogen on mitogen activated protein kinase signalling cascade and c-fos immediate early gene transcription. Endocrinology. 138:1997;4030-4033.